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4 results for “hnRNP”
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Genetic mutations in RNA-binding proteins and their roles in ALS.
Human genetics · 2017 · 136(9): 1193-1214
Mutations in genes that encode RNA-binding proteins (RBPs) have emerged as critical determinants of neurological diseases, especially motor neuron disorders such as amyotrophic lateral sclerosis (ALS). RBPs are involved in all aspects of RNA processing, controlling the life cycle of …
PMID 28762175 DOI ↗
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Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System.
Neuron · 2016 · 92(4): 780-795
HnRNPA2B1 encodes an RNA binding protein associated with neurodegeneration. However, its function in the nervous system is unclear. Transcriptome-wide crosslinking and immunoprecipitation in mouse spinal cord discover UAGG motifs enriched within ∼2,500 hnRNP A2/B1 binding sites and an unexpected role …
PMID 27773581 DOI ↗
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Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins.
Cell reports · 2012 · 1(2): 167-78
Understanding how RNA binding proteins control the splicing code is fundamental to human biology and disease. Here, we present a comprehensive study to elucidate how heterogeneous nuclear ribonucleoparticle (hnRNP) proteins, among the most abundant RNA binding proteins, coordinate to regulate …
PMID 22574288 DOI ↗
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Discovery and analysis of evolutionarily conserved intronic splicing regulatory elements.
PLoS genetics · 2007 · 3(5): e85
Knowledge of the functional cis-regulatory elements that regulate constitutive and alternative pre-mRNA splicing is fundamental for biology and medicine. Here we undertook a genome-wide comparative genomics approach using available mammalian genomes to identify conserved intronic splicing regulatory elements (ISREs). Our …
PMID 17530930 DOI ↗
Datasets 25+
RNA-seq on K562 cells treated with a CRISPR gRNA against HNRNPF. (HNRNPF_BGKcLV02)
Homo sapiens
RNA-seq on K562 cells treated with an shRNA knockdown against HNRNPF. (HNRNPF_BGKLV21)
Homo sapiens
RNA-seq on HepG2 cells treated with a CRISPR gRNA against HNRNPF. (HNRNPF_BGHcLV03)
Homo sapiens
RNA-seq on K562 cells treated with an shRNA knockdown against HNRNPM. (HNRNPM_BGKLV29)
Homo sapiens
RNA-seq on K562 cells treated with an shRNA knockdown against HNRNPAB. (HNRNPAB_BGKLV24_B)
Homo sapiens
RNA-seq on HepG2 cells treated with an shRNA knockdown against HNRNPLL. (HNRNPLL_BGHLV35)
Homo sapiens
Showing first 25 dataset results.
Analyses 15
GSE176012 · 12 steps · RNA-Seq · code_examples
ADAR and hnRNPC deficiency synergize in activating endogenous dsRNA-induced type I IFN responses. (2021)
GSE86038 · 3 steps · GSE · code_examples
Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System. (2016)
GSE86040 · 6 steps · RIP-Seq · code_examples
Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System. (2016)
GSE86041 · 7 steps · RIP-Seq · code_examples
Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System. (2016)
GSE86043 · 8 steps · RNA-Seq · code_examples
Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System. (2016)
GSE86218 · 3 steps · GSE · code_examples
Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System. (2016)
GSE86223 · 6 steps · GSE · code_examples
Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System. (2016)
GSE86224 · 3 steps · GSE · code_examples
Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System. (2016)
GSE86227 · 5 steps · ncRNA-Seq · code_examples
Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System. (2016)
GSE86462 · 3 steps · GSE · code_examples
Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System. (2016)
GSE86464 · 3 steps · GSE · code_examples
Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System. (2016)
GSE34992 · 2 steps · GSE · code_examples
Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins. (2012)
GSE34993 · 2 steps · RNA-Seq · code_examples
Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins. (2012)
GSE34995 · 2 steps · RNA-Seq · code_examples
Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins. (2012)
GSE34996 · 2 steps · GSE · code_examples
Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins. (2012)