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GSE301408

GSE GEO Potentially related
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Mitochondrial double-stranded RNA triggers chronic stress in aged neurons

Organism: Homo sapiens
Platform: GPL24676, GPL30173
Samples: 100

Summary

Neurodegenerative diseases are linked with dysregulation of the integrated stress response (ISR), which coordinates cellular homeostasis during and after stress events. We previously showed that aged neurons suffer from chronic stress that compromises cellular resiliency to new stress events; however, the cause of aging-linked chronic stress was unclear. Here, we leverage directed transdifferentiation of human fibroblasts into aged neurons to determine the source of ISR activation. We demonstrate that increased accumulation of cytoplasmic double-stranded RNA (dsRNA) activates the eIF2α kinase PKR, which in turn triggers the ISR in aged neurons and leads to sequestration of dsRNA in stress granules. Aged neurons accumulate endogenous mitochondria-derived dsRNA that directly binds to PKR. This mitochondrial dsRNA leaks through damaged mitochondrial membranes and forms cytoplasmic foci in aged neurons. Finally, we demonstrate that PKR inhibition leads to the cessation of stress, resumption of cellular translation, and restoration of RNA-binding protein expression. Together, our results identify a source of RNA stress that destabilizes aged neurons and may contribute to neurodegeneration.

Overall Design

This accession code contains four types of RNA-seq: (1) bulk RNA-seq, (2) dsRNA-seq relying on a J2 immunoprecipitation following RNA isolation; (3) eCLIP-seq relying on RNA purified from an immunoprecipitated protein; and (4) Riboseq relying RNA shielded from digestion by ribosomal footprints.

Analysis page is available for GSE301408.

Supplementary Files (21)

GSE301408_Brain_dsRNA-seq_counts.tsv.gz Download
GSE301408_PKR_eCLIP_HumanBrain_Mid-09-04-2025-14-55-04.reproducible_enriched_re.tsv.gz Download
GSE301408_PKR_eCLIP_HumanBrain_Mid-09-04-2025-14-55-04.reproducible_enriched_windows.tsv.gz Download
GSE301408_PKR_eCLIP_HumanBrain_Old-09-04-2025-14-55-04.reproducible_enriched_re.tsv.gz Download
GSE301408_PKR_eCLIP_HumanBrain_Old-09-04-2025-14-55-04.reproducible_enriched_windows.tsv.gz Download
GSE301408_PKR_eCLIP_NK-09-04-2025-14-53-14.reproducible_enriched_windows.tsv.gz Download
GSE301408_PKR_eCLIP_Ngn2-09-04-2025-14-53-14.reproducible_enriched_windows.tsv.gz Download
GSE301408_PKR_eCLIP_iPSC-diff_10uMAntimycinA-12-06-2025-13-26-50.reproducible_enriched_windows.tsv.gz Download
GSE301408_PKR_eCLIP_iPSC-diff_5nMAntimycinA-12-06-2025-13-26-50.reproducible_enriched_windows.tsv.gz Download
GSE301408_PNPT1_eCLIP_NK-09-04-2025-14-54-28.reproducible_enriched_windows.tsv.gz Download
GSE301408_PNPT1_eCLIP_Ngn2-09-04-2025-14-54-28.reproducible_enriched_windows.tsv.gz Download
GSE301408_RNA_all_reads.csv.gz Download
GSE301408_RP_all_reads.csv.gz Download
GSE301408_SUV3_eCLIP_NK-09-04-2025-14-53-49.reproducible_enriched_windows.tsv.gz Download
GSE301408_SUV3_eCLIP_Ngn2-09-04-2025-14-53-49.reproducible_enriched_windows.tsv.gz Download
GSE301408_Tdiff.1_bulk_PKRi_RNA-seq_counts.tsv.gz Download
GSE301408_Tdiff.1_dsRNA-seq_counts.tsv.gz Download
GSE301408_Tdiff.2_dsRNA-seq_counts.tsv.gz Download
GSE301408_Tdiff.5_dsRNA-seq_counts.tsv.gz Download
GSE301408_Tdiff_bulk_RNA-seq_counts.tsv.gz Download
GSE301408_iPSC-diff.1_dsRNA-seq_counts.tsv.gz Download
GEO Samples (100)

