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  1. RNA-targeting CRISPR systems from metagenomic discovery to transcriptomic engineering.

    Nature cell biology · 2020 · 22(2): 143-150

    Deployment of RNA-guided DNA endonuclease CRISPR-Cas technology has led to radical advances in biology. As the functional diversity of CRISPR-Cas and parallel systems is further explored, RNA manipulation is emerging as a powerful mode of CRISPR-based engineering. In this Perspective, …

    PMID 32015437 DOI ↗

Datasets 2

GSE152033 GSE · GEO

RNA-targeting Cas9 corrects molecular and physiological features in pre-clinical model of myotonic dystrophy type 1

Mus musculus · GPL21103

GSE100943 GSE · GEO

Microsatellite expansion RNA visualization, elimination, and reversal of molecular pathology by RNA-targeting Cas9

Homo sapiens · GPL20301

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