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GSE290282

GSE GEO
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Large-scale tethered screen of RNA-binding proteins reveals novel regulators of poly(A) site selection [RNA-Seq]

Organism: Homo sapiens
Platform: Illumina
Status: manual

Summary

Alternative polyadenylation (APA) is a widespread mechanism of gene regulation that generates transcript isoforms with distinct 3' ends. While several RNA-binding proteins (RBPs) are known to regulate APA, the roles of the vast majority of RBPs in this process remain poorly characterized. Using a large-scale tethered function assay, we screened a library of 879 human RBPs to identify regulators of APA. We discovered 52 RBPs that modulate APA, validated their functions through knockdown PAS-seq and enhanced crosslinking and immunoprecipitation (eCLIP), and developed a fine-tuned transformer model to predict activators of PAS selection. We focused on two unexpected hits: GRB2, an adaptor protein with crucial roles in cell signaling, and RNPS1, a member of the exon junction complex (EJC). We uncovered mechanisms by which they modulate APA using affinity purification mass spectrometry (AP-MS) and biochemical assays. Our screen provides a comprehensive resource of RBPs involved in APA and reveals unexpected roles of signaling factors in APA regulation.

Analysis

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Analysis page is available for GSE290282.

Supplementary Files (1)

GSE290282_RAW.tar Download
GEO Samples (92)
GSM8809714 GSM8809715 GSM8809716 GSM8809717 GSM8809718 GSM8809719 GSM8809720 GSM8809721 GSM8809722 GSM8809723 GSM8809724 GSM8809725 GSM8809726 GSM8809727 GSM8809728 GSM8809729 GSM8809730 GSM8809731 GSM8809732 GSM8809733 GSM8809734 GSM8809735 GSM8809736 GSM8809737 GSM8809738 GSM8809739 GSM8809740 GSM8809741 GSM8809742 GSM8809743 GSM8809744 GSM8809745 GSM8809746 GSM8809747 GSM8809748 GSM8809749 GSM8809750 GSM8809751 GSM8809752 GSM8809753 GSM8809754 GSM8809755 GSM8809756 GSM8809757 GSM8809758 GSM8809759 GSM8809760 GSM8809761 GSM8809762 GSM8809763 GSM8809764 GSM8809765 GSM8809766 GSM8809767 GSM8809768 GSM8809769 GSM8809770 GSM8809771 GSM8809772 GSM8809773 GSM8809774 GSM8809775 GSM8809776 GSM8809777 GSM8809778 GSM8809779 GSM8809780 GSM8809781 GSM8809782 GSM8809783 GSM8809784 GSM8809785 GSM8809786 GSM8809787 GSM8809788 GSM8809789 GSM8809790 GSM8809791 GSM8809792 GSM8809793 GSM8809794 GSM8809795 GSM8809796 GSM8809797 GSM8809798 GSM8809799 GSM8809800 GSM8809801 GSM8809802 GSM8809803 GSM8809804 GSM8809805

SRA Experiments (92) and Runs (92)

