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Splicing regulators: targets and drugs.

Gene Wei-Ming Yeo
Genome biology · 2005 · Vol. 6 (12) · pp. 240
PubMed DOI PMC Full Text

Abstract

Silencing of splicing regulators by RNA interference, combined with splicing-specific microarrays, has revealed a complex network of distinct alternative splicing events in Drosophila, while a high-throughput screen of more than 6,000 compounds has identified drugs that interfere specifically and directly with one class of splicing regulators in human cells.

Publication Types

["Journal Article", "Research Support, Non-U.S. Gov't", "Review"]

Keywords

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MeSH Terms

["Alternative Splicing", "Animals", "Drosophila melanogaster", "Drug Evaluation, Preclinical", "Drug-Related Side Effects and Adverse Reactions", "Humans", "RNA Splicing"]