The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression.
T Hung, G A Pratt, B Sundararaman, M J Townsend, C Chaivorapol, T Bhangale, R R Graham, W Ortmann, L A Criswell, G W Yeo, T W Behrens
Science (New York, N.Y.) · 2015 · Vol. 350 (6259) · pp. 455-9
Abstract
Autoantibodies target the RNA binding protein Ro60 in systemic lupus erythematosus (SLE) and Sjögren's syndrome. However, it is unclear whether Ro60 and its associated RNAs contribute to disease pathogenesis. We catalogued the Ro60-associated RNAs in human cell lines and found that among other RNAs, Ro60 bound an RNA motif derived from endogenous Alu retroelements. Alu transcripts were induced by type I interferon and stimulated proinflammatory cytokine secretion by human peripheral blood cells. Ro60 deletion resulted in enhanced expression of Alu RNAs and interferon-regulated genes. Anti-Ro60-positive SLE immune complexes contained Alu RNAs, and Alu transcripts were up-regulated in SLE whole blood samples relative to controls. These findings establish a link among the lupus autoantigen Ro60, Alu retroelements, and type I interferon.
Linked datasets 5
SLE lupus RNA-seq
Homo sapiens
236 data files
| File | Type | Size |
|---|---|---|
| LIB10005_SAM8749887_L1_R1.fastq.gz | RNA-Seq | 3.4 GB |
| LIB10005_SAM8749887_L1_R1.fastq.gz | RNA-Seq | 3.4 GB |
| LIB10008_SAM8749890_L1_R1.fastq.gz | RNA-Seq | 3.6 GB |
| LIB10011_SAM8749893_L2_R1.fastq.gz | RNA-Seq | 3.6 GB |
| LIB10014_SAM8749896_L3_R1.fastq.gz | RNA-Seq | 3.9 GB |
| LIB10019_SAM8749901_L2_R1.fastq.gz | RNA-Seq | 3.2 GB |
| LIB10022_SAM8749904_L1_R1.fastq.gz | RNA-Seq | 3.4 GB |
| LIB10025_SAM8749907_L1_R1.fastq.gz | RNA-Seq | 3.0 GB |
| LIB10031_SAM8749913_L4_R1.fastq.gz | RNA-Seq | 3.2 GB |
| LIB10034_SAM8749916_L2_R1.fastq.gz | RNA-Seq | 3.8 GB |
| LIB10037_SAM8749919_L3_R1.fastq.gz | RNA-Seq | 3.6 GB |
| LIB10040_SAM8749922_L2_R1.fastq.gz | RNA-Seq | 3.7 GB |
| LIB10042_SAM8749924_L1_R1.fastq.gz | RNA-Seq | 3.4 GB |
| LIB10045_SAM8749927_L3_R1.fastq.gz | RNA-Seq | 3.5 GB |
| LIB10048_SAM8749930_L4_R1.fastq.gz | RNA-Seq | 3.2 GB |
| LIB10051_SAM8749933_L2_R1.fastq.gz | RNA-Seq | 3.4 GB |
| LIB10054_SAM8749936_L1_R1.fastq.gz | RNA-Seq | 3.0 GB |
| LIB10057_SAM8749939_L2_R1.fastq.gz | RNA-Seq | 3.4 GB |
| LIB10060_SAM8749942_L4_R1.fastq.gz | RNA-Seq | 3.8 GB |
