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GSE145480

GSE GEO
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Rodents as models of human sarcopenia: a comparative analysis reveals conserved modulators of aging-dependent muscle loss

Organism: Mus musculus
Platform: GPL17021
Samples: 50
Experiment Types:
Expression profiling by high throughput sequencing
Submitted: Feb 18 2020
Last Updated: Mar 02 2021
Status: Public on Jan 30 2021
Contact: Anastasiya,,Boersch (University of Basel)

Relations

BioProject: https://www.ncbi.nlm.nih.gov/bioproject/PRJNA607292 SRA: https://www.ncbi.nlm.nih.gov/sra?term=SRP249850

Summary

Aims: Sarcopenia is the degenerative loss of skeletal muscle mass and function at high age, which affects 5-13% of people aged 60-70 years. Although a number of factors have been linked to sarcopenia, it remains unclear what determines its emergence in some but not all individuals and there are no medical treatments available. Mice and rats are widely used as model organisms to identify factors predisposing to sarcopenia, but the extent to which age-related molecular changes in wild-type mice and rats recapitulate those occurring in humans is not known. The aim of this project was to define a conserved set of regulators of aging-related reduction in muscle function that could be targeted by future therapies. Methods: We comparatively analyzed phenotypic parameters as well as the transcriptomes of the Gastrocnemius muscle from mice, rats and humans of a wide range of ages. We further inferred computationally the transcription regulators that likely underlie the molecular changes associated with aging-related loss in muscle functionality. Results: The analysis showed that the biological age of rodents that muscle mass is a better indicator of muscle functionality than the chronological age. Investigating the molecular changes associated with the aging-related loss of muscle mass, we discovered changes in gene expression that are shared between the studied species at the level of molecular pathways rather than at the level of individual genes. Beyond the known involvement of inflammation and mitochondrial function in aging, we found that the transcription regulators SPIB, ESRRB and YY1/YY2 consistently underlie aging-related molecular changes across the studied species. Conclusions: Rodents recapitulate well the molecular changes observed in human sarcopenia, but the conservation is stronger at the molecular pathway level than at the level of individual genes. Phenotypic parameters such as the muscle mass should be taken into account in stratifying samples for analyzing aging-related processes, as the chronological age is a poorer indicator of organ functionality. The shared regulators of aging-related muscle loss that we identified here can be studied further in rodent models of sarcopenia toward defining new targets for therapy in humans.

Overall Design

Gastrocnemius muscle mRNA profiles of 8, 18, 22, 24, 26 and 28 months old wild type mice were generated by next-generation sequencing.

Analysis (11 steps)

View Data Processing
Processing steps for GSE145480
  1. RNA-seq reads were subjected to 3’ adapter and poly(A)/poly(T) tail trimming using Cutadapt v1.9.1 from Martin et al., EMBnet.journal, 2011.
  2. The following 3’ adapter sequences were utilized for generating RNA-Seq libraries and subsequently trimmed: mate1 5’-AGATCGGAAGAGCACACGTC-3’, mate2 5’-AGATCGGAAGAGCGTCGTGT-3’.
  3. Reads shorter than 30 nucleotides were discarded.
  4. The kallisto v0.43.1 software from Bray et al., Nature Biotechnology, 2016 was used for building transcriptome index and aligning filtered reads.
  5. The default options of kallisto were utilized for building transcriptome index.
  6. For aligning filtered reads we used options “--rf-stranded” and “--pseudobam”.
  7. Mapped reads were assigned to transcripts in a weighted manner: if a read was uniquely mapped to a transcript, then the transcript’s read count was incremented by 1; if a read was mapped to n different transcripts, each transcript’s read count was incremented by 1/n.
  8. The expression of each transcript was estimated in transcripts per million (TPM) units by dividing its read count by the transcript length and normalizing to the library size.
Showing first 8 steps.

