GSE214110
GSE GEORNA-Targeting CRISPR/Cas13d System Alleviates Disease-Related Phenotypes in Pre-clinical Models of Huntingtonâs Disease
Organism:
Mus musculus
Platform:
GPL18573
Samples:
67
Experiment Types:
Expression profiling by high throughput sequencing
Submitted:
Sep 24 2022
Last Updated:
Jan 25 2023
Status:
Public on Nov 15 2022
Contact:
Gene,,Yeo (UCSD)
Relations
SuperSeries of: GSE214108
SuperSeries of: GSE214109
BioProject: https://www.ncbi.nlm.nih.gov/bioproject/PRJNA883961
Summary
This SuperSeries is composed of the SubSeries listed below.
Overall Design
Refer to individual Series
Analysis (3 steps)
View Data Processing
Processing steps for GSE214110
- RNAseq reads were adapter-trimmed using Cutadapt (v1.14) and mapped to human-specific repetitive elements from RepBase (version 18.05) by STAR (v2.4.0i) (Dobin et al., 2013).
- Repeat-mapping reads were removed, and remaining reads were mapped to the human genome assembly (hg19) with STAR
- Read counts for all genes annotated in GENCODE (hg19) were calculated using the read summarization program featureCounts (Liao et al., 2014).
GEO Samples (67)
GSM6599187
GSM6599188
GSM6599189
GSM6599190
GSM6599191
GSM6599192
GSM6599193
GSM6599194
GSM6599195
GSM6599196
GSM6599197
GSM6599198
GSM6599199
GSM6599200
GSM6599201
GSM6599202
GSM6599203
GSM6599204
GSM6599205
GSM6599206
GSM6599207
GSM6599208
GSM6599209
GSM6599210
GSM6599211
GSM6599212
GSM6599213
GSM6599214
GSM6599215
GSM6599216
GSM6599217
GSM6599218
GSM6599219
GSM6599220
GSM6599221
GSM6599222
GSM6599223
GSM6599224
GSM6599225
GSM6599226
GSM6599227
GSM6599228
GSM6599229
GSM6599230
GSM6599231
GSM6599232
GSM6599233
GSM6599234
GSM6599235
GSM6599236
GSM6599237
GSM6599238
GSM6599239
GSM6599240
GSM6599241
GSM6599242
GSM6599243
GSM6599244
GSM6599245
GSM6599246
GSM6599247
GSM6599248
GSM6599249
GSM6599250
GSM6599251
GSM6599252
GSM6599253
Dataset Citations (1)
An RNA-targeting CRISPR-Cas13d system alleviates disease-related phenotypes in Huntington's disease models.
PMID 36510111
· 2023
· Nature neuroscience
Kathryn H Morelli, Qian Wu, Maya L Gosztyla, Hongshuai Liu, Minmin Yao, Chuangchuang Zhang, Jiaxu Chen, Ryan J Marina, Kari Lee, Krysten L Jones, Megan Y Huang, Allison Li, Charlene Smith-Geater, Leslie M Thompson, Wenzhen Duan, Gene W Yeo
Linked Publications (2)
An RNA-targeting CRISPR-Cas13d system alleviates disease-related phenotypes in Huntington's disease models.
Nature neuroscience · 2023
An RNA-targeting CRISPR-Cas13d system alleviates disease-related phenotypes in Huntington's disease models.
Nature neuroscience · 2023