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GSE290248

GSE GEO
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Large-scale tethered screen of RNA-binding proteins reveals novel regulators of poly(A) site selection [PAS-seq]

Organism: Homo sapiens
Platform: Illumina
Status: manual

Summary

Alternative polyadenylation (APA) is a widespread mechanism of gene regulation that generates transcript isoforms with distinct 3' ends. While several RNA-binding proteins (RBPs) are known to regulate APA, the roles of the vast majority of RBPs in this process remain poorly characterized. Using a large scale tethered function assay, we screened a library of 879 human RBPs to identify regulators of APA. We discovered 52 RBPs that modulate APA, validated their functions through knockdown PAS-seq and enhanced crosslinking and immunoprecipitation (eCLIP), and developed a fine-tuned transformer model to predict activators of PAS selection. We focused on two unexpected hits: GRB2, an adaptor protein with crucial roles in cell signaling, and RNPS1, a member of the exon junction complex (EJC). We uncovered mechanisms by which they modulate APA using affinity purification mass spectrometry (AP-MS) and biochemical assays. Our screennprovides a comprehensive resource of RBPs involved in APA and reveals unexpected roles of signaling factors in APA regulation.

Analysis

View Data Processing
Analysis page is available for GSE290248.

Supplementary Files (1)

GSE290248_RAW.tar Download
GEO Samples (97)
GSM8809176 GSM8809177 GSM8809178 GSM8809179 GSM8809180 GSM8809181 GSM8809182 GSM8809183 GSM8809184 GSM8809185 GSM8809186 GSM8809187 GSM8809188 GSM8809189 GSM8809190 GSM8809191 GSM8809192 GSM8809193 GSM8809194 GSM8809195 GSM8809196 GSM8809197 GSM8809198 GSM8809199 GSM8809200 GSM8809201 GSM8809202 GSM8809203 GSM8809204 GSM8809205 GSM8809206 GSM8809207 GSM8809208 GSM8809209 GSM8809210 GSM8809211 GSM8809212 GSM8809213 GSM8809214 GSM8809215 GSM8809216 GSM8809217 GSM8809218 GSM8809219 GSM8809220 GSM8809221 GSM8809222 GSM8809223 GSM8809224 GSM8809225 GSM8809226 GSM8809227 GSM8809228 GSM8809229 GSM8809230 GSM8809231 GSM8809232 GSM8809233 GSM8809234 GSM8809235 GSM8809236 GSM8809237 GSM8809238 GSM8809239 GSM8809240 GSM8809241 GSM8809242 GSM8809243 GSM8809244 GSM8809245 GSM8809246 GSM8809247 GSM8809248 GSM8809249 GSM8809250 GSM8809251 GSM8809252 GSM8809253 GSM8809254 GSM8809255 GSM8809256 GSM8809257 GSM8809258 GSM8809259 GSM8809260 GSM8809261 GSM8809262 GSM8809263 GSM8809264 GSM8809265 GSM8809266 GSM8809267 GSM8809268 GSM8809269 GSM8809270 GSM8809271 GSM8809272

SRA Experiments (97) and Runs (97)

Total: 73813 MB
SRX27759267 SRP565555 RNA-Seq SINGLE
Sample: SRS24144509
BioProject: PRJNA1226647
BioSample: SAMN46955674
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430359 14235785 2149603535 792.0 SRA
SRX27759268 SRP565555 RNA-Seq SINGLE
Sample: SRS24144510
BioProject: PRJNA1226647
BioSample: SAMN46955673
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430358 17839289 2693732639 991.0 SRA
SRX27759269 SRP565555 RNA-Seq SINGLE
Sample: SRS24144511
BioProject: PRJNA1226647
BioSample: SAMN46955672
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430357 15496395 2339955645 863.0 SRA
SRX27759270 SRP565555 RNA-Seq SINGLE
Sample: SRS24144512
BioProject: PRJNA1226647
BioSample: SAMN46955671
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430356 13897914 2098585014 780.0 SRA
SRX27759271 SRP565555 RNA-Seq SINGLE
Sample: SRS24144513
BioProject: PRJNA1226647
BioSample: SAMN46955670
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430355 14331456 2164049856 799.0 SRA