Total: 195139 MB
SRX27771379 SRP565737 RNA-Seq PAIRED
Sample: SRS24150563
BioProject: PRJNA1227128
BioSample: SAMN46971724
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32457015 49245910 9849182000 2942.0 SRA
SRX27771380 SRP565737 RNA-Seq PAIRED
Sample: SRS24150565
BioProject: PRJNA1227128
BioSample: SAMN46971723
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32457014 37890019 7578003800 2255.0 SRA
SRX27771381 SRP565737 RNA-Seq PAIRED
Sample: SRS24150564
BioProject: PRJNA1227128
BioSample: SAMN46971722
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32457013 27957605 5591521000 1666.0 SRA
SRX27771382 SRP565737 RNA-Seq PAIRED
Sample: SRS24150566
BioProject: PRJNA1227128
BioSample: SAMN46971721
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32457012 27889486 5577897200 1665.0 SRA
SRX27771383 SRP565737 RNA-Seq PAIRED
Sample: SRS24150567
BioProject: PRJNA1227128
BioSample: SAMN46971720
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32457011 37866996 7573399200 2259.0 SRA
SRX27771384 SRP565737 RNA-Seq PAIRED
Sample: SRS24150568
BioProject: PRJNA1227128
BioSample: SAMN46971719
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32457010 34401638 6880327600 2049.0 SRA
SRX27771385 SRP565737 RNA-Seq PAIRED
Sample: SRS24150569
BioProject: PRJNA1227128
BioSample: SAMN46971718
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32457009 38073953 7614790600 2261.0 SRA
SRX27771386 SRP565737 RNA-Seq PAIRED
Sample: SRS24150570
BioProject: PRJNA1227128
BioSample: SAMN46971717
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32457008 42200153 8440030600 2507.0 SRA
SRX27771387 SRP565737 RNA-Seq PAIRED
Sample: SRS24150571
BioProject: PRJNA1227128
BioSample: SAMN46971716
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32457007 37512035 7502407000 2259.0 SRA
SRX27771388 SRP565737 RNA-Seq PAIRED
Sample: SRS24150572
BioProject: PRJNA1227128
BioSample: SAMN46971715
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32457006 28800798 5760159600 1713.0 SRA
SRX27771389 SRP565737 RNA-Seq PAIRED
Sample: SRS24150574
BioProject: PRJNA1227128
BioSample: SAMN46971714
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32457005 27074964 5414992800 1640.0 SRA
SRX27771390 SRP565737 RNA-Seq PAIRED
Sample: SRS24150573
BioProject: PRJNA1227128
BioSample: SAMN46971713
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32457004 30502103 6100420600 1815.0 SRA
SRX27771391 SRP565737 RNA-Seq PAIRED
Sample: SRS24150575
BioProject: PRJNA1227128
BioSample: SAMN46971712
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32457003 34738368 6947673600 2081.0 SRA
SRX27771392 SRP565737 RNA-Seq PAIRED
Sample: SRS24150576
BioProject: PRJNA1227128
BioSample: SAMN46971711
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32457002 34713251 6942650200 2062.0 SRA
SRX27771393 SRP565737 RNA-Seq PAIRED
Sample: SRS24150577
BioProject: PRJNA1227128
BioSample: SAMN46971710
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32457001 23478729 4695745800 1404.0 SRA
SRX27771394 SRP565737 RNA-Seq PAIRED
Sample: SRS24150578
BioProject: PRJNA1227128
BioSample: SAMN46971709
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32457000 22072263 4414452600 1327.0 SRA
SRX27771395 SRP565737 RNA-Seq PAIRED
Sample: SRS24150579
BioProject: PRJNA1227128
BioSample: SAMN46971708
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456999 28451960 5690392000 1698.0 SRA
SRX27771396 SRP565737 RNA-Seq PAIRED
Sample: SRS24150580
BioProject: PRJNA1227128
BioSample: SAMN46971707
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456998 29665811 5933162200 1780.0 SRA
SRX27771397 SRP565737 RNA-Seq PAIRED
Sample: SRS24150581
BioProject: PRJNA1227128
BioSample: SAMN46971706
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456997 26883856 5376771200 1626.0 SRA
SRX27771398 SRP565737 RNA-Seq PAIRED
Sample: SRS24150582
BioProject: PRJNA1227128
BioSample: SAMN46971705
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456996 22178840 4435768000 1324.0 SRA
SRX27771399 SRP565737 RNA-Seq PAIRED
Sample: SRS24150583
BioProject: PRJNA1227128
BioSample: SAMN46971704
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456995 44330038 8866007600 2628.0 SRA
SRX27771400 SRP565737 RNA-Seq PAIRED
Sample: SRS24150584
BioProject: PRJNA1227128
BioSample: SAMN46971703
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456994 47016212 9403242400 2801.0 SRA
SRX27771401 SRP565737 RNA-Seq PAIRED
Sample: SRS24150585
BioProject: PRJNA1227128
BioSample: SAMN46971702
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456993 43011917 8602383400 2558.0 SRA
