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GSE157048

GSE GEO
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RNA-seq of metformin treatment in primary murine hepatocytes in WT, Raptor Ser-Ala mutant, Tsc2-null, Raptor mutant;Tsc2-null, and Ampk-null cells

Organism: Mus musculus
Platform: GPL17021
Samples: 65
Experiment Types:
Expression profiling by high throughput sequencing
Submitted: Aug 28 2020
Last Updated: Aug 10 2023
Status: Public on Aug 10 2023
Contact: April,Elizabeth,Williams (Salk Institute for Biological Studies)

Relations

SubSeries of: GSE157051 BioProject: https://www.ncbi.nlm.nih.gov/bioproject/PRJNA659989 SRA: https://www.ncbi.nlm.nih.gov/sra?term=SRP279197

Summary

Despite being the frontline therapy for Type 2 diabetes, the mechanisms of action of the biguanide drug metformin are still being discovered. In particular, the detailed molecular interplays between the AMPK and the mTORC1 pathway in the hepatic benefits of metformin are still ill-defined. Metformin-dependent activation of AMPK classically inhibits mTORC1 via TSC/RHEB. But several lines of evidence suggest additional mechanisms at play in metformin inhibition of mTORC1. Here we investigated the role of direct AMPK-mediated serine phosphorylation of RAPTOR in a new RaptorAA mouse model, in which AMPK phospho-serine sites Ser722 and Ser792 of RAPTOR were mutated to alanine. Metformin treatment of primary hepatocytes and intact murine liver requires AMPK regulation of both RAPTOR and TSC2 to fully inhibit mTORC1, and this regulation is critical for the transcriptional response to metformin. Transcriptionally, AMPK and mTORC1 were both important for regulation of anabolic metabolism and inflammatory programs triggered by metformin treatment.

Overall Design

5h treatment of 2mM Metformin or 0.1uM INK-128 in serum-starved primary murine hepatocytes in the absence or presence of 15 minute pre-treatment with 1nM Insulin

Analysis (14 steps)

View Data Processing
Processing steps for GSE157048
  1. Raw RNA sequencing reads in FASTQ files were quality-tested using FASTQC (v0.11.8) (Andrews 2010) and mapped to the mouse reference genome (mm10) with STAR (v2.5.3a) aligner with default parameters (Dobin et al.
  2. 2012).
  3. Raw or normalized gene expression levels were quantified across all the exons of RefSeq genes with analyzeRepeats.pl in HOMER (v4.11.1) (Heinz et al.
  4. 2010).
  5. Differential expression analysis was performed with raw gene counts using R package, edgeR (v3.26.7) (Robinson et al.
  6. 2010), using replicates to compute within-group dispersion and correcting for batch effects.
  7. Genes with false discovery rate (FDR) < 0.05 and an absolute fold-change (FC) >= 1.5 were identified as significantly different when comparing two conditions.
  8. Normalized counts were log transformed, filtered, scaled, and centered prior to clustering and heatmap generation with Cluster3 (de Hoon et al.
Showing first 8 steps.

Supplementary Files (1)

GSE157048_normed_heps.txt.gz Download
GEO Samples (65)
GSM4751546 GSM4751547 GSM4751548 GSM4751549 GSM4751550 GSM4751551 GSM4751552 GSM4751553 GSM4751554 GSM4751555 GSM4751556 GSM4751557 GSM4751558 GSM4751559 GSM4751560 GSM4751561 GSM4751562 GSM4751563 GSM4751564 GSM4751565 GSM4751566 GSM4751567 GSM4751568 GSM4751569 GSM4751570 GSM4751571 GSM4751572 GSM4751573 GSM4751574 GSM4751575 GSM4751576 GSM4751577 GSM4751578 GSM4751579 GSM4751580 GSM4751581 GSM4751582 GSM4751583 GSM4751584 GSM4751585 GSM4751586 GSM4751587 GSM4751588 GSM4751589 GSM4751590 GSM4751591 GSM4751592 GSM4751593 GSM4751594 GSM4751595 GSM4751596 GSM4751597 GSM4751598 GSM4751599 GSM4751600 GSM4751601 GSM4751602 GSM4751603 GSM4751604 GSM4751605 GSM4751606 GSM4751607 GSM4751608 GSM4751609 GSM4751610

Dataset Citations (1)

AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation.
PMID 32912901 · 2020 · Genes & development
Jeanine L Van Nostrand, Kristina Hellberg, En-Ching Luo, Eric L Van Nostrand, Alina Dayn, Jingting Yu, Maxim N Shokhirev, Yelena Dayn, Gene W Yeo, Reuben J Shaw

SRA Experiments (65) and Runs (65)

