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  1. Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes.

    Cell reports · 2024 · 43(8): 114637

    Reactive changes of glial cells during neuroinflammation impact brain disorders and disease progression. Elucidating the mechanisms that control reactive gliosis may help us to understand brain pathophysiology and improve outcomes. Here, we report that adult ablation of autism spectrum disorder …

    PMID 39154337 DOI ↗

Datasets 3

GSE271650 GSE · GEO

Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [bulk RNA-seq]

Mus musculus · GPL24247

GSE271652 GSE · GEO

Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [ATAC-seq]

Mus musculus · GPL24247

GSE271651 GSE · GEO

Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [Microglia RNA-seq]

Mus musculus · GPL24247

Analyses 3

GSE271650 Processing Pipeline

GSE271650 · 5 steps · RNA-Seq · code_examples

Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes. (2024)

GSE271651 Processing Pipeline

GSE271651 · 8 steps · RNA-Seq · code_examples

Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes. (2024)

GSE271652 Processing Pipeline

GSE271652 · 5 steps · ATAC-seq · code_examples

Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes. (2024)