Large-scale tethered function assays identify factors that regulate mRNA stability and translation.
En-Ching Luo, Jason L Nathanson, Frederick E Tan, Joshua L Schwartz, Jonathan C Schmok, Archana Shankar, Sebastian Markmiller, Brian A Yee, Shashank Sathe, Gabriel A Pratt, Duy B Scaletta, Yuanchi Ha, David E Hill, Stefan Aigner, Gene W Yeo
Nature structural & molecular biology · 2020 · Vol. 27 (10) · pp. 989-1000
Abstract
The molecular functions of the majority of RNA-binding proteins (RBPs) remain unclear, highlighting a major bottleneck to a full understanding of gene expression regulation. Here, we develop a plasmid resource of 690 human RBPs that we subject to luciferase-based 3'-untranslated-region tethered function assays to pinpoint RBPs that regulate RNA stability or translation. Enhanced UV-cross-linking and immunoprecipitation of these RBPs identifies thousands of endogenous mRNA targets that respond to changes in RBP level, recapitulating effects observed in tethered function assays. Among these RBPs, the ubiquitin-associated protein 2-like (UBAP2L) protein interacts with RNA via its RGG domain and cross-links to mRNA and rRNA. Fusion of UBAP2L to RNA-targeting CRISPR-Cas9 demonstrates programmable translational enhancement. Polysome profiling indicates that UBAP2L promotes translation of target mRNAs, particularly global regulators of translation. Our tethering survey allows rapid assignment of the molecular activity of proteins, such as UBAP2L, to specific steps of mRNA metabolism.
Linked datasets 4
Large-scale tethered function assays identify factors that regulate mRNA stability and translation (eCLIP)
Homo sapiens
113 data files
| File | Type | Size |
|---|---|---|
| EC_AIMP1_R1_IN_S41_L004_R1_001.fastq.gz | OTHER | 520.5 MB |
| EC_AIMP1_R1_IP_S43_L004_R1_001.fastq.gz | OTHER | 624.5 MB |
| EC_AIMP1_R2_IN_S42_L004_R1_001.fastq.gz | OTHER | 731.0 MB |
| EC_AIMP1_R2_IP_S44_L004_R1_001.fastq.gz | OTHER | 615.3 MB |
| EC_BOLL_R1_IN_S49_L005_R1_001.fastq.gz | OTHER | 716.2 MB |
| EC_BOLL_R1_IP_S51_L005_R1_001.fastq.gz | OTHER | 646.9 MB |
| EC_BOLL_R2_IN_S50_L005_R1_001.fastq.gz | OTHER | 780.6 MB |
| EC_BOLL_R2_IP_S52_L005_R1_001.fastq.gz | OTHER | 813.4 MB |
| EC_CLK3_R1_IN_S29_L003_R1_001.fastq.gz | OTHER | 525.5 MB |
| EC_CLK3_R1_IP_S31_L003_R1_001.fastq.gz | OTHER | 563.0 MB |