SRA Experiments (100) and Runs (100)

Total: 118271 MB
SRX29489619 SRP596504 RNA-Seq PAIRED
Sample: SRS25631961
BioProject: PRJNA1284943
BioSample: SAMN49742711
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324152 8105466 1637304132 471.0 SRA
SRX29489620 SRP596504 RNA-Seq PAIRED
Sample: SRS25631962
BioProject: PRJNA1284943
BioSample: SAMN49742710
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324151 11195473 2261485546 650.0 SRA
SRX29489621 SRP596504 RNA-Seq PAIRED
Sample: SRS25631963
BioProject: PRJNA1284943
BioSample: SAMN49742709
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324150 1885131 380796462 110.0 SRA
SRX29489622 SRP596504 RNA-Seq PAIRED
Sample: SRS25631964
BioProject: PRJNA1284943
BioSample: SAMN49742708
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324149 1491812 301346024 87.0 SRA
SRX29489623 SRP596504 RNA-Seq PAIRED
Sample: SRS25631965
BioProject: PRJNA1284943
BioSample: SAMN49742707
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324148 618531 124943262 36.0 SRA
SRX29489624 SRP596504 RNA-Seq PAIRED
Sample: SRS25631966
BioProject: PRJNA1284943
BioSample: SAMN49742706
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324147 1725949 348641698 100.0 SRA
SRX29489625 SRP596504 RNA-Seq PAIRED
Sample: SRS25631967
BioProject: PRJNA1284943
BioSample: SAMN49742705
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324146 9516779 1922389358 557.0 SRA
SRX29489626 SRP596504 RNA-Seq PAIRED
Sample: SRS25631968
BioProject: PRJNA1284943
BioSample: SAMN49742704
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324145 116163189 23464964178 6715.0 SRA
SRX29489627 SRP596504 RNA-Seq PAIRED
Sample: SRS25631969
BioProject: PRJNA1284943
BioSample: SAMN49742703
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324144 167326330 33799918660 9647.0 SRA
SRX29489628 SRP596504 RNA-Seq PAIRED
Sample: SRS25631970
BioProject: PRJNA1284943
BioSample: SAMN49742702
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324143 1146445 231581890 66.0 SRA
SRX29489629 SRP596504 RNA-Seq PAIRED
Sample: SRS25631971
BioProject: PRJNA1284943
BioSample: SAMN49742701
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324142 4452570 899419140 259.0 SRA
SRX29489630 SRP596504 RNA-Seq PAIRED
Sample: SRS25631972
BioProject: PRJNA1284943
BioSample: SAMN49742700
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324141 6869148 1387567896 400.0 SRA
SRX29489631 SRP596504 RNA-Seq PAIRED
Sample: SRS25631973
BioProject: PRJNA1284943
BioSample: SAMN49742699
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324140 2700565 545514130 158.0 SRA
SRX29489632 SRP596504 RNA-Seq PAIRED
Sample: SRS25631974
BioProject: PRJNA1284943
BioSample: SAMN49742698
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324139 3537356 714545912 206.0 SRA
SRX29489633 SRP596504 RNA-Seq PAIRED
Sample: SRS25631975
BioProject: PRJNA1284943
BioSample: SAMN49742697
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324138 961043 194130686 55.0 SRA
SRX29489634 SRP596504 RNA-Seq PAIRED
Sample: SRS25631976
BioProject: PRJNA1284943
BioSample: SAMN49742696
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324137 3324180 671484360 194.0 SRA
SRX29489635 SRP596504 RNA-Seq PAIRED
Sample: SRS25631977
BioProject: PRJNA1284943
BioSample: SAMN49742695
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324136 10490358 2119052316 609.0 SRA
SRX29489636 SRP596504 RNA-Seq PAIRED
Sample: SRS25631978
BioProject: PRJNA1284943
BioSample: SAMN49742694
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324135 8313593 1679345786 484.0 SRA
SRX29489637 SRP596504 RNA-Seq PAIRED
Sample: SRS25631979
BioProject: PRJNA1284943
BioSample: SAMN49742693
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324134 24076642 4863481684 1389.0 SRA
SRX29489638 SRP596504 RNA-Seq PAIRED
Sample: SRS25631980
BioProject: PRJNA1284943
BioSample: SAMN49742692
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324133 21304999 4303609798 1230.0 SRA
