Gene W Yeo
309
Publications
8
First Author
113
Last Author
Top Co-Authors
Brian A Yee
(46)
Stefan Aigner
(43)
Eric L Van Nostrand
(39)
Steven M Blue
(29)
Shashank Sathe
(29)
Gabriel A Pratt
(22)
Wenhao Jin
(19)
Brenton R Graveley
(17)
Christopher B Burge
(16)
Rob Knight
(16)
Xiang-Dong Fu
(14)
John T Chang
(14)
Emily C Wheeler
(14)
Jasmine R Mueller
(14)
Louise C Laurent
(14)
Fred H Gage
(14)
Samuel S Park
(13)
Orel Mizrahi
(13)
Hsuan-Lin Her
(13)
Sebastian Markmiller
(13)
Publications
High-resolution mapping of CCR4-NOT recruitment elements reveals transcriptome-wide drivers of mRNA decay.
Cell reports · 2026
Comprehensive RNA-binding protein analyses and deep learning uncover genetic constraints and disease associations in protein-RNA interfaces.
Cell systems · 2026
Localized regulation of cell junction mRNAs is required for epithelial cell integrity.
RNA (New York, N.Y.) · 2026
System-level measurement, modeling, and manipulation of RNA.
RNA (New York, N.Y.) · 2026
Flipper: An advanced framework for identifying differential RNA binding behavior with eCLIP data.
bioRxiv : the preprint server for biology · 2026
Organizing research at scale: Reflections on leading multi-team scientific collaborations.
Molecular cell · 2026
Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO.
Cell chemical biology · 2026
RNA-binding protein LARP6 coordinates hepatic stellate cell activation and liver fibrosis.
The Journal of clinical investigation · 2026
MBNL2 dysfunction in outer radial glial cells is associated with disrupted corticogenesis in congenital myotonic dystrophy.
Neurobiology of disease · 2026
Identification of RBP binding sites using RNA deaminases.
Methods in enzymology · 2025
Integrative CRISPR Screening and RNA Analyses Discover an Essential Role for PUF60 Interactions with 3' Splice Sites in Cancer Progression.
Cancer research · 2025
Dual-targeting snRNA gene therapy rescues STMN2 and UNC13A splicing in TDP-43 proteinopathies.
bioRxiv : the preprint server for biology · 2025
Dosage-sensitive <i>RBFOX2</i> autoregulation promotes cardiomyocyte differentiation by maturing the transcriptome.
bioRxiv : the preprint server for biology · 2025
KIF5A binds RNA to orchestrate synaptic mRNA localization and stress granules in ALS.
bioRxiv : the preprint server for biology · 2025
The IFIT2-IFIT3 antiviral complex targets short 5' untranslated regions on viral mRNAs for translation inhibition.
Nature microbiology · 2025
Human AUTS2 regulates neurodevelopmental pathways via dual DNA/RNA binding.
bioRxiv : the preprint server for biology · 2025
A splice-switching antisense oligonucleotide approach for pediatric genetic epilepsies.
bioRxiv : the preprint server for biology · 2025
Imaging Cellular Metabolic Rewiring with SuMMIT-SRS.
bioRxiv : the preprint server for biology · 2025
Enhancing RNA base editing on mammalian transcripts with small nuclear RNAs.
Nature chemical biology · 2025
RNA triggers chronic stress during neuronal aging.
bioRxiv : the preprint server for biology · 2025
Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial.
Nature communications · 2025
Evaluation of novel computational methods to identify RNA-binding protein footprints from structural data.
RNA (New York, N.Y.) · 2025
Human CCR4 deadenylase homolog Angel1 is a non-stop mRNA decay factor.
RNA (New York, N.Y.) · 2025
Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress.
