Large-scale tethered function assays identify factors that regulate mRNA stability and translation.
En-Ching Luo,
Jason L Nathanson,
Frederick E Tan,
Joshua L Schwartz,
Jonathan C Schmok,
Archana Shankar,
Sebastian Markmiller,
Brian A Yee,
Shashank Sathe,
Gabriel A Pratt,
Duy B Scaletta,
Yuanchi Ha,
David E Hill,
Stefan Aigner,
Gene W Yeo
Nature structural & molecular biology
· 2020
· Vol. 27
(10)
· pp. 989-1000
Abstract
The molecular functions of the majority of RNA-binding proteins (RBPs) remain unclear, highlighting a major bottleneck to a full understanding of gene expression regulation. Here, we develop a plasmid resource of 690 human RBPs that we subject to luciferase-based 3'-untranslated-region tethered function assays to pinpoint RBPs that regulate RNA stability or translation. Enhanced UV-cross-linking and immunoprecipitation of these RBPs identifies thousands of endogenous mRNA targets that respond to changes in RBP level, recapitulating effects observed in tethered function assays. Among these RBPs, the ubiquitin-associated protein 2-like (UBAP2L) protein interacts with RNA via its RGG domain and cross-links to mRNA and rRNA. Fusion of UBAP2L to RNA-targeting CRISPR-Cas9 demonstrates programmable translational enhancement. Polysome profiling indicates that UBAP2L promotes translation of target mRNAs, particularly global regulators of translation. Our tethering survey allows rapid assignment of the molecular activity of proteins, such as UBAP2L, to specific steps of mRNA metabolism.
Publication Types
["Journal Article", "Research Support, N.I.H., Extramural", "Research Support, Non-U.S. Gov't", "Research Support, U.S. Gov't, Non-P.H.S."]
Keywords
MeSH Terms
["3' Untranslated Regions", "Binding Sites", "CRISPR-Cas Systems", "Carrier Proteins", "Cell Line", "Humans", "Luciferases", "Open Reading Frames", "Polyribosomes", "Protein Biosynthesis", "RNA Stability", "RNA-Binding Proteins", "Recombinant Proteins", "Ultraviolet Rays"]
Funding
R01 HG004659
NHGRI NIH HHS
(United States)
R01 NS103172
NINDS NIH HHS
(United States)
U41 HG009889
NHGRI NIH HHS
(United States)
U19 MH107367
NIMH NIH HHS
(United States)
Linked Datasets (4)
Large-scale tethered function assays identify factors that regulate mRNA stability and translation (eCLIP)
Homo sapiens112 data files
| File | Type | Size |
|---|---|---|
| EC_AIMP1_R1_IN_S41_L004_R1_001.fastq.gz | OTHER | 520.5 MB |
| EC_AIMP1_R1_IN_S41_L004_R1_001.fastq.gz | OTHER | 520.5 MB |
| EC_AIMP1_R1_IP_S43_L004_R1_001.fastq.gz | OTHER | 624.5 MB |
| EC_AIMP1_R1_IP_S43_L004_R1_001.fastq.gz | OTHER | 624.5 MB |
| EC_AIMP1_R2_IN_S42_L004_R1_001.fastq.gz | OTHER | 731.0 MB |