Supplementary Files (2)

GSE145480_counts_mouse_aging_timecourse.txt.gz Download
GSE145480_tpms_mouse_aging_timecourse.txt.gz Download
GEO Samples (50)
GSM4318861 GSM4318862 GSM4318863 GSM4318864 GSM4318865 GSM4318866 GSM4318867 GSM4318868 GSM4318869 GSM4318870 GSM4318871 GSM4318872 GSM4318873 GSM4318874 GSM4318875 GSM4318876 GSM4318877 GSM4318878 GSM4318879 GSM4318880 GSM4318881 GSM4318882 GSM4318883 GSM4318884 GSM4318885 GSM4318886 GSM4318887 GSM4318888 GSM4318889 GSM4318890 GSM4318891 GSM4318892 GSM4318893 GSM4318894 GSM4318895 GSM4318896 GSM4318897 GSM4318898 GSM4318899 GSM4318900 GSM4318901 GSM4318902 GSM4318903 GSM4318904 GSM4318905 GSM4318906 GSM4318907 GSM4318908 GSM4318909 GSM4318910

Dataset Citations (1)

PubMed citation (PMID 33580198)

SRA Experiments (50) and Runs (50)

Total: 111060 MB
SRX7740624 SRP249850 RNA-Seq PAIRED
GSM4318861: 8m_GAS_rep1; Mus musculus; RNA-Seq
Sample: SRS6160519
BioProject: PRJNA607292
BioSample: SAMN14126858
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 8
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102034 22378672 4520491744 2113.68 Sample_98058_R1.fastq.gz, Sample_98058_R2.fastq.gz, SRR11102034, SRR1… SRA
SRX7740625 SRP249850 RNA-Seq PAIRED
GSM4318862: 8m_GAS_rep2; Mus musculus; RNA-Seq
Sample: SRS6160520
BioProject: PRJNA607292
BioSample: SAMN14126857
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 8
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102035 27224280 5499304560 2570.91 Sample_98059_R1.fastq.gz, Sample_98059_R2.fastq.gz, SRR11102035, SRR1… SRA
SRX7740626 SRP249850 RNA-Seq PAIRED
GSM4318863: 8m_GAS_rep3; Mus musculus; RNA-Seq
Sample: SRS6160521
BioProject: PRJNA607292
BioSample: SAMN14126856
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 8
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102036 30824458 6226540516 2887.25 Sample_98060_R1.fastq.gz, Sample_98060_R2.fastq.gz, SRR11102036, SRR1… SRA
SRX7740627 SRP249850 RNA-Seq PAIRED
GSM4318864: 8m_GAS_rep4; Mus musculus; RNA-Seq
Sample: SRS6160522
BioProject: PRJNA607292
BioSample: SAMN14126855
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 8
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102037 27852803 5626266206 2649.38 Sample_98061_R1.fastq.gz, Sample_98061_R2.fastq.gz, SRR11102037, SRR1… SRA
SRX7740628 SRP249850 RNA-Seq PAIRED
GSM4318865: 8m_GAS_rep5; Mus musculus; RNA-Seq
Sample: SRS6160523
BioProject: PRJNA607292
BioSample: SAMN14126854
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 8
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102038 22928504 4631557808 2177.08 Sample_98062_R1.fastq.gz, Sample_98062_R2.fastq.gz, SRR11102038, SRR1… SRA
SRX7740629 SRP249850 RNA-Seq PAIRED
GSM4318866: 8m_GAS_rep6; Mus musculus; RNA-Seq
Sample: SRS6160524
BioProject: PRJNA607292
BioSample: SAMN14126853
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 8
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102039 31764726 6416474652 2993.36 Sample_98063_R1.fastq.gz, Sample_98063_R2.fastq.gz, SRR11102039, SRR1… SRA
SRX7740630 SRP249850 RNA-Seq PAIRED
GSM4318867: 8m_GAS_rep7; Mus musculus; RNA-Seq
Sample: SRS6160525
BioProject: PRJNA607292
BioSample: SAMN14126852
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 8