| EC_CLK3_R2_IN_S30_L003_R1_001.fastq.gz | OTHER | 436.9 MB |
| EC_CLK3_R2_IP_S32_L003_R1_001.fastq.gz | OTHER | 861.6 MB |
| EC_CNOT7_R1_IN_S53_L005_R1_001.fastq.gz | OTHER | 676.6 MB |
| EC_CNOT7_R1_IP_S55_L005_R1_001.fastq.gz | OTHER | 542.1 MB |
| EC_CNOT7_R2_IN_S54_L005_R1_001.fastq.gz | OTHER | 661.8 MB |
| EC_CNOT7_R2_IP_S56_L005_R1_001.fastq.gz | OTHER | 624.3 MB |
| EC_DDX6_R1-IN_S5_L001_R1_001.fastq.gz | OTHER | 870.3 MB |
| EC_DDx6_R1-IP_S7_L001_R1_001.fastq.gz | OTHER | 990.0 MB |
| EC_DDx6_R2-IN_S6_L001_R1_001.fastq.gz | OTHER | 809.9 MB |
| EC_DDX6_R2-IP_S8_L001_R1_001.fastq.gz | OTHER | 1.1 GB |
| EC_IFIT2_R1-IN_S9_L002_R1_001.fastq.gz | OTHER | 545.5 MB |
| EC_IFIT2_R1-IP_S13_L002_R1_001.fastq.gz | OTHER | 611.7 MB |
| EC_IFIT2_R2-IN_S10_L002_R1_001.fastq.gz | OTHER | 616.1 MB |
| EC_IFIT2_R2-IP_S14_L002_R1_001.fastq.gz | OTHER | 681.2 MB |
| EC_MEX3C_R1-IN_S21_L003_R1_001.fastq.gz | OTHER | 573.1 MB |
| EC_MEX3C_R1-IP_S23_L003_R1_001.fastq.gz | OTHER | 1.1 GB |
| EC_MEX3C_R2-IN_S22_L003_R1_001.fastq.gz | OTHER | 599.9 MB |
| EC_MEX3C_R2-IP_S24_L003_R1_001.fastq.gz | OTHER | 933.6 MB |
| EC_MTDH_R1_IN_S33_L004_R1_001.fastq.gz | OTHER | 782.9 MB |
| EC_MTDH_R1_IP_S35_L004_R1_001.fastq.gz | OTHER | 848.6 MB |
| EC_MTDH_R2_IN_S34_L004_R1_001.fastq.gz | OTHER | 853.8 MB |
| EC_MTDH_R2_IP_S36_L004_R1_001.fastq.gz | OTHER | 625.0 MB |
| EC_NANOS3_R1-IN_S17_L002_R1_001.fastq.gz | OTHER | 566.0 MB |
| EC_NANOS3_R1-IP_S19_L002_R1_001.fastq.gz | OTHER | 746.0 MB |
| EC_NANOS3_R2-IN_S18_L002_R1_001.fastq.gz | OTHER | 576.9 MB |
| EC_NANOS3_R2-IP_S20_L002_R1_001.fastq.gz | OTHER | 598.6 MB |
| EC_PARN_R1-IN_S25_L003_R1_001.fastq.gz | OTHER | 617.7 MB |
| EC_PARN_R1-IP_S27_L003_R1_001.fastq.gz | OTHER | 551.6 MB |
| EC_PARN_R2-IN_S26_L003_R1_001.fastq.gz | OTHER | 549.8 MB |
| EC_PARN_R2-IP_S28_L003_R1_001.fastq.gz | OTHER | 1.2 GB |
| EC_SNRPA_R1_IN_S45_L005_R1_001.fastq.gz | OTHER | 755.7 MB |
| EC_SNRPA_R1_IP_S47_L005_R1_001.fastq.gz | OTHER | 1.1 GB |
| EC_SNRPA_R2_IN_S46_L005_R1_001.fastq.gz | OTHER | 642.7 MB |
| EC_SNRPA_R2_IP_S48_L005_R1_001.fastq.gz | OTHER | 618.8 MB |
| EC_TBO2_R1-IN_S11_L002_R1_001.fastq.gz | OTHER | 564.3 MB |
| EC_TBO2_R1-IP_S15_L002_R1_001.fastq.gz | OTHER | 1.5 GB |
| EC_TBO2_R2-IN_S12_L002_R1_001.fastq.gz | OTHER | 428.8 MB |
| EC_TBO2_R2-IP_S16_L002_R1_001.fastq.gz | OTHER | 559.1 MB |
