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Modeling the Neuropathology of Tuberous Sclerosis with Human Stem Cells Reveals a Role for Inflammation and Angiogenic Growth Factors

Organism: Homo sapiens
Platform: GPL16791
Samples: 72
Experiment Types:
Expression profiling by high throughput sequencing
Submitted: Mar 07 2016
Last Updated: Nov 08 2020
Status: Public on Jul 25 2016
Contact: Jitao David,,Zhang (F. Hoffmann-La Roche)

Relations

SuperSeries of: GSE78959 SuperSeries of: GSE78960 BioProject: https://www.ncbi.nlm.nih.gov/bioproject/PRJNA314504

Summary

This SuperSeries is composed of the SubSeries listed below.

Overall Design

Refer to individual Series

Analysis (3 steps)

View Data Processing
Processing steps for GSE78961
  1. Linker tags were removed from RNA sequencing and ribosome profiling reads by the FASTX Toolkit, v0.0.13 (http://hannonlab.cshl.edu/fastx_toolkit/)
  2. All reads that mapped to rRNAs, tRNAs or mitochondrial rRNAs were removed, and the remaining reads were mapped to RefSeq (v38) by TopHat v2.0.13.
  3. Finally all read counts that mapped uniquely to genes were extracted for expression analysis with the help of samtools, v1.1.
GEO Samples (72)

Dataset Citations (1)

Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model.
PMID 27655340 · 2016 · Genome medicine
Nils Grabole, Jitao David Zhang, Stefan Aigner, Nadine Ruderisch, Veronica Costa, Felix C Weber, Michel Theron, Nikolaos Berntenis, Olivia Spleiss, Martin Ebeling, Gene W Yeo, Ravi Jagasia, Anna Kiialainen

Linked Publications (1)