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102040 26645099 5382309998 2524.52 Sample_98064_R1.fastq.gz, Sample_98064_R2.fastq.gz, SRR11102040, SRR1… SRA
SRX7740631 SRP249850 RNA-Seq PAIRED
GSM4318868: 8m_GAS_rep8; Mus musculus; RNA-Seq
Sample: SRS6160526
BioProject: PRJNA607292
BioSample: SAMN14126851
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 8
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102041 26089108 5269999816 2459.93 Sample_98065_R1.fastq.gz, Sample_98065_R2.fastq.gz, SRR11102041, SRR1… SRA
SRX7740632 SRP249850 RNA-Seq PAIRED
GSM4318869: 18m_GAS_rep1; Mus musculus; RNA-Seq
Sample: SRS6160527
BioProject: PRJNA607292
BioSample: SAMN14126850
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 18
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102042 21891933 4422170466 2063.27 Sample_98066_R1.fastq.gz, Sample_98066_R2.fastq.gz, SRR11102042, SRR1… SRA
SRX7740633 SRP249850 RNA-Seq PAIRED
GSM4318870: 18m_GAS_rep2; Mus musculus; RNA-Seq
Sample: SRS6160528
BioProject: PRJNA607292
BioSample: SAMN14126849
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 18
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102043 21979132 4439784664 2103.98 Sample_98067_R1.fastq.gz, Sample_98067_R2.fastq.gz, SRR11102043, SRR1… SRA
SRX7740634 SRP249850 RNA-Seq PAIRED
GSM4318871: 18m_GAS_rep3; Mus musculus; RNA-Seq
Sample: SRS6160529
BioProject: PRJNA607292
BioSample: SAMN14126893
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 18
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102044 22105872 4465386144 2075.9 Sample_98068_R1.fastq.gz, Sample_98068_R2.fastq.gz, SRR11102044, SRR1… SRA
SRX7740635 SRP249850 RNA-Seq PAIRED
GSM4318872: 18m_GAS_rep4; Mus musculus; RNA-Seq
Sample: SRS6160530
BioProject: PRJNA607292
BioSample: SAMN14126892
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 18
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102045 21777449 4399044698 2096.43 Sample_98069_R1.fastq.gz, Sample_98069_R2.fastq.gz, SRR11102045, SRR1… SRA
SRX7740636 SRP249850 RNA-Seq PAIRED
GSM4318873: 18m_GAS_rep5; Mus musculus; RNA-Seq
Sample: SRS6160531
BioProject: PRJNA607292
BioSample: SAMN14126891
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 18
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102046 21780679 4399697158 2076.36 Sample_98070_R1.fastq.gz, Sample_98070_R2.fastq.gz, SRR11102046, SRR1… SRA
SRX7740637 SRP249850 RNA-Seq PAIRED
GSM4318874: 18m_GAS_rep6; Mus musculus; RNA-Seq
Sample: SRS6160532
BioProject: PRJNA607292
BioSample: SAMN14126890
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 18
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102047 24520989 4953239778 2332.38 Sample_98071_R1.fastq.gz, Sample_98071_R2.fastq.gz, SRR11102047, SRR1… SRA
SRX7740638 SRP249850 RNA-Seq PAIRED
GSM4318875: 18m_GAS_rep7; Mus musculus; RNA-Seq
Sample: SRS6160533
BioProject: PRJNA607292
BioSample: SAMN14126889
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 18
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102048 28383189 5733404178 2749.48 Sample_98072_R1.fastq.gz, Sample_98072_R2.fastq.gz, SRR11102048, SRR1… SRA
SRX7740639 SRP249850 RNA-Seq PAIRED
GSM4318876: 18m_GAS_rep8; Mus musculus; RNA-Seq
Sample: SRS6160534
BioProject: PRJNA607292
BioSample: SAMN14126888