SRX29489639 SRP596504 RNA-Seq PAIRED
Sample: SRS25631981
BioProject: PRJNA1284943
BioSample: SAMN49742691
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324132 21841915 4412066830 1262.0 SRA
SRX29489640 SRP596504 RNA-Seq PAIRED
Sample: SRS25631982
BioProject: PRJNA1284943
BioSample: SAMN49742690
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324131 2032491 207314082 77.0 SRA
SRX29489641 SRP596504 RNA-Seq PAIRED
Sample: SRS25631983
BioProject: PRJNA1284943
BioSample: SAMN49742689
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324115 55864715 5698200930 2119.0 SRA
SRX29489642 SRP596504 RIP-Seq PAIRED
Sample: SRS25631984
BioProject: PRJNA1284943
BioSample: SAMN49742626
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324129 14556335 1484746170 443.0 SRA
SRX29489643 SRP596504 RIP-Seq PAIRED
Sample: SRS25631985
BioProject: PRJNA1284943
BioSample: SAMN49742625
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324128 13152559 1341561018 392.0 SRA
SRX29489644 SRP596504 RIP-Seq PAIRED
Sample: SRS25631986
BioProject: PRJNA1284943
BioSample: SAMN49742624
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324127 15074456 1537594512 456.0 SRA
SRX29489645 SRP596504 RIP-Seq PAIRED
Sample: SRS25631987
BioProject: PRJNA1284943
BioSample: SAMN49742623
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324126 31311297 3193752294 936.0 SRA
SRX29489646 SRP596504 RIP-Seq PAIRED
Sample: SRS25631988
BioProject: PRJNA1284943
BioSample: SAMN49742622
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324125 26772270 2730771540 525.0 SRA
SRX29489647 SRP596504 RIP-Seq PAIRED
Sample: SRS25631989
BioProject: PRJNA1284943
BioSample: SAMN49742621
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324124 15963505 1628277510 481.0 SRA
SRX29489648 SRP596504 RIP-Seq PAIRED
Sample: SRS25631990
BioProject: PRJNA1284943
BioSample: SAMN49742620
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324123 21039150 2145993300 627.0 SRA
SRX29489649 SRP596504 OTHER SINGLE
Sample: SRS25631991
BioProject: PRJNA1284943
BioSample: SAMN49742619
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324122 48475620 4896037620 1514.0 SRA
SRX29489650 SRP596504 OTHER SINGLE
Sample: SRS25631992
BioProject: PRJNA1284943
BioSample: SAMN49742618
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324121 34229476 3457177076 1075.0 SRA
SRX29489651 SRP596504 OTHER SINGLE
Sample: SRS25631993
BioProject: PRJNA1284943
BioSample: SAMN49742617
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324120 49814319 5031246219 1563.0 SRA
SRX29489652 SRP596504 OTHER SINGLE
Sample: SRS25631994
BioProject: PRJNA1284943
BioSample: SAMN49742616
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324119 54188936 5473082536 1698.0 SRA
SRX29489653 SRP596504 OTHER SINGLE
Sample: SRS25631995
BioProject: PRJNA1284943
BioSample: SAMN49742615
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324118 60144134 6074557534 2187.0 SRA
SRX29489654 SRP596504 OTHER SINGLE
Sample: SRS25631996
BioProject: PRJNA1284943
BioSample: SAMN49742614
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324117 62303869 6292690769 2231.0 SRA
SRX29489655 SRP596504 OTHER SINGLE
Sample: SRS25631997
BioProject: PRJNA1284943
BioSample: SAMN49742613
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324116 44437485 4488185985 1610.0 SRA
SRX29489656 SRP596504 OTHER SINGLE
Sample: SRS25631998
BioProject: PRJNA1284943
BioSample: SAMN49742612
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324114 59161840 5975345840 2140.0 SRA
SRX29489657 SRP596504 RNA-Seq PAIRED
Sample: SRS25631999
BioProject: PRJNA1284943
BioSample: SAMN49742688
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324113 1634837 166753374 63.0 SRA
SRX29489658 SRP596504 RNA-Seq PAIRED
Sample: SRS25632000
BioProject: PRJNA1284943
BioSample: SAMN49742687
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324112 221164815 22558811130 8268.0 SRA
SRX29489659 SRP596504 RNA-Seq PAIRED