| LIB10063_SAM8749945_L7_R1.fastq.gz | RNA-Seq | 3.2 GB |
| LIB10066_SAM8749948_L2_R1.fastq.gz | RNA-Seq | 3.6 GB |
| LIB10068_SAM8749950_L3_R1.fastq.gz | RNA-Seq | 3.7 GB |
| LIB10071_SAM8749953_L2_R1.fastq.gz | RNA-Seq | 3.4 GB |
| LIB10074_SAM8749956_L3_R1.fastq.gz | RNA-Seq | 3.4 GB |
| LIB10076_SAM8749958_L5_R1.fastq.gz | RNA-Seq | 3.4 GB |
| LIB10082_SAM8749964_L6_R1.fastq.gz | RNA-Seq | 3.3 GB |
| LIB10085_SAM8749967_L8_R1.fastq.gz | RNA-Seq | 3.1 GB |
| LIB10088_SAM8749970_L1_R1.fastq.gz | RNA-Seq | 3.4 GB |
| LIB10091_SAM8749973_L3_R1.fastq.gz | RNA-Seq | 3.3 GB |
| LIB10093_SAM8749975_L2_R1.fastq.gz | RNA-Seq | 3.1 GB |
| LIB10096_SAM8749978_L3_R1.fastq.gz | RNA-Seq | 3.6 GB |
| LIB10098_SAM8749980_L3_R1.fastq.gz | RNA-Seq | 3.0 GB |
| LIB10101_SAM8749983_L1_R1.fastq.gz | RNA-Seq | 3.3 GB |
| LIB10104_SAM8749986_L6_R1.fastq.gz | RNA-Seq | 3.3 GB |
| LIB10106_SAM8749988_L2_R1.fastq.gz | RNA-Seq | 3.1 GB |
| LIB10109_SAM8749991_L4_R1.fastq.gz | RNA-Seq | 3.4 GB |
| LIB10112_SAM8749994_L5_R1.fastq.gz | RNA-Seq | 3.4 GB |
| LIB10115_SAM8749997_L1_R1.fastq.gz | RNA-Seq | 3.4 GB |
| LIB10120_SAM8750002_L1_R1.fastq.gz | RNA-Seq | 2.9 GB |
| LIB10123_SAM8750005_L7_R1.fastq.gz | RNA-Seq | 3.3 GB |
| LIB10125_SAM8750007_L1_R1.fastq.gz | RNA-Seq | 3.2 GB |
| LIB10128_SAM8750010_L1_R1.fastq.gz | RNA-Seq | 3.4 GB |
| LIB10130_SAM8750012_L2_R1.fastq.gz | RNA-Seq | 3.4 GB |
| LIB10133_SAM8750015_L4_R1.fastq.gz | RNA-Seq | 3.7 GB |
| LIB10135_SAM8750017_L6_R1.fastq.gz | RNA-Seq | 2.7 GB |
| LIB10138_SAM8750020_L1_R1.fastq.gz | RNA-Seq | 3.3 GB |
| LIB10141_SAM8750023_L4_R1.fastq.gz | RNA-Seq | 3.5 GB |
| LIB10143_SAM8750025_L1_R1.fastq.gz | RNA-Seq | 3.1 GB |
| LIB10146_SAM8750028_L2_R1.fastq.gz | RNA-Seq | 3.6 GB |
| LIB10150_SAM8750032_L4_R1.fastq.gz | RNA-Seq | 3.1 GB |
| LIB10153_SAM8750035_L3_R1.fastq.gz | RNA-Seq | 3.1 GB |
| LIB10158_SAM8750040_L4_R1.fastq.gz | RNA-Seq | 3.1 GB |
| LIB10163_SAM8750045_L2_R1.fastq.gz | RNA-Seq | 3.7 GB |
| LIB10166_SAM8750048_L3_R1.fastq.gz | RNA-Seq | 3.8 GB |
| LIB10169_SAM8750051_L3_R1.fastq.gz | RNA-Seq | 3.3 GB |
| LIB10172_SAM8750054_L3_R1.fastq.gz | RNA-Seq | 3.0 GB |
| LIB10175_SAM8750057_L1_R1.fastq.gz | RNA-Seq | 3.7 GB |
| LIB10178_SAM8750060_L2_R1.fastq.gz | RNA-Seq | 3.4 GB |
| LIB10181_SAM8750063_L6_R1.fastq.gz | RNA-Seq | 3.4 GB |
| LIB10183_SAM8750065_L3_R1.fastq.gz | RNA-Seq | 4.2 GB |