| EC_TOB1_R1_IN_S37_L004_R1_001.fastq.gz | OTHER | 691.3 MB |
| EC_TOB1_R1_IP_S39_L004_R1_001.fastq.gz | OTHER | 881.0 MB |
| EC_TOB1_R2_IN_S38_L004_R1_001.fastq.gz | OTHER | 720.5 MB |
| EC_TOB1_R2_IP_S40_L004_R1_001.fastq.gz | OTHER | 778.4 MB |
| EC_UBAP2L_R1_IN_S7_L007_R1_001.fastq.gz | OTHER | 755.7 MB |
| EC_UBAP2L_R1_IP_S8_L007_R1_001.fastq.gz | OTHER | 566.8 MB |
| EC_UBAP2L_R2_IN_S9_L007_R1_001.fastq.gz | OTHER | 1.2 GB |
| EC_UBAP2L_R2_IP_S10_L007_R1_001.fastq.gz | OTHER | 885.1 MB |
| SRR11683564_GSM4512262 | OTHER | 676.0 MB |
| SRR11683565_GSM4512263 | OTHER | 542.0 MB |
| SRR11683566_GSM4512264 | OTHER | 661.0 MB |
| SRR11683567_GSM4512265 | OTHER | 624.0 MB |
| SRR11683568_GSM4512266 | OTHER | 520.0 MB |
| SRR11683569_GSM4512267 | OTHER | 624.0 MB |
| SRR11683570_GSM4512268 | OTHER | 730.0 MB |
| SRR11683571_GSM4512269 | OTHER | 615.0 MB |
| SRR11683572_GSM4512270 | OTHER | 782.0 MB |
| SRR11683573_GSM4512271 | OTHER | 848.0 MB |
| SRR11683574_GSM4512272 | OTHER | 853.0 MB |
| SRR11683575_GSM4512273 | OTHER | 625.0 MB |
| SRR11683576_GSM4512274 | OTHER | 755.0 MB |
| SRR11683577_GSM4512275 | OTHER | 566.0 MB |
| SRR11683578_GSM4512276 | OTHER | 1.2 GB |
| SRR11683579_GSM4512277 | OTHER | 885.0 MB |
| SRR11683580_GSM4512278 | OTHER | 525.0 MB |
| SRR11683581_GSM4512279 | OTHER | 562.0 MB |
| SRR11683582_GSM4512280 | OTHER | 436.0 MB |
| SRR11683583_GSM4512281 | OTHER | 861.0 MB |
| SRR11683584_GSM4512282 | OTHER | 870.0 MB |
| SRR11683585_GSM4512283 | OTHER | 989.0 MB |
| SRR11683586_GSM4512284 | OTHER | 809.0 MB |
| SRR11683587_GSM4512285 | OTHER | 1.1 GB |
| SRR11683588_GSM4512286 | OTHER | 573.0 MB |
| SRR11683589_GSM4512287 | OTHER | 1.1 GB |
| SRR11683590_GSM4512288 | OTHER | 599.0 MB |
| SRR11683591_GSM4512289 | OTHER | 933.0 MB |
| SRR11683592_GSM4512290 | OTHER | 617.0 MB |
| SRR11683593_GSM4512291 | OTHER | 551.0 MB |
| SRR11683594_GSM4512292 | OTHER | 549.0 MB |
| SRR11683595_GSM4512293 | OTHER | 1.2 GB |
| SRR11683596_GSM4512294 | OTHER | 755.0 MB |
| SRR11683597_GSM4512295 | OTHER | 1.1 GB |
| SRR11683598_GSM4512296 | OTHER | 642.0 MB |
| SRR11683599_GSM4512297 | OTHER | 618.0 MB |
| SRR11683600_GSM4512298 | OTHER | 564.0 MB |
| SRR11683601_GSM4512299 | OTHER | 1.5 GB |
| SRR11683602_GSM4512300 | OTHER | 428.0 MB |
| SRR11683603_GSM4512301 | OTHER | 559.0 MB |
