Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal β Cell Proliferation.
Chun Zeng,
Francesca Mulas,
Yinghui Sui,
Tiffany Guan,
Nathanael Miller,
Yuliang Tan,
Fenfen Liu,
Wen Jin,
Andrea C Carrano,
Mark O Huising,
Orian S Shirihai,
Gene W Yeo,
Maike Sander
Cell metabolism
· 2017
· Vol. 25
(5)
· pp. 1160-1175.e11
Abstract
Pancreatic β cell mass for appropriate blood glucose control is established during early postnatal life. β cell proliferative capacity declines postnatally, but the extrinsic cues and intracellular signals that cause this decline remain unknown. To obtain a high-resolution map of β cell transcriptome dynamics after birth, we generated single-cell RNA-seq data of β cells from multiple postnatal time points and ordered cells based on transcriptional similarity using a new analytical tool. This analysis captured signatures of immature, proliferative β cells and established high expression of amino acid metabolic, mitochondrial, and Srf/Jun/Fos transcription factor genes as their hallmark feature. Experimental validation revealed high metabolic activity in immature β cells and a role for reactive oxygen species and Srf/Jun/Fos transcription factors in driving postnatal β cell proliferation and mass expansion. Our work provides the first high-resolution molecular characterization of state changes in postnatal β cells and paves the way for the identification of novel therapeutic targets to stimulate β cell regeneration.
Publication Types
["Journal Article"]
MeSH Terms
["Amino Acids", "Animals", "Cell Proliferation", "Cells, Cultured", "Female", "Gene Expression Regulation, Developmental", "HEK293 Cells", "Humans", "Insulin-Secreting Cells", "Male", "Metabolic Networks and Pathways", "Mice, Inbred C57BL", "Mitochondria", "Reactive Oxygen Species", "Transcriptome"]
Funding
P30 DK063491
NIDDK NIH HHS
(United States)
R01 DK068471
NIDDK NIH HHS
(United States)
R01 DK078803
NIDDK NIH HHS
(United States)
R01 DK099618
NIDDK NIH HHS
(United States)
R01 DK064391
NIDDK NIH HHS
(United States)
Linked Datasets (1)
Pseudotemporal ordering of single cells reveals metabolic control of postnatal beta cell proliferation
Mus musculus416 data files
| File | Type | Size |
|---|---|---|
| C1_S12_L003_R1_001.fastq.gz | RNA-Seq | 530.9 MB |
| C2_S13_L003_R1_001.fastq.gz | RNA-Seq | 543.8 MB |
| C3_S14_L003_R1_001.fastq.gz | RNA-Seq | 612.0 MB |
| CZ01_S1_L005_R1_001.fastq.gz | RNA-Seq | 618.7 MB |
| CZ02_S2_L005_R1_001.fastq.gz | RNA-Seq | 634.4 MB |
| CZ03_S3_L005_R1_001.fastq.gz | RNA-Seq | 527.0 MB |
| CZ04_S4_L005_R1_001.fastq.gz | RNA-Seq | 544.8 MB |
| CZ05_S5_L005_R1_001.fastq.gz | RNA-Seq | 554.3 MB |
| CZ06_S6_L005_R1_001.fastq.gz | RNA-Seq | 560.2 MB |
| CZ07_S7_L005_R1_001.fastq.gz | RNA-Seq | 592.5 MB |
| CZ08_S8_L005_R1_001.fastq.gz | RNA-Seq | 573.6 MB |