SRX27771402 SRP565737 RNA-Seq PAIRED
Sample: SRS24150586
BioProject: PRJNA1227128
BioSample: SAMN46971701
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456992 30304534 6060906800 1797.0 SRA
SRX27771403 SRP565737 RNA-Seq PAIRED
Sample: SRS24150587
BioProject: PRJNA1227128
BioSample: SAMN46971700
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456991 29456082 5891216400 1767.0 SRA
SRX27771404 SRP565737 RNA-Seq PAIRED
Sample: SRS24150588
BioProject: PRJNA1227128
BioSample: SAMN46971699
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456990 31936624 6387324800 1914.0 SRA
SRX27771405 SRP565737 RNA-Seq PAIRED
Sample: SRS24150589
BioProject: PRJNA1227128
BioSample: SAMN46971698
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456989 31723213 6344642600 1885.0 SRA
SRX27771406 SRP565737 RNA-Seq PAIRED
Sample: SRS24150590
BioProject: PRJNA1227128
BioSample: SAMN46971697
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456988 26145049 5229009800 1578.0 SRA
SRX27771407 SRP565737 RNA-Seq PAIRED
Sample: SRS24150591
BioProject: PRJNA1227128
BioSample: SAMN46971696
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456987 35313034 7062606800 2118.0 SRA
SRX27771408 SRP565737 RNA-Seq PAIRED
Sample: SRS24150592
BioProject: PRJNA1227128
BioSample: SAMN46971695
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456986 43476492 8695298400 2575.0 SRA
SRX27771409 SRP565737 RNA-Seq PAIRED
Sample: SRS24150593
BioProject: PRJNA1227128
BioSample: SAMN46971694
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456985 72274876 14454975200 4275.0 SRA
SRX27771410 SRP565737 RNA-Seq PAIRED
Sample: SRS24150594
BioProject: PRJNA1227128
BioSample: SAMN46971693
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456984 26436526 5287305200 1575.0 SRA
SRX27771411 SRP565737 RNA-Seq PAIRED
Sample: SRS24150595
BioProject: PRJNA1227128
BioSample: SAMN46971692
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456983 39071991 7814398200 2301.0 SRA
SRX27771412 SRP565737 RNA-Seq PAIRED
Sample: SRS24150596
BioProject: PRJNA1227128
BioSample: SAMN46971691
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456982 35401746 7080349200 2101.0 SRA
SRX27771413 SRP565737 RNA-Seq PAIRED
Sample: SRS24150597
BioProject: PRJNA1227128
BioSample: SAMN46971690
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456981 43277099 8655419800 2576.0 SRA
SRX27771414 SRP565737 RNA-Seq PAIRED
Sample: SRS24150598
BioProject: PRJNA1227128
BioSample: SAMN46971689
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456980 35497833 7099566600 2112.0 SRA
SRX27771415 SRP565737 RNA-Seq PAIRED
Sample: SRS24150599
BioProject: PRJNA1227128
BioSample: SAMN46971688
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456979 33094924 6618984800 1966.0 SRA
SRX27771416 SRP565737 RNA-Seq PAIRED
Sample: SRS24150600
BioProject: PRJNA1227128
BioSample: SAMN46971687
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456978 36813052 7362610400 2199.0 SRA
SRX27771417 SRP565737 RNA-Seq PAIRED
Sample: SRS24150601
BioProject: PRJNA1227128
BioSample: SAMN46971686
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456977 27328758 5465751600 1640.0 SRA
SRX27771418 SRP565737 RNA-Seq PAIRED
Sample: SRS24150602
BioProject: PRJNA1227128
BioSample: SAMN46971685
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456976 34686411 6937282200 2074.0 SRA
SRX27771419 SRP565737 RNA-Seq PAIRED
Sample: SRS24150603
BioProject: PRJNA1227128
BioSample: SAMN46971684
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456975 48134527 9626905400 2844.0 SRA
SRX27771420 SRP565737 RNA-Seq PAIRED
Sample: SRS24150604
BioProject: PRJNA1227128
BioSample: SAMN46971683
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456974 25193586 5038717200 1525.0 SRA
SRX27771421 SRP565737 RNA-Seq PAIRED
Sample: SRS24150605
BioProject: PRJNA1227128
BioSample: SAMN46971682
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456973 41444201 8288840200 2448.0 SRA
SRX27771422 SRP565737 RNA-Seq PAIRED
Sample: SRS24150606
BioProject: PRJNA1227128
BioSample: SAMN46971681
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456972 36434660 7286932000 2184.0 SRA
SRX27771423 SRP565737 RNA-Seq PAIRED
Sample: SRS24150607
BioProject: PRJNA1227128
BioSample: SAMN46971680
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456971 31744250 6348850000 1885.0 SRA
SRX27771424 SRP565737 RNA-Seq PAIRED
Sample: SRS24150608
BioProject: PRJNA1227128
BioSample: SAMN46971679
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456970 26283782 5256756400 1567.0 SRA
