GSE110701

GSE GEO

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Disruption in A-to-I editing levels affects C. elegans development more than a complete lack of editing

Organism: 6239

Platform: GPL18245

Samples: 42

Experiment Types:

Expression profiling by high throughput sequencing Other

Submitted: Feb 15 2018

Last Updated: Feb 11 2026

Status: Public on Apr 22 2019

Contact: Ayelet,,Lamm (Technion)

Relations

BioProject: https://www.ncbi.nlm.nih.gov/bioproject/PRJNA434314 SRA: https://www.ncbi.nlm.nih.gov/sra?term=SRP132953

Summary

A-to-I RNA editing is widespread in eukaryotic transcriptomes and plays an essential role in the creation of proteomic and phenotypic diversity. Loss of ADARs, the proteins responsible for A-to-I editing, results in lethality in mammals. In C. elegans, knocking out both ADARs, ADR-1 and ADR-2, results in aberrant behavior and abnormal development. Studies have shown that ADR-2 can actively deaminate dsRNA while ADR-1 cannot. However, as most studies of C. elegans ADARs were performed on worms mutated in both ADAR genes, the effects observed cannot be attributed to a single ADAR or to the interactions between ADAR genes. Therefore, we set to study the effects of each C. elegans ADAR on RNA editing, gene expression, protein levels and the contribution of each of ADAR to the phenotypes observed in worms mutated in both genes, in order to elucidate their distinct functions. We found significant differences in the phenotypes observed in worms mutated in a single ADAR gene. Worms harboring adr-1 mutations have a significant reduction in their lifespan, while worms harboring adr-2 mutations have extended lifespan. We also observed severe abnormalities in vulva formation mainly in adr-1 mutants, and we suggest that these phenotypes are a result of an RNA editing independent function of ADR-1. Mutations in each ADAR resulted in expressional changes in hundreds of genes, and a significant downregulation of edited genes. However, very few changes in the protein levels were observed. In addition, we found that ADR-1 binds many edited genes. Our results suggest that ADR-1 has a significant function in the RNA editing process and by altering editing levels it causes the severe phenotypes that we observed. In contrast, a complete lack of RNA editing is less harmful to the worms. Furthermore, our results indicate that the effect of RNA editing on the protein content in the cell is minor and probably the main purpose of these modifications is to antagonize or enhance other gene regulatory mechanisms that act on RNA.

Overall Design

RNA was extracted from wildtype C. elegans synchronized to embryo or L4 larval stage. For each stage, 3 independent biological replica RNA samples were used for construction of mRNA libraries.

Analysis (7 steps)

View Data Processing

Processing steps for GSE110701

Filter sequences with irrelevant barcodes
Split relevant sequences by barcode
Remove the linker from each sequence.
Trim additional 3 bases.
Merge identical reads.
Sequences were aligned to gene transcripts using Bowtie, aloowing multiple alignments.
DEseq package in R (http://www.r-project.org) was used from the data obtained from bowtie to identify differentially expressed genes.

Supplementary Files (3)

GSE110701_Supp_Table2.xlsx Download

GSE110701_Supp_Table3.xlsx Download

GSE110701_Supp_Table5.xlsx Download

GEO Samples (42)

GSM3014729 GSM3014730 GSM3014731 GSM3014732 GSM3014733 GSM3014734 GSM3014735 GSM3014736 GSM3014737 GSM3014738 GSM3014739 GSM3014740 GSM3014741 GSM3014742 GSM3014743 GSM3014744 GSM3014745 GSM3014746 GSM3014747 GSM3014748 GSM3014749 GSM3014750 GSM3014751 GSM3014752 GSM3014753 GSM3014754 GSM3014755 GSM3014756 GSM3014757 GSM3014758 GSM3014759 GSM3014760 GSM3014761 GSM3014762 GSM3014763 GSM3014764 GSM3014765 GSM3014766 GSM3014767 GSM3014768 GSM3014769 GSM3014770

Dataset Citations (2)

Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing.