SRX27759272 SRP565555 RNA-Seq SINGLE
Sample: SRS24144514
BioProject: PRJNA1226647
BioSample: SAMN46955669
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430354 12966015 1957868265 726.0 SRA
SRX27759273 SRP565555 RNA-Seq SINGLE
Sample: SRS24144515
BioProject: PRJNA1226647
BioSample: SAMN46955668
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430353 12849779 1940316629 719.0 SRA
SRX27759274 SRP565555 RNA-Seq SINGLE
Sample: SRS24144516
BioProject: PRJNA1226647
BioSample: SAMN46955667
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430352 13572865 2049502615 759.0 SRA
SRX27759275 SRP565555 RNA-Seq SINGLE
Sample: SRS24144517
BioProject: PRJNA1226647
BioSample: SAMN46955666
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430351 344587 52032637 19.0 SRA
SRX27759276 SRP565555 RNA-Seq SINGLE
Sample: SRS24144518
BioProject: PRJNA1226647
BioSample: SAMN46955665
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430350 12499764 1887464364 705.0 SRA
SRX27759277 SRP565555 RNA-Seq SINGLE
Sample: SRS24144519
BioProject: PRJNA1226647
BioSample: SAMN46955664
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430349 10489077 1583850627 592.0 SRA
SRX27759278 SRP565555 RNA-Seq SINGLE
Sample: SRS24144520
BioProject: PRJNA1226647
BioSample: SAMN46955663
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430348 11349300 1713744300 637.0 SRA
SRX27759279 SRP565555 RNA-Seq SINGLE
Sample: SRS24144521
BioProject: PRJNA1226647
BioSample: SAMN46955662
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430347 15952368 2408807568 893.0 SRA
SRX27759280 SRP565555 RNA-Seq SINGLE
Sample: SRS24144522
BioProject: PRJNA1226647
BioSample: SAMN46955661
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430346 5938604 896729204 333.0 SRA
SRX27759281 SRP565555 RNA-Seq SINGLE
Sample: SRS24144523
BioProject: PRJNA1226647
BioSample: SAMN46955660
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430345 9977983 1506675433 558.0 SRA
SRX27759282 SRP565555 RNA-Seq SINGLE
Sample: SRS24144524
BioProject: PRJNA1226647
BioSample: SAMN46955659
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430344 26427826 3990601726 1472.0 SRA
SRX27759283 SRP565555 RNA-Seq SINGLE
Sample: SRS24144525
BioProject: PRJNA1226647
BioSample: SAMN46955658
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430343 21529652 3250977452 1201.0 SRA
SRX27759284 SRP565555 RNA-Seq SINGLE
Sample: SRS24144526
BioProject: PRJNA1226647
BioSample: SAMN46955657
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430342 17462777 2636879327 975.0 SRA
SRX27759285 SRP565555 RNA-Seq SINGLE
Sample: SRS24144527
BioProject: PRJNA1226647
BioSample: SAMN46955656
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430341 20676772 3122192572 1145.0 SRA
SRX27759286 SRP565555 RNA-Seq SINGLE
Sample: SRS24144528
BioProject: PRJNA1226647
BioSample: SAMN46955655
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430340 17914876 2705146276 1000.0 SRA
SRX27759287 SRP565555 RNA-Seq SINGLE
Sample: SRS24144529
BioProject: PRJNA1226647
BioSample: SAMN46955654
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430339 16503711 2492060361 928.0 SRA
SRX27759288 SRP565555 RNA-Seq SINGLE
Sample: SRS24144530
BioProject: PRJNA1226647
BioSample: SAMN46955653
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430338 16228582 2450515882 913.0 SRA
SRX27759289 SRP565555 RNA-Seq SINGLE
Sample: SRS24144531
BioProject: PRJNA1226647
BioSample: SAMN46955652
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430337 14420205 2177450955 814.0 SRA
SRX27759290 SRP565555 RNA-Seq SINGLE
Sample: SRS24144532
BioProject: PRJNA1226647
BioSample: SAMN46955651