Nature neuroscience · 2025
Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO.
bioRxiv : the preprint server for biology · 2025
Genome-Wide Interrogation of SARS-CoV-2 RNA-Protein Interactions Uncovers Hidden Regulatory Sites.
bioRxiv : the preprint server for biology · 2025
Integrative CRISPR Screens and RNA-Omics Discover an Essential Role for PUF60-3' Splice Site Interactions in Cancer Progression.
bioRxiv : the preprint server for biology · 2025
Integrated multi-omic characterizations of the synapse reveal RNA processing factors and ubiquitin ligases associated with neurodevelopmental disorders.
Cell systems · 2025
Foxo1 regulates intestinal tissue-resident memory CD8 T cell biology in an anatomic compartment- and context-specific manner.
Science immunology · 2025
Short 5' UTRs serve as a marker for viral mRNA translation inhibition by the IFIT2-IFIT3 antiviral complex.
bioRxiv : the preprint server for biology · 2025
LARP6 regulates the mRNA translation of fibrogenic genes in liver fibrosis.
bioRxiv : the preprint server for biology · 2025
Rational design yields RNA-binding zinc finger domains with altered sequence specificity.
RNA (New York, N.Y.) · 2025
Stratification of enterochromaffin cells by single-cell expression analysis.
bioRxiv : the preprint server for biology · 2025
Localized molecular chaperone synthesis maintains neuronal dendrite proteostasis.
Nature communications · 2024
Steering research on mRNA splicing in cancer towards clinical translation.
Nature reviews. Cancer · 2024
Decoding protein-RNA interactions using CLIP-based methodologies.
Nature reviews. Genetics · 2024
Supra- and sub-threshold intracellular-like recording of 2D and 3D neuronal networks using nanopillar electrode arrays.
Microsystems & nanoengineering · 2024
Strategies for programmable manipulation of alternative splicing.
Current opinion in genetics & development · 2024
Long-read Ribo-STAMP simultaneously measures transcription and translation with isoform resolution.
Genome research · 2024
Large-scale map of RNA-binding protein interactomes across the mRNA life cycle.
Molecular cell · 2024
Localized synthesis of molecular chaperones sustains neuronal proteostasis.
bioRxiv : the preprint server for biology · 2024
Integrated multi-omics analysis of zinc-finger proteins uncovers roles in RNA regulation.
Molecular cell · 2024
Author Correction: Large-scale evaluation of the ability of RNA-binding proteins to activate exon inclusion.
Nature biotechnology · 2024
Large-scale evaluation of the ability of RNA-binding proteins to activate exon inclusion.
Nature biotechnology · 2024
Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and remodeling.
Proceedings of the National Academy of Sciences of the United States of America · 2024
High-sensitivity in situ capture of endogenous RNA-protein interactions in fixed cells and primary tissues.
Nature communications · 2024
Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes.
Cell reports · 2024
Mudskipper detects combinatorial RNA binding protein interactions in multiplexed CLIP data.
Cell genomics · 2024
Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size.
Neuron · 2024
Protocol to process crosslinking and immunoprecipitation data into annotated binding sites.
STAR protocols · 2024
Small nuclear RNAs enhance protein-free RNA-programmable base conversion on mammalian coding transcripts.
bioRxiv : the preprint server for biology · 2024
circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA.
bioRxiv : the preprint server for biology · 2024
ePRINT: exonuclease assisted mapping of protein-RNA interactions.
Genome biology · 2024
A phage nucleus-associated RNA-binding protein is required for jumbo phage infection.
Nucleic acids research · 2024
Bento: a toolkit for subcellular analysis of spatial transcriptomics data.
Genome biology · 2024
Functional Diversity of Memory CD8 T Cells is Spatiotemporally Imprinted.
bioRxiv : the preprint server for biology · 2024
LARP4 is an RNA-binding protein that binds nuclear-encoded mitochondrial mRNAs to promote mitochondrial function.
RNA (New York, N.Y.) · 2024
Computational cell-cell interaction technologies drive mechanistic and biomarker discovery in the tumor microenvironment.
Current opinion in biotechnology · 2024
Expanded palette of RNA base editors for comprehensive RBP-RNA interactome studies.