| CZ09_S9_L005_R1_001.fastq.gz | RNA-Seq | 505.9 MB |
| L1_AA10_merged.fastq.gz | RNA-Seq | 75.1 MB |
| L1_AA11_merged.fastq.gz | RNA-Seq | 79.0 MB |
| L1_AA1_merged.fastq.gz | RNA-Seq | 142.9 MB |
| L1_AA2_merged.fastq.gz | RNA-Seq | 89.6 MB |
| L1_AA5_merged.fastq.gz | RNA-Seq | 87.1 MB |
| L1_AA6_merged.fastq.gz | RNA-Seq | 150.5 MB |
| L1_AA7_merged.fastq.gz | RNA-Seq | 41.0 MB |
| L1_AA8_merged.fastq.gz | RNA-Seq | 103.0 MB |
| L1_AA9_merged.fastq.gz | RNA-Seq | 70.9 MB |
| L1_AB10_merged.fastq.gz | RNA-Seq | 85.1 MB |
| L1_AB11_merged.fastq.gz | RNA-Seq | 71.9 MB |
| L1_AB1_merged.fastq.gz | RNA-Seq | 106.9 MB |
| L1_AB2_merged.fastq.gz | RNA-Seq | 95.1 MB |
| L1_AB5_merged.fastq.gz | RNA-Seq | 86.2 MB |
| L1_AB6_merged.fastq.gz | RNA-Seq | 95.0 MB |
| L1_AB7_merged.fastq.gz | RNA-Seq | 26.4 MB |
| L1_AB8_merged.fastq.gz | RNA-Seq | 85.4 MB |
| L1_AB9_merged.fastq.gz | RNA-Seq | 64.9 MB |
| L1_AC10_merged.fastq.gz | RNA-Seq | 84.8 MB |
| L1_AC11_merged.fastq.gz | RNA-Seq | 78.7 MB |
| L1_AC12_merged.fastq.gz | RNA-Seq | 77.1 MB |
| L1_AC1_merged.fastq.gz | RNA-Seq | 79.3 MB |
| L1_AC2_merged.fastq.gz | RNA-Seq | 71.4 MB |
| L1_AC5_merged.fastq.gz | RNA-Seq | 88.2 MB |
| L1_AC6_merged.fastq.gz | RNA-Seq | 110.5 MB |
| L1_AC7_merged.fastq.gz | RNA-Seq | 60.7 MB |
| L1_AC8_merged.fastq.gz | RNA-Seq | 94.2 MB |
| L1_AC9_merged.fastq.gz | RNA-Seq | 67.6 MB |
| L1_AD10_merged.fastq.gz | RNA-Seq | 84.7 MB |
| L1_AD11_merged.fastq.gz | RNA-Seq | 75.1 MB |
| L1_AD12_merged.fastq.gz | RNA-Seq | 64.8 MB |
| L1_AD1_merged.fastq.gz | RNA-Seq | 87.0 MB |
| L1_AD2_merged.fastq.gz | RNA-Seq | 89.6 MB |
| L1_AD5_merged.fastq.gz | RNA-Seq | 85.0 MB |
| L1_AD6_merged.fastq.gz | RNA-Seq | 94.5 MB |
| L1_AD7_merged.fastq.gz | RNA-Seq | 62.0 MB |
| L1_AD8_merged.fastq.gz | RNA-Seq | 101.5 MB |
| L1_AD9_merged.fastq.gz | RNA-Seq | 51.9 MB |
| L1_AE10_merged.fastq.gz | RNA-Seq | 87.3 MB |
| L1_AE11_merged.fastq.gz | RNA-Seq | 77.9 MB |
| L1_AE1_merged.fastq.gz | RNA-Seq | 77.2 MB |
| L1_AE2_merged.fastq.gz | RNA-Seq | 81.0 MB |
| L1_AE7_merged.fastq.gz | RNA-Seq | 62.4 MB |
| L1_AE8_merged.fastq.gz | RNA-Seq | 65.5 MB |
| L1_AE9_merged.fastq.gz | RNA-Seq | 58.5 MB |
| L1_AF10_merged.fastq.gz | RNA-Seq | 58.9 MB |
| L1_AF11_merged.fastq.gz | RNA-Seq | 76.7 MB |
| L1_AF12_merged.fastq.gz | RNA-Seq | 79.1 MB |
| L1_AF1_merged.fastq.gz | RNA-Seq | 73.3 MB |
| L1_AF2_merged.fastq.gz | RNA-Seq | 61.2 MB |
| L1_AF5_merged.fastq.gz | RNA-Seq | 90.1 MB |
| L1_AF7_merged.fastq.gz | RNA-Seq | 88.1 MB |
| L1_AF8_merged.fastq.gz | RNA-Seq | 91.0 MB |
| L1_AF9_merged.fastq.gz | RNA-Seq | 65.5 MB |
| L1_AG10_merged.fastq.gz | RNA-Seq | 94.2 MB |
| L1_AG11_merged.fastq.gz | RNA-Seq | 82.9 MB |
| L1_AG1_merged.fastq.gz | RNA-Seq | 66.7 MB |
| L1_AG2_merged.fastq.gz | RNA-Seq | 76.2 MB |
| L1_AG6_merged.fastq.gz | RNA-Seq | 55.3 MB |