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 18
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102049 21973652 4438677704 2077.38 Sample_98073_R1.fastq.gz, Sample_98073_R2.fastq.gz, SRR11102049, SRR1… SRA
SRX7740640 SRP249850 RNA-Seq PAIRED
GSM4318877: 22m_GAS_rep1; Mus musculus; RNA-Seq
Sample: SRS6160535
BioProject: PRJNA607292
BioSample: SAMN14126887
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 22
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102050 22715822 4588596044 2141.42 Sample_98074_R1.fastq.gz, Sample_98074_R2.fastq.gz, SRR11102050, SRR1… SRA
SRX7740641 SRP249850 RNA-Seq PAIRED
GSM4318878: 22m_GAS_rep2; Mus musculus; RNA-Seq
Sample: SRS6160536
BioProject: PRJNA607292
BioSample: SAMN14126886
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 22
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102051 22978968 4641751536 2170.61 Sample_98075_R1.fastq.gz, Sample_98075_R2.fastq.gz, SRR11102051, SRR1… SRA
SRX7740642 SRP249850 RNA-Seq PAIRED
GSM4318879: 22m_GAS_rep3; Mus musculus; RNA-Seq
Sample: SRS6160537
BioProject: PRJNA607292
BioSample: SAMN14126885
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 22
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102052 22710598 4587540796 2140.74 Sample_98076_R1.fastq.gz, Sample_98076_R2.fastq.gz, SRR11102052, SRR1… SRA
SRX7740643 SRP249850 RNA-Seq PAIRED
GSM4318880: 22m_GAS_rep4; Mus musculus; RNA-Seq
Sample: SRS6160538
BioProject: PRJNA607292
BioSample: SAMN14126884
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 22
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102053 29016264 5861285328 2765.64 Sample_98077_R1.fastq.gz, Sample_98077_R2.fastq.gz, SRR11102053, SRR1… SRA
SRX7740644 SRP249850 RNA-Seq PAIRED
GSM4318881: 22m_GAS_rep5; Mus musculus; RNA-Seq
Sample: SRS6160539
BioProject: PRJNA607292
BioSample: SAMN14126883
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 22
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102054 23166276 4679587752 2215.46 Sample_98078_R1.fastq.gz, Sample_98078_R2.fastq.gz, SRR11102054, SRR1… SRA
SRX7740645 SRP249850 RNA-Seq PAIRED
GSM4318882: 22m_GAS_rep6; Mus musculus; RNA-Seq
Sample: SRS6160540
BioProject: PRJNA607292
BioSample: SAMN14126882
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 22
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102055 25193580 5089103160 2397.2 Sample_98079_R1.fastq.gz, Sample_98079_R2.fastq.gz, SRR11102055, SRR1… SRA
SRX7740646 SRP249850 RNA-Seq PAIRED
GSM4318883: 22m_GAS_rep7; Mus musculus; RNA-Seq
Sample: SRS6160541
BioProject: PRJNA607292
BioSample: SAMN14126881
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 22
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102056 21917944 4427424688 2082.55 Sample_98080_R1.fastq.gz, Sample_98080_R2.fastq.gz, SRR11102056, SRR1… SRA
SRX7740647 SRP249850 RNA-Seq PAIRED
GSM4318884: 22m_GAS_rep8; Mus musculus; RNA-Seq
Sample: SRS6160542
BioProject: PRJNA607292
BioSample: SAMN14126880
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 22
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102057 23592465 4765677930 2229.41 Sample_98081_R1.fastq.gz, Sample_98081_R2.fastq.gz, SRR11102057, SRR1… SRA
SRX7740648 SRP249850 RNA-Seq PAIRED
GSM4318885: 24m_GAS_rep1; Mus musculus; RNA-Seq