Nature communications · 2024
Junior scientists spotlight social bonds in seminars for diversity, equity, and inclusion in STEM.
PloS one · 2023
RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression.
Molecular cell · 2023
FLARE: a fast and flexible workflow for identifying RNA editing foci.
BMC bioinformatics · 2023
Seryl-tRNA synthetase promotes translational readthrough by mRNA binding and involvement of the selenocysteine incorporation machinery.
Nucleic acids research · 2023
A phage nucleus-associated RNA-binding protein is required for jumbo phage infection.
bioRxiv : the preprint server for biology · 2023
A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer.
Nature communications · 2023
Expanded palette of RNA base editors for comprehensive RBP-RNA interactome studies.
bioRxiv : the preprint server for biology · 2023
HydRA: Deep-learning models for predicting RNA-binding capacity from protein interaction association context and protein sequence.
Molecular cell · 2023
Pyruvate Kinase M (PKM) binds ribosomes in a poly-ADP ribosylation dependent manner to induce translational stalling.
Nucleic acids research · 2023
Remodeling oncogenic transcriptomes by small molecules targeting NONO.
Nature chemical biology · 2023
Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration.
bioRxiv : the preprint server for biology · 2023
Skipper analysis of eCLIP datasets enables sensitive detection of constrained translation factor binding sites.
Cell genomics · 2023
Large-scale map of RNA binding protein interactomes across the mRNA life-cycle.
bioRxiv : the preprint server for biology · 2023
In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target.
Blood cancer discovery · 2023
Proteomic discovery of chemical probes that perturb protein complexes in human cells.
Molecular cell · 2023
Programmable macromolecule-based RNA-targeting therapies to treat human neurological disorders.
RNA (New York, N.Y.) · 2023
Xiphoid nucleus of the midline thalamus controls cold-induced food seeking.
bioRxiv : the preprint server for biology · 2023
Splicing factor SRSF1 deficiency in the liver triggers NASH-like pathology and cell death.
Nature communications · 2023
RNA binding protein DDX5 restricts RORγt<sup>+</sup> T<sub>reg</sub> suppressor function to promote intestine inflammation.
Science advances · 2023
Early transcriptional and epigenetic divergence of CD8+ T cells responding to acute versus chronic infection.
PLoS biology · 2023
Author Correction: Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma.
Nature communications · 2023
Small intestine and colon tissue-resident memory CD8<sup>+</sup> T cells exhibit molecular heterogeneity and differential dependence on Eomes.
Immunity · 2023
RBP Image Database: A resource for the systematic characterization of the subcellular distribution properties of human RNA binding proteins.
Nucleic acids research · 2023
Multiplexed transcriptome discovery of RNA-binding protein binding sites by antibody-barcode eCLIP.
Nature methods · 2023
An RNA-targeting CRISPR-Cas13d system alleviates disease-related phenotypes in Huntington's disease models.
Nature neuroscience · 2023
The Host-Microbiome Response to Hyperbaric Oxygen Therapy in Ulcerative Colitis Patients.
Cellular and molecular gastroenterology and hepatology · 2022
APEX Proximity Labeling of Stress Granule Proteins.
Methods in molecular biology (Clifton, N.J.) · 2022
Antibody-Oligonucleotide Conjugation Using a SPAAC Copper-Free Method Compatible with 10× Genomics' Single-Cell RNA-Seq.
Methods in molecular biology (Clifton, N.J.) · 2022
Metadensity: a background-aware python pipeline for summarizing CLIP signals on various transcriptomic sites.
Bioinformatics advances · 2022
Aging RNA granule dynamics in neurodegeneration.
Frontiers in molecular biosciences · 2022
Examination of the Cell Cycle Dependence of Cytosine and Adenine Base Editors.
Frontiers in genome editing · 2022
VPS13A and VPS13C Influence Lipid Droplet Abundance.
Contact (Thousand Oaks (Ventura County, Calif.)) · 2022
Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma.
Nature communications · 2022
Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus.