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430336 14093761 2128157911 792.0 SRA
SRX27759291 SRP565555 RNA-Seq SINGLE
Sample: SRS24144533
BioProject: PRJNA1226647
BioSample: SAMN46955650
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430335 14186188 2142114388 800.0 SRA
SRX27759292 SRP565555 RNA-Seq SINGLE
Sample: SRS24144534
BioProject: PRJNA1226647
BioSample: SAMN46955649
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430334 12680953 1914823903 719.0 SRA
SRX27759293 SRP565555 RNA-Seq SINGLE
Sample: SRS24144535
BioProject: PRJNA1226647
BioSample: SAMN46955648
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430333 11319006 1709169906 641.0 SRA
SRX27759294 SRP565555 RNA-Seq SINGLE
Sample: SRS24144536
BioProject: PRJNA1226647
BioSample: SAMN46955647
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430332 10445809 1577317159 592.0 SRA
SRX27759295 SRP565555 RNA-Seq SINGLE
Sample: SRS24144538
BioProject: PRJNA1226647
BioSample: SAMN46955646
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430331 9900235 1494935485 559.0 SRA
SRX27759296 SRP565555 RNA-Seq SINGLE
Sample: SRS24144537
BioProject: PRJNA1226647
BioSample: SAMN46955645
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430330 10926832 1649951632 622.0 SRA
SRX27759297 SRP565555 RNA-Seq SINGLE
Sample: SRS24144539
BioProject: PRJNA1226647
BioSample: SAMN46955644
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430329 8888240 1342124240 504.0 SRA
SRX27759298 SRP565555 RNA-Seq SINGLE
Sample: SRS24144540
BioProject: PRJNA1226647
BioSample: SAMN46955643
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430319 9041410 1365252910 511.0 SRA
SRX27759299 SRP565555 RNA-Seq SINGLE
Sample: SRS24144541
BioProject: PRJNA1226647
BioSample: SAMN46955586
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430327 14788382 2233045682 806.0 SRA
SRX27759300 SRP565555 RNA-Seq SINGLE
Sample: SRS24144542
BioProject: PRJNA1226647
BioSample: SAMN46955585
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430326 14142165 2135466915 775.0 SRA
SRX27759301 SRP565555 RNA-Seq SINGLE
Sample: SRS24144543
BioProject: PRJNA1226647
BioSample: SAMN46955584
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430325 14995558 2264329258 787.0 SRA
SRX27759302 SRP565555 RNA-Seq SINGLE
Sample: SRS24144544
BioProject: PRJNA1226647
BioSample: SAMN46955583
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430324 13547808 2045719008 733.0 SRA
SRX27759303 SRP565555 RNA-Seq SINGLE
Sample: SRS24144545
BioProject: PRJNA1226647
BioSample: SAMN46955582
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430323 10564683 1595267133 573.0 SRA
SRX27759304 SRP565555 RNA-Seq SINGLE
Sample: SRS24144546
BioProject: PRJNA1226647
BioSample: SAMN46955581
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430322 13005097 1963769647 711.0 SRA
SRX27759305 SRP565555 RNA-Seq SINGLE
Sample: SRS24144547
BioProject: PRJNA1226647
BioSample: SAMN46955580
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430321 12683954 1915277054 697.0 SRA
SRX27759306 SRP565555 RNA-Seq SINGLE
Sample: SRS24144548
BioProject: PRJNA1226647
BioSample: SAMN46955579
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430320 13856077 2092267627 760.0 SRA
SRX27759307 SRP565555 RNA-Seq SINGLE
Sample: SRS24144550
BioProject: PRJNA1226647
BioSample: SAMN46955578
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430318 30798273 4650539223 1552.0 SRA
SRX27759308 SRP565555 RNA-Seq SINGLE
Sample: SRS24144549
BioProject: PRJNA1226647
BioSample: SAMN46955642
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430317 20237724 3055896324 1134.0 SRA
SRX27759309 SRP565555 RNA-Seq SINGLE