Total: 22956 MB
SRX9029447 SRP279197 RNA-Seq SINGLE
GSM4751546: hepatocyte_WT UT rep3; Mus musculus; RNA-Seq
Sample: SRS7280729
BioProject: PRJNA659989
BioSample: SAMN15931589
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: wild type
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539766 22548979 1149997929 346.86 WTUT_JVN7_S7_R1_001.fastq.gz, SRR12539766, SRR12539766.lite SRA
SRX9029448 SRP279197 RNA-Seq SINGLE
GSM4751547: hepatocyte_WT UT rep2; Mus musculus; RNA-Seq
Sample: SRS7280730
BioProject: PRJNA659989
BioSample: SAMN15931588
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: wild type
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539767 20141686 1027225986 323.13 WTUT_JVN2_S56_R1_001.fastq.gz, SRR12539767, SRR12539767.lite SRA
SRX9029449 SRP279197 RNA-Seq SINGLE
GSM4751548: hepatocyte_WT UT Rep1; Mus musculus; RNA-Seq
Sample: SRS7280731
BioProject: PRJNA659989
BioSample: SAMN15931587
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: wild type
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539768 21397498 1091272398 343.42 WTUT_JVN1_S55_R1_001.fastq.gz, SRR12539768, SRR12539768.lite SRA
SRX9029450 SRP279197 RNA-Seq SINGLE
GSM4751549: hepatocyte_WT Met rep3; Mus musculus; RNA-Seq
Sample: SRS7280732
BioProject: PRJNA659989
BioSample: SAMN15931586
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: wild type
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539769 21180171 1080188721 326.09 WTMet_JVN8_S8_R1_001.fastq.gz, SRR12539769, SRR12539769.lite SRA
SRX9029451 SRP279197 RNA-Seq SINGLE
GSM4751550: hepatocyte_WT Met rep2; Mus musculus; RNA-Seq
Sample: SRS7280733
BioProject: PRJNA659989
BioSample: SAMN15931585
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: wild type
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539770 22747248 1160109648 362.83 WTMet_JVN4_S58_R1_001.fastq.gz, SRR12539770, SRR12539770.lite SRA
SRX9029452 SRP279197 RNA-Seq SINGLE
GSM4751551: hepatocyte_WT Met rep1; Mus musculus; RNA-Seq
Sample: SRS7280734
BioProject: PRJNA659989
BioSample: SAMN15931584
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: wild type
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539771 22309454 1137782154 358.21 WTMet_JVN3_S57_R1_001.fastq.gz, SRR12539771, SRR12539771.lite SRA
SRX9029453 SRP279197 RNA-Seq SINGLE
GSM4751552: hepatocyte_WT InsMet rep3; Mus musculus; RNA-Seq
Sample: SRS7280735
BioProject: PRJNA659989
BioSample: SAMN15931583
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: wild type
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539772 21425133 1092681783 329.2 WTInsMet_JVN6_S6_R1_001.fastq.gz, SRR12539772, SRR12539772.lite SRA
SRX9029454 SRP279197 RNA-Seq SINGLE
GSM4751553: hepatocyte_WT InsMet rep2; Mus musculus; RNA-Seq
Sample: SRS7280736
BioProject: PRJNA659989
BioSample: SAMN15931582
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: wild type
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539773 20304496 1035529296 311.19 WTInsMet_JVN5_S5_R1_001.fastq.gz, SRR12539773, SRR12539773.lite SRA
SRX9029455 SRP279197 RNA-Seq SINGLE
GSM4751554: hepatocyte_WT InsMet rep1; Mus musculus; RNA-Seq
Sample: SRS7280737
BioProject: PRJNA659989
BioSample: SAMN15931581
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: wild type
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539774 20545575 1047824325 317.04 WTInsMet_JVN4_S4_R1_001.fastq.gz, SRR12539774, SRR12539774.lite SRA
SRX9029456 SRP279197 RNA-Seq SINGLE
GSM4751555: hepatocyte_WT InsInk; Mus musculus; RNA-Seq
Sample: SRS7280738
BioProject: PRJNA659989
BioSample: SAMN15931580
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: wild type
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 0.1uM INK-128 for 5h serum-starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539775 23980880 1223024880 390.25 WTInsInk_JVN43_S43_R1_001.fastq.gz, SRR12539775, SRR12539775.lite SRA
SRX9029457 SRP279197 RNA-Seq SINGLE
GSM4751556: hepatocyte_WT Ins rep4; Mus musculus; RNA-Seq
Sample: SRS7280739
BioProject: PRJNA659989
BioSample: SAMN15931579
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: wild type
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539776 24854345 1267571595 404.71 WTIns_JVN42_S42_R1_001.fastq.gz, SRR12539776, SRR12539776.lite SRA
SRX9029458 SRP279197 RNA-Seq SINGLE
GSM4751557: hepatocyte_WT Ins rep3; Mus musculus; RNA-Seq
Sample: SRS7280740
BioProject: PRJNA659989
BioSample: SAMN15931578
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: wild type
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539777 21076574 1074905274 324.88 WTIns_JVN3_S3_R1_001.fastq.gz, SRR12539777, SRR12539777.lite SRA
SRX9029459 SRP279197 RNA-Seq SINGLE
GSM4751558: hepatocyte_WT Ins rep2; Mus musculus; RNA-Seq
Sample: SRS7280741
BioProject: PRJNA659989
BioSample: SAMN15931577
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: wild type