PMID 31018137 · 2019 · Cell reports

Nabeel S Ganem, Noa Ben-Asher, Aidan C Manning, Sarah N Deffit, Michael C Washburn, Emily C Wheeler, Gene W Yeo, Orna Ben-Naim Zgayer, Einav Mantsur, Heather A Hundley, Ayelet T Lamm

PubMed citation (PMID 40909659)

SRA Experiments (42) and Runs (42)

Total: 50143 MB

SRX3712664 SRP132953 RNA-Seq SINGLE

GSM3014729: BB19_embryo_1_131216_CGATGT; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971161

BioProject: PRJNA434314

BioSample: SAMN08553260

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: BB19

Stage: Embryo

bio replicate no: 1

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739731	79864313	4073079963	1387.77	BB19_embryo_1_131216_CGATGT.fastq.gz, SRR6739731, SRR6739731.sralite	SRA

SRX3712665 SRP132953 RNA-Seq SINGLE

GSM3014730: BB19_embryo_2_051216_TTAGGC; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971162

BioProject: PRJNA434314

BioSample: SAMN08553259

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: BB19

Stage: Embryo

bio replicate no: 2

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739732	74016026	3774817326	1286.69	BB19_embryo_2_051216_TTAGGC.fastq.gz, SRR6739732, SRR6739732.sralite	SRA

SRX3712666 SRP132953 RNA-Seq SINGLE

GSM3014731: BB19_embryo_310816_TTAGGC; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971163

BioProject: PRJNA434314

BioSample: SAMN08553258

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: BB19

Stage: Embryo

bio replicate no: 3

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739733	63438262	3235351362	1016.14	BB19_embryo_310816_TTAGGC.fastq.gz, SRR6739733, SRR6739733.sralite	SRA

SRX3712667 SRP132953 RNA-Seq SINGLE

GSM3014732: BB19_L4_220816_GCCAAT; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971164

BioProject: PRJNA434314

BioSample: SAMN08553257

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: BB19

Stage: L4

bio replicate no: 1

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739734	78938779	4025877729	1313.68	BB19_L4_220816_GCCAAT.fastq.gz, SRR6739734, SRR6739734.sralite	SRA

SRX3712668 SRP132953 RNA-Seq SINGLE

GSM3014733: BB19_L4_6_10_16_TAGCTT; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971165

BioProject: PRJNA434314

BioSample: SAMN08553256

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: BB19

Stage: L4

bio replicate no: 2

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739735	73820492	3764845092	1313.61	BB19_L4_6_10_16_TAGCTT.fastq.gz, SRR6739735, SRR6739735.sralite	SRA

SRX3712669 SRP132953 RNA-Seq SINGLE

GSM3014734: BB19_L4_Ayya_GGCTAC; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971166

BioProject: PRJNA434314

BioSample: SAMN08553255

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: BB19

Stage: L4

bio replicate no: 3

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739736	66899129	3411855579	1186.58	BB19_L4_Ayya_GGCTAC.fastq.gz, SRR6739736, SRR6739736.sralite	SRA

SRX3712670 SRP132953 RNA-Seq SINGLE

GSM3014735: BB2_E_18_12_16_CAGATC; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971167

BioProject: PRJNA434314

BioSample: SAMN08553254

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: BB2

Stage: Embryo

bio replicate no: 1

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739737	70492238	3595104138	1280.04	BB2_E_18_12_16_CAGATC.fastq.gz, SRR6739737, SRR6739737.sralite	SRA

SRX3712671 SRP132953 RNA-Seq SINGLE

GSM3014736: BB2_embryo_070916_TTAGGC; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971168

BioProject: PRJNA434314

BioSample: SAMN08553253

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: BB2

Stage: Embryo

bio replicate no: 2

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739738	75709388	3861178788	1263.21	BB2_embryo_070916_TTAGGC.fastq.gz, SRR6739738, SRR6739738.sralite	SRA

SRX3712672 SRP132953 RNA-Seq SINGLE

GSM3014737: BB2_L4_221216_ACAGTG; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971169

BioProject: PRJNA434314

BioSample: SAMN08553252

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: BB2

Stage: L4

bio replicate no: 1

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739739	78708259	4014121209	1368.61	BB2_L4_221216_ACAGTG.fastq.gz, SRR6739739, SRR6739739.sralite	SRA

SRX3712673 SRP132953 RNA-Seq SINGLE

GSM3014738: BB2_L4_230816_CAGATC; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971170