| SRR11683604_GSM4512302 | OTHER | 716.0 MB |
| SRR11683605_GSM4512303 | OTHER | 646.0 MB |
| SRR11683606_GSM4512304 | OTHER | 780.0 MB |
| SRR11683607_GSM4512305 | OTHER | 813.0 MB |
| SRR11683608_GSM4512306 | OTHER | 545.0 MB |
| SRR11683609_GSM4512307 | OTHER | 611.0 MB |
| SRR11683610_GSM4512308 | OTHER | 616.0 MB |
| SRR11683611_GSM4512309 | OTHER | 681.0 MB |
| SRR11683611.lite | OTHER | 681.2 MB |
| SRR11683612_GSM4512310 | OTHER | 565.0 MB |
| SRR11683613_GSM4512311 | OTHER | 745.0 MB |
| SRR11683614_GSM4512312 | OTHER | 576.0 MB |
| SRR11683615_GSM4512313 | OTHER | 598.0 MB |
| SRR11683616_GSM4512314 | OTHER | 691.0 MB |
| SRR11683617_GSM4512315 | OTHER | 881.0 MB |
| SRR11683618_GSM4512316 | OTHER | 720.0 MB |
| SRR11683619_GSM4512317 | OTHER | 778.0 MB |
Large-scale tethered function assays identify factors that regulate mRNA stability and translation (polysome profiling)
Homo sapiens
24 data files
| File | Type | Size |
|---|---|---|
| EC_Input_293T_1_S1_L001_R1_001.fastq.gz | RNA-Seq | 1.6 GB |
| EC_Input_293T_2_S2_L001_R1_001.fastq.gz | RNA-Seq | 1.7 GB |
| EC_Input_KO1_1_S3_L001_R1_001.fastq.gz | RNA-Seq | 873.8 MB |
| EC_Input_KO1_2_S4_L001_R1_001.fastq.gz | RNA-Seq | 527.9 MB |
| EC_Input_KO9_1_S5_L001_R1_001.fastq.gz | RNA-Seq | 1016.5 MB |
| EC_Input_KO9_2_S6_L001_R1_001.fastq.gz | RNA-Seq | 723.3 MB |
| EC_Poly_293T_1_S7_L001_R1_001.fastq.gz | RNA-Seq | 893.3 MB |
| EC_Poly_293T_2_S8_L001_R1_001.fastq.gz | RNA-Seq | 534.6 MB |
| EC_Poly_KO1_1_S9_L001_R1_001.fastq.gz | RNA-Seq | 665.6 MB |
| EC_Poly_KO1_2_S10_L001_R1_001.fastq.gz | RNA-Seq | 624.7 MB |
| EC_Poly_KO9_1_S11_L001_R1_001.fastq.gz | RNA-Seq | 222.8 MB |
| EC_Poly_KO9_2_S12_L001_R1_001.fastq.gz | RNA-Seq | 395.0 MB |
| SRR7547726_GSM3290512 | RNA-Seq | 1.6 GB |
| SRR7547727_GSM3290513 | RNA-Seq | 1.7 GB |
| SRR7547728_GSM3290514 | RNA-Seq | 873.0 MB |
| SRR7547729_GSM3290515 | RNA-Seq | 527.0 MB |
| SRR7547730_GSM3290516 | RNA-Seq | 1016.0 MB |
| SRR7547731_GSM3290517 | RNA-Seq | 723.0 MB |
| SRR7547732_GSM3290518 | RNA-Seq | 893.0 MB |
| SRR7547733_GSM3290519 | RNA-Seq | 534.0 MB |
| SRR7547734_GSM3290520 | RNA-Seq | 665.0 MB |
| SRR7547735_GSM3290521 | RNA-Seq | 624.0 MB |
| SRR7547736_GSM3290522 | RNA-Seq | 222.0 MB |
| SRR7547737_GSM3290523 | RNA-Seq | 394.0 MB |
Large-scale tethered function assays identify factors that regulate mRNA stability and translation