Sample: SRS25632001
BioProject: PRJNA1284943
BioSample: SAMN49742686
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324111 13686834 1396057068 520.0 SRA
SRX29489660 SRP596504 RNA-Seq PAIRED
Sample: SRS25632002
BioProject: PRJNA1284943
BioSample: SAMN49742685
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324110 113717165 11599150830 4291.0 SRA
SRX29489661 SRP596504 RNA-Seq PAIRED
Sample: SRS25632003
BioProject: PRJNA1284943
BioSample: SAMN49742684
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324109 14414415 1470270330 421.0 SRA
SRX29489662 SRP596504 RNA-Seq PAIRED
Sample: SRS25632004
BioProject: PRJNA1284943
BioSample: SAMN49742683
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324108 23274476 2373996552 675.0 SRA
SRX29489663 SRP596504 RNA-Seq PAIRED
Sample: SRS25632005
BioProject: PRJNA1284943
BioSample: SAMN49742682
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324107 17466537 1781586774 510.0 SRA
SRX29489664 SRP596504 RNA-Seq PAIRED
Sample: SRS25632006
BioProject: PRJNA1284943
BioSample: SAMN49742681
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324106 27155735 2769884970 793.0 SRA
SRX29489665 SRP596504 RNA-Seq PAIRED
Sample: SRS25632007
BioProject: PRJNA1284943
BioSample: SAMN49742680
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324105 14184360 1446804720 413.0 SRA
SRX29489666 SRP596504 RNA-Seq PAIRED
Sample: SRS25632008
BioProject: PRJNA1284943
BioSample: SAMN49742679
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324104 8 816 SRA
SRX29489667 SRP596504 RNA-Seq PAIRED
Sample: SRS25632009
BioProject: PRJNA1284943
BioSample: SAMN49742678
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324103 13952938 1423199676 413.0 SRA
SRX29489668 SRP596504 RNA-Seq PAIRED
Sample: SRS25632010
BioProject: PRJNA1284943
BioSample: SAMN49742677
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324102 12517066 1276740732 370.0 SRA
SRX29489669 SRP596504 RNA-Seq PAIRED
Sample: SRS25632011
BioProject: PRJNA1284943
BioSample: SAMN49742676
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324101 29950911 3054992922 858.0 SRA
SRX29489670 SRP596504 RNA-Seq PAIRED
Sample: SRS25632012
BioProject: PRJNA1284943
BioSample: SAMN49742675
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324100 26554422 2708551044 774.0 SRA
SRX29489671 SRP596504 RNA-Seq PAIRED
Sample: SRS25632013
BioProject: PRJNA1284943
BioSample: SAMN49742674
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324099 59156979 6034011858 1704.0 SRA
SRX29489672 SRP596504 RNA-Seq PAIRED
Sample: SRS25632014
BioProject: PRJNA1284943
BioSample: SAMN49742673
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324098 43193017 4405687734 1261.0 SRA
SRX29489673 SRP596504 RNA-Seq PAIRED
Sample: SRS25632015
BioProject: PRJNA1284943
BioSample: SAMN49742672
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324097 24389802 2487759804 715.0 SRA
SRX29489674 SRP596504 RNA-Seq PAIRED
Sample: SRS25632016
BioProject: PRJNA1284943
BioSample: SAMN49742671
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324096 13677512 1395106224 402.0 SRA
SRX29489675 SRP596504 RNA-Seq PAIRED
Sample: SRS25632017
BioProject: PRJNA1284943
BioSample: SAMN49742670
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324095 25089171 2559095442 724.0 SRA
SRX29489676 SRP596504 RNA-Seq PAIRED
Sample: SRS25632018
BioProject: PRJNA1284943
BioSample: SAMN49742669
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324094 21915726 2235404052 633.0 SRA
SRX29489677 SRP596504 RNA-Seq PAIRED
Sample: SRS25632019
BioProject: PRJNA1284943
BioSample: SAMN49742668
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324093 24878163 2537572626 725.0 SRA
SRX29489678 SRP596504 RNA-Seq SINGLE
Sample: SRS25632020
BioProject: PRJNA1284943
BioSample: SAMN49742667
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324092 22229323 2162167618 704.0 SRA
SRX29489679 SRP596504 RNA-Seq SINGLE
Sample: SRS25632021
BioProject: PRJNA1284943