BioProject: PRJNA434314

BioSample: SAMN08553251

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: BB2

Stage: L4

bio replicate no: 2

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739740	67505926	3442802226	1127.73	BB2_L4_230816_CAGATC.fastq.gz, SRR6739740, SRR6739740.sralite	SRA

SRX3712674 SRP132953 RNA-Seq SINGLE

GSM3014739: BB2_L4_Ayya_ATCACG; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971171

BioProject: PRJNA434314

BioSample: SAMN08553250

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: BB2

Stage: L4

bio replicate no: 3

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739741	65348107	3332753457	1165.18	BB2_L4_Ayya_ATCACG.fastq.gz, SRR6739741, SRR6739741.sralite	SRA

SRX3712675 SRP132953 RNA-Seq SINGLE

GSM3014740: BB3_E_19_12_16_GATCAG; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971172

BioProject: PRJNA434314

BioSample: SAMN08553249

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: BB3

Stage: Embryo

bio replicate no: 1

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739742	65297564	3330175764	1182.24	BB3_E_19_12_16_GATCAG.fastq.gz, SRR6739742, SRR6739742.sralite	SRA

SRX3712676 SRP132953 RNA-Seq SINGLE

GSM3014741: BB3_embryo_011216_TAGCTT; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971173

BioProject: PRJNA434314

BioSample: SAMN08553248

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: BB3

Stage: Embryo

bio replicate no: 2

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739743	75822071	3866925621	1324.68	BB3_embryo_011216_TAGCTT.fastq.gz, SRR6739743, SRR6739743.sralite	SRA

SRX3712677 SRP132953 RNA-Seq SINGLE

GSM3014742: BB3_embryo_230816_ACAGTG; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971174

BioProject: PRJNA434314

BioSample: SAMN08553247

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: BB3

Stage: Embryo

bio replicate no: 3

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739744	77664892	3960909492	1290.7	BB3_embryo_230816_ACAGTG.fastq.gz, SRR6739744, SRR6739744.sralite	SRA

SRX3712678 SRP132953 RNA-Seq SINGLE

GSM3014743: BB3_L4_10_10_16_ACTTGA; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971175

BioProject: PRJNA434314

BioSample: SAMN08553246

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: BB3

Stage: L4

bio replicate no: 1

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739745	63661280	3246725280	1156.65	BB3_L4_10_10_16_ACTTGA.fastq.gz, SRR6739745, SRR6739745.sralite	SRA

SRX3712679 SRP132953 RNA-Seq SINGLE

GSM3014744: BB3_L4_160816_GATCAG; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971181

BioProject: PRJNA434314

BioSample: SAMN08553245

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: BB3

Stage: L4

bio replicate no: 2

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739746	80329959	4096827909	1335.52	BB3_L4_160816_GATCAG.fastq.gz, SRR6739746, SRR6739746.sralite	SRA

SRX3712680 SRP132953 RNA-Seq SINGLE

GSM3014745: BB3_L4_Ayya_CTTGTA; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971176

BioProject: PRJNA434314

BioSample: SAMN08553244

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: BB3

Stage: L4

bio replicate no: 3

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739747	73044631	3725276181	1299.27	BB3_L4_Ayya_CTTGTA.fastq.gz, SRR6739747, SRR6739747.sralite	SRA

SRX3712681 SRP132953 RNA-Seq SINGLE

GSM3014746: N2_E_15_12_16_CGATGT; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971177

BioProject: PRJNA434314

BioSample: SAMN08553243

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: N2

Stage: Embryo

bio replicate no: 1

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739748	72456264	3695269464	1288.12	N2_E_15_12_16_CGATGT.fastq.gz, SRR6739748, SRR6739748.sralite	SRA

SRX3712682 SRP132953 RNA-Seq SINGLE

GSM3014747: N2_E_15_9_16_CGATGT; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971178

BioProject: PRJNA434314

BioSample: SAMN08553242

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: N2

Stage: Embryo

bio replicate no: 2

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739749	68486787	3492826137	1241.6	N2_E_15_9_16_CGATGT.fastq.gz, SRR6739749, SRR6739749.sralite	SRA

SRX3712683 SRP132953 RNA-Seq SINGLE

GSM3014748: N2_embryo_111216_TAGCTT; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971179