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539778 21345697 1088630547 327.38 WTIns_JVN2_S2_R1_001.fastq.gz, SRR12539778, SRR12539778.lite SRA
SRX9029460 SRP279197 RNA-Seq SINGLE
GSM4751559: hepatocyte_WT Ins rep1; Mus musculus; RNA-Seq
Sample: SRS7280742
BioProject: PRJNA659989
BioSample: SAMN15931576
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: wild type
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539779 19328153 985735803 296.17 WTIns_JVN1_S1_R1_001.fastq.gz, SRR12539779, SRR12539779.lite SRA
SRX9029461 SRP279197 RNA-Seq SINGLE
GSM4751560: hepatocyte_WT Ink rep3; Mus musculus; RNA-Seq
Sample: SRS7280743
BioProject: PRJNA659989
BioSample: SAMN15931575
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: wild type
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 0.1uM INK-128 for 5h serum-starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539780 21419225 1092380475 349.49 WTInk_JVN41_S41_R1_001.fastq.gz, SRR12539780, SRR12539780.lite SRA
SRX9029462 SRP279197 RNA-Seq SINGLE
GSM4751561: hepatocyte_WT Ink rep2; Mus musculus; RNA-Seq
Sample: SRS7280744
BioProject: PRJNA659989
BioSample: SAMN15931574
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: wild type
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 0.1uM INK-128 for 5h serum-starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539781 16404299 836619249 345.79 WTInk_JVN22_S76_R1_001.fastq.gz, SRR12539781, SRR12539781.lite SRA
SRX9029463 SRP279197 RNA-Seq SINGLE
GSM4751562: hepatocyte_WT Ink rep1; Mus musculus; RNA-Seq
Sample: SRS7280745
BioProject: PRJNA659989
BioSample: SAMN15931573
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: wild type
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 0.1uM INK-128 for 5h serum-starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539782 14468252 737880852 307.19 WTInk_JVN21_S75_R1_001.fastq.gz, SRR12539782, SRR12539782.lite SRA
SRX9029464 SRP279197 RNA-Seq SINGLE
GSM4751563: hepatocyte_AA UT rep3; Mus musculus; RNA-Seq
Sample: SRS7280746
BioProject: PRJNA659989
BioSample: SAMN15931572
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539783 21835799 1113625749 353.48 AAUT_JVN6_S60_R1_001.fastq.gz, SRR12539783, SRR12539783.lite SRA
SRX9029465 SRP279197 RNA-Seq SINGLE
GSM4751564: hepatocyte_AA UT rep2; Mus musculus; RNA-Seq
Sample: SRS7280747
BioProject: PRJNA659989
BioSample: SAMN15931571
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539784 21119979 1077118929 341.81 AAUT_JVN5_S59_R1_001.fastq.gz, SRR12539784, SRR12539784.lite SRA
SRX9029466 SRP279197 RNA-Seq SINGLE
GSM4751565: hepatocyte_AA UT rep1; Mus musculus; RNA-Seq
Sample: SRS7280748
BioProject: PRJNA659989
BioSample: SAMN15931570
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539785 20533036 1047184836 318.25 AAUT_JVN15_S15_R1_001.fastq.gz, SRR12539785, SRR12539785.lite SRA
SRX9029467 SRP279197 RNA-Seq SINGLE
GSM4751566: hepatocyte_AA Met rep3; Mus musculus; RNA-Seq
Sample: SRS7280749
BioProject: PRJNA659989
BioSample: SAMN15931569
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539786 25497318 1300363218 413.52 AAMet_JVN8_S62_R1_001.fastq.gz, SRR12539786, SRR12539786.lite SRA
SRX9029468 SRP279197 RNA-Seq SINGLE
GSM4751567: hepatocyte_AA Met rep2; Mus musculus; RNA-Seq
Sample: SRS7280750
BioProject: PRJNA659989
BioSample: SAMN15931568
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539787 22196862 1132039962 361.65 AAMet_JVN7_S61_R1_001.fastq.gz, SRR12539787, SRR12539787.lite SRA
SRX9029469 SRP279197 RNA-Seq SINGLE
GSM4751568: hepatocyte_AA Met rep1; Mus musculus; RNA-Seq
Sample: SRS7280751
BioProject: PRJNA659989
BioSample: SAMN15931567
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539788 19670001 1003170051 305.56 AAMet_JVN16_S16_R1_001.fastq.gz, SRR12539788, SRR12539788.lite SRA
SRX9029470 SRP279197 RNA-Seq SINGLE
GSM4751569: hepatocyte_AA InsMet rep3; Mus musculus; RNA-Seq
Sample: SRS7280752
BioProject: PRJNA659989
BioSample: SAMN15931566
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539789 24588105 1253993355 378.94 AAInsMet_JVN14_S14_R1_001.fastq.gz, SRR12539789, SRR12539789.lite SRA
SRX9029471 SRP279197 RNA-Seq SINGLE
GSM4751570: hepatocyte_AA InsMet rep2; Mus musculus; RNA-Seq
Sample: SRS7280753
BioProject: PRJNA659989
BioSample: SAMN15931565
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539790 18737580 955616580 288.59 AAInsMet_JVN13_S13_R1_001.fastq.gz, SRR12539790, SRR12539790.lite SRA
SRX9029472 SRP279197 RNA-Seq SINGLE
GSM4751571: hepatocyte_AA InsMet rep1; Mus musculus; RNA-Seq
Sample: SRS7280754
BioProject: PRJNA659989
BioSample: SAMN15931564
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539791 19122642 975254742 296.32 AAInsMet_JVN12_S12_R1_001.fastq.gz, SRR12539791, SRR12539791.lite SRA
SRX9029473 SRP279197 RNA-Seq SINGLE
GSM4751572: hepatocyte_AA Ins rep3; Mus musculus; RNA-Seq