Sample: SRS24144551
BioProject: PRJNA1226647
BioSample: SAMN46955641
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430316 18972731 2864882381 1063.0 SRA
SRX27759310 SRP565555 RNA-Seq SINGLE
Sample: SRS24144552
BioProject: PRJNA1226647
BioSample: SAMN46955640
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430315 16605192 2507383992 934.0 SRA
SRX27759311 SRP565555 RNA-Seq SINGLE
Sample: SRS24144553
BioProject: PRJNA1226647
BioSample: SAMN46955639
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430314 20626384 3114583984 1160.0 SRA
SRX27759312 SRP565555 RNA-Seq SINGLE
Sample: SRS24144555
BioProject: PRJNA1226647
BioSample: SAMN46955638
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430313 13770597 2079360147 773.0 SRA
SRX27759313 SRP565555 RNA-Seq SINGLE
Sample: SRS24144554
BioProject: PRJNA1226647
BioSample: SAMN46955637
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430312 12134735 1832344985 687.0 SRA
SRX27759314 SRP565555 RNA-Seq SINGLE
Sample: SRS24144556
BioProject: PRJNA1226647
BioSample: SAMN46955636
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430311 13749445 2076166195 776.0 SRA
SRX27759315 SRP565555 RNA-Seq SINGLE
Sample: SRS24144557
BioProject: PRJNA1226647
BioSample: SAMN46955635
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430310 18123925 2736712675 1015.0 SRA
SRX27759316 SRP565555 RNA-Seq SINGLE
Sample: SRS24144558
BioProject: PRJNA1226647
BioSample: SAMN46955634
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430309 13708144 2069929744 769.0 SRA
SRX27759317 SRP565555 RNA-Seq SINGLE
Sample: SRS24144559
BioProject: PRJNA1226647
BioSample: SAMN46955633
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430308 15880026 2397883926 891.0 SRA
SRX27759318 SRP565555 RNA-Seq SINGLE
Sample: SRS24144560
BioProject: PRJNA1226647
BioSample: SAMN46955632
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430307 12964329 1957613679 729.0 SRA
SRX27759319 SRP565555 RNA-Seq SINGLE
Sample: SRS24144562
BioProject: PRJNA1226647
BioSample: SAMN46955631
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430306 13655641 2062001791 774.0 SRA
SRX27759320 SRP565555 RNA-Seq SINGLE
Sample: SRS24144561
BioProject: PRJNA1226647
BioSample: SAMN46955630
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430305 12914240 1950050240 726.0 SRA
SRX27759321 SRP565555 RNA-Seq SINGLE
Sample: SRS24144564
BioProject: PRJNA1226647
BioSample: SAMN46955629
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430304 13218754 1996031854 746.0 SRA
SRX27759322 SRP565555 RNA-Seq SINGLE
Sample: SRS24144563
BioProject: PRJNA1226647
BioSample: SAMN46955628
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430303 12206120 1843124120 692.0 SRA
SRX27759323 SRP565555 RNA-Seq SINGLE
Sample: SRS24144565
BioProject: PRJNA1226647
BioSample: SAMN46955627
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430302 13626946 2057668846 769.0 SRA
SRX27759324 SRP565555 RNA-Seq SINGLE
Sample: SRS24144566
BioProject: PRJNA1226647
BioSample: SAMN46955626
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430301 11906892 1797940692 678.0 SRA
SRX27759325 SRP565555 RNA-Seq SINGLE
Sample: SRS24144567
BioProject: PRJNA1226647
BioSample: SAMN46955625
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430300 12781450 1929998950 727.0 SRA
SRX27759326 SRP565555 RNA-Seq SINGLE
Sample: SRS24144568
BioProject: PRJNA1226647
BioSample: SAMN46955624
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430299 18505969 2794401319 1040.0 SRA
SRX27759327 SRP565555 RNA-Seq SINGLE
Sample: SRS24144570
BioProject: PRJNA1226647
BioSample: SAMN46955623