Neurobiology of disease · 2022
Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis.
Acta neuropathologica · 2022
Engineered U1 snRNAs to modulate alternatively spliced exons.
Methods (San Diego, Calif.) · 2022
AKT constitutes a signal-promoted alternative exon-junction complex that regulates nonsense-mediated mRNA decay.
Molecular cell · 2022
The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors.
Nature communications · 2022
Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans.
Nature medicine · 2022
SARS-CoV-2 Distribution in Residential Housing Suggests Contact Deposition and Correlates with <i>Rothia</i> sp.
mSystems · 2022
Illuminating RNA biology through imaging.
Nature cell biology · 2022
The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression.
The Journal of experimental medicine · 2022
MECP2-related pathways are dysregulated in a cortical organoid model of myotonic dystrophy.
Science translational medicine · 2022
Transcriptome-wide identification of RNA-binding protein binding sites using seCLIP-seq.
Nature protocols · 2022
Author Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes.
Nature · 2022
Nuclear and cytoplasmic poly(A) binding proteins (PABPs) favor distinct transcripts and isoforms.
Nucleic acids research · 2022
Wastewater sequencing uncovers early, cryptic SARS-CoV-2 variant transmission.
medRxiv : the preprint server for health sciences · 2022
The ViReflow pipeline enables user friendly large scale viral consensus genome reconstruction.
Scientific reports · 2022
Discovery and functional interrogation of SARS-CoV-2 protein-RNA interactions.
Research square · 2022
Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML.
Cell reports · 2022
Crosstalk between CRISPR-Cas9 and the human transcriptome.
Nature communications · 2022
Integrative RNA-omics Discovers GNAS Alternative Splicing as a Phenotypic Driver of Splicing Factor-Mutant Neoplasms.
Cancer discovery · 2022
Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis.
Cellular and molecular life sciences : CMLS · 2022
Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing.
Molecular cell · 2022
Discovery and functional interrogation of SARS-CoV-2 protein-RNA interactions.
bioRxiv : the preprint server for biology · 2022
SARS-CoV-2 Distribution in Residential Housing Suggests Contact Deposition and Correlates with <i>Rothia</i> sp.
medRxiv : the preprint server for health sciences · 2021
Analysis of SARS-CoV-2 RNA Persistence across Indoor Surface Materials Reveals Best Practices for Environmental Monitoring Programs.
mSystems · 2021
Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies.
Nature communications · 2021
ADAR and hnRNPC deficiency synergize in activating endogenous dsRNA-induced type I IFN responses.
The Journal of experimental medicine · 2021
fSHAPE, fSHAPE-eCLIP, and SHAPE-eCLIP probe transcript regions that interact with specific proteins.
STAR protocols · 2021
Persistent mRNA localization defects and cell death in ALS neurons caused by transient cellular stress.
Cell reports · 2021
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer.
Molecular cell · 2021
Non-microRNA binding competitively inhibits LIN28 regulation.
Cell reports · 2021
Comparison of heat-inactivated and infectious SARS-CoV-2 across indoor surface materials shows comparable RT-qPCR viral signal intensity and persistence.
bioRxiv : the preprint server for biology · 2021
Huntington's disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization.
The Journal of clinical investigation · 2021
Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS.
Molecular cell · 2021
Robust single-cell discovery of RNA targets of RNA-binding proteins and ribosomes.
Nature methods · 2021
S-nitrosylated TDP-43 triggers aggregation, cell-to-cell spread, and neurotoxicity in hiPSCs and in vivo models of ALS/FTD.
Proceedings of the National Academy of Sciences of the United States of America · 2021
A CRISPR RNA-binding protein screen reveals regulators of RUNX1 isoform generation.
Blood advances · 2021
Erratum: A role for alternative splicing in circadian control of exocytosis and glucose homeostasis.
Genes & development · 2021
Zika virus is transmitted in neural progenitor cells via cell-to-cell spread and infection is inhibited by the autophagy inducer trehalose.