| EC_AIMP1_R2_IN_S42_L004_R1_001.fastq.gz | OTHER | 731.0 MB |
| EC_AIMP1_R2_IP_S44_L004_R1_001.fastq.gz | OTHER | 615.3 MB |
| EC_AIMP1_R2_IP_S44_L004_R1_001.fastq.gz | OTHER | 615.3 MB |
| EC_BOLL_R1_IN_S49_L005_R1_001.fastq.gz | OTHER | 716.2 MB |
| EC_BOLL_R1_IN_S49_L005_R1_001.fastq.gz | OTHER | 716.2 MB |
| EC_BOLL_R1_IP_S51_L005_R1_001.fastq.gz | OTHER | 646.9 MB |
| EC_BOLL_R1_IP_S51_L005_R1_001.fastq.gz | OTHER | 646.9 MB |
| EC_BOLL_R2_IN_S50_L005_R1_001.fastq.gz | OTHER | 780.6 MB |
| EC_BOLL_R2_IN_S50_L005_R1_001.fastq.gz | OTHER | 780.6 MB |
| EC_BOLL_R2_IP_S52_L005_R1_001.fastq.gz | OTHER | 813.4 MB |
| EC_BOLL_R2_IP_S52_L005_R1_001.fastq.gz | OTHER | 813.4 MB |
| EC_CLK3_R1_IN_S29_L003_R1_001.fastq.gz | OTHER | 525.5 MB |
| EC_CLK3_R1_IN_S29_L003_R1_001.fastq.gz | OTHER | 525.5 MB |
| EC_CLK3_R1_IP_S31_L003_R1_001.fastq.gz | OTHER | 563.0 MB |
| EC_CLK3_R1_IP_S31_L003_R1_001.fastq.gz | OTHER | 563.0 MB |
| EC_CLK3_R2_IN_S30_L003_R1_001.fastq.gz | OTHER | 436.9 MB |
| EC_CLK3_R2_IN_S30_L003_R1_001.fastq.gz | OTHER | 436.9 MB |
| EC_CLK3_R2_IP_S32_L003_R1_001.fastq.gz | OTHER | 861.6 MB |
| EC_CLK3_R2_IP_S32_L003_R1_001.fastq.gz | OTHER | 861.6 MB |
| EC_CNOT7_R1_IN_S53_L005_R1_001.fastq.gz | OTHER | 676.6 MB |
| EC_CNOT7_R1_IN_S53_L005_R1_001.fastq.gz | OTHER | 676.6 MB |
| EC_CNOT7_R1_IP_S55_L005_R1_001.fastq.gz | OTHER | 542.1 MB |
| EC_CNOT7_R1_IP_S55_L005_R1_001.fastq.gz | OTHER | 542.1 MB |
| EC_CNOT7_R2_IN_S54_L005_R1_001.fastq.gz | OTHER | 661.8 MB |
| EC_CNOT7_R2_IN_S54_L005_R1_001.fastq.gz | OTHER | 661.8 MB |
| EC_CNOT7_R2_IP_S56_L005_R1_001.fastq.gz | OTHER | 624.3 MB |
| EC_CNOT7_R2_IP_S56_L005_R1_001.fastq.gz | OTHER | 624.3 MB |
| EC_DDX6_R1-IN_S5_L001_R1_001.fastq.gz | OTHER | 870.3 MB |
| EC_DDX6_R1-IN_S5_L001_R1_001.fastq.gz | OTHER | 870.3 MB |
| EC_DDx6_R1-IP_S7_L001_R1_001.fastq.gz | OTHER | 990.0 MB |
| EC_DDx6_R1-IP_S7_L001_R1_001.fastq.gz | OTHER | 990.0 MB |
| EC_DDx6_R2-IN_S6_L001_R1_001.fastq.gz | OTHER | 809.9 MB |
| EC_DDx6_R2-IN_S6_L001_R1_001.fastq.gz | OTHER | 809.9 MB |
| EC_DDX6_R2-IP_S8_L001_R1_001.fastq.gz | OTHER | 1.1 GB |
| EC_DDX6_R2-IP_S8_L001_R1_001.fastq.gz | OTHER | 1.1 GB |
| EC_IFIT2_R1-IN_S9_L002_R1_001.fastq.gz | OTHER | 545.5 MB |
| EC_IFIT2_R1-IN_S9_L002_R1_001.fastq.gz | OTHER | 545.5 MB |
| EC_IFIT2_R1-IP_S13_L002_R1_001.fastq.gz | OTHER | 611.7 MB |
| EC_IFIT2_R1-IP_S13_L002_R1_001.fastq.gz | OTHER | 611.7 MB |
| EC_IFIT2_R2-IN_S10_L002_R1_001.fastq.gz | OTHER | 616.1 MB |
| EC_IFIT2_R2-IN_S10_L002_R1_001.fastq.gz | OTHER | 616.1 MB |
| EC_IFIT2_R2-IP_S14_L002_R1_001.fastq.gz | OTHER | 681.2 MB |
| EC_MEX3C_R1-IN_S21_L003_R1_001.fastq.gz | OTHER | 573.1 MB |