BioProject: PRJNA434314

BioSample: SAMN08553241

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: N2

Stage: Embryo

bio replicate no: 3

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739750	77891916	3972487716	1297.59	N2_embryo_111216_TAGCTT.fastq.gz, SRR6739750, SRR6739750.sralite	SRA

SRX3712684 SRP132953 RNA-Seq SINGLE

GSM3014749: N2_embryo_230816_ATCACG; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971180

BioProject: PRJNA434314

BioSample: SAMN08553240

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: N2

Stage: Embryo

bio replicate no: 4

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739751	67904007	3463104357	1080.85	N2_embryo_230816_ATCACG.fastq.gz, SRR6739751, SRR6739751.sralite	SRA

SRX3712685 SRP132953 RNA-Seq SINGLE

GSM3014750: N2_L4_18_9_16_ATCACG; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971189

BioProject: PRJNA434314

BioSample: SAMN08553239

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: N2

Stage: L4

bio replicate no: 1

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739752	60486009	3084786459	1101.54	N2_L4_18_9_16_ATCACG.fastq.gz, SRR6739752, SRR6739752.sralite	SRA

SRX3712686 SRP132953 RNA-Seq SINGLE

GSM3014751: N2_L4_220816_ATCACG; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971182

BioProject: PRJNA434314

BioSample: SAMN08553238

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: N2

Stage: L4

bio replicate no: 2

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739753	75681138	3859738038	1261.47	N2_L4_220816_ATCACG.fastq.gz, SRR6739753, SRR6739753.sralite	SRA

SRX3712687 SRP132953 RNA-Seq SINGLE

GSM3014752: N2_L4_AYYA_TTAGGC; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971183

BioProject: PRJNA434314

BioSample: SAMN08553237

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: N2

Stage: L4

bio replicate no: 3

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739754	61395795	3131185545	1114.16	N2_L4_AYYA_TTAGGC.fastq.gz, SRR6739754, SRR6739754.sralite	SRA

SRX3712688 SRP132953 RNA-Seq SINGLE

GSM3014753: RB886_E_11_9_16_ACAGTG; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971184

BioProject: PRJNA434314

BioSample: SAMN08553236

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: RB886

Stage: Embryo

bio replicate no: 1

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739755	69764561	3557992611	1263.43	RB886_E_11_9_16_ACAGTG.fastq.gz, SRR6739755, SRR6739755.sralite	SRA

SRX3712689 SRP132953 RNA-Seq SINGLE

GSM3014754: RB886_E_15_12_16_TTAGGC; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971185

BioProject: PRJNA434314

BioSample: SAMN08553235

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: RB886

Stage: Embryo

bio replicate no: 2

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739756	70218593	3581148243	1249.47	RB886_E_15_12_16_TTAGGC.fastq.gz, SRR6739756, SRR6739756.sralite	SRA

SRX3712690 SRP132953 RNA-Seq SINGLE

GSM3014755: RB886_embryo_110916_CGATGT; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971186

BioProject: PRJNA434314

BioSample: SAMN08553234

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: RB886

Stage: Embryo

bio replicate no: 3

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739757	76325488	3892599888	1270.72	RB886_embryo_110916_CGATGT.fastq.gz, SRR6739757, SRR6739757.sralite	SRA

SRX3712691 SRP132953 RNA-Seq SINGLE

GSM3014756: RB886_L4_160816_TGACCA; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971187

BioProject: PRJNA434314

BioSample: SAMN08553233

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: RB886

Stage: L4

bio replicate no: 1

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739758	72322256	3688435056	1203.78	RB886_L4_160816_TGACCA.fastq.gz, SRR6739758, SRR6739758.sralite	SRA

SRX3712692 SRP132953 RNA-Seq SINGLE

GSM3014757: RB886_L4_20_9_16_TGACCA; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971188

BioProject: PRJNA434314

BioSample: SAMN08553232

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: RB886

Stage: L4

bio replicate no: 2

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739759	67725595	3454005345	1227.31	RB886_L4_20_9_16_TGACCA.fastq.gz, SRR6739759, SRR6739759.sralite	SRA