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430298 12042112 1818358912 675.0 SRA
SRX27759328 SRP565555 RNA-Seq SINGLE
Sample: SRS24144571
BioProject: PRJNA1226647
BioSample: SAMN46955622
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430297 15480290 2337523790 873.0 SRA
SRX27759329 SRP565555 RNA-Seq SINGLE
Sample: SRS24144569
BioProject: PRJNA1226647
BioSample: SAMN46955621
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430296 12053157 1820026707 679.0 SRA
SRX27759330 SRP565555 RNA-Seq SINGLE
Sample: SRS24144572
BioProject: PRJNA1226647
BioSample: SAMN46955620
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430295 12448188 1879676388 704.0 SRA
SRX27759331 SRP565555 RNA-Seq SINGLE
Sample: SRS24144574
BioProject: PRJNA1226647
BioSample: SAMN46955619
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430294 11266837 1701292387 637.0 SRA
SRX27759332 SRP565555 RNA-Seq SINGLE
Sample: SRS24144573
BioProject: PRJNA1226647
BioSample: SAMN46955618
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430293 12374546 1868556446 707.0 SRA
SRX27759333 SRP565555 RNA-Seq SINGLE
Sample: SRS24144575
BioProject: PRJNA1226647
BioSample: SAMN46955617
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430292 9189164 1387563764 522.0 SRA
SRX27759334 SRP565555 RNA-Seq SINGLE
Sample: SRS24144576
BioProject: PRJNA1226647
BioSample: SAMN46955616
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430291 11943298 1803437998 676.0 SRA
SRX27759335 SRP565555 RNA-Seq SINGLE
Sample: SRS24144578
BioProject: PRJNA1226647
BioSample: SAMN46955615
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430290 9633283 1454625733 548.0 SRA
SRX27759336 SRP565555 RNA-Seq SINGLE
Sample: SRS24144577
BioProject: PRJNA1226647
BioSample: SAMN46955614
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430289 9502213 1434834163 541.0 SRA
SRX27759337 SRP565555 RNA-Seq SINGLE
Sample: SRS24144579
BioProject: PRJNA1226647
BioSample: SAMN46955613
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430288 9577099 1446141949 546.0 SRA
SRX27759338 SRP565555 RNA-Seq SINGLE
Sample: SRS24144580
BioProject: PRJNA1226647
BioSample: SAMN46955612
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430287 8999280 1358891280 513.0 SRA
SRX27759339 SRP565555 RNA-Seq SINGLE
Sample: SRS24144582
BioProject: PRJNA1226647
BioSample: SAMN46955611
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430286 8608516 1299885916 491.0 SRA
SRX27759340 SRP565555 RNA-Seq SINGLE
Sample: SRS24144581
BioProject: PRJNA1226647
BioSample: SAMN46955610
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430285 9004556 1359687956 512.0 SRA
SRX27759341 SRP565555 RNA-Seq SINGLE
Sample: SRS24144583
BioProject: PRJNA1226647
BioSample: SAMN46955609
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430284 9110133 1375630083 518.0 SRA
SRX27759342 SRP565555 RNA-Seq SINGLE
Sample: SRS24144584
BioProject: PRJNA1226647
BioSample: SAMN46955608
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430283 16799825 2536773575 950.0 SRA
SRX27759343 SRP565555 RNA-Seq SINGLE
Sample: SRS24144585
BioProject: PRJNA1226647
BioSample: SAMN46955607
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430282 16296907 2460832957 924.0 SRA
SRX27759344 SRP565555 RNA-Seq SINGLE
Sample: SRS24144587
BioProject: PRJNA1226647
BioSample: SAMN46955606
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430281 15486810 2338508310 878.0 SRA
SRX27759345 SRP565555 RNA-Seq SINGLE
Sample: SRS24144586
BioProject: PRJNA1226647
BioSample: SAMN46955605
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430280 13807052 2084864852 790.0 SRA
SRX27759346 SRP565555 RNA-Seq SINGLE