BioSample: SAMN49742666
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324091 14317598 1359141442 456.0 SRA
SRX29489680 SRP596504 RNA-Seq SINGLE
Sample: SRS25632022
BioProject: PRJNA1284943
BioSample: SAMN49742665
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324090 15711417 1508623934 486.0 SRA
SRX29489681 SRP596504 RNA-Seq SINGLE
Sample: SRS25632023
BioProject: PRJNA1284943
BioSample: SAMN49742664
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324089 13079473 1281599743 411.0 SRA
SRX29489682 SRP596504 RNA-Seq SINGLE
Sample: SRS25632024
BioProject: PRJNA1284943
BioSample: SAMN49742663
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324088 8464155 833677320 265.0 SRA
SRX29489683 SRP596504 RNA-Seq SINGLE
Sample: SRS25632025
BioProject: PRJNA1284943
BioSample: SAMN49742662
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324087 16982175 1642688174 533.0 SRA
SRX29489684 SRP596504 RNA-Seq SINGLE
Sample: SRS25632026
BioProject: PRJNA1284943
BioSample: SAMN49742661
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324086 18073167 1788593332 562.0 SRA
SRX29489685 SRP596504 RNA-Seq SINGLE
Sample: SRS25632027
BioProject: PRJNA1284943
BioSample: SAMN49742660
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324085 13944618 1369258596 447.0 SRA
SRX29489686 SRP596504 RIP-Seq PAIRED
Sample: SRS25632028
BioProject: PRJNA1284943
BioSample: SAMN49742659
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324084 122264693 24697467986 8321.0 SRA
SRX29489687 SRP596504 RIP-Seq PAIRED
Sample: SRS25632029
BioProject: PRJNA1284943
BioSample: SAMN49742658
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324083 97080677 19610296754 6687.0 SRA
SRX29489688 SRP596504 RIP-Seq PAIRED
Sample: SRS25632030
BioProject: PRJNA1284943
BioSample: SAMN49742657
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324082 53085003 10723170606 3596.0 SRA
SRX29489689 SRP596504 RIP-Seq PAIRED
Sample: SRS25632031
BioProject: PRJNA1284943
BioSample: SAMN49742656
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324081 107690119 21753404038 7327.0 SRA
SRX29489690 SRP596504 RIP-Seq PAIRED
Sample: SRS25632032
BioProject: PRJNA1284943
BioSample: SAMN49742655
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324080 11400060 1162806120 344.0 SRA
SRX29489691 SRP596504 RIP-Seq PAIRED
Sample: SRS25632033
BioProject: PRJNA1284943
BioSample: SAMN49742654
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324079 21243687 2166856074 638.0 SRA
SRX29489692 SRP596504 RIP-Seq PAIRED
Sample: SRS25632034
BioProject: PRJNA1284943
BioSample: SAMN49742653
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324078 3220241 328464582 98.0 SRA
SRX29489693 SRP596504 RIP-Seq PAIRED
Sample: SRS25632035
BioProject: PRJNA1284943
BioSample: SAMN49742652
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324077 3292217 335806134 100.0 SRA
SRX29489694 SRP596504 RIP-Seq PAIRED
Sample: SRS25632036
BioProject: PRJNA1284943
BioSample: SAMN49742651
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324076 18703923 1907800146 561.0 SRA
SRX29489695 SRP596504 RIP-Seq PAIRED
Sample: SRS25632037
BioProject: PRJNA1284943
BioSample: SAMN49742650
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324075 33726704 3440123808 1010.0 SRA
SRX29489696 SRP596504 RIP-Seq PAIRED
Sample: SRS25632038
BioProject: PRJNA1284943
BioSample: SAMN49742649
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324074 38693883 3946776066 1140.0 SRA
SRX29489697 SRP596504 RIP-Seq PAIRED
Sample: SRS25632039
BioProject: PRJNA1284943
BioSample: SAMN49742648
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324073 26736345 2727107190 797.0 SRA
SRX29489698 SRP596504 RIP-Seq PAIRED
Sample: SRS25632040
BioProject: PRJNA1284943
BioSample: SAMN49742647
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324072 19262864 1964812128 565.0 SRA
SRX29489699 SRP596504 RIP-Seq PAIRED
Sample: SRS25632041
BioProject: PRJNA1284943