SRX3712693 SRP132953 RNA-Seq SINGLE

GSM3014758: RB886_L4_Ayya_GCCAAT; Caenorhabditis elegans; RNA-Seq

Sample: SRS2971191

BioProject: PRJNA434314

BioSample: SAMN08553231

Platform: ILLUMINA

Instrument: Illumina HiSeq 2500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: RB886

Stage: L4

bio replicate no: 3

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739760	64203141	3274360191	1163.74	RB886_L4_Ayya_GCCAAT.fastq.gz, SRR6739760, SRR6739760.sralite	SRA

SRX3712694 SRP132953 RIP-Seq SINGLE

GSM3014759: GSF-896-134-Input-24June_S6_R1_001; Caenorhabditis elegans; RIP-Seq

Sample: SRS2971190

BioProject: PRJNA434314

BioSample: SAMN08553230

Platform: ILLUMINA

Instrument: NextSeq 500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: HH134

Stage: Young Adult

bio replicate no: 1

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739761	19663719	2793803179	1009.56	GSF-896-134-Input-24June_S6_R1_001.fastq.gz, SRR6739761, SRR6739761.s…	SRA

SRX3712695 SRP132953 RIP-Seq SINGLE

GSM3014760: GSF-896-134-Input-30Mar_S3_R1_001; Caenorhabditis elegans; RIP-Seq

Sample: SRS2971192

BioProject: PRJNA434314

BioSample: SAMN08553229

Platform: ILLUMINA

Instrument: NextSeq 500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: HH134

Stage: Young Adult

bio replicate no: 2

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739762	36388062	5035665781	1819.93	GSF-896-134-Input-30Mar_S3_R1_001.fastq.gz, SRR6739762, SRR6739762.sr…	SRA

SRX3712696 SRP132953 RIP-Seq SINGLE

GSM3014761: GSF-896-134-RIP-24June_S15_R1_001; Caenorhabditis elegans; RIP-Seq

Sample: SRS2971193

BioProject: PRJNA434314

BioSample: SAMN08553228

Platform: ILLUMINA

Instrument: NextSeq 500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: HH134

Stage: Young Adult

bio replicate no: 1

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739763	14274009	2078006954	760.11	GSF-896-134-RIP-24June_S15_R1_001.fastq.gz, SRR6739763, SRR6739763.sr…	SRA

SRX3712697 SRP132953 RIP-Seq SINGLE

GSM3014762: GSF-896-134-RIP-30Mar_S12_R1_001; Caenorhabditis elegans; RIP-Seq

Sample: SRS2971194

BioProject: PRJNA434314

BioSample: SAMN08553227

Platform: ILLUMINA

Instrument: NextSeq 500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: HH134

Stage: Young Adult

bio replicate no: 2

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739764	15306510	2153466004	792.49	GSF-896-134-RIP-30Mar_S12_R1_001.fastq.gz, SRR6739764, SRR6739764.sra…	SRA

SRX3712698 SRP132953 RIP-Seq SINGLE

GSM3014763: GSF-896-76-Input-24June_S4_R1_001; Caenorhabditis elegans; RIP-Seq

Sample: SRS2971195

BioProject: PRJNA434314

BioSample: SAMN08553226

Platform: ILLUMINA

Instrument: NextSeq 500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: HH76

Stage: Young Adult

bio replicate no: 1

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739765	18433124	2627811478	955.52	GSF-896-76-Input-24June_S4_R1_001.fastq.gz, SRR6739765, SRR6739765.sr…	SRA

SRX3712699 SRP132953 RIP-Seq SINGLE

GSM3014764: GSF-896-76-Input-30Mar_S1_R1_001; Caenorhabditis elegans; RIP-Seq

Sample: SRS2971196

BioProject: PRJNA434314

BioSample: SAMN08553225

Platform: ILLUMINA

Instrument: NextSeq 500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: HH76

Stage: Young Adult

bio replicate no: 2

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739766	34753008	4757740624	1722.79	GSF-896-76-Input-30Mar_S1_R1_001.fastq.gz, SRR6739766, SRR6739766.sra…	SRA

SRX3712700 SRP132953 RIP-Seq SINGLE

GSM3014765: GSF-896-76-RIP-24June_S13_R1_001; Caenorhabditis elegans; RIP-Seq

Sample: SRS2971197

BioProject: PRJNA434314

BioSample: SAMN08553224

Platform: ILLUMINA

Instrument: NextSeq 500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: HH76