Sample: SRS6160543
BioProject: PRJNA607292
BioSample: SAMN14126879
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 24
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102058 22420247 4528889894 2090.67 Sample_98082_R1.fastq.gz, Sample_98082_R2.fastq.gz, SRR11102058, SRR1… SRA
SRX7740649 SRP249850 RNA-Seq PAIRED
GSM4318886: 24m_GAS_rep2; Mus musculus; RNA-Seq
Sample: SRS6160544
BioProject: PRJNA607292
BioSample: SAMN14126878
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 24
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102059 22197745 4483944490 2071.63 Sample_98083_R1.fastq.gz, Sample_98083_R2.fastq.gz, SRR11102059, SRR1… SRA
SRX7740650 SRP249850 RNA-Seq PAIRED
GSM4318887: 24m_GAS_rep3; Mus musculus; RNA-Seq
Sample: SRS6160545
BioProject: PRJNA607292
BioSample: SAMN14126877
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 24
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102060 22729277 4591313954 2115.84 Sample_98084_R1.fastq.gz, Sample_98084_R2.fastq.gz, SRR11102060, SRR1… SRA
SRX7740651 SRP249850 RNA-Seq PAIRED
GSM4318888: 24m_GAS_rep4; Mus musculus; RNA-Seq
Sample: SRS6160546
BioProject: PRJNA607292
BioSample: SAMN14126876
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 24
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102061 21980006 4439961212 2086.79 Sample_98085_R1.fastq.gz, Sample_98085_R2.fastq.gz, SRR11102061, SRR1… SRA
SRX7740652 SRP249850 RNA-Seq PAIRED
GSM4318889: 24m_GAS_rep5; Mus musculus; RNA-Seq
Sample: SRS6160547
BioProject: PRJNA607292
BioSample: SAMN14126875
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 24
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102062 21960839 4436089478 2071.98 Sample_98086_R1.fastq.gz, Sample_98086_R2.fastq.gz, SRR11102062, SRR1… SRA
SRX7740653 SRP249850 RNA-Seq PAIRED
GSM4318890: 24m_GAS_rep6; Mus musculus; RNA-Seq
Sample: SRS6160548
BioProject: PRJNA607292
BioSample: SAMN14126874
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 24
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102063 22079035 4459965070 2060.11 Sample_98087_R1.fastq.gz, Sample_98087_R2.fastq.gz, SRR11102063, SRR1… SRA
SRX7740654 SRP249850 RNA-Seq PAIRED
GSM4318891: 24m_GAS_rep7; Mus musculus; RNA-Seq
Sample: SRS6160549
BioProject: PRJNA607292
BioSample: SAMN14126873
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 24
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102064 21544601 4352009402 2024.2 Sample_98088_R1.fastq.gz, Sample_98088_R2.fastq.gz, SRR11102064, SRR1… SRA
SRX7740655 SRP249850 RNA-Seq PAIRED
GSM4318892: 24m_GAS_rep8; Mus musculus; RNA-Seq
Sample: SRS6160550
BioProject: PRJNA607292
BioSample: SAMN14126872
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 24
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102065 21594433 4362075466 2020.12 Sample_98089_R1.fastq.gz, Sample_98089_R2.fastq.gz, SRR11102065, SRR1… SRA
SRX7740656 SRP249850 RNA-Seq PAIRED
GSM4318893: 26m_GAS_rep1; Mus musculus; RNA-Seq
Sample: SRS6160551
BioProject: PRJNA607292
BioSample: SAMN14126908
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 26
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102066 24460353 4940991306 2299.31 Sample_98090_R1.fastq.gz, Sample_98090_R2.fastq.gz, SRR11102066, SRR1… SRA