Sample: SRS7280756
BioProject: PRJNA659989
BioSample: SAMN15931563
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539792 20540840 1047582840 315.92 AAIns_JVN9_S9_R1_001.fastq.gz, SRR12539792, SRR12539792.lite SRA
SRX9029474 SRP279197 RNA-Seq SINGLE
GSM4751573: hepatocyte_AA Ins rep2; Mus musculus; RNA-Seq
Sample: SRS7280755
BioProject: PRJNA659989
BioSample: SAMN15931562
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539793 21527502 1097902602 332.59 AAIns_JVN11_S11_R1_001.fastq.gz, SRR12539793, SRR12539793.lite SRA
SRX9029475 SRP279197 RNA-Seq SINGLE
GSM4751574: hepatocyte_AA Ins rep1; Mus musculus; RNA-Seq
Sample: SRS7280758
BioProject: PRJNA659989
BioSample: SAMN15931561
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539794 20774104 1059479304 320.08 AAIns_JVN10_S10_R1_001.fastq.gz, SRR12539794, SRR12539794.lite SRA
SRX9029476 SRP279197 RNA-Seq SINGLE
GSM4751575: hepatocyte_Tsc UT rep3; Mus musculus; RNA-Seq
Sample: SRS7280757
BioProject: PRJNA659989
BioSample: SAMN15931560
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539795 22097834 1126989534 352.32 TscUT_JVN9_S63_R1_001.fastq.gz, SRR12539795, SRR12539795.lite SRA
SRX9029477 SRP279197 RNA-Seq SINGLE
GSM4751576: hepatocyte_Tsc UT rep2; Mus musculus; RNA-Seq
Sample: SRS7280760
BioProject: PRJNA659989
BioSample: SAMN15931559
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539796 17668863 901112013 376.28 TscUT_JVN23_S23_R1_001.fastq.gz, SRR12539796, SRR12539796.lite SRA
SRX9029478 SRP279197 RNA-Seq SINGLE
GSM4751577: hepatocyte_Tsc UT rep1; Mus musculus; RNA-Seq
Sample: SRS7280759
BioProject: PRJNA659989
BioSample: SAMN15931558
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539797 22064800 1125304800 349.43 TscUT_JVN10_S64_R1_001.fastq.gz, SRR12539797, SRR12539797.lite SRA
SRX9029479 SRP279197 RNA-Seq SINGLE
GSM4751578: hepatocyte_Tsc Met rep2; Mus musculus; RNA-Seq
Sample: SRS7280761
BioProject: PRJNA659989
BioSample: SAMN15931557
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539798 15410440 785932440 328.07 TscMet_JVN24_S24_R1_001.fastq.gz, SRR12539798, SRR12539798.lite SRA
SRX9029480 SRP279197 RNA-Seq SINGLE
GSM4751579: hepatocyte_Tsc Met rep1; Mus musculus; RNA-Seq
Sample: SRS7280762
BioProject: PRJNA659989
BioSample: SAMN15931556
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539799 20068416 1023489216 338.48 TscMet_JVN12_S66_R1_001.fastq.gz, SRR12539799, SRR12539799.lite SRA
SRX9029481 SRP279197 RNA-Seq SINGLE
GSM4751580: hepatocyte_Tsc Met rep3; Mus musculus; RNA-Seq
Sample: SRS7280763
BioProject: PRJNA659989
BioSample: SAMN15931555
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539800 20715310 1056480810 329.4 TscMet_JVN11_S65_R1_001.fastq.gz, SRR12539800, SRR12539800.lite SRA
SRX9029482 SRP279197 RNA-Seq SINGLE
GSM4751581: hepatocyte_Tsc InsMet rep3; Mus musculus; RNA-Seq
Sample: SRS7280764
BioProject: PRJNA659989
BioSample: SAMN15931554
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539801 22355362 1140123462 364.1 TscInsMet_JVN22_S22_R1_001.fastq.gz, SRR12539801, SRR12539801.lite SRA
SRX9029483 SRP279197 RNA-Seq SINGLE
GSM4751582: hepatocyte_Tsc InsMet rep2; Mus musculus; RNA-Seq
Sample: SRS7280765
BioProject: PRJNA659989
BioSample: SAMN15931553
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539802 21816701 1112651751 335.5 TscInsMet_JVN21_S21_R1_001.fastq.gz, SRR12539802, SRR12539802.lite SRA
SRX9029484 SRP279197 RNA-Seq SINGLE
GSM4751583: hepatocyte_Tsc InsMet rep1; Mus musculus; RNA-Seq
Sample: SRS7280766
BioProject: PRJNA659989
BioSample: SAMN15931552
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539803 22698438 1157620338 349.44 TscInsMet_JVN20_S20_R1_001.fastq.gz, SRR12539803, SRR12539803.lite SRA
SRX9029485 SRP279197 RNA-Seq SINGLE
GSM4751584: hepatocyte_Tsc Ins rep3; Mus musculus; RNA-Seq
Sample: SRS7280767
BioProject: PRJNA659989
BioSample: SAMN15931551
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539804 23076428 1176897828 355.75 TscIns_JVN19_S19_R1_001.fastq.gz, SRR12539804, SRR12539804.lite SRA
SRX9029486 SRP279197 RNA-Seq SINGLE
GSM4751585: hepatocyte_Tsc Ins rep2; Mus musculus; RNA-Seq
Sample: SRS7280768
BioProject: PRJNA659989
BioSample: SAMN15931550
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539805 22171409 1130741859 340.74 TscIns_JVN18_S18_R1_001.fastq.gz, SRR12539805, SRR12539805.lite SRA
SRX9029487 SRP279197 RNA-Seq SINGLE
GSM4751586: hepatocyte_Tsc Ins rep1; Mus musculus; RNA-Seq
Sample: SRS7280769
BioProject: PRJNA659989
BioSample: SAMN15931549
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539806 22989697 1172474547 357.6 TscIns_JVN17_S17_R1_001.fastq.gz, SRR12539806, SRR12539806.lite SRA
SRX9029488 SRP279197 RNA-Seq SINGLE
GSM4751587: hepatocyte_AATsc UT rep3; Mus musculus; RNA-Seq
Sample: SRS7280770
BioProject: PRJNA659989
BioSample: SAMN15931548