Homo sapiens
Large-scale tethered function assays identify factors that regulate mRNA stability and translation (HEK293T_RNA-seq)
Homo sapiens
100 data files
| File | Type | Size |
|---|---|---|
| EC-KD-s1-CLK3-1-1_S7_L001_R1_001.fastq.gz | RNA-Seq | 647.4 MB |
| EC-KD-s1-CLK3-1-2_S8_L001_R1_001.fastq.gz | RNA-Seq | 597.8 MB |
| EC-KD-s1-CNOT7-1-1_S3_L001_R1_001.fastq.gz | RNA-Seq | 532.8 MB |
| EC-KD-s1-CNOT7-1-2_S4_L001_R1_001.fastq.gz | RNA-Seq | 603.4 MB |
| EC-KD-s1-CNOT7-2-1_S5_L001_R1_001.fastq.gz | RNA-Seq | 480.6 MB |
| EC-KD-s1-CNOT7-2-2_S6_L001_R1_001.fastq.gz | RNA-Seq | 536.8 MB |
| EC-KD-s1-ctrl-2_S1_L001_R1_001.fastq.gz | RNA-Seq | 515.5 MB |
| EC-KD-s1-ctrl-3_S2_L001_R1_001.fastq.gz | RNA-Seq | 524.1 MB |
| EC-KD-s1-UBAP2L-1-1_S9_L001_R1_001.fastq.gz | RNA-Seq | 521.0 MB |
| EC-KD-s1-UBAP2L-1-2_S10_L001_R1_001.fastq.gz | RNA-Seq | 499.4 MB |
| EC-KD-s1-UBAP2L-2-1_S11_L001_R1_001.fastq.gz | RNA-Seq | 496.5 MB |
| EC-KD-s1-UBAP2L-2-2_S12_L001_R1_001.fastq.gz | RNA-Seq | 477.8 MB |
| EC-KD-s2-AIMP1-1-1_S13_L002_R1_001.fastq.gz | RNA-Seq | 882.9 MB |
| EC-KD-s2-AIMP1-1-2_S14_L002_R1_001.fastq.gz | RNA-Seq | 534.1 MB |
| EC-KD-s2-AIMP1-2-1_S15_L002_R1_001.fastq.gz | RNA-Seq | 428.5 MB |
| EC-KD-s2-AIMP1-2-2_S16_L002_R1_001.fastq.gz | RNA-Seq | 562.2 MB |
| EC-KD-s2-ctrl-1-1_S25_L003_R1_001.fastq.gz | RNA-Seq | 512.6 MB |
| EC-KD-s2-ctrl-1-2_S26_L003_R1_001.fastq.gz | RNA-Seq | 509.2 MB |
| EC-KD-s2-DDX6-1-1_S17_L002_R1_001.fastq.gz | RNA-Seq | 481.4 MB |
| EC-KD-s2-DDX6-1-2_S18_L002_R1_001.fastq.gz | RNA-Seq | 551.1 MB |
| EC-KD-s2-DDX6-2-1_S19_L002_R1_001.fastq.gz | RNA-Seq | 590.2 MB |
| EC-KD-s2-DDX6-2-2_S20_L002_R1_001.fastq.gz | RNA-Seq | 438.8 MB |
| EC-KD-s2-MEX3C-1-1_S21_L002_R1_001.fastq.gz | RNA-Seq | 383.7 MB |
| EC-KD-s2-MEX3C-1-2_S22_L002_R1_001.fastq.gz | RNA-Seq | 647.6 MB |
| EC-KD-s2-MEX3C-2-1_S23_L002_R1_001.fastq.gz | RNA-Seq | 340.8 MB |
| EC-KD-s2-MEX3C-2-2_S24_L002_R1_001.fastq.gz | RNA-Seq | 569.3 MB |
| EC-KD-s3-ctrl-1-1_S39_L004_R1_001.fastq.gz | RNA-Seq | 678.9 MB |
| EC-KD-s3-ctrl-1-2_S40_L004_R1_001.fastq.gz | RNA-Seq | 563.8 MB |
| EC-KD-s3-MTDH-1-1_S27_L003_R1_001.fastq.gz | RNA-Seq | 390.9 MB |
| EC-KD-s3-MTDH-1-2_S28_L003_R1_001.fastq.gz | RNA-Seq | 425.8 MB |
| EC-KD-s3-MTDH-2-1_S29_L003_R1_001.fastq.gz | RNA-Seq | 664.9 MB |
