GSE9650
GSE GEOChronic viral infection of naive, effector, memory and exhausted virus-specific CD8 T cells
Organism:
Mus musculus
Platform:
GPL81
Samples:
25
Experiment Types:
Expression profiling by array
Submitted:
Nov 20 2007
Last Updated:
Feb 18 2018
Status:
Public on Nov 27 2007
Contact:
Shruti,,Subramaniam (Emory University)
Relations
BioProject: https://www.ncbi.nlm.nih.gov/bioproject/PRJNA103517
Summary
CD8 T cells normally differentiate from resting naïve T cells into function effector and then memory CD8 T cells following acute infections. During chronic viral infections, however, virus-specific CD8 T cells often become exhausted. We used microarrays to examine the gene expression differences between naive, effector, memory and exhausted virus-specific CD8 T cells following lymphocytic choriomeningitis virus infection. Keywords: infection response
Overall Design
Three or four independent samples were sorted by flow cytometry for each cell type (naive, effector, memory and exhausted) virus-specific CD8 T cells. RNA was extracted and hybridized to Affymetrix microarrays.
Supplementary Files (1)
GSE9650_RAW.tar
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