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A; Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539807 25424023 1296625173 413.59 AATscUT_JVN31_S31_R1_001.fastq.gz, SRR12539807, SRR12539807.lite SRA
SRX9029489 SRP279197 RNA-Seq SINGLE
GSM4751588: hepatocyte_AATsc UT rep2; Mus musculus; RNA-Seq
Sample: SRS7280772
BioProject: PRJNA659989
BioSample: SAMN15931547
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A; Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539808 22608036 1153009836 385.03 AATscUT_JVN14_S68_R1_001.fastq.gz, SRR12539808, SRR12539808.lite SRA
SRX9029490 SRP279197 RNA-Seq SINGLE
GSM4751589: hepatocyte_AATsc UT rep1; Mus musculus; RNA-Seq
Sample: SRS7280771
BioProject: PRJNA659989
BioSample: SAMN15931546
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A; Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539809 20513952 1046211552 348.28 AATscUT_JVN13_S67_R1_001.fastq.gz, SRR12539809, SRR12539809.lite SRA
SRX9029491 SRP279197 RNA-Seq SINGLE
GSM4751590: hepatocyte_AATsc Met rep3; Mus musculus; RNA-Seq
Sample: SRS7280773
BioProject: PRJNA659989
BioSample: SAMN15931545
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A; Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539810 22685909 1156981359 368.59 AATscMet_JVN32_S32_R1_001.fastq.gz, SRR12539810, SRR12539810.lite SRA
SRX9029492 SRP279197 RNA-Seq SINGLE
GSM4751591: hepatocyte_AATsc Met rep2; Mus musculus; RNA-Seq
Sample: SRS7280774
BioProject: PRJNA659989
BioSample: SAMN15931544
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A; Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539811 22913160 1168571160 392.18 AATscMet_JVN16_S70_R1_001.fastq.gz, SRR12539811, SRR12539811.lite SRA
SRX9029493 SRP279197 RNA-Seq SINGLE
GSM4751592: hepatocyte_AATsc Met rep1; Mus musculus; RNA-Seq
Sample: SRS7280776
BioProject: PRJNA659989
BioSample: SAMN15931543
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A; Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539812 23292770 1187931270 398.3 AATscMet_JVN15_S69_R1_001.fastq.gz, SRR12539812, SRR12539812.lite SRA
SRX9029494 SRP279197 RNA-Seq SINGLE
GSM4751593: hepatocyte_AATsc InsMet rep3; Mus musculus; RNA-Seq
Sample: SRS7280775
BioProject: PRJNA659989
BioSample: SAMN15931542
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A; Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539813 23677594 1207557294 384.59 AATSCInsMET_JVN30_S30_R1_001.fastq.gz, SRR12539813, SRR12539813.lite SRA
SRX9029495 SRP279197 RNA-Seq SINGLE
GSM4751594: hepatocyte_AATsc InsMet rep2; Mus musculus; RNA-Seq
Sample: SRS7280777
BioProject: PRJNA659989
BioSample: SAMN15931541
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A; Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539814 23018295 1173933045 375.35 AATSCInsMET_JVN29_S29_R1_001.fastq.gz, SRR12539814, SRR12539814.lite SRA
SRX9029496 SRP279197 RNA-Seq SINGLE
GSM4751595: hepatocyte_AATsc InsMet rep1; Mus musculus; RNA-Seq
Sample: SRS7280778
BioProject: PRJNA659989
BioSample: SAMN15931540
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A; Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539815 23281035 1187332785 379.45 AATSCInsMET_JVN28_S28_R1_001.fastq.gz, SRR12539815, SRR12539815.lite SRA
SRX9029497 SRP279197 RNA-Seq SINGLE
GSM4751596: hepatocyte_AATsc Ins rep3; Mus musculus; RNA-Seq
Sample: SRS7280779
BioProject: PRJNA659989
BioSample: SAMN15931539
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A; Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539816 21949503 1119424653 358.09 AATSCIns_JVN27_S27_R1_001.fastq.gz, SRR12539816, SRR12539816.lite SRA
SRX9029498 SRP279197 RNA-Seq SINGLE
GSM4751597: hepatocyte_AATsc Ins rep2; Mus musculus; RNA-Seq
Sample: SRS7280781
BioProject: PRJNA659989
BioSample: SAMN15931602
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A; Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539817 22782909 1161928359 370.23 AATSCIns_JVN26_S26_R1_001.fastq.gz, SRR12539817, SRR12539817.lite SRA
SRX9029499 SRP279197 RNA-Seq SINGLE
GSM4751598: hepatocyte_AATsc Ins rep1; Mus musculus; RNA-Seq
Sample: SRS7280780
BioProject: PRJNA659989
BioSample: SAMN15931601
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Raptor - S722A; S792A; Tsc2 fl/fl; AlbCreEr
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539818 23781417 1212852267 388.22 AATSCIns_JVN25_S25_R1_001.fastq.gz, SRR12539818, SRR12539818.lite SRA
SRX9029500 SRP279197 RNA-Seq SINGLE
GSM4751599: hepatocyte_Ampk UT rep3; Mus musculus; RNA-Seq
Sample: SRS7280782
BioProject: PRJNA659989
BioSample: SAMN15931600
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Ampka1 fl/fl; Ampka2 fl/fl; AlbCreER
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539819 21863684 1115047884 355.96 AmpKUT_JVN39_S39_R1_001.fastq.gz, SRR12539819, SRR12539819.lite SRA
SRX9029501 SRP279197 RNA-Seq SINGLE
GSM4751600: hepatocyte_Ampk UT rep2; Mus musculus; RNA-Seq
Sample: SRS7280783