Sample: SRS24144588
BioProject: PRJNA1226647
BioSample: SAMN46955604
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430279 12029021 1816382171 685.0 SRA
SRX27759347 SRP565555 RNA-Seq SINGLE
Sample: SRS24144589
BioProject: PRJNA1226647
BioSample: SAMN46955603
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430278 12082423 1824445873 691.0 SRA
SRX27759348 SRP565555 RNA-Seq SINGLE
Sample: SRS24144591
BioProject: PRJNA1226647
BioSample: SAMN46955602
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430277 13822244 2087158844 795.0 SRA
SRX27759349 SRP565555 RNA-Seq SINGLE
Sample: SRS24144592
BioProject: PRJNA1226647
BioSample: SAMN46955601
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430276 11880905 1794016655 679.0 SRA
SRX27759350 SRP565555 RNA-Seq SINGLE
Sample: SRS24144590
BioProject: PRJNA1226647
BioSample: SAMN46955600
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430275 10863827 1640437877 611.0 SRA
SRX27759351 SRP565555 RNA-Seq SINGLE
Sample: SRS24144594
BioProject: PRJNA1226647
BioSample: SAMN46955599
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430274 12850752 1940463552 728.0 SRA
SRX27759352 SRP565555 RNA-Seq SINGLE
Sample: SRS24144593
BioProject: PRJNA1226647
BioSample: SAMN46955598
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430273 9318689 1407122039 529.0 SRA
SRX27759353 SRP565555 RNA-Seq SINGLE
Sample: SRS24144598
BioProject: PRJNA1226647
BioSample: SAMN46955597
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430272 8459731 1277419381 480.0 SRA
SRX27759354 SRP565555 RNA-Seq SINGLE
Sample: SRS24144595
BioProject: PRJNA1226647
BioSample: SAMN46955596
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430271 14968663 2260268113 839.0 SRA
SRX27759355 SRP565555 RNA-Seq SINGLE
Sample: SRS24144596
BioProject: PRJNA1226647
BioSample: SAMN46955595
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430270 12341153 1863514103 697.0 SRA
SRX27759356 SRP565555 RNA-Seq SINGLE
Sample: SRS24144597
BioProject: PRJNA1226647
BioSample: SAMN46955594
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430269 13920717 2102028267 790.0 SRA
SRX27759357 SRP565555 RNA-Seq SINGLE
Sample: SRS24144600
BioProject: PRJNA1226647
BioSample: SAMN46955593
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430268 15569555 2351002805 880.0 SRA
SRX27759358 SRP565555 RNA-Seq SINGLE
Sample: SRS24144599
BioProject: PRJNA1226647
BioSample: SAMN46955592
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430267 13222660 1996621660 753.0 SRA
SRX27759359 SRP565555 RNA-Seq SINGLE
Sample: SRS24144601
BioProject: PRJNA1226647
BioSample: SAMN46955591
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430266 13359320 2017257320 756.0 SRA
SRX27759360 SRP565555 RNA-Seq SINGLE
Sample: SRS24144603
BioProject: PRJNA1226647
BioSample: SAMN46955590
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430265 16099579 2431036429 878.0 SRA
SRX27759361 SRP565555 RNA-Seq SINGLE
Sample: SRS24144602
BioProject: PRJNA1226647
BioSample: SAMN46955589
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430264 17494900 2641729900 946.0 SRA
SRX27759362 SRP565555 RNA-Seq SINGLE
Sample: SRS24144605
BioProject: PRJNA1226647
BioSample: SAMN46955588
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430263 14508690 2190812190 789.0 SRA
SRX27759363 SRP565555 RNA-Seq SINGLE
Sample: SRS24144604
BioProject: PRJNA1226647
BioSample: SAMN46955587
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR32430328 14376879 2170908729 772.0 SRA

Linked Publications (1)

Large-scale tethered screen of RNA-binding proteins reveals novel regulators of poly(A) site selection.
