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GSE75214

GSE GEO
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Mucosal gene expression profiling in patients with inflammatory bowel disease study

Organism: Homo sapiens
Platform: GPL6244
Samples: 194
Experiment Types:
Expression profiling by array
Submitted: Nov 19 2015
Last Updated: Jul 26 2018
Status: Public on Sep 14 2017
Contact: Ingrid,,Arijs (KULeuven)

Relations

BioProject: https://www.ncbi.nlm.nih.gov/bioproject/PRJNA302811

Summary

Microarrays were used to analyze the gene expression in endoscopic-derived intestinal mucosal biopsies from patients with inflammatory bowel diseas (IBD) and controls

Overall Design

Mucosal biopsies were obtained at endoscopy from the colon of 97 ulcerative colitis (UC), 8 Crohn's disease (CD) patients and 11 controls and from the (neo-)terminal ileum of 67 CD patients and 11 controls. The biopsies were taken at the most affected sites but at a distance of ulcerations. Disease activity was endoscopically assessed. Total RNA extracted from mucosal biopsies was used to analyze mRNA expression via Affymetrix Human Gene 1.0 ST arrays

Analysis (1 step)

View Data Processing
Processing steps for GSE75214
  1. Probe level analysis was performed on the Affymetrix raw data (.cel files) with the robust multichip average (RMA) method implemented in the Bioconductor package 'aroma.affymetrix' to obtain a log2 expression value for each gene probe set

Supplementary Files (1)

GSE75214_RAW.tar Download
GEO Samples (194)
GSM1426071 GSM1426072 GSM1426073 GSM1426074 GSM1426075 GSM1426076 GSM1426077 GSM1426078 GSM1426079 GSM1426080 GSM1426081 GSM1426082 GSM1426083 GSM1426084 GSM1426085 GSM1426086 GSM1426087 GSM1426088 GSM1426089 GSM1426090 GSM1426091 GSM1426092 GSM1426093 GSM1426094 GSM1426095 GSM1426096 GSM1426097 GSM1426098 GSM1426099 GSM1426100 GSM1426101 GSM1426102 GSM1426103 GSM1426104 GSM1426105 GSM1426106 GSM1426107 GSM1426108 GSM1426109 GSM1426110 GSM1426111 GSM1426112 GSM1426113 GSM1426114 GSM1426115 GSM1426116 GSM1426117 GSM1426118 GSM1426119 GSM1426120 GSM1426121 GSM1426122 GSM1426123 GSM1426124 GSM1426125 GSM1426126 GSM1426127 GSM1426128 GSM1426129 GSM1426130 GSM1426131 GSM1426132 GSM1426133 GSM1426134 GSM1426135 GSM1426136 GSM1426137 GSM1426138 GSM1426139 GSM1426140 GSM1426141 GSM1426142 GSM1426143 GSM1426144 GSM1426145 GSM1426146 GSM1426147 GSM1426148 GSM1426149 GSM1426150 GSM1426151 GSM1426152 GSM1426153 GSM1426154 GSM1426155 GSM1426156 GSM1426157 GSM1426158 GSM1426159 GSM1426160 GSM1426161 GSM1426162 GSM1426163 GSM1426164 GSM1426165 GSM1426166 GSM1426167 GSM1426168 GSM1426169 GSM1426170 GSM1426171 GSM1426172 GSM1426173 GSM1426174 GSM1426175 GSM1426176 GSM1426177 GSM1426178 GSM1426179 GSM1426180 GSM1426181 GSM1426182 GSM1426183 GSM1426184 GSM1426185 GSM1426186 GSM1945759 GSM1945760 GSM1945761 GSM1945762 GSM1945763 GSM1945764 GSM1945765 GSM1945766 GSM1945767 GSM1945768 GSM1945769 GSM1945770 GSM1945771 GSM1945772 GSM1945773 GSM1945774 GSM1945775 GSM1945776 GSM1945777 GSM1945778 GSM1945779 GSM1945780 GSM1945781 GSM1945782 GSM1945783 GSM1945784 GSM1945785 GSM1945786 GSM1945787 GSM1945788 GSM1945789 GSM1945790 GSM1945791 GSM1945792 GSM1945793 GSM1945794 GSM1945795 GSM1945796 GSM1945797 GSM1945798 GSM1945799 GSM1945800 GSM1945801 GSM1945802 GSM1945803 GSM1945804 GSM1945805 GSM1945806 GSM1945807 GSM1945808 GSM1945809 GSM1945810 GSM1945811 GSM1945812 GSM1945813 GSM1945814 GSM1945815 GSM1945816 GSM1945817 GSM1945818 GSM1945819 GSM1945820 GSM1945821 GSM1945822 GSM1945823 GSM1945824 GSM1945825 GSM1945826 GSM1945827 GSM1945828 GSM1945829 GSM1945830 GSM1945831 GSM1945832 GSM1945833 GSM1945834 GSM1945835 GSM1945836

Dataset Citations (1)

PubMed citation (PMID 28885228)

Linked Publications (1)

RNA binding protein DDX5 directs tuft cell specification and function to regulate microbial repertoire and disease susceptibility in the intestine.
Gut · 2022