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1 result for “alternative cleavage and polyadenylation”

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  1. Large-scale tethered screen of RNA-binding proteins reveals novel regulators of poly(A) site selection.

    Molecular cell · 2026

    Alternative polyadenylation (APA) generates transcript isoforms with distinct 3' ends, yet the repertoire of its protein regulators remains poorly defined. Using a large-scale tethered function screen, we profiled 879 human RNA-binding proteins (RBPs) and identified 63 high-confidence activators of poly(A) …

    PMID 42361791 DOI ↗

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