| L1_AG7_merged.fastq.gz | RNA-Seq | 76.9 MB |
| L1_AG8_merged.fastq.gz | RNA-Seq | 65.1 MB |
| L1_AG9_merged.fastq.gz | RNA-Seq | 131.6 MB |
| L1_AH10_merged.fastq.gz | RNA-Seq | 108.9 MB |
| L1_AH11_merged.fastq.gz | RNA-Seq | 106.6 MB |
| L1_AH12_merged.fastq.gz | RNA-Seq | 73.0 MB |
| L1_AH1_merged.fastq.gz | RNA-Seq | 92.1 MB |
| L1_AH2_merged.fastq.gz | RNA-Seq | 67.3 MB |
| L1_AH5_merged.fastq.gz | RNA-Seq | 104.2 MB |
| L1_AH6_merged.fastq.gz | RNA-Seq | 72.3 MB |
| L1_AH7_merged.fastq.gz | RNA-Seq | 70.8 MB |
| L1_AH8_merged.fastq.gz | RNA-Seq | 72.7 MB |
| L1_AH9_merged.fastq.gz | RNA-Seq | 71.8 MB |
| L2_BA10_merged.fastq.gz | RNA-Seq | 72.8 MB |
| L2_BA11_merged.fastq.gz | RNA-Seq | 91.4 MB |
| L2_BA12_merged.fastq.gz | RNA-Seq | 215.9 MB |
| L2_BA1_merged.fastq.gz | RNA-Seq | 123.9 MB |
| L2_BA2_merged.fastq.gz | RNA-Seq | 125.2 MB |
| L2_BA5_merged.fastq.gz | RNA-Seq | 49.6 MB |
| L2_BA6_merged.fastq.gz | RNA-Seq | 115.9 MB |
| L2_BA7_merged.fastq.gz | RNA-Seq | 108.1 MB |
| L2_BA8_merged.fastq.gz | RNA-Seq | 157.6 MB |
| L2_BA9_merged.fastq.gz | RNA-Seq | 72.9 MB |
| L2_BB10_merged.fastq.gz | RNA-Seq | 51.6 MB |
| L2_BB11_merged.fastq.gz | RNA-Seq | 90.4 MB |
| L2_BB12_merged.fastq.gz | RNA-Seq | 114.8 MB |
| L2_BB1_merged.fastq.gz | RNA-Seq | 61.4 MB |
| L2_BB2_merged.fastq.gz | RNA-Seq | 71.2 MB |
| L2_BB5_merged.fastq.gz | RNA-Seq | 44.9 MB |
| L2_BB6_merged.fastq.gz | RNA-Seq | 69.8 MB |
| L2_BB7_merged.fastq.gz | RNA-Seq | 95.1 MB |
| L2_BB8_merged.fastq.gz | RNA-Seq | 132.0 MB |
| L2_BB9_merged.fastq.gz | RNA-Seq | 50.9 MB |
| L2_BC10_merged.fastq.gz | RNA-Seq | 57.7 MB |
| L2_BC12_merged.fastq.gz | RNA-Seq | 156.1 MB |
| L2_BC1_merged.fastq.gz | RNA-Seq | 89.2 MB |
| L2_BC2_merged.fastq.gz | RNA-Seq | 40.9 MB |
| L2_BC5_merged.fastq.gz | RNA-Seq | 40.2 MB |
| L2_BC6_merged.fastq.gz | RNA-Seq | 62.3 MB |
| L2_BC7_merged.fastq.gz | RNA-Seq | 58.0 MB |
| L2_BC8_merged.fastq.gz | RNA-Seq | 151.8 MB |
| L2_BC9_merged.fastq.gz | RNA-Seq | 60.4 MB |
| L2_BD10_merged.fastq.gz | RNA-Seq | 62.1 MB |
| L2_BD12_merged.fastq.gz | RNA-Seq | 102.5 MB |
| L2_BD1_merged.fastq.gz | RNA-Seq | 68.7 MB |
| L2_BD2_merged.fastq.gz | RNA-Seq | 40.3 MB |
| L2_BD5_merged.fastq.gz | RNA-Seq | 65.4 MB |
| L2_BD6_merged.fastq.gz | RNA-Seq | 61.7 MB |
| L2_BD7_merged.fastq.gz | RNA-Seq | 76.8 MB |
| L2_BD8_merged.fastq.gz | RNA-Seq | 120.6 MB |
| L2_BD9_merged.fastq.gz | RNA-Seq | 42.6 MB |
| L2_BE10_merged.fastq.gz | RNA-Seq | 127.2 MB |
| L2_BE11_merged.fastq.gz | RNA-Seq | 153.8 MB |
| L2_BE12_merged.fastq.gz | RNA-Seq | 100.1 MB |
| L2_BE1_merged.fastq.gz | RNA-Seq | 113.3 MB |
| L2_BE2_merged.fastq.gz | RNA-Seq | 59.3 MB |
| L2_BE5_merged.fastq.gz | RNA-Seq | 58.1 MB |
| L2_BE6_merged.fastq.gz | RNA-Seq | 144.7 MB |
| L2_BE7_merged.fastq.gz | RNA-Seq | 72.6 MB |