| LIB10185_SAM8750067_L5_R1.fastq.gz | RNA-Seq | 2.9 GB |
| LIB10188_SAM8750070_L3_R1.fastq.gz | RNA-Seq | 2.8 GB |
| LIB10191_SAM8750073_L7_R1.fastq.gz | RNA-Seq | 3.1 GB |
| LIB10194_SAM8750076_L3_R1.fastq.gz | RNA-Seq | 3.5 GB |
| LIB10199_SAM8750081_L5_R1.fastq.gz | RNA-Seq | 3.3 GB |
| LIB10202_SAM8750084_L5_R1.fastq.gz | RNA-Seq | 2.8 GB |
| LIB10205_SAM8750087_L2_R1.fastq.gz | RNA-Seq | 3.5 GB |
| LIB10208_SAM8750090_L2_R1.fastq.gz | RNA-Seq | 3.6 GB |
| LIB10213_SAM8750095_L3_R1.fastq.gz | RNA-Seq | 3.7 GB |
| LIB10215_SAM8750097_L7_R1.fastq.gz | RNA-Seq | 3.3 GB |
| LIB10218_SAM8750100_L3_R1.fastq.gz | RNA-Seq | 3.4 GB |
| LIB10221_SAM8750103_L2_R1.fastq.gz | RNA-Seq | 3.6 GB |
| LIB10221_SAM8750103_L2_R1.fastq.gz | RNA-Seq | 3.6 GB |
| LIB10222_SAM8750104_L2_R1.fastq.gz | RNA-Seq | 3.8 GB |
| LIB10224_SAM8750106_L6_R1.fastq.gz | RNA-Seq | 3.8 GB |
| LIB10226_SAM8750108_L3_R1.fastq.gz | RNA-Seq | 3.6 GB |
| LIB10229_SAM8750111_L1_R1.fastq.gz | RNA-Seq | 2.9 GB |
| LIB10231_SAM8750113_L4_R1.fastq.gz | RNA-Seq | 3.3 GB |
| LIB10234_SAM8750116_L7_R1.fastq.gz | RNA-Seq | 3.0 GB |
| LIB10237_SAM8750119_L2_R1.fastq.gz | RNA-Seq | 3.3 GB |
| LIB10240_SAM8750122_L2_R1.fastq.gz | RNA-Seq | 3.6 GB |
| LIB10242_SAM8750124_L1_R1.fastq.gz | RNA-Seq | 3.0 GB |
| LIB10247_SAM8750129_L4_R1.fastq.gz | RNA-Seq | 3.4 GB |
| LIB10250_SAM8750132_L4_R1.fastq.gz | RNA-Seq | 3.0 GB |
| LIB10253_SAM8750135_L7_R1.fastq.gz | RNA-Seq | 3.8 GB |
| LIB10256_SAM8750138_L2_R1.fastq.gz | RNA-Seq | 3.0 GB |
| LIB10258_SAM8750140_L3_R1.fastq.gz | RNA-Seq | 3.2 GB |
| LIB10261_SAM8750143_L6_R1.fastq.gz | RNA-Seq | 2.7 GB |
| LIB10268_SAM8750150_L2_R1.fastq.gz | RNA-Seq | 3.3 GB |
| LIB10271_SAM8750153_L2_R1.fastq.gz | RNA-Seq | 3.9 GB |
| LIB10275_SAM8750157_L7_R1.fastq.gz | RNA-Seq | 3.2 GB |
| LIB10278_SAM8750160_L3_R1.fastq.gz | RNA-Seq | 3.4 GB |
| LIB10281_SAM8750163_L3_R1.fastq.gz | RNA-Seq | 4.2 GB |
| LIB10284_SAM8750166_L1_R1.fastq.gz | RNA-Seq | 3.3 GB |
| LIB10287_SAM8750169_L2_R1.fastq.gz | RNA-Seq | 2.9 GB |
| LIB10290_SAM8750172_L2_R1.fastq.gz | RNA-Seq | 4.0 GB |
| LIB10292_SAM8750174_L3_R1.fastq.gz | RNA-Seq | 3.8 GB |
| LIB10293_SAM8750175_L1_R1.fastq.gz | RNA-Seq | 3.2 GB |
| LIB10294_SAM8750176_L1_R1.fastq.gz | RNA-Seq | 3.2 GB |
| LIB10295_SAM8750177_L8_R1.fastq.gz | RNA-Seq | 2.9 GB |