Journal of virology · 2021
The sustained expression of Cas9 targeting toxic RNAs reverses disease phenotypes in mouse models of myotonic dystrophy type 1.
Nature biomedical engineering · 2021
Reintroduction of the archaic variant of <i>NOVA1</i> in cortical organoids alters neurodevelopment.
Science (New York, N.Y.) · 2021
Emergence of an early SARS-CoV-2 epidemic in the United States.
medRxiv : the preprint server for health sciences · 2021
Genomic epidemiology identifies emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States.
medRxiv : the preprint server for health sciences · 2021
Repeat RNA expansion disorders of the nervous system: post-transcriptional mechanisms and therapeutic strategies.
Critical reviews in biochemistry and molecular biology · 2021
Author Correction: A large-scale binding and functional map of human RNA-binding proteins.
Nature · 2021
Base editing: advances and therapeutic opportunities.
Nature reviews. Drug discovery · 2020
Footprinting SHAPE-eCLIP Reveals Transcriptome-wide Hydrogen Bonds at RNA-Protein Interfaces.
Molecular cell · 2020
Transcriptome-wide profiles of circular RNA and RNA-binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression.
Genome medicine · 2020
Evaluation of Engineered CRISPR-Cas-Mediated Systems for Site-Specific RNA Editing.
Cell reports · 2020
The <i>Thermus thermophilus</i> DEAD-box protein Hera is a general RNA binding protein and plays a key role in tRNA metabolism.
RNA (New York, N.Y.) · 2020
Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program.
Molecular cell · 2020
Context-dependent functional compensation between Ythdf m<sup>6</sup>A reader proteins.
Genes & development · 2020
Handwashing and Detergent Treatment Greatly Reduce SARS-CoV-2 Viral Load on Halloween Candy Handled by COVID-19 Patients.
mSystems · 2020
AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation.
Genes & development · 2020
DDX5 promotes oncogene C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesis.
Life science alliance · 2020
Large-scale tethered function assays identify factors that regulate mRNA stability and translation.
Nature structural & molecular biology · 2020
Transcriptome-wide analysis of PGC-1α-binding RNAs identifies genes linked to glucagon metabolic action.
Proceedings of the National Academy of Sciences of the United States of America · 2020
G<sub>4</sub>C<sub>2</sub> Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD.
Neuron · 2020
Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination.
The Journal of biological chemistry · 2020
A role for alternative splicing in circadian control of exocytosis and glucose homeostasis.
Genes & development · 2020
Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses.
Science immunology · 2020
Suppression of Endothelial AGO1 Promotes Adipose Tissue Browning and Improves Metabolic Dysfunction.
Circulation · 2020
Pooled CRISPR screens with imaging on microraft arrays reveals stress granule-regulatory factors.
Nature methods · 2020
Heterogenous Populations of Tissue-Resident CD8<sup>+</sup> T Cells Are Generated in Response to Infection and Malignancy.
Immunity · 2020
Early precursors and molecular determinants of tissue-resident memory CD8<sup>+</sup> T lymphocytes revealed by single-cell RNA sequencing.
Science immunology · 2020
An in vivo genome-wide CRISPR screen identifies the RNA-binding protein Staufen2 as a key regulator of myeloid leukemia.
Nature cancer · 2020
How RNA-Binding Proteins Interact with RNA: Molecules and Mechanisms.
Molecular cell · 2020
Principles of RNA processing from analysis of enhanced CLIP maps for 150 RNA binding proteins.
Genome biology · 2020
Author Correction: Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells.
Nature communications · 2020
The mRNA Decay Factor CAR-1/LSM14 Regulates Axon Regeneration via Mitochondrial Calcium Dynamics.
Current biology : CB · 2020
RNA-targeting CRISPR systems from metagenomic discovery to transcriptomic engineering.
Nature cell biology · 2020
Direct RNA sequencing enables m<sup>6</sup>A detection in endogenous transcript isoforms at base-specific resolution.