Molecular cell · 2026

Data Files (97)

Accession File Name Stored Type Output Type Mapping Assembly Size Download
— SRR32430263_GSM8809262 RNA-Seq 789.0 MB link
— SRR32430264_GSM8809261 RNA-Seq 946.0 MB link
— SRR32430265_GSM8809260 RNA-Seq 878.0 MB link
— SRR32430266_GSM8809259 RNA-Seq 756.0 MB link
— SRR32430267_GSM8809258 RNA-Seq 753.0 MB link
— SRR32430268_GSM8809257 RNA-Seq 880.0 MB link
— SRR32430269_GSM8809256 RNA-Seq 790.0 MB link
— SRR32430270_GSM8809255 RNA-Seq 697.0 MB link
— SRR32430271_GSM8809254 RNA-Seq 839.0 MB link
— SRR32430272_GSM8809253 RNA-Seq 480.0 MB link
— SRR32430273_GSM8809252 RNA-Seq 529.0 MB link
— SRR32430274_GSM8809251 RNA-Seq 728.0 MB link
— SRR32430275_GSM8809250 RNA-Seq 611.0 MB link
— SRR32430276_GSM8809249 RNA-Seq 679.0 MB link
— SRR32430277_GSM8809248 RNA-Seq 795.0 MB link
— SRR32430278_GSM8809247 RNA-Seq 691.0 MB link
— SRR32430279_GSM8809246 RNA-Seq 685.0 MB link
— SRR32430280_GSM8809245 RNA-Seq 790.0 MB link
— SRR32430281_GSM8809244 RNA-Seq 878.0 MB link
— SRR32430282_GSM8809243 RNA-Seq 924.0 MB link
— SRR32430283_GSM8809242 RNA-Seq 950.0 MB link
— SRR32430284_GSM8809241 RNA-Seq 518.0 MB link
— SRR32430285_GSM8809240 RNA-Seq 512.0 MB link
— SRR32430286_GSM8809239 RNA-Seq 491.0 MB link
— SRR32430287_GSM8809238 RNA-Seq 513.0 MB link
— SRR32430288_GSM8809237 RNA-Seq 546.0 MB link
— SRR32430289_GSM8809236 RNA-Seq 541.0 MB link
— SRR32430290_GSM8809235 RNA-Seq 548.0 MB link
— SRR32430291_GSM8809234 RNA-Seq 676.0 MB link
— SRR32430292_GSM8809233 RNA-Seq 522.0 MB link
— SRR32430293_GSM8809232 RNA-Seq 707.0 MB link
— SRR32430294_GSM8809231 RNA-Seq 637.0 MB link
— SRR32430295_GSM8809230 RNA-Seq 704.0 MB link
— SRR32430296_GSM8809229 RNA-Seq 679.0 MB link
— SRR32430297_GSM8809228 RNA-Seq 873.0 MB link
— SRR32430298_GSM8809227 RNA-Seq 675.0 MB link
— SRR32430299_GSM8809226 RNA-Seq 1.0 GB link
— SRR32430300_GSM8809225 RNA-Seq 727.0 MB link
— SRR32430301_GSM8809224 RNA-Seq 678.0 MB link
— SRR32430302_GSM8809223 RNA-Seq 769.0 MB link
— SRR32430303_GSM8809222 RNA-Seq 692.0 MB link
— SRR32430304_GSM8809221 RNA-Seq 746.0 MB link
— SRR32430305_GSM8809220 RNA-Seq 726.0 MB link
— SRR32430306_GSM8809219 RNA-Seq 774.0 MB link
— SRR32430307_GSM8809218 RNA-Seq 729.0 MB link
— SRR32430308_GSM8809217 RNA-Seq 891.0 MB link
— SRR32430309_GSM8809216 RNA-Seq 769.0 MB link