Stage: Young Adult

bio replicate no: 1

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739767	14759283	2143633930	780.01	GSF-896-76-RIP-24June_S13_R1_001.fastq.gz, SRR6739767, SRR6739767.sra…	SRA

SRX3712701 SRP132953 RIP-Seq SINGLE

GSM3014766: GSF-896-76-RIP-30Mar_S10_R1_001; Caenorhabditis elegans; RIP-Seq

Sample: SRS2971198

BioProject: PRJNA434314

BioSample: SAMN08553223

Platform: ILLUMINA

Instrument: NextSeq 500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: HH76

Stage: Young Adult

bio replicate no: 2

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739768	15149223	2121932774	781.97	GSF-896-76-RIP-30Mar_S10_R1_001.fastq.gz, SRR6739768, SRR6739768.sral…	SRA

SRX3712702 SRP132953 RIP-Seq SINGLE

GSM3014767: GSF-896-Adr-1-Input-24June_S5_R1_001; Caenorhabditis elegans; RIP-Seq

Sample: SRS2971199

BioProject: PRJNA434314

BioSample: SAMN08553222

Platform: ILLUMINA

Instrument: NextSeq 500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: BB21

Stage: Young Adult

bio replicate no: 1

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739769	16243485	2333388406	849.74	GSF-896-Adr-1-Input-24June_S5_R1_001.fastq.gz, SRR6739769, SRR6739769…	SRA

SRX3712703 SRP132953 RIP-Seq SINGLE

GSM3014768: GSF-896-Adr-1-Input-30Mar_S2_R1_001; Caenorhabditis elegans; RIP-Seq

Sample: SRS2971200

BioProject: PRJNA434314

BioSample: SAMN08553221

Platform: ILLUMINA

Instrument: NextSeq 500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: BB21

Stage: Young Adult

bio replicate no: 2

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739770	41087660	5642758118	2040.08	GSF-896-Adr-1-Input-30Mar_S2_R1_001.fastq.gz, SRR6739770, SRR6739770.…	SRA

SRX3712704 SRP132953 RIP-Seq SINGLE

GSM3014769: GSF-896-Adr-1-RIP-24June_S14_R1_001; Caenorhabditis elegans; RIP-Seq

Sample: SRS2971201

BioProject: PRJNA434314

BioSample: SAMN08553220

Platform: ILLUMINA

Instrument: NextSeq 500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: BB21

Stage: Young Adult

bio replicate no: 1

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739771	14472088	2122764125	785.42	GSF-896-Adr-1-RIP-24June_S14_R1_001.fastq.gz, SRR6739771, SRR6739771.…	SRA

SRX3712705 SRP132953 RIP-Seq SINGLE

GSM3014770: GSF-896-Adr1-RIP-30Mar_S11_R1_001; Caenorhabditis elegans; RIP-Seq

Sample: SRS2971202

BioProject: PRJNA434314

BioSample: SAMN08553219

Platform: ILLUMINA

Instrument: NextSeq 500

Organism: Caenorhabditis elegans

Sample attributes

source_name: whole worm

strain: BB21

Stage: Young Adult

bio replicate no: 2

Original files (1)

whole worm

Runs (1)

Run	Spots	Bases	Size (MB)	Files	Link
SRR6739772	15624491	2157678024	783.77	GSF-896-Adr1-RIP-30Mar_S11_R1_001.fastq.gz, SRR6739772, SRR6739772.sr…	SRA

Linked Publications (1)

Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing.

Cell reports · 2019

Data Files (42)