SRX7740657 SRP249850 RNA-Seq PAIRED
GSM4318894: 26m_GAS_rep2; Mus musculus; RNA-Seq
Sample: SRS6160552
BioProject: PRJNA607292
BioSample: SAMN14126907
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 26
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102067 22887596 4623294392 2163.83 Sample_98091_R1.fastq.gz, Sample_98091_R2.fastq.gz, SRR11102067, SRR1… SRA
SRX7740658 SRP249850 RNA-Seq PAIRED
GSM4318895: 26m_GAS_rep3; Mus musculus; RNA-Seq
Sample: SRS6160553
BioProject: PRJNA607292
BioSample: SAMN14126906
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 26
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102068 21612053 4365634706 2024.42 Sample_98092_R1.fastq.gz, Sample_98092_R2.fastq.gz, SRR11102068, SRR1… SRA
SRX7740659 SRP249850 RNA-Seq PAIRED
GSM4318896: 26m_GAS_rep4; Mus musculus; RNA-Seq
Sample: SRS6160554
BioProject: PRJNA607292
BioSample: SAMN14126905
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 26
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102069 23032460 4652556920 2196.46 Sample_98093_R1.fastq.gz, Sample_98093_R2.fastq.gz, SRR11102069, SRR1… SRA
SRX7740660 SRP249850 RNA-Seq PAIRED
GSM4318897: 26m_GAS_rep5; Mus musculus; RNA-Seq
Sample: SRS6160555
BioProject: PRJNA607292
BioSample: SAMN14126904
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 26
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102070 22638079 4572891958 2142.27 Sample_98094_R1.fastq.gz, Sample_98094_R2.fastq.gz, SRR11102070, SRR1… SRA
SRX7740661 SRP249850 RNA-Seq PAIRED
GSM4318898: 26m_GAS_rep6; Mus musculus; RNA-Seq
Sample: SRS6160556
BioProject: PRJNA607292
BioSample: SAMN14126903
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 26
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102071 21878176 4419391552 2058.39 Sample_98095_R1.fastq.gz, Sample_98095_R2.fastq.gz, SRR11102071, SRR1… SRA
SRX7740662 SRP249850 RNA-Seq PAIRED
GSM4318899: 26m_GAS_rep7; Mus musculus; RNA-Seq
Sample: SRS6160557
BioProject: PRJNA607292
BioSample: SAMN14126902
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 26
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102072 21883507 4420468414 2062.79 Sample_98096_R1.fastq.gz, Sample_98096_R2.fastq.gz, SRR11102072, SRR1… SRA
SRX7740663 SRP249850 RNA-Seq PAIRED
GSM4318900: 26m_GAS_rep8; Mus musculus; RNA-Seq
Sample: SRS6160558
BioProject: PRJNA607292
BioSample: SAMN14126901
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 26
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102073 22092063 4462596726 2060.81 Sample_98097_R1.fastq.gz, Sample_98097_R2.fastq.gz, SRR11102073, SRR1… SRA
SRX7740664 SRP249850 RNA-Seq PAIRED
GSM4318901: 26m_GAS_rep9; Mus musculus; RNA-Seq
Sample: SRS6160559
BioProject: PRJNA607292
BioSample: SAMN14126900
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 26
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102074 22352186 4515141572 2097.6 Sample_98098_R1.fastq.gz, Sample_98098_R2.fastq.gz, SRR11102074, SRR1… SRA
SRX7740665 SRP249850 RNA-Seq PAIRED
GSM4318902: 28m_GAS_rep1; Mus musculus; RNA-Seq
Sample: SRS6160560
BioProject: PRJNA607292
BioSample: SAMN14126899
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 28