BioSample: SAMN49742646
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324071 19483369 1987303638 575.0 SRA
SRX29489700 SRP596504 RIP-Seq PAIRED
Sample: SRS25632042
BioProject: PRJNA1284943
BioSample: SAMN49742645
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324070 23083530 2354520060 642.0 SRA
SRX29489701 SRP596504 RIP-Seq PAIRED
Sample: SRS25632044
BioProject: PRJNA1284943
BioSample: SAMN49742644
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324069 16356144 1668326688 489.0 SRA
SRX29489702 SRP596504 RIP-Seq SINGLE
Sample: SRS25632043
BioProject: PRJNA1284943
BioSample: SAMN49742643
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324068 23537413 2377278713 782.0 SRA
SRX29489703 SRP596504 RIP-Seq SINGLE
Sample: SRS25632045
BioProject: PRJNA1284943
BioSample: SAMN49742642
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324067 38106840 3848790840 1267.0 SRA
SRX29489704 SRP596504 RIP-Seq SINGLE
Sample: SRS25632047
BioProject: PRJNA1284943
BioSample: SAMN49742641
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324066 16107102 1626817302 526.0 SRA
SRX29489705 SRP596504 RIP-Seq SINGLE
Sample: SRS25632046
BioProject: PRJNA1284943
BioSample: SAMN49742640
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324065 23549013 2378450313 772.0 SRA
SRX29489706 SRP596504 RIP-Seq SINGLE
Sample: SRS25632048
BioProject: PRJNA1284943
BioSample: SAMN49742639
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324064 25113737 2536487437 831.0 SRA
SRX29489707 SRP596504 RIP-Seq SINGLE
Sample: SRS25632049
BioProject: PRJNA1284943
BioSample: SAMN49742638
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324063 17246170 1741863170 587.0 SRA
SRX29489708 SRP596504 RIP-Seq SINGLE
Sample: SRS25632050
BioProject: PRJNA1284943
BioSample: SAMN49742637
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324062 36496218 3686118018 1245.0 SRA
SRX29489709 SRP596504 RIP-Seq SINGLE
Sample: SRS25632051
BioProject: PRJNA1284943
BioSample: SAMN49742636
Platform: ILLUMINA
Instrument: NextSeq 2000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324061 22268836 2249152436 752.0 SRA
SRX29489710 SRP596504 RIP-Seq PAIRED
Sample: SRS25632053
BioProject: PRJNA1284943
BioSample: SAMN49742635
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324060 21412877 2184113454 631.0 SRA
SRX29489711 SRP596504 RIP-Seq PAIRED
Sample: SRS25632052
BioProject: PRJNA1284943
BioSample: SAMN49742634
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324059 18486322 1885604844 545.0 SRA
SRX29489712 SRP596504 RIP-Seq PAIRED
Sample: SRS25632054
BioProject: PRJNA1284943
BioSample: SAMN49742633
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324058 16674737 1700823174 529.0 SRA
SRX29489713 SRP596504 RIP-Seq PAIRED
Sample: SRS25632055
BioProject: PRJNA1284943
BioSample: SAMN49742632
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324057 9714711 990900522 291.0 SRA
SRX29489714 SRP596504 RIP-Seq PAIRED
Sample: SRS25632056
BioProject: PRJNA1284943
BioSample: SAMN49742631
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324056 24270363 2475577026 714.0 SRA
SRX29489715 SRP596504 RIP-Seq PAIRED
Sample: SRS25632057
BioProject: PRJNA1284943
BioSample: SAMN49742630
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324055 32274065 3291954630 946.0 SRA
SRX29489716 SRP596504 RIP-Seq PAIRED
Sample: SRS25632058
BioProject: PRJNA1284943
BioSample: SAMN49742629
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324054 18755626 1913073852 559.0 SRA
SRX29489717 SRP596504 RIP-Seq PAIRED
Sample: SRS25632060
BioProject: PRJNA1284943
BioSample: SAMN49742628
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324053 26128471 2665104042 773.0 SRA
SRX29489718 SRP596504 RIP-Seq PAIRED
Sample: SRS25632059
BioProject: PRJNA1284943
BioSample: SAMN49742627
Platform: ILLUMINA
Instrument: Illumina NovaSeq 6000
Organism: Homo sapiens
Runs (1)
Run Spots Bases Size (MB) Files Link
SRR34324130 15605920 1591803840 475.0 SRA