| LIB10296_SAM8750178_L8_R1.fastq.gz | RNA-Seq | 2.7 GB |
| LIB10297_SAM8750179_L7_R1.fastq.gz | RNA-Seq | 3.5 GB |
| LIB10298_SAM8750180_L1_R1.fastq.gz | RNA-Seq | 4.2 GB |
| LIB10299_SAM8750181_L8_R1.fastq.gz | RNA-Seq | 2.8 GB |
| LIB10300_SAM8750182_L3_R1.fastq.gz | RNA-Seq | 3.5 GB |
| LIB10302_SAM8750184_L8_R1.fastq.gz | RNA-Seq | 6.1 GB |
| LIB10303_SAM8750185_L3_R1.fastq.gz | RNA-Seq | 3.4 GB |
| LIB10304_SAM8750186_L3_R1.fastq.gz | RNA-Seq | 3.3 GB |
| LIB10305_SAM8750187_L1_R1.fastq.gz | RNA-Seq | 3.1 GB |
| LIB10306_SAM8750188_L3_R1.fastq.gz | RNA-Seq | 3.1 GB |
| LIB10307_SAM8750189_L3_R1.fastq.gz | RNA-Seq | 4.0 GB |
| LIB10309_SAM8750191_L2_R1.fastq.gz | RNA-Seq | 3.1 GB |
| LIB10310_SAM8750192_L2_R1.fastq.gz | RNA-Seq | 3.4 GB |
| LIB10311_SAM8750193_L1_R1.fastq.gz | RNA-Seq | 2.8 GB |
| LIB10722_SAM9103789_L3_R1.fastq.gz | RNA-Seq | 3.6 GB |
| LIB10725_SAM9103792_L4_R1.fastq.gz | RNA-Seq | 3.6 GB |
| LIB10726_SAM9103793_L1_R1.fastq.gz | RNA-Seq | 2.8 GB |
| LIB11106_SAM9260118_L2_R1.fastq.gz | RNA-Seq | 2.9 GB |
| LIB11110_SAM9260122_L2_R1.fastq.gz | RNA-Seq | 2.8 GB |
| SRR2443147_GSM1863633 | RNA-Seq | 3.2 GB |
| SRR2443148_GSM1863634 | RNA-Seq | 3.9 GB |
| SRR2443149_GSM1863635 | RNA-Seq | 3.7 GB |
| SRR2443150_GSM1863636 | RNA-Seq | 3.1 GB |
| SRR2443151_GSM1863637 | RNA-Seq | 2.8 GB |
| SRR2443152_GSM1863638 | RNA-Seq | 3.3 GB |
| SRR2443153_GSM1863639 | RNA-Seq | 3.3 GB |
| SRR2443154_GSM1863640 | RNA-Seq | 2.7 GB |
| SRR2443155_GSM1863641 | RNA-Seq | 3.4 GB |
| SRR2443156_GSM1863642 | RNA-Seq | 2.9 GB |
| SRR2443157_GSM1863643 | RNA-Seq | 3.4 GB |
| SRR2443158_GSM1863644 | RNA-Seq | 3.4 GB |
| SRR2443159_GSM1863645 | RNA-Seq | 3.1 GB |
| SRR2443160_GSM1863646 | RNA-Seq | 3.6 GB |
| SRR2443161_GSM1863647 | RNA-Seq | 3.6 GB |
| SRR2443162_GSM1863648 | RNA-Seq | 3.5 GB |
| SRR2443163_GSM1863649 | RNA-Seq | 3.2 GB |
| SRR2443164_GSM1863650 | RNA-Seq | 2.8 GB |
| SRR2443165_GSM1863651 | RNA-Seq | 3.0 GB |
| SRR2443166_GSM1863652 | RNA-Seq | 3.7 GB |
| SRR2443167_GSM1863653 | RNA-Seq | 2.9 GB |
| SRR2443168_GSM1863654 | RNA-Seq | 3.7 GB |
| SRR2443169_GSM1863655 | RNA-Seq | 3.6 GB |
| SRR2443170_GSM1863656 | RNA-Seq | 3.4 GB |
| SRR2443171_GSM1863657 | RNA-Seq | 3.8 GB |
| SRR2443172_GSM1863658 | RNA-Seq | 3.0 GB |
| SRR2443173_GSM1863659 | RNA-Seq | 3.3 GB |
| SRR2443174_GSM1863660 | RNA-Seq | 3.3 GB |