SRX27771425 SRP565737 RNA-Seq PAIRED
Sample: SRS24150609
BioProject: PRJNA1227128
BioSample: SAMN46971678
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456969 30350156 6070031200 1820.0 SRA
SRX27771426 SRP565737 RNA-Seq PAIRED
Sample: SRS24150610
BioProject: PRJNA1227128
BioSample: SAMN46971677
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456968 49793185 9958637000 2958.0 SRA
SRX27771427 SRP565737 RNA-Seq PAIRED
Sample: SRS24150611
BioProject: PRJNA1227128
BioSample: SAMN46971676
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456967 55793878 11158775600 3322.0 SRA
SRX27771428 SRP565737 RNA-Seq PAIRED
Sample: SRS24150612
BioProject: PRJNA1227128
BioSample: SAMN46971675
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456966 31587021 6317404200 1912.0 SRA
SRX27771429 SRP565737 RNA-Seq PAIRED
Sample: SRS24150613
BioProject: PRJNA1227128
BioSample: SAMN46971674
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456965 46847362 9369472400 2768.0 SRA
SRX27771430 SRP565737 RNA-Seq PAIRED
Sample: SRS24150614
BioProject: PRJNA1227128
BioSample: SAMN46971649
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456964 40885491 8177098200 2433.0 SRA
SRX27771431 SRP565737 RNA-Seq PAIRED
Sample: SRS24150615
BioProject: PRJNA1227128
BioSample: SAMN46971648
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456963 37457522 7491504400 2236.0 SRA
SRX27771432 SRP565737 RNA-Seq PAIRED
Sample: SRS24150616
BioProject: PRJNA1227128
BioSample: SAMN46971647
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456962 39610518 7922103600 2344.0 SRA
SRX27771433 SRP565737 RNA-Seq PAIRED
Sample: SRS24150617
BioProject: PRJNA1227128
BioSample: SAMN46971646
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456961 36343510 7268702000 2159.0 SRA
SRX27771434 SRP565737 RNA-Seq PAIRED
Sample: SRS24150618
BioProject: PRJNA1227128
BioSample: SAMN46971645
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456960 42345053 8469010600 2507.0 SRA
SRX27771435 SRP565737 RNA-Seq PAIRED
Sample: SRS24150619
BioProject: PRJNA1227128
BioSample: SAMN46971644
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456959 37928873 7585774600 2259.0 SRA
SRX27771436 SRP565737 RNA-Seq PAIRED
Sample: SRS24150620
BioProject: PRJNA1227128
BioSample: SAMN46971643
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456958 28493190 5698638000 1708.0 SRA
SRX27771437 SRP565737 RNA-Seq PAIRED
Sample: SRS24150621
BioProject: PRJNA1227128
BioSample: SAMN46971642
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456957 25290922 5058184400 1511.0 SRA
SRX27771438 SRP565737 RNA-Seq PAIRED
Sample: SRS24150622
BioProject: PRJNA1227128
BioSample: SAMN46971641
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456956 20508516 4101703200 1237.0 SRA
SRX27771439 SRP565737 RNA-Seq PAIRED
Sample: SRS24150623
BioProject: PRJNA1227128
BioSample: SAMN46971640
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456955 21073534 4214706800 1261.0 SRA
SRX27771440 SRP565737 RNA-Seq PAIRED
Sample: SRS24150624
BioProject: PRJNA1227128
BioSample: SAMN46971639
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456954 28953572 5790714400 1715.0 SRA
SRX27771441 SRP565737 RNA-Seq PAIRED
Sample: SRS24150625
BioProject: PRJNA1227128
BioSample: SAMN46971638
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456953 15053324 3010664800 909.0 SRA
SRX27771442 SRP565737 RNA-Seq PAIRED
Sample: SRS24150627
BioProject: PRJNA1227128
BioSample: SAMN46971637
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456952 31448397 6289679400 1863.0 SRA
SRX27771443 SRP565737 RNA-Seq PAIRED
Sample: SRS24150626
BioProject: PRJNA1227128
BioSample: SAMN46971636
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456951 32342825 6468565000 1930.0 SRA
SRX27771444 SRP565737 RNA-Seq PAIRED
Sample: SRS24150628
BioProject: PRJNA1227128
BioSample: SAMN46971635
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456950 23182988 4636597600 1394.0 SRA
SRX27771445 SRP565737 RNA-Seq PAIRED
Sample: SRS24150630
BioProject: PRJNA1227128
BioSample: SAMN46971634
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456949 47723253 9544650600 2837.0 SRA
SRX27771446 SRP565737 RNA-Seq PAIRED
Sample: SRS24150629
BioProject: PRJNA1227128
BioSample: SAMN46971633
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456948 24255673 4851134600 1453.0 SRA
SRX27771447 SRP565737 RNA-Seq PAIRED
Sample: SRS24150631
BioProject: PRJNA1227128
BioSample: SAMN46971673
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456947 39684737 7936947400 2354.0 SRA
