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GSE51741

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Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for amyotrophic lateral sclerosis and frontotemporal dementia

Organism: Mus musculus
Platform: GPL11154
Samples: 33
Experiment Types:
Expression profiling by high throughput sequencing
Submitted: Oct 25 2013
Last Updated: May 15 2019
Status: Public on Nov 12 2013
Contact: John,,Ravits (UCSD)

Relations

SuperSeries of: GSE51684 SuperSeries of: GSE51685 BioProject: https://www.ncbi.nlm.nih.gov/bioproject/PRJNA224742

Summary

This SuperSeries is composed of the SubSeries listed below.

Overall Design

Refer to individual Series

Analysis (4 steps)

View Data Processing
Processing steps for GSE51741
  1. Illumina Casava1.8.2 software used for basecalling.
  2. Demultiplexing based on index sequences
  3. Sequenced reads were mapped to Refseq RNA sequences using bowtie v0.12.7 with parameters -q -e 100 -m 10 --best --strata
  4. Count reads for each genes
GEO Samples (33)
GSM1250452 GSM1250453 GSM1250454 GSM1250455 GSM1250456 GSM1250457 GSM1250458 GSM1250459 GSM1250460 GSM1250461 GSM1250462 GSM1250463 GSM1250464 GSM1250465 GSM1250466 GSM1250467 GSM1250468 GSM1250469 GSM1250470 GSM1250471 GSM1250472 GSM1250473 GSM1250474 GSM1250475 GSM1251885 GSM1251886 GSM1251887 GSM1251888 GSM1251889 GSM1251890 GSM1251891 GSM1251892 GSM1251893

Dataset Citations (1)

Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration.
PMID 24170860 · 2013 · Proceedings of the National Academy of Sciences of the United States of America
Clotilde Lagier-Tourenne, Michael Baughn, Frank Rigo, Shuying Sun, Patrick Liu, Hai-Ri Li, Jie Jiang, Andrew T Watt, Seung Chun, Melanie Katz, Jinsong Qiu, Ying Sun, Shuo-Chien Ling, Qiang Zhu, Magdalini Polymenidou, Kevin Drenner, Jonathan W Artates, Melissa McAlonis-Downes, Sebastian Markmiller, Kasey R Hutt, Donald P Pizzo, Janet Cady, Matthew B Harms, Robert H Baloh, Scott R Vandenberg, Gene W Yeo, Xiang-Dong Fu, C Frank Bennett, Don W Cleveland, John Ravits

Linked Publications (1)

Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration.
Proceedings of the National Academy of Sciences of the United States of America · 2013