RNA (New York, N.Y.) · 2020
Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells.
Nature communications · 2020
Regulation of RNA editing by RNA-binding proteins in human cells.
Communications biology · 2019
Corrigendum: Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells.
Frontiers in molecular neuroscience · 2019
The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis.
Cell stem cell · 2019
Peptide Brush Polymers for Efficient Delivery of a Gene Editing Protein to Stem Cells.
Angewandte Chemie (International ed. in English) · 2019
Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development.
Cell stem cell · 2019
Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD.
Neuron · 2019
A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.
Scientific reports · 2019
Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription.
Cell · 2019
Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease.
Cell stem cell · 2019
Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing.
Cell reports · 2019
Disruption of RNA Metabolism in Neurological Diseases and Emerging Therapeutic Interventions.
Neuron · 2019
Active Protein Neddylation or Ubiquitylation Is Dispensable for Stress Granule Dynamics.
Cell reports · 2019
Allele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA.
Nature communications · 2019
Glial cells maintain synapses by inhibiting an activity-dependent retrograde protease signal.
PLoS genetics · 2019
RBP-Maps enables robust generation of splicing regulatory maps.
RNA (New York, N.Y.) · 2019
A Transcriptome-wide Translational Program Defined by LIN28B Expression Level.
Molecular cell · 2019
Widespread RNA editing dysregulation in brains from autistic individuals.
Nature neuroscience · 2019
Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells.
Frontiers in molecular neuroscience · 2018
Transcriptome-pathology correlation identifies interplay between TDP-43 and the expression of its kinase CK1E in sporadic ALS.
Acta neuropathologica · 2018
An important class of intron retention events in human erythroblasts is regulated by cryptic exons proposed to function as splicing decoys.
RNA (New York, N.Y.) · 2018
Tissue-selective restriction of RNA editing of CaV1.3 by splicing factor SRSF9.
Nucleic acids research · 2018
Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease.
Cell stem cell · 2018
Sequence, Structure, and Context Preferences of Human RNA Binding Proteins.
Molecular cell · 2018
Systematic Discovery of RNA Binding Proteins that Regulate MicroRNA Levels.
Molecular cell · 2018
Advances and challenges in the detection of transcriptome-wide protein-RNA interactions.
Wiley interdisciplinary reviews. RNA · 2018
Self-Transfecting Micellar RNA: Modulating Nanoparticle Cell Interactions via High Density Display of Small Molecule Ligands on Micelle Coronas.
Bioconjugate chemistry · 2018
Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules.
Cell · 2018
Erratum to: Robust, Cost-Effective Profiling of RNA Binding Protein Targets with Single-end Enhanced Crosslinking and Immunoprecipitation (seCLIP).
Methods in molecular biology (Clifton, N.J.) · 2017
Robust, Cost-Effective Profiling of RNA Binding Protein Targets with Single-end Enhanced Crosslinking and Immunoprecipitation (seCLIP).
Methods in molecular biology (Clifton, N.J.) · 2017
Short poly(A) tails are a conserved feature of highly expressed genes.
Nature structural & molecular biology · 2017
Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism.
Nucleic acids research · 2017
NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing.
Nature structural & molecular biology · 2017
The <i>C. elegans</i> neural editome reveals an ADAR target mRNA required for proper chemotaxis.
eLife · 2017
Genetic mutations in RNA-binding proteins and their roles in ALS.
Human genetics · 2017
Variation in single-nucleotide sensitivity of eCLIP derived from reverse transcription conditions.
Methods (San Diego, Calif.) · 2017
Single-Cell Alternative Splicing Analysis with Expedition Reveals Splicing Dynamics during Neuron Differentiation.
Molecular cell · 2017
Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal β Cell Proliferation.
Cell metabolism · 2017
Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer.
Cancer discovery · 2017
Early transcriptional and epigenetic regulation of CD8<sup>+</sup> T cell differentiation revealed by single-cell RNA sequencing.
Nature immunology · 2017
iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types.