SRX27771448 SRP565737 RNA-Seq PAIRED
Sample: SRS24150632
BioProject: PRJNA1227128
BioSample: SAMN46971672
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456946 46024703 9204940600 2734.0 SRA
SRX27771449 SRP565737 RNA-Seq PAIRED
Sample: SRS24150633
BioProject: PRJNA1227128
BioSample: SAMN46971671
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456945 36199365 7239873000 2153.0 SRA
SRX27771450 SRP565737 RNA-Seq PAIRED
Sample: SRS24150634
BioProject: PRJNA1227128
BioSample: SAMN46971670
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456944 35986302 7197260400 2145.0 SRA
SRX27771451 SRP565737 RNA-Seq PAIRED
Sample: SRS24150635
BioProject: PRJNA1227128
BioSample: SAMN46971669
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456943 40907514 8181502800 2457.0 SRA
SRX27771452 SRP565737 RNA-Seq PAIRED
Sample: SRS24150636
BioProject: PRJNA1227128
BioSample: SAMN46971668
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456942 25781619 5156323800 1550.0 SRA
SRX27771453 SRP565737 RNA-Seq PAIRED
Sample: SRS24150637
BioProject: PRJNA1227128
BioSample: SAMN46971667
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456941 37366336 7473267200 2207.0 SRA
SRX27771454 SRP565737 RNA-Seq PAIRED
Sample: SRS24150638
BioProject: PRJNA1227128
BioSample: SAMN46971666
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456940 39851978 7970395600 2355.0 SRA
SRX27771455 SRP565737 RNA-Seq PAIRED
Sample: SRS24150639
BioProject: PRJNA1227128
BioSample: SAMN46971665
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456939 33962299 6792459800 2019.0 SRA
SRX27771456 SRP565737 RNA-Seq PAIRED
Sample: SRS24150640
BioProject: PRJNA1227128
BioSample: SAMN46971664
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456938 94288197 18857639400 5567.0 SRA
SRX27771457 SRP565737 RNA-Seq PAIRED
Sample: SRS24150641
BioProject: PRJNA1227128
BioSample: SAMN46971663
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456937 37445492 7489098400 2219.0 SRA
SRX27771458 SRP565737 RNA-Seq PAIRED
Sample: SRS24150643
BioProject: PRJNA1227128
BioSample: SAMN46971662
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456936 38441443 7688288600 2284.0 SRA
SRX27771459 SRP565737 RNA-Seq PAIRED
Sample: SRS24150642
BioProject: PRJNA1227128
BioSample: SAMN46971661
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456935 41648076 8329615200 2453.0 SRA
SRX27771460 SRP565737 RNA-Seq PAIRED
Sample: SRS24150644
BioProject: PRJNA1227128
BioSample: SAMN46971660
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456934 35170400 7034080000 2092.0 SRA
SRX27771461 SRP565737 RNA-Seq PAIRED
Sample: SRS24150645
BioProject: PRJNA1227128
BioSample: SAMN46971659
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456933 22564208 4512841600 1355.0 SRA
SRX27771462 SRP565737 RNA-Seq PAIRED
Sample: SRS24150646
BioProject: PRJNA1227128
BioSample: SAMN46971658
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456932 53688736 10737747200 3186.0 SRA
SRX27771463 SRP565737 RNA-Seq PAIRED
Sample: SRS24150647
BioProject: PRJNA1227128
BioSample: SAMN46971657
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456931 43168243 8633648600 2569.0 SRA
SRX27771464 SRP565737 RNA-Seq PAIRED
Sample: SRS24150648
BioProject: PRJNA1227128
BioSample: SAMN46971656
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456930 35008612 7001722400 2066.0 SRA
SRX27771465 SRP565737 RNA-Seq PAIRED
Sample: SRS24150650
BioProject: PRJNA1227128
BioSample: SAMN46971655
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456929 24549625 4909925000 1468.0 SRA
SRX27771466 SRP565737 RNA-Seq PAIRED
Sample: SRS24150649
BioProject: PRJNA1227128
BioSample: SAMN46971654
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456928 25969173 5193834600 1543.0 SRA
SRX27771467 SRP565737 RNA-Seq PAIRED
Sample: SRS24150651
BioProject: PRJNA1227128
BioSample: SAMN46971653
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456927 36489963 7297992600 2176.0 SRA
SRX27771468 SRP565737 RNA-Seq PAIRED
Sample: SRS24150652
BioProject: PRJNA1227128
BioSample: SAMN46971652
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456926 21649674 4329934800 1314.0 SRA
SRX27771469 SRP565737 RNA-Seq PAIRED
Sample: SRS24150654
BioProject: PRJNA1227128
BioSample: SAMN46971651
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456925 26446422 5289284400 1583.0 SRA
SRX27771470 SRP565737 RNA-Seq PAIRED
Sample: SRS24150653
BioProject: PRJNA1227128
BioSample: SAMN46971650
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32456924 59077729 11815545800 3528.0 SRA