| SRR2443175_GSM1863661 | RNA-Seq | 3.3 GB |
| SRR2443176_GSM1863662 | RNA-Seq | 2.8 GB |
| SRR2443177_GSM1863663 | RNA-Seq | 2.7 GB |
| SRR2443178_GSM1863664 | RNA-Seq | 2.9 GB |
| SRR2443179_GSM1863665 | RNA-Seq | 3.6 GB |
| SRR2443180_GSM1863666 | RNA-Seq | 3.5 GB |
| SRR2443181_GSM1863667 | RNA-Seq | 3.6 GB |
| SRR2443182_GSM1863668 | RNA-Seq | 3.0 GB |
| SRR2443183_GSM1863669 | RNA-Seq | 3.6 GB |
| SRR2443184_GSM1863670 | RNA-Seq | 3.4 GB |
| SRR2443185_GSM1863671 | RNA-Seq | 3.4 GB |
| SRR2443186_GSM1863672 | RNA-Seq | 3.3 GB |
| SRR2443187_GSM1863673 | RNA-Seq | 3.0 GB |
| SRR2443188_GSM1863674 | RNA-Seq | 3.6 GB |
| SRR2443189_GSM1863675 | RNA-Seq | 3.2 GB |
| SRR2443190_GSM1863676 | RNA-Seq | 3.1 GB |
| SRR2443191_GSM1863677 | RNA-Seq | 3.5 GB |
| SRR2443192_GSM1863678 | RNA-Seq | 3.5 GB |
| SRR2443193_GSM1863679 | RNA-Seq | 3.6 GB |
| SRR2443194_GSM1863680 | RNA-Seq | 3.3 GB |
| SRR2443195_GSM1863681 | RNA-Seq | 3.3 GB |
| SRR2443196_GSM1863682 | RNA-Seq | 3.0 GB |
| SRR2443197_GSM1863683 | RNA-Seq | 3.4 GB |
| SRR2443198_GSM1863684 | RNA-Seq | 2.8 GB |
| SRR2443199_GSM1863685 | RNA-Seq | 3.2 GB |
| SRR2443200_GSM1863686 | RNA-Seq | 3.0 GB |
| SRR2443201_GSM1863687 | RNA-Seq | 2.9 GB |
| SRR2443202_GSM1863688 | RNA-Seq | 3.4 GB |
| SRR2443203_GSM1863689 | RNA-Seq | 3.2 GB |
| SRR2443204_GSM1863690 | RNA-Seq | 3.3 GB |
| SRR2443205_GSM1863691 | RNA-Seq | 3.4 GB |
| SRR2443206_GSM1863692 | RNA-Seq | 3.8 GB |
| SRR2443207_GSM1863693 | RNA-Seq | 3.4 GB |
| SRR2443208_GSM1863694 | RNA-Seq | 3.2 GB |
| SRR2443209_GSM1863695 | RNA-Seq | 3.6 GB |
| SRR2443210_GSM1863696 | RNA-Seq | 4.2 GB |
| SRR2443211_GSM1863697 | RNA-Seq | 3.1 GB |
| SRR2443212_GSM1863698 | RNA-Seq | 3.4 GB |
| SRR2443213_GSM1863699 | RNA-Seq | 3.1 GB |
| SRR2443214_GSM1863700 | RNA-Seq | 3.8 GB |
| SRR2443215_GSM1863701 | RNA-Seq | 3.7 GB |
| SRR2443216_GSM1863702 | RNA-Seq | 3.4 GB |
| SRR2443217_GSM1863703 | RNA-Seq | 2.9 GB |
| SRR2443218_GSM1863704 | RNA-Seq | 3.6 GB |
| SRR2443219_GSM1863705 | RNA-Seq | 3.4 GB |
| SRR2443220_GSM1863706 | RNA-Seq | 3.0 GB |
| SRR2443221_GSM1863707 | RNA-Seq | 3.4 GB |
| SRR2443222_GSM1863708 | RNA-Seq | 3.4 GB |
| SRR2443223_GSM1863709 | RNA-Seq | 3.8 GB |
| SRR2443224_GSM1863710 | RNA-Seq | 3.1 GB |
| SRR2443225_GSM1863711 | RNA-Seq | 3.4 GB |
| SRR2443226_GSM1863712 | RNA-Seq | 3.0 GB |
