GSE27394
GSE GEODisrupted processing of long pre-mRNAs and widespread RNA missplicing are components of neuronal vulnerability from loss of nuclear TDP-43
Organism:
Mus musculus
Platform:
GPL9250
Samples:
29
Experiment Types:
Genome binding/occupancy profiling by array
Genome binding/occupancy profiling by high throughput sequencing
Submitted:
Feb 17 2011
Last Updated:
May 15 2019
Status:
Public on Mar 03 2011
Contact:
Gene,,Yeo (UCSD)
Relations
SuperSeries of: GSE27201
SuperSeries of: GSE27218
SuperSeries of: GSE27371
BioProject: https://www.ncbi.nlm.nih.gov/bioproject/PRJNA137005
Summary
This SuperSeries is composed of the SubSeries listed below.
Overall Design
Refer to individual Series
Analysis (1 step)
View Data Processing
Processing steps for GSE27394
- Sequenced reads were trimmed for adaptor sequence, and masked for low-complexity or low-quality sequence, then mapped to mm8 whole genome using bowtie v0.12.2 with parameters -q -p 4 -e 100 -y -a -m 10 --best --strata
Supplementary Files (1)
GSE27394_RAW.tar
Download
GEO Samples (29)
Dataset Citations (1)
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.
PMID 21358643
· 2011
· Nature neuroscience
Magdalini Polymenidou, Clotilde Lagier-Tourenne, Kasey R Hutt, Stephanie C Huelga, Jacqueline Moran, Tiffany Y Liang, Shuo-Chien Ling, Eveline Sun, Edward Wancewicz, Curt Mazur, Holly Kordasiewicz, Yalda Sedaghat, John Paul Donohue, Lily Shiue, C Frank Bennett, Gene W Yeo, Don W Cleveland
Linked Publications (2)
Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis.
Acta neuropathologica · 2022
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.
Nature neuroscience · 2011