| EC-KD-s3-MTDH-2-2_S30_L003_R1_001.fastq.gz | RNA-Seq | 619.9 MB |
| EC-KD-s3-PARN-1-1_S31_L003_R1_001.fastq.gz | RNA-Seq | 322.0 MB |
| EC-KD-s3-PARN-1-2_S32_L003_R1_001.fastq.gz | RNA-Seq | 479.3 MB |
| EC-KD-s3-PARN-2-1_S33_L003_R1_001.fastq.gz | RNA-Seq | 564.2 MB |
| EC-KD-s3-PARN-2-2_S34_L003_R1_001.fastq.gz | RNA-Seq | 660.1 MB |
| EC-OE-BOLL-1_S49_L005_R1_001.fastq.gz | RNA-Seq | 622.9 MB |
| EC-OE-BOLL-2_S50_L005_R1_001.fastq.gz | RNA-Seq | 545.8 MB |
| EC-OE-FLAG-1_S57_L005_R1_001.fastq.gz | RNA-Seq | 713.2 MB |
| EC-OE-FLAG-2_S58_L005_R1_001.fastq.gz | RNA-Seq | 678.1 MB |
| EC-OE-IFIT2-1_S43_L004_R1_001.fastq.gz | RNA-Seq | 533.2 MB |
| EC-OE-IFIT2-2_S44_L004_R1_001.fastq.gz | RNA-Seq | 560.3 MB |
| EC-OE-NANOS3-1_S41_L004_R1_001.fastq.gz | RNA-Seq | 617.8 MB |
| EC-OE-NANOS3-2_S42_L004_R1_001.fastq.gz | RNA-Seq | 532.1 MB |
| EC-OE-SNRPA-1_S55_L005_R1_001.fastq.gz | RNA-Seq | 688.4 MB |
| EC-OE-SNRPA-2_S56_L005_R1_001.fastq.gz | RNA-Seq | 676.4 MB |
| EC-OE-TOB1-1_S51_L005_R1_001.fastq.gz | RNA-Seq | 771.7 MB |
| EC-OE-TOB1-2_S52_L005_R1_001.fastq.gz | RNA-Seq | 568.2 MB |
| EC-OE-TOB2-1_S53_L005_R1_001.fastq.gz | RNA-Seq | 601.9 MB |
| EC-OE-TOB2-2_S54_L005_R1_001.fastq.gz | RNA-Seq | 641.4 MB |
| SRR7547754_GSM3290532 | RNA-Seq | 647.0 MB |
| SRR7547755_GSM3290533 | RNA-Seq | 597.0 MB |
| SRR7547756_GSM3290534 | RNA-Seq | 532.0 MB |
| SRR7547757_GSM3290535 | RNA-Seq | 603.0 MB |
| SRR7547758_GSM3290536 | RNA-Seq | 480.0 MB |
| SRR7547759_GSM3290537 | RNA-Seq | 536.0 MB |
| SRR7547760_GSM3290538 | RNA-Seq | 515.0 MB |
| SRR7547761_GSM3290539 | RNA-Seq | 524.0 MB |
| SRR7547762_GSM3290540 | RNA-Seq | 521.0 MB |
| SRR7547763_GSM3290541 | RNA-Seq | 499.0 MB |
| SRR7547764_GSM3290542 | RNA-Seq | 496.0 MB |
| SRR7547765_GSM3290543 | RNA-Seq | 477.0 MB |
| SRR7547766_GSM3290544 | RNA-Seq | 882.0 MB |
| SRR7547767_GSM3290545 | RNA-Seq | 534.0 MB |
| SRR7547768_GSM3290546 | RNA-Seq | 428.0 MB |
| SRR7547769_GSM3290547 | RNA-Seq | 562.0 MB |
| SRR7547770_GSM3290548 | RNA-Seq | 512.0 MB |
| SRR7547771_GSM3290549 | RNA-Seq | 509.0 MB |
| SRR7547772_GSM3290550 | RNA-Seq | 481.0 MB |
| SRR7547773_GSM3290551 | RNA-Seq | 551.0 MB |
| SRR7547774_GSM3290552 | RNA-Seq | 590.0 MB |
| SRR7547775_GSM3290553 | RNA-Seq | 438.0 MB |
| SRR7547776_GSM3290554 | RNA-Seq | 383.0 MB |
