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5 results for “electrophysiology”

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  1. Reintroduction of the archaic variant of <i>NOVA1</i> in cortical organoids alters neurodevelopment.

    Science (New York, N.Y.) · 2021 · 371(6530)

    The evolutionarily conserved splicing regulator neuro-oncological ventral antigen 1 (<i>NOVA1</i>) plays a key role in neural development and function. <i>NOVA1</i> also includes a protein-coding difference between the modern human genome and Neanderthal and Denisovan genomes. To investigate the functional importance …

    PMID 33574182 DOI ↗

  2. Corrigendum: Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells.

    Frontiers in molecular neuroscience · 2019 · 12: 150

    [This corrects the article DOI: 10.3389/fnmol.2018.00261.].

    PMID 31244603 DOI ↗

  3. Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells.

    Frontiers in molecular neuroscience · 2018 · 11: 261

    The human brain is composed of a complex assembly of about 171 billion heterogeneous cellular units (86 billion neurons and 85 billion non-neuronal glia cells). A comprehensive description of brain cells is necessary to understand the nervous system in health …

    PMID 30147644 DOI ↗

  4. Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology.

    Molecular psychiatry · 2016 · 21(11): 1573-1588

    Human neural progenitors derived from pluripotent stem cells develop into electrophysiologically active neurons at heterogeneous rates, which can confound disease-relevant discoveries in neurology and psychiatry. By combining patch clamping, morphological and transcriptome analysis on single-human neurons in vitro, we defined …

    PMID 27698428 DOI ↗

  5. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells.

    Cell · 2010 · 143(4): 527-39

    Autism spectrum disorders (ASD) are complex neurodevelopmental diseases in which different combinations of genetic mutations may contribute to the phenotype. Using Rett syndrome (RTT) as an ASD genetic model, we developed a culture system using induced pluripotent stem cells (iPSCs) …

    PMID 21074045 DOI ↗

Datasets 1

GSE159074 GSE · GEO

Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology

Homo sapiens · GPL11154

Analyses 1

GSE159074 Processing Pipeline

GSE159074 · 4 steps · RNA-Seq · code_examples

Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology. (2016)