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102075 21286659 4299905118 2007.17 Sample_98099_R1.fastq.gz, Sample_98099_R2.fastq.gz, SRR11102075, SRR1… SRA
SRX7740666 SRP249850 RNA-Seq PAIRED
GSM4318903: 28m_GAS_rep2; Mus musculus; RNA-Seq
Sample: SRS6160561
BioProject: PRJNA607292
BioSample: SAMN14126898
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 28
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102076 24488152 4946606704 2283.71 Sample_98100_R1.fastq.gz, Sample_98100_R2.fastq.gz, SRR11102076, SRR1… SRA
SRX7740667 SRP249850 RNA-Seq PAIRED
GSM4318904: 28m_GAS_rep3; Mus musculus; RNA-Seq
Sample: SRS6160562
BioProject: PRJNA607292
BioSample: SAMN14126897
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 28
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102077 22568619 4558861038 2173.78 Sample_98101_R1.fastq.gz, Sample_98101_R2.fastq.gz, SRR11102077, SRR1… SRA
SRX7740668 SRP249850 RNA-Seq PAIRED
GSM4318905: 28m_GAS_rep4; Mus musculus; RNA-Seq
Sample: SRS6160563
BioProject: PRJNA607292
BioSample: SAMN14126896
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 28
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102078 23478928 4742743456 2243.14 Sample_98102_R1.fastq.gz, Sample_98102_R2.fastq.gz, SRR11102078, SRR1… SRA
SRX7740669 SRP249850 RNA-Seq PAIRED
GSM4318906: 28m_GAS_rep5; Mus musculus; RNA-Seq
Sample: SRS6160564
BioProject: PRJNA607292
BioSample: SAMN14126895
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 28
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102079 22289071 4502392342 2106.03 Sample_98103_R1.fastq.gz, Sample_98103_R2.fastq.gz, SRR11102079, SRR1… SRA
SRX7740670 SRP249850 RNA-Seq PAIRED
GSM4318907: 28m_GAS_rep6; Mus musculus; RNA-Seq
Sample: SRS6160565
BioProject: PRJNA607292
BioSample: SAMN14126894
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 28
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102080 23071957 4660535314 2194.08 Sample_98104_R1.fastq.gz, Sample_98104_R2.fastq.gz, SRR11102080, SRR1… SRA
SRX7740671 SRP249850 RNA-Seq PAIRED
GSM4318908: 28m_GAS_rep7; Mus musculus; RNA-Seq
Sample: SRS6160566
BioProject: PRJNA607292
BioSample: SAMN14126871
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 28
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102081 22073807 4458909014 2071.09 Sample_98105_R1.fastq.gz, Sample_98105_R2.fastq.gz, SRR11102081, SRR1… SRA
SRX7740672 SRP249850 RNA-Seq PAIRED
GSM4318909: 28m_GAS_rep8; Mus musculus; RNA-Seq
Sample: SRS6160567
BioProject: PRJNA607292
BioSample: SAMN14126870
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 28
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102082 23320149 4710670098 2193.9 Sample_98106_R1.fastq.gz, Sample_98106_R2.fastq.gz, SRR11102082, SRR1… SRA
SRX7740673 SRP249850 RNA-Seq PAIRED
GSM4318910: 28m_GAS_rep9; Mus musculus; RNA-Seq
Sample: SRS6160568
BioProject: PRJNA607292
BioSample: SAMN14126869
Platform: ILLUMINA
Instrument: Illumina HiSeq 2500
Organism: Mus musculus
Sample attributes
source_name: Gastrocnemius muscle
strain: C57BL/6JRj
genotype: Wild type
tissue: Gastrocnemius muscle
age: Postnatal month 28
Original files (1)
Gastrocnemius muscle
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR11102083 21648112 4372918624 2045.92 Sample_98107_R1.fastq.gz, Sample_98107_R2.fastq.gz, SRR11102083, SRR1… SRA

