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4 results for “multiplex”

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  1. Imaging Cellular Metabolic Rewiring with SuMMIT-SRS.

    bioRxiv : the preprint server for biology · 2025

    Cells dynamically rewire their metabolic pathways in response to physiological and pathological cues. Such plasticity is particularly critical in neurons, stem cells, cancer cells, and immune cells, where biosynthetic demands can shift rapidly. However, current metabolic imaging techniques using isotope …

    PMID 41279865 DOI ↗

  2. Mudskipper detects combinatorial RNA binding protein interactions in multiplexed CLIP data.

    Cell genomics · 2024 · 4(7): 100603

    The uncovering of protein-RNA interactions enables a deeper understanding of RNA processing. Recent multiplexed crosslinking and immunoprecipitation (CLIP) technologies such as antibody-barcoded eCLIP (ABC) dramatically increase the throughput of mapping RNA binding protein (RBP) binding sites. However, multiplex CLIP datasets …

    PMID 38955188 DOI ↗

  3. Multiplexed transcriptome discovery of RNA-binding protein binding sites by antibody-barcode eCLIP.

    Nature methods · 2023 · 20(1): 65-69

    Ultraviolet crosslinking and immunoprecipitation (CLIP) methodologies enable the identification of RNA binding sites of RNA-binding proteins (RBPs). Despite improvements in the library preparation of RNA fragments, the enhanced CLIP (eCLIP) protocol requires 4 days of hands-on time and lacks the …

    PMID 36550273 DOI ↗

  4. L1 retrotransposition in human neural progenitor cells.

    Nature · 2009 · 460(7259): 1127-31

    Long interspersed element 1 (LINE-1 or L1) retrotransposons have markedly affected the human genome. L1s must retrotranspose in the germ line or during early development to ensure their evolutionary success, yet the extent to which this process affects somatic cells …

    PMID 19657334 DOI ↗

Datasets 3

GSE55887 GSE · GEO

Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease

Homo sapiens · GPL15520

GSE51684 GSE · GEO

Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for amyotrophic lateral sclerosis and frontotemporal dementia (Multiplex Analysis of PolyA-linked Sequences)

Homo sapiens · GPL11154

GSE205536 GSE · GEO

Multiplexed transcriptome discovery of RNA binding protein binding sites by antibody-barcode eCLIP

Homo sapiens · GPL18573

Analyses 3

GSE122425 Processing Pipeline

GSE122425 · 5 steps · RNA-Seq · code_examples

Multiplexed transcriptome discovery of RNA-binding protein binding sites by antibody-barcode eCLIP. (2023)

GSE205536 Processing Pipeline

GSE205536 · 13 steps · OTHER · code_examples

Multiplexed transcriptome discovery of RNA-binding protein binding sites by antibody-barcode eCLIP. (2023)

GSE51684 Processing Pipeline

GSE51684 · 4 steps · RNA-Seq · code_examples

Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration. (2013)