| SRR7547777_GSM3290555 | RNA-Seq | 647.0 MB |
| SRR7547778_GSM3290556 | RNA-Seq | 340.0 MB |
| SRR7547779_GSM3290557 | RNA-Seq | 569.0 MB |
| SRR7547780_GSM3290558 | RNA-Seq | 678.0 MB |
| SRR7547781_GSM3290559 | RNA-Seq | 563.0 MB |
| SRR7547782_GSM3290560 | RNA-Seq | 390.0 MB |
| SRR7547783_GSM3290561 | RNA-Seq | 425.0 MB |
| SRR7547784_GSM3290562 | RNA-Seq | 664.0 MB |
| SRR7547785_GSM3290563 | RNA-Seq | 619.0 MB |
| SRR7547786_GSM3290564 | RNA-Seq | 322.0 MB |
| SRR7547787_GSM3290565 | RNA-Seq | 479.0 MB |
| SRR7547788_GSM3290566 | RNA-Seq | 564.0 MB |
| SRR7547789_GSM3290567 | RNA-Seq | 660.0 MB |
| SRR7547790_GSM3290568 | RNA-Seq | 622.0 MB |
| SRR7547791_GSM3290569 | RNA-Seq | 545.0 MB |
| SRR7547792_GSM3290570 | RNA-Seq | 713.0 MB |
| SRR7547793_GSM3290571 | RNA-Seq | 678.0 MB |
| SRR7547794_GSM3290572 | RNA-Seq | 533.0 MB |
| SRR7547795_GSM3290573 | RNA-Seq | 560.0 MB |
| SRR7547796_GSM3290574 | RNA-Seq | 617.0 MB |
| SRR7547797_GSM3290575 | RNA-Seq | 532.0 MB |
| SRR7547798_GSM3290576 | RNA-Seq | 688.0 MB |
| SRR7547799_GSM3290577 | RNA-Seq | 676.0 MB |
| SRR7547800_GSM3290578 | RNA-Seq | 771.0 MB |
| SRR7547801_GSM3290579 | RNA-Seq | 568.0 MB |
| SRR7547802_GSM3290580 | RNA-Seq | 601.0 MB |
| SRR7547803_GSM3290581 | RNA-Seq | 641.0 MB |
Potentially related datasets 2
These accessions were text-mined from the PMC full text. They may be referenced for comparison, cited from other studies, or otherwise mentioned without being primary data for this paper.
| Accession | Source | Title |
|---|---|---|
| ENCSR456FVU | ENCSR · ENCODE | No title in the index |
| GSE117294 | GSE · GEO GEO ↗ | Large-scale tethered function assays identify factors that regulate mRNA stability and translation |
Analysis pipelines 4
| Pipeline | Assay | Steps | Dataset |
|---|---|---|---|
| GSE117290 eCLIP Data Processing geo_data_processing | eCLIP | 7 | GSE117290 |
| GSE117291 RNA-seq Data Processing geo_data_processing | RNA-seq | 5 | GSE117291 |
| GSE117293 RNA-seq Data Processing geo_data_processing | RNA-seq | 5 | GSE117293 |
| GSE117294 Data Processing geo_data_processing | — | 5 | GSE117294 |
Funding 4 grants
| Grant | Funder |
|---|---|
| R01 HG004659 | NHGRI NIH HHS (United States) |
| R01 NS103172 | NINDS NIH HHS (United States) |
| U41 HG009889 | NHGRI NIH HHS (United States) |
| U19 MH107367 | NIMH NIH HHS (United States) |