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2 results for “ribosome occupancy”
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A Transcriptome-wide Translational Program Defined by LIN28B Expression Level.
Molecular cell · 2019 · 73(2): 304-313.e3
LIN28 RNA binding proteins are dynamically expressed throughout mammalian development and during disease. However, it remains unclear how changes in LIN28 expression define patterns of post-transcriptional gene regulation. Here we show that LIN28 expression level is a key variable that …
PMID 30527666 DOI ↗
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Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model.
Genome medicine · 2016 · 8(1): 94
Tuberous sclerosis complex (TSC) is a genetic disease characterized by benign tumor growths in multiple organs and neurological symptoms induced by mTOR hyperfunction. Because the molecular pathology is highly complex and the etiology poorly understood, we employed a defined human …
PMID 27655340 DOI ↗
Datasets 3
Single cell and isoform-specific translational profiling of the mouse brain [Bulk RNA-seq]
GPL24247
A transcriptome-wide divergence in protein translation scales with LIN28B expression
Mus musculus · GPL20301
Non-microRNA Binding Competitively Inhibits LIN28 Regulation
Mus musculus · GPL20301
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