BioProject: PRJNA659989
BioSample: SAMN15931599
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Ampka1 fl/fl; Ampka2 fl/fl; AlbCreER
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539820 22288026 1136689326 380.36 AmpkUT_JVN18_S72_R1_001.fastq.gz, SRR12539820, SRR12539820.lite SRA
SRX9029502 SRP279197 RNA-Seq SINGLE
GSM4751601: hepatocyte_Ampk UT rep1; Mus musculus; RNA-Seq
Sample: SRS7280784
BioProject: PRJNA659989
BioSample: SAMN15931598
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Ampka1 fl/fl; Ampka2 fl/fl; AlbCreER
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539821 21058817 1073999667 359.07 AmpkUT_JVN17_S71_R1_001.fastq.gz, SRR12539821, SRR12539821.lite SRA
SRX9029503 SRP279197 RNA-Seq SINGLE
GSM4751602: hepatocyte_Ampk Met rep3; Mus musculus; RNA-Seq
Sample: SRS7280785
BioProject: PRJNA659989
BioSample: SAMN15931596
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Ampka1 fl/fl; Ampka2 fl/fl; AlbCreER
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539822 21942434 1119064134 357.52 AMPKMet_JVN40_S40_R1_001.fastq.gz, SRR12539822, SRR12539822.lite SRA
SRX9029504 SRP279197 RNA-Seq SINGLE
GSM4751603: hepatocyte_Ampk Met rep2; Mus musculus; RNA-Seq
Sample: SRS7280786
BioProject: PRJNA659989
BioSample: SAMN15931595
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Ampka1 fl/fl; Ampka2 fl/fl; AlbCreER
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539823 19157767 977046117 328.79 AmpkMet_JVN20_S74_R1_001.fastq.gz, SRR12539823, SRR12539823.lite SRA
SRX9029505 SRP279197 RNA-Seq SINGLE
GSM4751604: hepatocyte_Ampk Met rep1; Mus musculus; RNA-Seq
Sample: SRS7280787
BioProject: PRJNA659989
BioSample: SAMN15931538
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Ampka1 fl/fl; Ampka2 fl/fl; AlbCreER
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: Untreated
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539824 20087106 1024442406 345.81 AmpkMet_JVN19_S73_R1_001.fastq.gz, SRR12539824, SRR12539824.lite SRA
SRX9029506 SRP279197 RNA-Seq SINGLE
GSM4751605: hepatocyte_Ampk InsMet rep3; Mus musculus; RNA-Seq
Sample: SRS7280788
BioProject: PRJNA659989
BioSample: SAMN15931594
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Ampka1 fl/fl; Ampka2 fl/fl; AlbCreER
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539825 20683679 1054867629 336.77 AMPKInsMet_JVN38_S38_R1_001.fastq.gz, SRR12539825, SRR12539825.lite SRA
SRX9029507 SRP279197 RNA-Seq SINGLE
GSM4751606: hepatocyte_Ampk InsMet rep2; Mus musculus; RNA-Seq
Sample: SRS7280789
BioProject: PRJNA659989
BioSample: SAMN15931597
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Ampka1 fl/fl; Ampka2 fl/fl; AlbCreER
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539826 22860044 1165862244 372.68 AMPKInsMet_JVN37_S37_R1_001.fastq.gz, SRR12539826, SRR12539826.lite SRA
SRX9029508 SRP279197 RNA-Seq SINGLE
GSM4751607: hepatocyte_Ampk InsMet rep1; Mus musculus; RNA-Seq
Sample: SRS7280790
BioProject: PRJNA659989
BioSample: SAMN15931593
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Ampka1 fl/fl; Ampka2 fl/fl; AlbCreER
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: 2mM Metformin for 5h serum-starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539827 22564257 1150777107 366.2 AMPKInsMet_JVN36_S36_R1_001.fastq.gz, SRR12539827, SRR12539827.lite SRA
SRX9029509 SRP279197 RNA-Seq SINGLE
GSM4751608: hepatocyte_Ampk Ins rep3; Mus musculus; RNA-Seq
Sample: SRS7280792
BioProject: PRJNA659989
BioSample: SAMN15931592
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Ampka1 fl/fl; Ampka2 fl/fl; AlbCreER
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539828 24638934 1256585634 400.36 AMPKIns_JVN35_S35_R1_001.fastq.gz, SRR12539828, SRR12539828.lite SRA
SRX9029510 SRP279197 RNA-Seq SINGLE
GSM4751609: hepatocyte_Ampk Ins rep2; Mus musculus; RNA-Seq
Sample: SRS7280791
BioProject: PRJNA659989
BioSample: SAMN15931591
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Ampka1 fl/fl; Ampka2 fl/fl; AlbCreER
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539829 23975385 1222744635 388.51 AMPKIns_JVN34_S34_R1_001.fastq.gz, SRR12539829, SRR12539829.lite SRA
SRX9029511 SRP279197 RNA-Seq SINGLE
GSM4751610: hepatocyte_Ampk Ins rep1; Mus musculus; RNA-Seq
Sample: SRS7280793
BioProject: PRJNA659989
BioSample: SAMN15931590
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Primary Hepatocytes
strain: C57BL/6 (F3 generation)
tissue: primary hepatocytes
age: 8-16 weeks old
genotype: Ampka1 fl/fl; Ampka2 fl/fl; AlbCreER
tamoxifen treatment: Tamoxifen treatment 3x 14-17 days prior to hepatocyte isolation
treatment: untreated - serum starved
pre-treatment: 15 minute pre-treatment with 1nM Insulin
Original files (1)
Primary Hepatocytes
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR12539830 26668501 1360093551 434.06 AMPKIns_JVN33_S33_R1_001.fastq.gz, SRR12539830, SRR12539830.lite SRA