Linked Publications (1)

Large-scale tethered screen of RNA-binding proteins reveals novel regulators of poly(A) site selection.
Molecular cell · 2026

Data Files (92)

Accession File Name Stored Type Output Type Mapping Assembly Size Download
— SRR32456924_GSM8809788 RNA-Seq 3.4 GB link
— SRR32456925_GSM8809787 RNA-Seq 1.5 GB link
— SRR32456926_GSM8809786 RNA-Seq 1.3 GB link
— SRR32456927_GSM8809785 RNA-Seq 2.1 GB link
— SRR32456928_GSM8809784 RNA-Seq 1.5 GB link
— SRR32456929_GSM8809783 RNA-Seq 1.4 GB link
— SRR32456930_GSM8809782 RNA-Seq 2.0 GB link
— SRR32456931_GSM8809781 RNA-Seq 2.5 GB link
— SRR32456932_GSM8809780 RNA-Seq 3.1 GB link
— SRR32456933_GSM8809779 RNA-Seq 1.3 GB link
— SRR32456934_GSM8809778 RNA-Seq 2.0 GB link
— SRR32456935_GSM8809777 RNA-Seq 2.4 GB link
— SRR32456936_GSM8809776 RNA-Seq 2.2 GB link
— SRR32456937_GSM8809775 RNA-Seq 2.2 GB link
— SRR32456938_GSM8809774 RNA-Seq 5.4 GB link
— SRR32456939_GSM8809773 RNA-Seq 2.0 GB link
— SRR32456940_GSM8809772 RNA-Seq 2.3 GB link
— SRR32456941_GSM8809771 RNA-Seq 2.2 GB link
— SRR32456942_GSM8809770 RNA-Seq 1.5 GB link
— SRR32456943_GSM8809769 RNA-Seq 2.4 GB link
— SRR32456944_GSM8809768 RNA-Seq 2.1 GB link
— SRR32456945_GSM8809767 RNA-Seq 2.1 GB link
— SRR32456946_GSM8809766 RNA-Seq 2.7 GB link
— SRR32456947_GSM8809765 RNA-Seq 2.3 GB link
— SRR32456948_GSM8809805 RNA-Seq 1.4 GB link
— SRR32456949_GSM8809804 RNA-Seq 2.8 GB link
— SRR32456950_GSM8809803 RNA-Seq 1.4 GB link
— SRR32456951_GSM8809802 RNA-Seq 1.9 GB link
— SRR32456952_GSM8809801 RNA-Seq 1.8 GB link
— SRR32456953_GSM8809800 RNA-Seq 909.0 MB link
— SRR32456954_GSM8809799 RNA-Seq 1.7 GB link
— SRR32456955_GSM8809798 RNA-Seq 1.2 GB link
— SRR32456956_GSM8809797 RNA-Seq 1.2 GB link
— SRR32456957_GSM8809796 RNA-Seq 1.5 GB link
— SRR32456958_GSM8809795 RNA-Seq 1.7 GB link
— SRR32456959_GSM8809794 RNA-Seq 2.2 GB link
— SRR32456960_GSM8809793 RNA-Seq 2.4 GB link
— SRR32456961_GSM8809792 RNA-Seq 2.1 GB link
— SRR32456962_GSM8809791 RNA-Seq 2.3 GB link
— SRR32456963_GSM8809790 RNA-Seq 2.2 GB link
— SRR32456964_GSM8809789 RNA-Seq 2.4 GB link
— SRR32456965_GSM8809764 RNA-Seq 2.7 GB link
— SRR32456966_GSM8809763 RNA-Seq 1.9 GB link