| SRR2443227_GSM1863713 | RNA-Seq | 3.6 GB |
| SRR2443228_GSM1863714 | RNA-Seq | 3.8 GB |
| SRR2443229_GSM1863715 | RNA-Seq | 3.3 GB |
| SRR2443230_GSM1863716 | RNA-Seq | 3.2 GB |
| SRR2443231_GSM1863717 | RNA-Seq | 3.1 GB |
| SRR2443232_GSM1863718 | RNA-Seq | 3.4 GB |
| SRR2443233_GSM1863719 | RNA-Seq | 3.3 GB |
| SRR2443234_GSM1863720 | RNA-Seq | 3.6 GB |
| SRR2443235_GSM1863721 | RNA-Seq | 3.4 GB |
| SRR2443236_GSM1863722 | RNA-Seq | 3.1 GB |
| SRR2443237_GSM1863723 | RNA-Seq | 4.0 GB |
| SRR2443238_GSM1863724 | RNA-Seq | 3.9 GB |
| SRR2443239_GSM1863725 | RNA-Seq | 3.3 GB |
| SRR2443240_GSM1863726 | RNA-Seq | 3.7 GB |
| SRR2443241_GSM1863727 | RNA-Seq | 3.3 GB |
| SRR2443242_GSM1863728 | RNA-Seq | 3.4 GB |
| SRR2443243_GSM1863729 | RNA-Seq | 3.8 GB |
| SRR2443244_GSM1863730 | RNA-Seq | 4.2 GB |
| SRR2443245_GSM1863731 | RNA-Seq | 3.7 GB |
| SRR2443246_GSM1863732 | RNA-Seq | 2.8 GB |
| SRR2443247_GSM1863733 | RNA-Seq | 3.2 GB |
| SRR2443248_GSM1863734 | RNA-Seq | 3.4 GB |
| SRR2443249_GSM1863735 | RNA-Seq | 3.5 GB |
| SRR2443250_GSM1863736 | RNA-Seq | 2.9 GB |
| SRR2443251_GSM1863737 | RNA-Seq | 3.1 GB |
| SRR2443252_GSM1863738 | RNA-Seq | 2.7 GB |
| SRR2443253_GSM1863739 | RNA-Seq | 6.1 GB |
| SRR2443254_GSM1863740 | RNA-Seq | 2.8 GB |
| SRR2443255_GSM1863741 | RNA-Seq | 3.1 GB |
| SRR2443256_GSM1863742 | RNA-Seq | 3.5 GB |
| SRR2443257_GSM1863743 | RNA-Seq | 3.0 GB |
| SRR2443258_GSM1863744 | RNA-Seq | 3.8 GB |
| SRR2443259_GSM1863745 | RNA-Seq | 3.3 GB |
| SRR2443260_GSM1863746 | RNA-Seq | 3.4 GB |
| SRR2443261_GSM1863747 | RNA-Seq | 4.2 GB |
| SRR2443262_GSM1863748 | RNA-Seq | 4.0 GB |
| SRR2443263_GSM1863749 | RNA-Seq | 3.2 GB |
Ro60-knockout cells
Homo sapiens
20 data files
| File | Type | Size |
|---|---|---|
| LIB23499_SAM19353342_R1.fastq.gz | RNA-Seq | 1.0 GB |
| LIB23501_SAM19353346_R1.fastq.gz | RNA-Seq | 863.2 MB |
| LIB23503_SAM19353350_R1.fastq.gz | RNA-Seq | 1.1 GB |
| LIB23505_SAM19353354_R1.fastq.gz | RNA-Seq | 1.1 GB |
| LIB23506_SAM19353355_R1.fastq.gz | RNA-Seq | 1.0 GB |
| LIB24542_SAM19590764_R1.fastq.gz | RNA-Seq | 1.0 GB |
| LIB24543_SAM19590765_R1.fastq.gz | RNA-Seq | 1.1 GB |
| LIB24544_SAM19590766_R1.fastq.gz | RNA-Seq | 860.2 MB |
| LIB24545_SAM19590767_R1.fastq.gz | RNA-Seq | 968.6 MB |
| LIB24546_SAM19590768_R1.fastq.gz | RNA-Seq | 1007.7 MB |
| SRR2192704_GSM1863315 | RNA-Seq | 1.1 GB |