Accession	File Name	Stored Type	Size	Download
—	GSF-896-134-Input-24June_S6_R1_001.fastq.gz	RIP-Seq	1009.6 MB	link
—	GSF-896-134-Input-30Mar_S3_R1_001.fastq.gz	RIP-Seq	1.8 GB	link
—	GSF-896-134-RIP-24June_S15_R1_001.fastq.gz	RIP-Seq	760.1 MB	link
—	GSF-896-134-RIP-30Mar_S12_R1_001.fastq.gz	RIP-Seq	792.5 MB	link
—	GSF-896-76-Input-24June_S4_R1_001.fastq.gz	RIP-Seq	955.5 MB	link
—	GSF-896-76-Input-30Mar_S1_R1_001.fastq.gz	RIP-Seq	1.7 GB	link
—	GSF-896-76-RIP-24June_S13_R1_001.fastq.gz	RIP-Seq	780.0 MB	link
—	GSF-896-76-RIP-30Mar_S10_R1_001.fastq.gz	RIP-Seq	782.0 MB	link
—	GSF-896-Adr-1-Input-24June_S5_R1_001.fastq.gz	RIP-Seq	849.7 MB	link
—	GSF-896-Adr-1-Input-30Mar_S2_R1_001.fastq.gz	RIP-Seq	2.0 GB	link
—	GSF-896-Adr-1-RIP-24June_S14_R1_001.fastq.gz	RIP-Seq	785.4 MB	link
—	GSF-896-Adr1-RIP-30Mar_S11_R1_001.fastq.gz	RIP-Seq	783.8 MB	link
—	BB19_embryo_1_131216_CGATGT.fastq.gz	RNA-Seq	1.4 GB	link
—	BB19_embryo_2_051216_TTAGGC.fastq.gz	RNA-Seq	1.3 GB	link
—	BB19_embryo_310816_TTAGGC.fastq.gz	RNA-Seq	1016.1 MB	link
—	BB19_L4_220816_GCCAAT.fastq.gz	RNA-Seq	1.3 GB	link
—	BB19_L4_6_10_16_TAGCTT.fastq.gz	RNA-Seq	1.3 GB	link
—	BB19_L4_Ayya_GGCTAC.fastq.gz	RNA-Seq	1.2 GB	link
—	BB2_E_18_12_16_CAGATC.fastq.gz	RNA-Seq	1.3 GB	link
—	BB2_embryo_070916_TTAGGC.fastq.gz	RNA-Seq	1.2 GB	link
—	BB2_L4_221216_ACAGTG.fastq.gz	RNA-Seq	1.3 GB	link
—	BB2_L4_230816_CAGATC.fastq.gz	RNA-Seq	1.1 GB	link
—	BB2_L4_Ayya_ATCACG.fastq.gz	RNA-Seq	1.1 GB	link
—	BB3_E_19_12_16_GATCAG.fastq.gz	RNA-Seq	1.2 GB	link
—	BB3_embryo_011216_TAGCTT.fastq.gz	RNA-Seq	1.3 GB	link
—	BB3_embryo_230816_ACAGTG.fastq.gz	RNA-Seq	1.3 GB	link
—	BB3_L4_10_10_16_ACTTGA.fastq.gz	RNA-Seq	1.1 GB	link
—	BB3_L4_160816_GATCAG.fastq.gz	RNA-Seq	1.3 GB	link
—	BB3_L4_Ayya_CTTGTA.fastq.gz	RNA-Seq	1.3 GB	link
—	N2_E_15_12_16_CGATGT.fastq.gz	RNA-Seq	1.3 GB	link
—	N2_E_15_9_16_CGATGT.fastq.gz	RNA-Seq	1.2 GB	link
—	N2_embryo_111216_TAGCTT.fastq.gz	RNA-Seq	1.3 GB	link
—	N2_embryo_230816_ATCACG.fastq.gz	RNA-Seq	1.1 GB	link
—	N2_L4_18_9_16_ATCACG.fastq.gz	RNA-Seq	1.1 GB	link
—	N2_L4_220816_ATCACG.fastq.gz	RNA-Seq	1.2 GB	link
—	N2_L4_AYYA_TTAGGC.fastq.gz	RNA-Seq	1.1 GB	link
—	RB886_E_11_9_16_ACAGTG.fastq.gz	RNA-Seq	1.2 GB	link
—	RB886_E_15_12_16_TTAGGC.fastq.gz	RNA-Seq	1.2 GB	link
—	RB886_embryo_110916_CGATGT.fastq.gz	RNA-Seq	1.2 GB	link
—	RB886_L4_160816_TGACCA.fastq.gz	RNA-Seq	1.2 GB	link
—	RB886_L4_20_9_16_TGACCA.fastq.gz	RNA-Seq	1.2 GB	link
—	RB886_L4_Ayya_GCCAAT.fastq.gz	RNA-Seq	1.1 GB	link