Linked Publications (1)

AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation.
Genes & development · 2020

Data Files (130)

Accession File Name Stored Type Output Type Mapping Assembly Size Download
— AAIns_JVN10_S10_R1_001.fastq.gz RNA-Seq 320.1 MB link
— AAIns_JVN11_S11_R1_001.fastq.gz RNA-Seq 332.6 MB link
— AAIns_JVN9_S9_R1_001.fastq.gz RNA-Seq 315.9 MB link
— AAInsMet_JVN12_S12_R1_001.fastq.gz RNA-Seq 296.3 MB link
— AAInsMet_JVN13_S13_R1_001.fastq.gz RNA-Seq 288.6 MB link
— AAInsMet_JVN14_S14_R1_001.fastq.gz RNA-Seq 378.9 MB link
— AAMet_JVN16_S16_R1_001.fastq.gz RNA-Seq 305.6 MB link
— AAMet_JVN7_S61_R1_001.fastq.gz RNA-Seq 361.6 MB link
— AAMet_JVN8_S62_R1_001.fastq.gz RNA-Seq 413.5 MB link
— AATSCIns_JVN25_S25_R1_001.fastq.gz RNA-Seq 388.2 MB link
— AATSCIns_JVN26_S26_R1_001.fastq.gz RNA-Seq 370.2 MB link
— AATSCIns_JVN27_S27_R1_001.fastq.gz RNA-Seq 358.1 MB link
— AATSCInsMET_JVN28_S28_R1_001.fastq.gz RNA-Seq 379.4 MB link
— AATSCInsMET_JVN29_S29_R1_001.fastq.gz RNA-Seq 375.3 MB link
— AATSCInsMET_JVN30_S30_R1_001.fastq.gz RNA-Seq 384.6 MB link
— AATscMet_JVN15_S69_R1_001.fastq.gz RNA-Seq 398.3 MB link
— AATscMet_JVN16_S70_R1_001.fastq.gz RNA-Seq 392.2 MB link
— AATscMet_JVN32_S32_R1_001.fastq.gz RNA-Seq 368.6 MB link
— AATscUT_JVN13_S67_R1_001.fastq.gz RNA-Seq 348.3 MB link
— AATscUT_JVN14_S68_R1_001.fastq.gz RNA-Seq 385.0 MB link
— AATscUT_JVN31_S31_R1_001.fastq.gz RNA-Seq 413.6 MB link
— AAUT_JVN15_S15_R1_001.fastq.gz RNA-Seq 318.2 MB link
— AAUT_JVN5_S59_R1_001.fastq.gz RNA-Seq 341.8 MB link
— AAUT_JVN6_S60_R1_001.fastq.gz RNA-Seq 353.5 MB link
— AMPKIns_JVN33_S33_R1_001.fastq.gz RNA-Seq 434.1 MB link
— AMPKIns_JVN34_S34_R1_001.fastq.gz RNA-Seq 388.5 MB link
— AMPKIns_JVN35_S35_R1_001.fastq.gz RNA-Seq 400.4 MB link
— AMPKInsMet_JVN36_S36_R1_001.fastq.gz RNA-Seq 366.2 MB link
— AMPKInsMet_JVN37_S37_R1_001.fastq.gz RNA-Seq 372.7 MB link
— AMPKInsMet_JVN38_S38_R1_001.fastq.gz RNA-Seq 336.8 MB link
— AmpkMet_JVN19_S73_R1_001.fastq.gz RNA-Seq 345.8 MB link
— AmpkMet_JVN20_S74_R1_001.fastq.gz RNA-Seq 328.8 MB link
— AMPKMet_JVN40_S40_R1_001.fastq.gz RNA-Seq 357.5 MB link
— AmpkUT_JVN17_S71_R1_001.fastq.gz RNA-Seq 359.1 MB link
— AmpkUT_JVN18_S72_R1_001.fastq.gz RNA-Seq 380.4 MB link
— AmpKUT_JVN39_S39_R1_001.fastq.gz RNA-Seq 356.0 MB link
— SRR12539766_GSM4751546 RNA-Seq 346.0 MB link
— SRR12539767_GSM4751547 RNA-Seq 323.0 MB link
— SRR12539768_GSM4751548 RNA-Seq 343.0 MB link
— SRR12539769_GSM4751549 RNA-Seq 326.0 MB link
— SRR12539770_GSM4751550 RNA-Seq 362.0 MB link
— SRR12539771_GSM4751551 RNA-Seq 358.0 MB link
— SRR12539772_GSM4751552 RNA-Seq 329.0 MB link
— SRR12539773_GSM4751553 RNA-Seq 311.0 MB link
— SRR12539774_GSM4751554 RNA-Seq 317.0 MB link
— SRR12539775_GSM4751555 RNA-Seq 390.0 MB link
— SRR12539776_GSM4751556 RNA-Seq 404.0 MB link
— SRR12539777_GSM4751557 RNA-Seq 324.0 MB link
— SRR12539778_GSM4751558 RNA-Seq 327.0 MB link
— SRR12539779_GSM4751559 RNA-Seq 296.0 MB link
— SRR12539780_GSM4751560 RNA-Seq 349.0 MB link
— SRR12539781_GSM4751561 RNA-Seq 345.0 MB link
— SRR12539782_GSM4751562 RNA-Seq 307.0 MB link
— SRR12539783_GSM4751563 RNA-Seq 353.0 MB link
— SRR12539784_GSM4751564 RNA-Seq 341.0 MB link
— SRR12539785_GSM4751565 RNA-Seq 318.0 MB link
— SRR12539786_GSM4751566 RNA-Seq 413.0 MB link
— SRR12539787_GSM4751567 RNA-Seq 361.0 MB link
— SRR12539788_GSM4751568 RNA-Seq 305.0 MB link
— SRR12539789_GSM4751569 RNA-Seq 378.0 MB link
— SRR12539790_GSM4751570 RNA-Seq 288.0 MB link