| SRR2192705_GSM1863316 | RNA-Seq | 1.0 GB |
| SRR2192706_GSM1863317 | RNA-Seq | 968.0 MB |
| SRR2192707_GSM1863318 | RNA-Seq | 1007.0 MB |
| SRR2192708_GSM1863319 | RNA-Seq | 1.0 GB |
| SRR2192709_GSM1863320 | RNA-Seq | 1.0 GB |
| SRR2192710_GSM1863321 | RNA-Seq | 1.1 GB |
| SRR2192711_GSM1863322 | RNA-Seq | 1.1 GB |
| SRR2192712_GSM1863323 | RNA-Seq | 863.0 MB |
| SRR2192713_GSM1863324 | RNA-Seq | 860.0 MB |
Healthy donor PBMC RNA-seq with or without interferon-alpha stimulation
Homo sapiens
12 data files
| File | Type | Size |
|---|---|---|
| LIB8209_SAM2707857_L1_R1.fastq.gz | RNA-Seq | 3.2 GB |
| LIB8210_SAM2707858_L1_R1.fastq.gz | RNA-Seq | 2.2 GB |
| LIB8212_SAM2707860_L1_R1.fastq.gz | RNA-Seq | 2.1 GB |
| LIB8213_SAM2707861_L1_R1.fastq.gz | RNA-Seq | 1.9 GB |
| LIB8215_SAM2707863_L1_R1.fastq.gz | RNA-Seq | 2.6 GB |
| LIB8566_SAM2707864_L5_R1.fastq.gz | RNA-Seq | 4.7 GB |
| SRR2192716_GSM1863325 | RNA-Seq | 2.1 GB |
| SRR2192717_GSM1863326 | RNA-Seq | 2.6 GB |
| SRR2192718_GSM1863327 | RNA-Seq | 3.2 GB |
| SRR2192719_GSM1863328 | RNA-Seq | 4.7 GB |
| SRR2192720_GSM1863329 | RNA-Seq | 1.9 GB |
| SRR2192721_GSM1863330 | RNA-Seq | 2.2 GB |
The Ro60 Autoantigen Binds Endogenous Retroelements and Regulates Inflammatory Gene Expression
Homo sapiens
Potentially related datasets 1
These accessions were text-mined from the PMC full text. They may be referenced for comparison, cited from other studies, or otherwise mentioned without being primary data for this paper.
Analysis pipelines 5
| Pipeline | Assay | Steps | Dataset |
|---|---|---|---|
| GSE72420 Data Processing geo_data_processing | — | 3 | GSE72420 |
| GSE72500 iCLIP Data Processing geo_data_processing | iCLIP | 3 | GSE72500 |
| GSE72501 Data Processing geo_data_processing | — | 5 | GSE72501 |
| GSE72502 RNA-seq Data Processing geo_data_processing | RNA-seq | 5 | GSE72502 |
| GSE72509 RNA-seq Data Processing geo_data_processing | RNA-seq | 5 | GSE72509 |
Funding 7 grants
| Grant | Funder |
|---|---|
| R01 HG004659 | NHGRI NIH HHS (United States) |
| U54 HG007005 | NHGRI NIH HHS (United States) |
| R01 NS075449 | NINDS NIH HHS (United States) |
| HG004659 | NHGRI NIH HHS (United States) |
| NS075449 | NINDS NIH HHS (United States) |
| HG007005 | NHGRI NIH HHS (United States) |
| R01 GM084317 | NIGMS NIH HHS (United States) |