Stem cell reports · 2017
High-Throughput and Cost-Effective Characterization of Induced Pluripotent Stem Cells.
Stem cell reports · 2017
CRISPR/Cas9-mediated integration enables TAG-eCLIP of endogenously tagged RNA binding proteins.
Methods (San Diego, Calif.) · 2017
Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing.
Nature genetics · 2017
Experimental and Computational Considerations in the Study of RNA-Binding Protein-RNA Interactions.
Advances in experimental medicine and biology · 2016
Tethered Function Assays as Tools to Elucidate the Molecular Roles of RNA-Binding Proteins.
Advances in experimental medicine and biology · 2016
MicroRNA-101 Regulates Multiple Developmental Programs to Constrain Excitation in Adult Neural Networks.
Neuron · 2016
RNA-binding protein CPEB1 remodels host and viral RNA landscapes.
Nature structural & molecular biology · 2016
The Calcineurin Variant CnAβ1 Controls Mouse Embryonic Stem Cell Differentiation by Directing mTORC2 Membrane Localization and Activation.
Cell chemical biology · 2016
Making the cut in the dark genome.
Science (New York, N.Y.) · 2016
From Protein-RNA Predictions toward a Peptide-RNA Code.
Molecular cell · 2016
Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System.
Neuron · 2016
Pairing beyond the Seed Supports MicroRNA Targeting Specificity.
Molecular cell · 2016
SONAR Discovers RNA-Binding Proteins from Analysis of Large-Scale Protein-Protein Interactomes.
Molecular cell · 2016
Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model.
Genome medicine · 2016
Rbfox2 function in RNA metabolism is impaired in hypoplastic left heart syndrome patient hearts.
Scientific reports · 2016
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses.
Nature communications · 2016
Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP).
Nature methods · 2016
Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes.
Cell reports · 2016
Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival.
Cell reports · 2016
A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions.
Cell · 2016
Resources for the Comprehensive Discovery of Functional RNA Elements.
Molecular cell · 2016
PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically.
Nature medicine · 2016
Blurred Boundaries: The RNA Binding Protein Lin28A Is Also an Epigenetic Regulator.
Molecular cell · 2016
The Clothes Make the mRNA: Past and Present Trends in mRNP Fashion.
Annual review of biochemistry · 2015
A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells.
Cell reports · 2015
Reply to: "CD8(+) T cell diversification by asymmetric cell division".
Nature immunology · 2015
Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity.
Molecular cell · 2015
Applications of Cas9 as an RNA-programmed RNA-binding protein.
BioEssays : news and reviews in molecular, cellular and developmental biology · 2015
RNA-binding proteins in neurodegeneration: Seq and you shall receive.
Trends in neurosciences · 2015
Nxf1 natural variant E610G is a semi-dominant suppressor of IAP-induced RNA processing defects.
PLoS genetics · 2015
Identification of novel long noncoding RNAs underlying vertebrate cardiovascular development.
Circulation · 2015
Regulation of asymmetric division and CD8+ T lymphocyte fate specification by protein kinase Cζ and protein kinase Cλ/ι.
Journal of immunology (Baltimore, Md. : 1950) · 2015
ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP.
Nature communications · 2015
Preface.
Advances in experimental medicine and biology · 2014
Preface.
Advances in experimental medicine and biology · 2014
The Period protein homolog LIN-42 negatively regulates microRNA biogenesis in C. elegans.
Developmental biology · 2014
Intracellular mRNA regulation with self-assembled locked nucleic acid polymer nanoparticles.
Journal of the American Chemical Society · 2014
Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses.
Nature immunology · 2014
Human cytomegalovirus infection of human embryonic stem cell-derived primitive neural stem cells is restricted at several steps but leads to the persistence of viral DNA.
Journal of virology · 2014
The dsRBP and inactive editor ADR-1 utilizes dsRNA binding to regulate A-to-I RNA editing across the C. elegans transcriptome.