— SRR12539791_GSM4751571 RNA-Seq 296.0 MB link
— SRR12539792_GSM4751572 RNA-Seq 315.0 MB link
— SRR12539793_GSM4751573 RNA-Seq 332.0 MB link
— SRR12539794_GSM4751574 RNA-Seq 320.0 MB link
— SRR12539795_GSM4751575 RNA-Seq 352.0 MB link
— SRR12539796_GSM4751576 RNA-Seq 376.0 MB link
— SRR12539797_GSM4751577 RNA-Seq 349.0 MB link
— SRR12539798_GSM4751578 RNA-Seq 328.0 MB link
— SRR12539799_GSM4751579 RNA-Seq 338.0 MB link
— SRR12539800_GSM4751580 RNA-Seq 329.0 MB link
— SRR12539801_GSM4751581 RNA-Seq 364.0 MB link
— SRR12539802_GSM4751582 RNA-Seq 335.0 MB link
— SRR12539803_GSM4751583 RNA-Seq 349.0 MB link
— SRR12539804_GSM4751584 RNA-Seq 355.0 MB link
— SRR12539805_GSM4751585 RNA-Seq 340.0 MB link
— SRR12539806_GSM4751586 RNA-Seq 357.0 MB link
— SRR12539807_GSM4751587 RNA-Seq 413.0 MB link
— SRR12539808_GSM4751588 RNA-Seq 385.0 MB link
— SRR12539809_GSM4751589 RNA-Seq 348.0 MB link
— SRR12539810_GSM4751590 RNA-Seq 368.0 MB link
— SRR12539811_GSM4751591 RNA-Seq 392.0 MB link
— SRR12539812_GSM4751592 RNA-Seq 398.0 MB link
— SRR12539813_GSM4751593 RNA-Seq 384.0 MB link
— SRR12539814_GSM4751594 RNA-Seq 375.0 MB link
— SRR12539815_GSM4751595 RNA-Seq 379.0 MB link
— SRR12539816_GSM4751596 RNA-Seq 358.0 MB link
— SRR12539817_GSM4751597 RNA-Seq 370.0 MB link
— SRR12539818_GSM4751598 RNA-Seq 388.0 MB link
— SRR12539819_GSM4751599 RNA-Seq 355.0 MB link
— SRR12539820_GSM4751600 RNA-Seq 380.0 MB link
— SRR12539821_GSM4751601 RNA-Seq 359.0 MB link
— SRR12539822_GSM4751602 RNA-Seq 357.0 MB link
— SRR12539823_GSM4751603 RNA-Seq 328.0 MB link
— SRR12539824_GSM4751604 RNA-Seq 345.0 MB link
— SRR12539825_GSM4751605 RNA-Seq 336.0 MB link
— SRR12539826_GSM4751606 RNA-Seq 372.0 MB link
— SRR12539827_GSM4751607 RNA-Seq 366.0 MB link
— SRR12539828_GSM4751608 RNA-Seq 400.0 MB link
— SRR12539829_GSM4751609 RNA-Seq 388.0 MB link
— SRR12539830_GSM4751610 RNA-Seq 434.0 MB link
— TscIns_JVN17_S17_R1_001.fastq.gz RNA-Seq 357.6 MB link
— TscIns_JVN18_S18_R1_001.fastq.gz RNA-Seq 340.7 MB link
— TscIns_JVN19_S19_R1_001.fastq.gz RNA-Seq 355.8 MB link
— TscInsMet_JVN20_S20_R1_001.fastq.gz RNA-Seq 349.4 MB link
— TscInsMet_JVN21_S21_R1_001.fastq.gz RNA-Seq 335.5 MB link
— TscInsMet_JVN22_S22_R1_001.fastq.gz RNA-Seq 364.1 MB link
— TscMet_JVN11_S65_R1_001.fastq.gz RNA-Seq 329.4 MB link
— TscMet_JVN12_S66_R1_001.fastq.gz RNA-Seq 338.5 MB link
— TscMet_JVN24_S24_R1_001.fastq.gz RNA-Seq 328.1 MB link
— TscUT_JVN10_S64_R1_001.fastq.gz RNA-Seq 349.4 MB link
— TscUT_JVN23_S23_R1_001.fastq.gz RNA-Seq 376.3 MB link
— TscUT_JVN9_S63_R1_001.fastq.gz RNA-Seq 352.3 MB link
— WTInk_JVN21_S75_R1_001.fastq.gz RNA-Seq 307.2 MB link
— WTInk_JVN22_S76_R1_001.fastq.gz RNA-Seq 345.8 MB link
— WTInk_JVN41_S41_R1_001.fastq.gz RNA-Seq 349.5 MB link
— WTInsInk_JVN43_S43_R1_001.fastq.gz RNA-Seq 390.2 MB link
— WTIns_JVN1_S1_R1_001.fastq.gz RNA-Seq 296.2 MB link
— WTIns_JVN2_S2_R1_001.fastq.gz RNA-Seq 327.4 MB link
— WTIns_JVN3_S3_R1_001.fastq.gz RNA-Seq 324.9 MB link
— WTIns_JVN42_S42_R1_001.fastq.gz RNA-Seq 404.7 MB link
— WTInsMet_JVN4_S4_R1_001.fastq.gz RNA-Seq 317.0 MB link
— WTInsMet_JVN5_S5_R1_001.fastq.gz RNA-Seq 311.2 MB link
— WTInsMet_JVN6_S6_R1_001.fastq.gz RNA-Seq 329.2 MB link
— WTMet_JVN3_S57_R1_001.fastq.gz RNA-Seq 358.2 MB link
— WTMet_JVN4_S58_R1_001.fastq.gz RNA-Seq 362.8 MB link
— WTMet_JVN8_S8_R1_001.fastq.gz RNA-Seq 326.1 MB link
— WTUT_JVN1_S55_R1_001.fastq.gz RNA-Seq 343.4 MB link
— WTUT_JVN2_S56_R1_001.fastq.gz RNA-Seq 323.1 MB link
— WTUT_JVN7_S7_R1_001.fastq.gz RNA-Seq 346.9 MB link