Linked Publications (1)

Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and remodeling.
Proceedings of the National Academy of Sciences of the United States of America · 2024

Data Files (50)

Accession File Name Stored Type Output Type Mapping Assembly Size Download
— Sample_98058_R1.fastq.gz RNA-Seq 2.1 GB link
— Sample_98059_R1.fastq.gz RNA-Seq 2.5 GB link
— Sample_98060_R1.fastq.gz RNA-Seq 2.8 GB link
— Sample_98061_R1.fastq.gz RNA-Seq 2.6 GB link
— Sample_98062_R1.fastq.gz RNA-Seq 2.1 GB link
— Sample_98063_R1.fastq.gz RNA-Seq 2.9 GB link
— Sample_98064_R1.fastq.gz RNA-Seq 2.5 GB link
— Sample_98065_R1.fastq.gz RNA-Seq 2.4 GB link
— Sample_98066_R1.fastq.gz RNA-Seq 2.0 GB link
— Sample_98067_R1.fastq.gz RNA-Seq 2.1 GB link
— Sample_98068_R1.fastq.gz RNA-Seq 2.0 GB link
— Sample_98069_R1.fastq.gz RNA-Seq 2.0 GB link
— Sample_98070_R1.fastq.gz RNA-Seq 2.0 GB link
— Sample_98071_R1.fastq.gz RNA-Seq 2.3 GB link
— Sample_98072_R1.fastq.gz RNA-Seq 2.7 GB link
— Sample_98073_R1.fastq.gz RNA-Seq 2.0 GB link
— Sample_98074_R1.fastq.gz RNA-Seq 2.1 GB link
— Sample_98075_R1.fastq.gz RNA-Seq 2.1 GB link
— Sample_98076_R1.fastq.gz RNA-Seq 2.1 GB link
— Sample_98077_R1.fastq.gz RNA-Seq 2.7 GB link
— Sample_98078_R1.fastq.gz RNA-Seq 2.2 GB link
— Sample_98079_R1.fastq.gz RNA-Seq 2.3 GB link
— Sample_98080_R1.fastq.gz RNA-Seq 2.0 GB link
— Sample_98081_R1.fastq.gz RNA-Seq 2.2 GB link
— Sample_98082_R1.fastq.gz RNA-Seq 2.0 GB link
— Sample_98083_R1.fastq.gz RNA-Seq 2.0 GB link
— Sample_98084_R1.fastq.gz RNA-Seq 2.1 GB link
— Sample_98085_R1.fastq.gz RNA-Seq 2.0 GB link
— Sample_98086_R1.fastq.gz RNA-Seq 2.0 GB link
— Sample_98087_R1.fastq.gz RNA-Seq 2.0 GB link
— Sample_98088_R1.fastq.gz RNA-Seq 2.0 GB link
— Sample_98089_R1.fastq.gz RNA-Seq 2.0 GB link
— Sample_98090_R1.fastq.gz RNA-Seq 2.2 GB link
— Sample_98091_R1.fastq.gz RNA-Seq 2.1 GB link
— Sample_98092_R1.fastq.gz RNA-Seq 2.0 GB link
— Sample_98093_R1.fastq.gz RNA-Seq 2.1 GB link
— Sample_98094_R1.fastq.gz RNA-Seq 2.1 GB link
— Sample_98095_R1.fastq.gz RNA-Seq 2.0 GB link
— Sample_98096_R1.fastq.gz RNA-Seq 2.0 GB link
— Sample_98097_R1.fastq.gz RNA-Seq 2.0 GB link
— Sample_98098_R1.fastq.gz RNA-Seq 2.0 GB link
— Sample_98099_R1.fastq.gz RNA-Seq 2.0 GB link
— Sample_98100_R1.fastq.gz RNA-Seq 2.2 GB link
— Sample_98101_R1.fastq.gz RNA-Seq 2.1 GB link
— Sample_98102_R1.fastq.gz RNA-Seq 2.2 GB link
— Sample_98103_R1.fastq.gz RNA-Seq 2.1 GB link
— Sample_98104_R1.fastq.gz RNA-Seq 2.1 GB link
— Sample_98105_R1.fastq.gz RNA-Seq 2.0 GB link
— Sample_98106_R1.fastq.gz RNA-Seq 2.1 GB link
— Sample_98107_R1.fastq.gz RNA-Seq 2.0 GB link