| L2_BE8_merged.fastq.gz | RNA-Seq | 75.1 MB |
| L2_BE9_merged.fastq.gz | RNA-Seq | 35.8 MB |
| L2_BF10_merged.fastq.gz | RNA-Seq | 105.9 MB |
| L2_BF11_merged.fastq.gz | RNA-Seq | 102.2 MB |
| L2_BF12_merged.fastq.gz | RNA-Seq | 110.9 MB |
| L2_BF1_merged.fastq.gz | RNA-Seq | 103.3 MB |
| L2_BF2_merged.fastq.gz | RNA-Seq | 44.5 MB |
| L2_BF5_merged.fastq.gz | RNA-Seq | 65.7 MB |
| L2_BF6_merged.fastq.gz | RNA-Seq | 131.9 MB |
| L2_BF7_merged.fastq.gz | RNA-Seq | 55.5 MB |
| L2_BF8_merged.fastq.gz | RNA-Seq | 105.6 MB |
| L2_BF9_merged.fastq.gz | RNA-Seq | 42.4 MB |
| L2_BG10_merged.fastq.gz | RNA-Seq | 97.8 MB |
| L2_BG11_merged.fastq.gz | RNA-Seq | 68.8 MB |
| L2_BG12_merged.fastq.gz | RNA-Seq | 102.9 MB |
| L2_BG1_merged.fastq.gz | RNA-Seq | 108.8 MB |
| L2_BG2_merged.fastq.gz | RNA-Seq | 66.4 MB |
| L2_BG5_merged.fastq.gz | RNA-Seq | 67.6 MB |
| L2_BG6_merged.fastq.gz | RNA-Seq | 150.9 MB |
| L2_BG7_merged.fastq.gz | RNA-Seq | 34.3 MB |
| L2_BG8_merged.fastq.gz | RNA-Seq | 65.9 MB |
| L2_BG9_merged.fastq.gz | RNA-Seq | 62.2 MB |
| L2_BH10_merged.fastq.gz | RNA-Seq | 176.4 MB |
| L2_BH11_merged.fastq.gz | RNA-Seq | 101.0 MB |
| L2_BH12_merged.fastq.gz | RNA-Seq | 102.5 MB |
| L2_BH1_merged.fastq.gz | RNA-Seq | 91.4 MB |
| L2_BH2_merged.fastq.gz | RNA-Seq | 125.4 MB |
| L2_BH5_merged.fastq.gz | RNA-Seq | 75.5 MB |
| L2_BH6_merged.fastq.gz | RNA-Seq | 81.9 MB |
| L2_BH7_merged.fastq.gz | RNA-Seq | 52.7 MB |
| L2_BH8_merged.fastq.gz | RNA-Seq | 107.3 MB |
| L2_BH9_merged.fastq.gz | RNA-Seq | 112.0 MB |
| L3_DA10_merged.fastq.gz | RNA-Seq | 102.2 MB |
| L3_DA11_merged.fastq.gz | RNA-Seq | 119.9 MB |
| L3_DA12_merged.fastq.gz | RNA-Seq | 85.7 MB |
| L3_DA1_merged.fastq.gz | RNA-Seq | 118.3 MB |
| L3_DA2_merged.fastq.gz | RNA-Seq | 76.3 MB |
| L3_DA5_merged.fastq.gz | RNA-Seq | 52.5 MB |
| L3_DA6_merged.fastq.gz | RNA-Seq | 44.6 MB |
| L3_DA7_merged.fastq.gz | RNA-Seq | 76.4 MB |
| L3_DA8_merged.fastq.gz | RNA-Seq | 72.6 MB |
| L3_DA9_merged.fastq.gz | RNA-Seq | 100.0 MB |
| L3_DB10_merged.fastq.gz | RNA-Seq | 66.8 MB |
| L3_DB11_merged.fastq.gz | RNA-Seq | 111.6 MB |
| L3_DB12_merged.fastq.gz | RNA-Seq | 102.7 MB |
| L3_DB1_merged.fastq.gz | RNA-Seq | 68.9 MB |
| L3_DB2_merged.fastq.gz | RNA-Seq | 94.3 MB |
| L3_DB5_merged.fastq.gz | RNA-Seq | 68.1 MB |
| L3_DB6_merged.fastq.gz | RNA-Seq | 63.0 MB |
| L3_DB7_merged.fastq.gz | RNA-Seq | 79.4 MB |
| L3_DB8_merged.fastq.gz | RNA-Seq | 69.9 MB |
| L3_DB9_merged.fastq.gz | RNA-Seq | 67.9 MB |
| L3_DC10_merged.fastq.gz | RNA-Seq | 72.6 MB |
| L3_DC11_merged.fastq.gz | RNA-Seq | 109.1 MB |
| L3_DC12_merged.fastq.gz | RNA-Seq | 89.1 MB |
| L3_DC1_merged.fastq.gz | RNA-Seq | 52.3 MB |
| L3_DC2_merged.fastq.gz | RNA-Seq | 87.7 MB |
| L3_DC5_merged.fastq.gz | RNA-Seq | 47.4 MB |
| L3_DC6_merged.fastq.gz | RNA-Seq | 74.5 MB |
