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  1. Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus.

    Neurobiology of disease · 2022 · 172: 105834

    Synapse dysfunction and loss are central features of neurodegenerative diseases, caused in part by the accumulation of protein oligomers. Amyloid-β, tau, prion, and α-synuclein oligomers bind to the cellular prion protein (PrP<sup>C),</sup> resulting in the activation of macromolecular complexes and …

    PMID 35905927 DOI ↗

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GSE207251 GSE · GEO

Prions induce an early Arc response in the hippocampus of prion-infected mice

Mus musculus · GPL21103

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