Cell reports · 2014
Functional genomic analysis of the let-7 regulatory network in Caenorhabditis elegans.
PLoS genetics · 2013
Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges.
Nature structural & molecular biology · 2013
Reactivation of fetal splicing programs in diabetic hearts is mediated by protein kinase C signaling.
The Journal of biological chemistry · 2013
Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration.
Proceedings of the National Academy of Sciences of the United States of America · 2013
Coordinate Nodal and BMP inhibition directs Baf60c-dependent cardiomyocyte commitment.
Genes & development · 2013
Genome-wide analysis reveals SR protein cooperation and competition in regulated splicing.
Molecular cell · 2013
ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.
Proceedings of the National Academy of Sciences of the United States of America · 2013
Genome-wide approaches to dissect the roles of RNA binding proteins in translational control: implications for neurological diseases.
Frontiers in neuroscience · 2012
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs.
Nature neuroscience · 2012
LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance.
Molecular cell · 2012
Retrotransposon long interspersed nucleotide element-1 (LINE-1) is activated during salamander limb regeneration.
Development, growth & differentiation · 2012
Evidence for premature aging due to oxidative stress in iPSCs from Cockayne syndrome.
Human molecular genetics · 2012
Misregulated RNA processing in amyotrophic lateral sclerosis.
Brain research · 2012
Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins.
Cell reports · 2012
High-resolution profiling and analysis of viral and host small RNAs during human cytomegalovirus infection.
Journal of virology · 2012
Genome-wide approaches in the study of microRNA biology.
Wiley interdisciplinary reviews. Systems biology and medicine · 2011
Comprehensive identification of miRNA target sites in live animals.
Methods in molecular biology (Clifton, N.J.) · 2011
RNA-seq analysis of gene expression and alternative splicing by double-random priming strategy.
Methods in molecular biology (Clifton, N.J.) · 2011
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.
Nature neuroscience · 2011
LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in Caenorhabditis elegans.
Nature structural & molecular biology · 2011
Alternative splicing in stem cell self-renewal and diferentiation.
Advances in experimental medicine and biology · 2010
A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells.
Cell · 2010
A distinct microRNA signature for definitive endoderm derived from human embryonic stem cells.
Stem cells and development · 2010
Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans.
Nature structural & molecular biology · 2010
Transcriptional signature and memory retention of human-induced pluripotent stem cells.
PloS one · 2009
Deep sequencing identifies new and regulated microRNAs in Schmidtea mediterranea.
RNA (New York, N.Y.) · 2009
L1 retrotransposition in human neural progenitor cells.
Nature · 2009
Hippocampus-dependent learning is associated with adult neurogenesis in MRL/MpJ mice.
Hippocampus · 2009
An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells.
Nature structural & molecular biology · 2009
Divergent transcription from active promoters.
Science (New York, N.Y.) · 2008
Determination of tag density required for digital transcriptome analysis: application to an androgen-sensitive prostate cancer model.
Proceedings of the National Academy of Sciences of the United States of America · 2008
The PIWI proteins SMEDWI-2 and SMEDWI-3 are required for stem cell function and piRNA expression in planarians.
RNA (New York, N.Y.) · 2008
Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells.
Human molecular genetics · 2008
A regulator of Dscam mutually exclusive splicing fidelity.
Nature structural & molecular biology · 2007
RNA sequence analysis defines Dicer's role in mouse embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America · 2007
Alternative splicing events identified in human embryonic stem cells and neural progenitors.
PLoS computational biology · 2007
Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007
Discovery and analysis of evolutionarily conserved intronic splicing regulatory elements.
PLoS genetics · 2007
Inference of splicing regulatory activities by sequence neighborhood analysis.
PLoS genetics · 2006
Identification and analysis of alternative splicing events conserved in human and mouse.
Proceedings of the National Academy of Sciences of the United States of America · 2005
RESCUE-ESE identifies candidate exonic splicing enhancers in vertebrate exons.
Nucleic acids research · 2004