| L3_DC7_merged.fastq.gz | RNA-Seq | 116.4 MB |
| L3_DC8_merged.fastq.gz | RNA-Seq | 60.4 MB |
| L3_DC9_merged.fastq.gz | RNA-Seq | 71.6 MB |
| L3_DD10_merged.fastq.gz | RNA-Seq | 65.1 MB |
| L3_DD11_merged.fastq.gz | RNA-Seq | 75.1 MB |
| L3_DD12_merged.fastq.gz | RNA-Seq | 110.5 MB |
| L3_DD1_merged.fastq.gz | RNA-Seq | 71.0 MB |
| L3_DD2_merged.fastq.gz | RNA-Seq | 75.2 MB |
| L3_DD5_merged.fastq.gz | RNA-Seq | 60.5 MB |
| L3_DD6_merged.fastq.gz | RNA-Seq | 139.8 MB |
| L3_DD7_merged.fastq.gz | RNA-Seq | 98.6 MB |
| L3_DD8_merged.fastq.gz | RNA-Seq | 131.8 MB |
| L3_DD9_merged.fastq.gz | RNA-Seq | 65.8 MB |
| L3_DE10_merged.fastq.gz | RNA-Seq | 46.5 MB |
| L3_DE11_merged.fastq.gz | RNA-Seq | 92.7 MB |
| L3_DE12_merged.fastq.gz | RNA-Seq | 110.9 MB |
| L3_DE1_merged.fastq.gz | RNA-Seq | 44.7 MB |
| L3_DE2_merged.fastq.gz | RNA-Seq | 40.5 MB |
| L3_DE5_merged.fastq.gz | RNA-Seq | 87.0 MB |
| L3_DE6_merged.fastq.gz | RNA-Seq | 132.0 MB |
| L3_DE7_merged.fastq.gz | RNA-Seq | 99.8 MB |
| L3_DE8_merged.fastq.gz | RNA-Seq | 142.9 MB |
| L3_DE9_merged.fastq.gz | RNA-Seq | 77.7 MB |
| L3_DF10_merged.fastq.gz | RNA-Seq | 61.4 MB |
| L3_DF11_merged.fastq.gz | RNA-Seq | 59.0 MB |
| L3_DF12_merged.fastq.gz | RNA-Seq | 157.0 MB |
| L3_DF1_merged.fastq.gz | RNA-Seq | 39.2 MB |
| L3_DF2_merged.fastq.gz | RNA-Seq | 76.4 MB |
| L3_DF5_merged.fastq.gz | RNA-Seq | 136.5 MB |
| L3_DF6_merged.fastq.gz | RNA-Seq | 117.2 MB |
| L3_DF7_merged.fastq.gz | RNA-Seq | 102.1 MB |
| L3_DF8_merged.fastq.gz | RNA-Seq | 129.1 MB |
| L3_DF9_merged.fastq.gz | RNA-Seq | 60.9 MB |
| L3_DG10_merged.fastq.gz | RNA-Seq | 64.8 MB |
| L3_DG11_merged.fastq.gz | RNA-Seq | 102.5 MB |
| L3_DG12_merged.fastq.gz | RNA-Seq | 122.4 MB |
| L3_DG1_merged.fastq.gz | RNA-Seq | 91.8 MB |
| L3_DG2_merged.fastq.gz | RNA-Seq | 70.3 MB |
| L3_DG5_merged.fastq.gz | RNA-Seq | 97.2 MB |
| L3_DG6_merged.fastq.gz | RNA-Seq | 152.7 MB |
| L3_DG7_merged.fastq.gz | RNA-Seq | 96.8 MB |
| L3_DG8_merged.fastq.gz | RNA-Seq | 114.5 MB |
| L3_DG9_merged.fastq.gz | RNA-Seq | 92.4 MB |
| L3_DH10_merged.fastq.gz | RNA-Seq | 93.4 MB |
| L3_DH11_merged.fastq.gz | RNA-Seq | 124.8 MB |
| L3_DH12_merged.fastq.gz | RNA-Seq | 151.8 MB |
| L3_DH1_merged.fastq.gz | RNA-Seq | 60.8 MB |
| L3_DH2_merged.fastq.gz | RNA-Seq | 89.1 MB |
| L3_DH5_merged.fastq.gz | RNA-Seq | 111.5 MB |
| L3_DH6_merged.fastq.gz | RNA-Seq | 106.4 MB |
| L3_DH7_merged.fastq.gz | RNA-Seq | 123.9 MB |
| L3_DH8_merged.fastq.gz | RNA-Seq | 106.4 MB |
| L3_DH9_merged.fastq.gz | RNA-Seq | 98.3 MB |
| L4_FA10_merged.fastq.gz | RNA-Seq | 54.2 MB |
| L4_FA11_merged.fastq.gz | RNA-Seq | 77.5 MB |
| L4_FA12_merged.fastq.gz | RNA-Seq | 88.8 MB |
| L4_FA1_merged.fastq.gz | RNA-Seq | 171.4 MB |
| L4_FA2_merged.fastq.gz | RNA-Seq | 35.2 MB |
| L4_FA5_merged.fastq.gz | RNA-Seq | 98.8 MB |