Potentially Related Publications (1)

This accession was text-mined from the PMC full text of these publications. It may be referenced for comparison or reused from another study rather than generated for them.

RNA triggers chronic stress during neuronal aging.
bioRxiv : the preprint server for biology · 2025

Data Files (100)

Accession File Name Stored Type Output Type Mapping Assembly Size Download
— SRR34324114_GSM9082659 OTHER 2.1 GB link
— SRR34324116_GSM9082658 OTHER 1.6 GB link
— SRR34324117_GSM9082657 OTHER 2.2 GB link
— SRR34324118_GSM9082656 OTHER 2.1 GB link
— SRR34324119_GSM9082655 OTHER 1.7 GB link
— SRR34324120_GSM9082654 OTHER 1.5 GB link
— SRR34324121_GSM9082653 OTHER 1.0 GB link
— SRR34324122_GSM9082652 OTHER 1.5 GB link
— SRR34324053_GSM9082643 RIP-Seq 773.0 MB link
— SRR34324054_GSM9082642 RIP-Seq 559.0 MB link
— SRR34324055_GSM9082641 RIP-Seq 946.0 MB link
— SRR34324056_GSM9082640 RIP-Seq 714.0 MB link
— SRR34324057_GSM9082639 RIP-Seq 291.0 MB link
— SRR34324058_GSM9082638 RIP-Seq 529.0 MB link
— SRR34324059_GSM9082637 RIP-Seq 545.0 MB link
— SRR34324060_GSM9082636 RIP-Seq 631.0 MB link
— SRR34324061_GSM9082635 RIP-Seq 752.0 MB link
— SRR34324062_GSM9082634 RIP-Seq 1.2 GB link
— SRR34324063_GSM9082633 RIP-Seq 587.0 MB link
— SRR34324064_GSM9082632 RIP-Seq 831.0 MB link
— SRR34324065_GSM9082631 RIP-Seq 772.0 MB link
— SRR34324066_GSM9082630 RIP-Seq 526.0 MB link
— SRR34324067_GSM9082629 RIP-Seq 1.2 GB link
— SRR34324068_GSM9082628 RIP-Seq 782.0 MB link
— SRR34324069_GSM9082627 RIP-Seq 489.0 MB link
— SRR34324070_GSM9082626 RIP-Seq 642.0 MB link
— SRR34324071_GSM9082625 RIP-Seq 575.0 MB link
— SRR34324072_GSM9082624 RIP-Seq 565.0 MB link
— SRR34324073_GSM9082623 RIP-Seq 797.0 MB link
— SRR34324074_GSM9082622 RIP-Seq 1.1 GB link
— SRR34324075_GSM9082621 RIP-Seq 1010.0 MB link
— SRR34324076_GSM9082620 RIP-Seq 561.0 MB link
— SRR34324077_GSM9082619 RIP-Seq 100.0 MB link
— SRR34324078_GSM9082618 RIP-Seq 98.0 MB link
— SRR34324079_GSM9082617 RIP-Seq 638.0 MB link
— SRR34324080_GSM9082616 RIP-Seq 344.0 MB link
— SRR34324081_GSM9082615 RIP-Seq 7.2 GB link
— SRR34324082_GSM9082614 RIP-Seq 3.5 GB link
— SRR34324083_GSM9082613 RIP-Seq 6.5 GB link
— SRR34324084_GSM9082612 RIP-Seq 8.1 GB link
— SRR34324123_GSM9082651 RIP-Seq 627.0 MB link
— SRR34324124_GSM9082650 RIP-Seq 481.0 MB link
— SRR34324125_GSM9082649 RIP-Seq 525.0 MB link
— SRR34324126_GSM9082648 RIP-Seq 936.0 MB link
— SRR34324127_GSM9082647 RIP-Seq 456.0 MB link
— SRR34324128_GSM9082646 RIP-Seq 392.0 MB link
