GSE31595
GSE GEOGene Expression Profiles in Stage II and III Colon Cancer. Application of a 128-gene signature
Organism:
Homo sapiens
Platform:
GPL570
Samples:
37
Experiment Types:
Expression profiling by array
Third-party reanalysis
Submitted:
Aug 23 2011
Last Updated:
Mar 25 2019
Status:
Public on Sep 01 2011
Contact:
Morten,,Thorsteinsson (Roskilde Hospital, University of Copenhagen)
Relations
Affiliated with: GSM437118
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Reanalysis of: GSM102472
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BioProject: https://www.ncbi.nlm.nih.gov/bioproject/PRJNA145569
Summary
Purpose: A 128-gene signature has been proposed to predict poor outcomes in patients with stage II and III colorectal cancer. In the present study we aimed to validate this previously published 128-gene signature on external and independent data from patients with stage II and III colon cancer.
Overall Design
Tumor samples were obtained from 37 patients with stage II and III colon cancer, who underwent colon resection at the Department of Surgery, Roskilde Hospital, Denmark and the Department of Surgery, Bispebjerg Hospital, Denmark between 2001 and 2008. Purified tumor RNA was reverse-transcribed, labelled and hybridized to Affymetrix Human Genome U133 Plus 2.0 GeneChip Array (Affymetrix, Santa Clara, USA) according to the manufacturers instructions and scanned at the RH Microarray Center, Rigshospitalet, University of Copenhagen.
Analysis (2 steps)
View Data Processing
Processing steps for GSE31595
- The processing and analysis of expression data were performed using the statistical software R and Bioconductor.
- For all Affymetrix CEL files the background were corrected and the expression were normalized using robust multiarray average (RMA).
Supplementary Files (3)
GEO Samples (37)
GSM782671
GSM782674
GSM784850
GSM784851
GSM784852
GSM784853
GSM784854
GSM784855
GSM784856
GSM784857
GSM784858
GSM784860
GSM784862
GSM784865
GSM784867
GSM784871
GSM784873
GSM784875
GSM784878
GSM784881
GSM784884
GSM784885
GSM784886
GSM784887
GSM784888
GSM784889
GSM784890
GSM784891
GSM784892
GSM784893
GSM784894
GSM784901
GSM784902
GSM784903
GSM784904
GSM784905
GSM784906
Dataset Citations (1)
Linked Publications (1)
DDX5 promotes oncogene C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesis.
Life science alliance · 2020