| L4_FA6_merged.fastq.gz | RNA-Seq | 31.5 MB |
| L4_FA7_merged.fastq.gz | RNA-Seq | 111.1 MB |
| L4_FA8_merged.fastq.gz | RNA-Seq | 63.9 MB |
| L4_FA9_merged.fastq.gz | RNA-Seq | 36.8 MB |
| L4_FB10_merged.fastq.gz | RNA-Seq | 37.0 MB |
| L4_FB11_merged.fastq.gz | RNA-Seq | 55.8 MB |
| L4_FB12_merged.fastq.gz | RNA-Seq | 95.4 MB |
| L4_FB1_merged.fastq.gz | RNA-Seq | 165.3 MB |
| L4_FB2_merged.fastq.gz | RNA-Seq | 54.8 MB |
| L4_FB5_merged.fastq.gz | RNA-Seq | 76.8 MB |
| L4_FB6_merged.fastq.gz | RNA-Seq | 42.1 MB |
| L4_FB7_merged.fastq.gz | RNA-Seq | 109.5 MB |
| L4_FB8_merged.fastq.gz | RNA-Seq | 59.8 MB |
| L4_FB9_merged.fastq.gz | RNA-Seq | 47.1 MB |
| L4_FC10_merged.fastq.gz | RNA-Seq | 52.3 MB |
| L4_FC11_merged.fastq.gz | RNA-Seq | 74.3 MB |
| L4_FC12_merged.fastq.gz | RNA-Seq | 132.4 MB |
| L4_FC1_merged.fastq.gz | RNA-Seq | 89.6 MB |
| L4_FC2_merged.fastq.gz | RNA-Seq | 72.6 MB |
| L4_FC5_merged.fastq.gz | RNA-Seq | 100.7 MB |
| L4_FC6_merged.fastq.gz | RNA-Seq | 42.7 MB |
| L4_FC7_merged.fastq.gz | RNA-Seq | 104.0 MB |
| L4_FC8_merged.fastq.gz | RNA-Seq | 101.5 MB |
| L4_FC9_merged.fastq.gz | RNA-Seq | 52.3 MB |
| L4_FD10_merged.fastq.gz | RNA-Seq | 58.4 MB |
| L4_FD11_merged.fastq.gz | RNA-Seq | 90.2 MB |
| L4_FD12_merged.fastq.gz | RNA-Seq | 97.9 MB |
| L4_FD1_merged.fastq.gz | RNA-Seq | 56.1 MB |
| L4_FD2_merged.fastq.gz | RNA-Seq | 95.3 MB |
| L4_FD5_merged.fastq.gz | RNA-Seq | 126.5 MB |
| L4_FD6_merged.fastq.gz | RNA-Seq | 42.9 MB |
| L4_FD7_merged.fastq.gz | RNA-Seq | 95.0 MB |
| L4_FD8_merged.fastq.gz | RNA-Seq | 59.0 MB |
| L4_FD9_merged.fastq.gz | RNA-Seq | 134.9 MB |
| L4_FE10_merged.fastq.gz | RNA-Seq | 67.2 MB |
| L4_FE11_merged.fastq.gz | RNA-Seq | 84.5 MB |
| L4_FE12_merged.fastq.gz | RNA-Seq | 97.4 MB |
| L4_FE1_merged.fastq.gz | RNA-Seq | 67.6 MB |
| L4_FE2_merged.fastq.gz | RNA-Seq | 43.3 MB |
| L4_FE5_merged.fastq.gz | RNA-Seq | 120.1 MB |
| L4_FE6_merged.fastq.gz | RNA-Seq | 44.2 MB |
| L4_FE7_merged.fastq.gz | RNA-Seq | 66.0 MB |
| L4_FE8_merged.fastq.gz | RNA-Seq | 62.6 MB |
| L4_FE9_merged.fastq.gz | RNA-Seq | 96.1 MB |
| L4_FF10_merged.fastq.gz | RNA-Seq | 72.6 MB |
| L4_FF11_merged.fastq.gz | RNA-Seq | 138.3 MB |
| L4_FF2_merged.fastq.gz | RNA-Seq | 106.8 MB |
| L4_FF6_merged.fastq.gz | RNA-Seq | 37.3 MB |
| L4_FF7_merged.fastq.gz | RNA-Seq | 81.7 MB |
| L4_FF8_merged.fastq.gz | RNA-Seq | 93.8 MB |
| L4_FF9_merged.fastq.gz | RNA-Seq | 101.1 MB |
| L4_FG10_merged.fastq.gz | RNA-Seq | 61.5 MB |
| L4_FG11_merged.fastq.gz | RNA-Seq | 53.0 MB |
| L4_FG12_merged.fastq.gz | RNA-Seq | 64.6 MB |
| L4_FG1_merged.fastq.gz | RNA-Seq | 127.1 MB |
| L4_FG2_merged.fastq.gz | RNA-Seq | 43.1 MB |
| L4_FG5_merged.fastq.gz | RNA-Seq | 89.4 MB |
| L4_FG6_merged.fastq.gz | RNA-Seq | 48.7 MB |
| L4_FG7_merged.fastq.gz | RNA-Seq | 109.4 MB |
| L4_FG8_merged.fastq.gz | RNA-Seq | 103.1 MB |