— SRR34324129_GSM9082645 RIP-Seq 443.0 MB link
— SRR34324130_GSM9082644 RIP-Seq 475.0 MB link
— SRR34324085_GSM9082611 RNA-Seq 447.0 MB link
— SRR34324086_GSM9082610 RNA-Seq 562.0 MB link
— SRR34324087_GSM9082609 RNA-Seq 533.0 MB link
— SRR34324088_GSM9082608 RNA-Seq 265.0 MB link
— SRR34324089_GSM9082607 RNA-Seq 411.0 MB link
— SRR34324090_GSM9082606 RNA-Seq 486.0 MB link
— SRR34324091_GSM9082605 RNA-Seq 456.0 MB link
— SRR34324092_GSM9082604 RNA-Seq 704.0 MB link
— SRR34324093_GSM9082603 RNA-Seq 725.0 MB link
— SRR34324094_GSM9082602 RNA-Seq 633.0 MB link
— SRR34324095_GSM9082601 RNA-Seq 724.0 MB link
— SRR34324096_GSM9082600 RNA-Seq 402.0 MB link
— SRR34324097_GSM9082599 RNA-Seq 715.0 MB link
— SRR34324098_GSM9082598 RNA-Seq 1.2 GB link
— SRR34324099_GSM9082597 RNA-Seq 1.7 GB link
— SRR34324100_GSM9082596 RNA-Seq 774.0 MB link
— SRR34324101_GSM9082595 RNA-Seq 858.0 MB link
— SRR34324102_GSM9082594 RNA-Seq 370.0 MB link
— SRR34324103_GSM9082593 RNA-Seq 413.0 MB link
— SRR34324104_GSM9082592 RNA-Seq link
— SRR34324105_GSM9082591 RNA-Seq 413.0 MB link
— SRR34324106_GSM9082590 RNA-Seq 793.0 MB link
— SRR34324107_GSM9082589 RNA-Seq 510.0 MB link
— SRR34324108_GSM9082588 RNA-Seq 675.0 MB link
— SRR34324109_GSM9082587 RNA-Seq 421.0 MB link
— SRR34324110_GSM9082586 RNA-Seq 4.2 GB link
— SRR34324111_GSM9082585 RNA-Seq 520.0 MB link
— SRR34324112_GSM9082584 RNA-Seq 8.1 GB link
— SRR34324113_GSM9082583 RNA-Seq 63.0 MB link
— SRR34324115_GSM9082582 RNA-Seq 2.1 GB link
— SRR34324131_GSM9082581 RNA-Seq 77.0 MB link
— SRR34324132_GSM9082580 RNA-Seq 1.2 GB link
— SRR34324133_GSM9082579 RNA-Seq 1.2 GB link
— SRR34324134_GSM9082578 RNA-Seq 1.4 GB link
— SRR34324135_GSM9082577 RNA-Seq 484.0 MB link
— SRR34324136_GSM9082576 RNA-Seq 609.0 MB link
— SRR34324137_GSM9082575 RNA-Seq 194.0 MB link
— SRR34324138_GSM9082574 RNA-Seq 55.0 MB link
— SRR34324139_GSM9082573 RNA-Seq 206.0 MB link
— SRR34324140_GSM9082572 RNA-Seq 158.0 MB link
— SRR34324141_GSM9082571 RNA-Seq 400.0 MB link
— SRR34324142_GSM9082570 RNA-Seq 259.0 MB link
— SRR34324143_GSM9082569 RNA-Seq 66.0 MB link
— SRR34324144_GSM9082568 RNA-Seq 9.4 GB link
— SRR34324145_GSM9082567 RNA-Seq 6.6 GB link
— SRR34324146_GSM9082566 RNA-Seq 557.0 MB link
— SRR34324147_GSM9082565 RNA-Seq 100.0 MB link
— SRR34324148_GSM9082564 RNA-Seq 36.0 MB link
— SRR34324149_GSM9082563 RNA-Seq 87.0 MB link
— SRR34324150_GSM9082562 RNA-Seq 110.0 MB link
— SRR34324151_GSM9082561 RNA-Seq 650.0 MB link
— SRR34324152_GSM9082560 RNA-Seq 471.0 MB link