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  1. Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis.

    eLife · 2019 · 8

    Mutations in coding and non-coding regions of FUS cause amyotrophic lateral sclerosis (ALS). The latter mutations may exert toxicity by increasing FUS accumulation. We show here that broad expression within the nervous system of wild-type or either of two ALS-linked …

    PMID 30747709 DOI ↗

Datasets 1

GSE125125 GSE · GEO

Overriding FUS autoregulation triggers gain-of-toxic dysfunctions in autophagy-lysosome axis and RNA metabolism

Mus musculus · GPL21103

Analyses 1

GSE125125 Processing Pipeline

GSE125125 · 3 steps · RNA-Seq · code_examples

Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis. (2019)