— SRR32456967_GSM8809762 RNA-Seq 3.2 GB link
— SRR32456968_GSM8809761 RNA-Seq 2.9 GB link
— SRR32456969_GSM8809760 RNA-Seq 1.8 GB link
— SRR32456970_GSM8809759 RNA-Seq 1.5 GB link
— SRR32456971_GSM8809758 RNA-Seq 1.8 GB link
— SRR32456972_GSM8809757 RNA-Seq 2.1 GB link
— SRR32456973_GSM8809756 RNA-Seq 2.4 GB link
— SRR32456974_GSM8809755 RNA-Seq 1.5 GB link
— SRR32456975_GSM8809754 RNA-Seq 2.8 GB link
— SRR32456976_GSM8809753 RNA-Seq 2.0 GB link
— SRR32456977_GSM8809752 RNA-Seq 1.6 GB link
— SRR32456978_GSM8809751 RNA-Seq 2.1 GB link
— SRR32456979_GSM8809750 RNA-Seq 1.9 GB link
— SRR32456980_GSM8809749 RNA-Seq 2.1 GB link
— SRR32456981_GSM8809748 RNA-Seq 2.5 GB link
— SRR32456982_GSM8809747 RNA-Seq 2.1 GB link
— SRR32456983_GSM8809746 RNA-Seq 2.2 GB link
— SRR32456984_GSM8809745 RNA-Seq 1.5 GB link
— SRR32456985_GSM8809744 RNA-Seq 4.2 GB link
— SRR32456986_GSM8809743 RNA-Seq 2.5 GB link
— SRR32456987_GSM8809742 RNA-Seq 2.1 GB link
— SRR32456988_GSM8809741 RNA-Seq 1.5 GB link
— SRR32456989_GSM8809740 RNA-Seq 1.8 GB link
— SRR32456990_GSM8809739 RNA-Seq 1.9 GB link
— SRR32456991_GSM8809738 RNA-Seq 1.7 GB link
— SRR32456992_GSM8809737 RNA-Seq 1.8 GB link
— SRR32456993_GSM8809736 RNA-Seq 2.5 GB link
— SRR32456994_GSM8809735 RNA-Seq 2.7 GB link
— SRR32456995_GSM8809734 RNA-Seq 2.6 GB link
— SRR32456996_GSM8809733 RNA-Seq 1.3 GB link
— SRR32456997_GSM8809732 RNA-Seq 1.6 GB link
— SRR32456998_GSM8809731 RNA-Seq 1.7 GB link
— SRR32456999_GSM8809730 RNA-Seq 1.7 GB link
— SRR32457000_GSM8809729 RNA-Seq 1.3 GB link
— SRR32457001_GSM8809728 RNA-Seq 1.4 GB link
— SRR32457002_GSM8809727 RNA-Seq 2.0 GB link
— SRR32457003_GSM8809726 RNA-Seq 2.0 GB link
— SRR32457004_GSM8809725 RNA-Seq 1.8 GB link
— SRR32457005_GSM8809724 RNA-Seq 1.6 GB link
— SRR32457006_GSM8809723 RNA-Seq 1.7 GB link
— SRR32457007_GSM8809722 RNA-Seq 2.2 GB link
— SRR32457008_GSM8809721 RNA-Seq 2.4 GB link
— SRR32457009_GSM8809720 RNA-Seq 2.2 GB link
— SRR32457010_GSM8809719 RNA-Seq 2.0 GB link
— SRR32457011_GSM8809718 RNA-Seq 2.2 GB link
— SRR32457012_GSM8809717 RNA-Seq 1.6 GB link
— SRR32457013_GSM8809716 RNA-Seq 1.6 GB link
— SRR32457014_GSM8809715 RNA-Seq 2.2 GB link
— SRR32457015_GSM8809714 RNA-Seq 2.9 GB link