— SRR32430310_GSM8809215 RNA-Seq 1015.0 MB link
— SRR32430311_GSM8809214 RNA-Seq 776.0 MB link
— SRR32430312_GSM8809213 RNA-Seq 687.0 MB link
— SRR32430313_GSM8809212 RNA-Seq 773.0 MB link
— SRR32430314_GSM8809211 RNA-Seq 1.1 GB link
— SRR32430315_GSM8809210 RNA-Seq 934.0 MB link
— SRR32430316_GSM8809209 RNA-Seq 1.0 GB link
— SRR32430317_GSM8809208 RNA-Seq 1.1 GB link
— SRR32430318_GSM8809272 RNA-Seq 1.5 GB link
— SRR32430319_GSM8809207 RNA-Seq 511.0 MB link
— SRR32430320_GSM8809271 RNA-Seq 760.0 MB link
— SRR32430321_GSM8809270 RNA-Seq 697.0 MB link
— SRR32430322_GSM8809269 RNA-Seq 711.0 MB link
— SRR32430323_GSM8809268 RNA-Seq 573.0 MB link
— SRR32430324_GSM8809267 RNA-Seq 733.0 MB link
— SRR32430325_GSM8809266 RNA-Seq 787.0 MB link
— SRR32430326_GSM8809265 RNA-Seq 775.0 MB link
— SRR32430327_GSM8809264 RNA-Seq 806.0 MB link
— SRR32430328_GSM8809263 RNA-Seq 772.0 MB link
— SRR32430329_GSM8809206 RNA-Seq 504.0 MB link
— SRR32430330_GSM8809205 RNA-Seq 622.0 MB link
— SRR32430331_GSM8809204 RNA-Seq 559.0 MB link
— SRR32430332_GSM8809203 RNA-Seq 592.0 MB link
— SRR32430333_GSM8809202 RNA-Seq 641.0 MB link
— SRR32430334_GSM8809201 RNA-Seq 719.0 MB link
— SRR32430335_GSM8809200 RNA-Seq 800.0 MB link
— SRR32430336_GSM8809199 RNA-Seq 792.0 MB link
— SRR32430337_GSM8809198 RNA-Seq 814.0 MB link
— SRR32430338_GSM8809197 RNA-Seq 913.0 MB link
— SRR32430339_GSM8809196 RNA-Seq 928.0 MB link
— SRR32430340_GSM8809195 RNA-Seq 1000.0 MB link
— SRR32430341_GSM8809194 RNA-Seq 1.1 GB link
— SRR32430342_GSM8809193 RNA-Seq 975.0 MB link
— SRR32430343_GSM8809192 RNA-Seq 1.2 GB link
— SRR32430344_GSM8809191 RNA-Seq 1.4 GB link
— SRR32430345_GSM8809190 RNA-Seq 558.0 MB link
— SRR32430346_GSM8809189 RNA-Seq 333.0 MB link
— SRR32430347_GSM8809188 RNA-Seq 893.0 MB link
— SRR32430348_GSM8809187 RNA-Seq 637.0 MB link
— SRR32430349_GSM8809186 RNA-Seq 592.0 MB link
— SRR32430350_GSM8809185 RNA-Seq 705.0 MB link
— SRR32430351_GSM8809184 RNA-Seq 19.0 MB link
— SRR32430352_GSM8809183 RNA-Seq 759.0 MB link
— SRR32430353_GSM8809182 RNA-Seq 719.0 MB link
— SRR32430354_GSM8809181 RNA-Seq 726.0 MB link
— SRR32430355_GSM8809180 RNA-Seq 799.0 MB link
— SRR32430356_GSM8809179 RNA-Seq 780.0 MB link
— SRR32430357_GSM8809178 RNA-Seq 863.0 MB link
— SRR32430358_GSM8809177 RNA-Seq 991.0 MB link
— SRR32430359_GSM8809176 RNA-Seq 792.0 MB link