| L4_FG9_merged.fastq.gz | RNA-Seq | 123.3 MB |
| L4_FH10_merged.fastq.gz | RNA-Seq | 91.7 MB |
| L4_FH11_merged.fastq.gz | RNA-Seq | 81.8 MB |
| L4_FH12_merged.fastq.gz | RNA-Seq | 87.2 MB |
| L4_FH1_merged.fastq.gz | RNA-Seq | 103.2 MB |
| L4_FH2_merged.fastq.gz | RNA-Seq | 57.9 MB |
| L4_FH5_merged.fastq.gz | RNA-Seq | 120.2 MB |
| L4_FH6_merged.fastq.gz | RNA-Seq | 30.2 MB |
| L4_FH7_merged.fastq.gz | RNA-Seq | 111.0 MB |
| L4_FH8_merged.fastq.gz | RNA-Seq | 92.2 MB |
| L4_FH9_merged.fastq.gz | RNA-Seq | 146.2 MB |
| L5_HA10_merged.fastq.gz | RNA-Seq | 50.7 MB |
| L5_HA11_merged.fastq.gz | RNA-Seq | 59.2 MB |
| L5_HA12_merged.fastq.gz | RNA-Seq | 59.9 MB |
| L5_HA1_merged.fastq.gz | RNA-Seq | 111.7 MB |
| L5_HA2_merged.fastq.gz | RNA-Seq | 96.8 MB |
| L5_HA3_merged.fastq.gz | RNA-Seq | 109.8 MB |
| L5_HA4_merged.fastq.gz | RNA-Seq | 53.4 MB |
| L5_HA5_merged.fastq.gz | RNA-Seq | 112.9 MB |
| L5_HA6_merged.fastq.gz | RNA-Seq | 52.4 MB |
| L5_HA7_merged.fastq.gz | RNA-Seq | 90.3 MB |
| L5_HA8_merged.fastq.gz | RNA-Seq | 84.7 MB |
| L5_HA9_merged.fastq.gz | RNA-Seq | 56.7 MB |
| L5_HB10_merged.fastq.gz | RNA-Seq | 90.6 MB |
| L5_HB11_merged.fastq.gz | RNA-Seq | 50.5 MB |
| L5_HB12_merged.fastq.gz | RNA-Seq | 52.3 MB |
| L5_HB1_merged.fastq.gz | RNA-Seq | 93.3 MB |
| L5_HB2_merged.fastq.gz | RNA-Seq | 48.7 MB |
| L5_HB3_merged.fastq.gz | RNA-Seq | 121.4 MB |
| L5_HB4_merged.fastq.gz | RNA-Seq | 81.0 MB |
| L5_HB5_merged.fastq.gz | RNA-Seq | 118.1 MB |
| L5_HB6_merged.fastq.gz | RNA-Seq | 76.9 MB |
| L5_HB7_merged.fastq.gz | RNA-Seq | 97.6 MB |
| L5_HB8_merged.fastq.gz | RNA-Seq | 80.3 MB |
| L5_HB9_merged.fastq.gz | RNA-Seq | 62.8 MB |
| L5_HC10_merged.fastq.gz | RNA-Seq | 88.3 MB |
| L5_HC12_merged.fastq.gz | RNA-Seq | 44.8 MB |
| L5_HC1_merged.fastq.gz | RNA-Seq | 86.3 MB |
| L5_HC2_merged.fastq.gz | RNA-Seq | 49.7 MB |
| L5_HC3_merged.fastq.gz | RNA-Seq | 135.0 MB |
| L5_HC4_merged.fastq.gz | RNA-Seq | 96.8 MB |
| L5_HC5_merged.fastq.gz | RNA-Seq | 117.4 MB |
| L5_HC6_merged.fastq.gz | RNA-Seq | 40.9 MB |
| L5_HC7_merged.fastq.gz | RNA-Seq | 77.6 MB |
| L5_HC8_merged.fastq.gz | RNA-Seq | 50.1 MB |
| L5_HC9_merged.fastq.gz | RNA-Seq | 85.3 MB |
| L5_HD10_merged.fastq.gz | RNA-Seq | 91.5 MB |
| L5_HD11_merged.fastq.gz | RNA-Seq | 84.6 MB |
| L5_HD12_merged.fastq.gz | RNA-Seq | 48.4 MB |
| L5_HD1_merged.fastq.gz | RNA-Seq | 73.9 MB |
| L5_HD2_merged.fastq.gz | RNA-Seq | 65.5 MB |
| L5_HD3_merged.fastq.gz | RNA-Seq | 56.8 MB |
| L5_HD4_merged.fastq.gz | RNA-Seq | 68.8 MB |
| L5_HD5_merged.fastq.gz | RNA-Seq | 158.8 MB |
| L5_HD6_merged.fastq.gz | RNA-Seq | 45.7 MB |
| L5_HD7_merged.fastq.gz | RNA-Seq | 64.1 MB |
| L5_HD8_merged.fastq.gz | RNA-Seq | 83.5 MB |
| L5_HD9_merged.fastq.gz | RNA-Seq | 98.8 MB |
| L5_HE10_merged.fastq.gz | RNA-Seq | 136.6 MB |
