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LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance.

Molecular cell · 2012 · 48(2): 195-206

LIN28 is a conserved RNA-binding protein implicated in pluripotency, reprogramming, and oncogenesis. It was previously shown to act primarily by blocking let-7 microRNA (miRNA) biogenesis, but here we elucidate distinct roles of LIN28 regulation via its direct messenger RNA (mRNA) …

PMID 22959275 DOI ↗