| L5_HE11_merged.fastq.gz | RNA-Seq | 87.5 MB |
| L5_HE12_merged.fastq.gz | RNA-Seq | 45.7 MB |
| L5_HE1_merged.fastq.gz | RNA-Seq | 122.3 MB |
| L5_HE2_merged.fastq.gz | RNA-Seq | 56.4 MB |
| L5_HE3_merged.fastq.gz | RNA-Seq | 74.7 MB |
| L5_HE4_merged.fastq.gz | RNA-Seq | 93.8 MB |
| L5_HE5_merged.fastq.gz | RNA-Seq | 83.1 MB |
| L5_HE6_merged.fastq.gz | RNA-Seq | 96.9 MB |
| L5_HE7_merged.fastq.gz | RNA-Seq | 67.3 MB |
| L5_HE8_merged.fastq.gz | RNA-Seq | 39.5 MB |
| L5_HE9_merged.fastq.gz | RNA-Seq | 69.4 MB |
| L5_HF10_merged.fastq.gz | RNA-Seq | 85.5 MB |
| L5_HF12_merged.fastq.gz | RNA-Seq | 34.4 MB |
| L5_HF1_merged.fastq.gz | RNA-Seq | 102.6 MB |
| L5_HF2_merged.fastq.gz | RNA-Seq | 76.5 MB |
| L5_HF3_merged.fastq.gz | RNA-Seq | 96.7 MB |
| L5_HF4_merged.fastq.gz | RNA-Seq | 175.0 MB |
| L5_HF5_merged.fastq.gz | RNA-Seq | 75.0 MB |
| L5_HF6_merged.fastq.gz | RNA-Seq | 90.0 MB |
| L5_HF7_merged.fastq.gz | RNA-Seq | 90.1 MB |
| L5_HF8_merged.fastq.gz | RNA-Seq | 98.2 MB |
| L5_HF9_merged.fastq.gz | RNA-Seq | 89.1 MB |
| L5_HG10_merged.fastq.gz | RNA-Seq | 119.4 MB |
| L5_HG11_merged.fastq.gz | RNA-Seq | 90.4 MB |
| L5_HG12_merged.fastq.gz | RNA-Seq | 61.8 MB |
| L5_HG1_merged.fastq.gz | RNA-Seq | 139.5 MB |
| L5_HG2_merged.fastq.gz | RNA-Seq | 158.4 MB |
| L5_HG3_merged.fastq.gz | RNA-Seq | 142.5 MB |
| L5_HG4_merged.fastq.gz | RNA-Seq | 118.9 MB |
| L5_HG5_merged.fastq.gz | RNA-Seq | 79.3 MB |
| L5_HG6_merged.fastq.gz | RNA-Seq | 89.3 MB |
| L5_HG7_merged.fastq.gz | RNA-Seq | 93.2 MB |
| L5_HG8_merged.fastq.gz | RNA-Seq | 80.3 MB |
| L5_HG9_merged.fastq.gz | RNA-Seq | 97.2 MB |
| L5_HH10_merged.fastq.gz | RNA-Seq | 98.0 MB |
| L5_HH11_merged.fastq.gz | RNA-Seq | 131.0 MB |
| L5_HH12_merged.fastq.gz | RNA-Seq | 56.1 MB |
| L5_HH1_merged.fastq.gz | RNA-Seq | 58.8 MB |
| L5_HH2_merged.fastq.gz | RNA-Seq | 126.5 MB |
| L5_HH3_merged.fastq.gz | RNA-Seq | 91.8 MB |
| L5_HH4_merged.fastq.gz | RNA-Seq | 182.1 MB |
| L5_HH5_merged.fastq.gz | RNA-Seq | 132.8 MB |
| L5_HH6_merged.fastq.gz | RNA-Seq | 174.9 MB |
| L5_HH7_merged.fastq.gz | RNA-Seq | 32.0 MB |
| L5_HH8_merged.fastq.gz | RNA-Seq | 67.3 MB |
| L5_HH9_merged.fastq.gz | RNA-Seq | 126.9 MB |
| S1_S18_L003_R1_001.fastq.gz | RNA-Seq | 482.8 MB |
| S2_S19_L003_R1_001.fastq.gz | RNA-Seq | 688.3 MB |
| S3_S20_L003_R1_001.fastq.gz | RNA-Seq | 928.3 MB |
Potentially Related Datasets (3)
These accessions were text-mined from the PMC full text. They may be referenced for comparison, cited from other studies, or otherwise mentioned without being primary data for this paper.
Aging-dependent demethylation of regulatory elements correlates with chromatin state and improved insulin secretion by pancreatic β cells
Analysis Pipelines (2)
GSE68618 RNA-seq Data Processing
11 steps
GSE86479 Data Processing
2 steps
geo_data_processing
GSE86479