| EC_MEX3C_R1-IN_S21_L003_R1_001.fastq.gz | OTHER | 573.1 MB |
| EC_MEX3C_R1-IP_S23_L003_R1_001.fastq.gz | OTHER | 1.1 GB |
| EC_MEX3C_R1-IP_S23_L003_R1_001.fastq.gz | OTHER | 1.1 GB |
| EC_MEX3C_R2-IN_S22_L003_R1_001.fastq.gz | OTHER | 599.9 MB |
| EC_MEX3C_R2-IN_S22_L003_R1_001.fastq.gz | OTHER | 599.9 MB |
| EC_MEX3C_R2-IP_S24_L003_R1_001.fastq.gz | OTHER | 933.6 MB |
| EC_MEX3C_R2-IP_S24_L003_R1_001.fastq.gz | OTHER | 933.6 MB |
| EC_MTDH_R1_IN_S33_L004_R1_001.fastq.gz | OTHER | 782.9 MB |
| EC_MTDH_R1_IN_S33_L004_R1_001.fastq.gz | OTHER | 782.9 MB |
| EC_MTDH_R1_IP_S35_L004_R1_001.fastq.gz | OTHER | 848.6 MB |
| EC_MTDH_R1_IP_S35_L004_R1_001.fastq.gz | OTHER | 848.6 MB |
| EC_MTDH_R2_IN_S34_L004_R1_001.fastq.gz | OTHER | 853.8 MB |
| EC_MTDH_R2_IN_S34_L004_R1_001.fastq.gz | OTHER | 853.8 MB |
| EC_MTDH_R2_IP_S36_L004_R1_001.fastq.gz | OTHER | 625.0 MB |
| EC_MTDH_R2_IP_S36_L004_R1_001.fastq.gz | OTHER | 625.0 MB |
| EC_NANOS3_R1-IN_S17_L002_R1_001.fastq.gz | OTHER | 566.0 MB |
| EC_NANOS3_R1-IN_S17_L002_R1_001.fastq.gz | OTHER | 566.0 MB |
| EC_NANOS3_R1-IP_S19_L002_R1_001.fastq.gz | OTHER | 746.0 MB |
| EC_NANOS3_R1-IP_S19_L002_R1_001.fastq.gz | OTHER | 746.0 MB |
| EC_NANOS3_R2-IN_S18_L002_R1_001.fastq.gz | OTHER | 576.9 MB |
| EC_NANOS3_R2-IN_S18_L002_R1_001.fastq.gz | OTHER | 576.9 MB |
| EC_NANOS3_R2-IP_S20_L002_R1_001.fastq.gz | OTHER | 598.6 MB |
| EC_NANOS3_R2-IP_S20_L002_R1_001.fastq.gz | OTHER | 598.6 MB |
| EC_PARN_R1-IN_S25_L003_R1_001.fastq.gz | OTHER | 617.7 MB |
| EC_PARN_R1-IN_S25_L003_R1_001.fastq.gz | OTHER | 617.7 MB |
| EC_PARN_R1-IP_S27_L003_R1_001.fastq.gz | OTHER | 551.6 MB |
| EC_PARN_R1-IP_S27_L003_R1_001.fastq.gz | OTHER | 551.6 MB |
| EC_PARN_R2-IN_S26_L003_R1_001.fastq.gz | OTHER | 549.8 MB |
| EC_PARN_R2-IN_S26_L003_R1_001.fastq.gz | OTHER | 549.8 MB |
| EC_PARN_R2-IP_S28_L003_R1_001.fastq.gz | OTHER | 1.2 GB |
| EC_PARN_R2-IP_S28_L003_R1_001.fastq.gz | OTHER | 1.2 GB |
| EC_SNRPA_R1_IN_S45_L005_R1_001.fastq.gz | OTHER | 755.7 MB |
| EC_SNRPA_R1_IN_S45_L005_R1_001.fastq.gz | OTHER | 755.7 MB |
| EC_SNRPA_R1_IP_S47_L005_R1_001.fastq.gz | OTHER | 1.1 GB |
| EC_SNRPA_R1_IP_S47_L005_R1_001.fastq.gz | OTHER | 1.1 GB |
| EC_SNRPA_R2_IN_S46_L005_R1_001.fastq.gz | OTHER | 642.7 MB |
| EC_SNRPA_R2_IN_S46_L005_R1_001.fastq.gz | OTHER | 642.7 MB |
| EC_SNRPA_R2_IP_S48_L005_R1_001.fastq.gz | OTHER | 618.8 MB |
| EC_SNRPA_R2_IP_S48_L005_R1_001.fastq.gz | OTHER | 618.8 MB |
| EC_TBO2_R1-IN_S11_L002_R1_001.fastq.gz | OTHER | 564.3 MB |
| EC_TBO2_R1-IN_S11_L002_R1_001.fastq.gz | OTHER | 564.3 MB |
| EC_TBO2_R1-IP_S15_L002_R1_001.fastq.gz | OTHER | 1.5 GB |
| EC_TBO2_R1-IP_S15_L002_R1_001.fastq.gz | OTHER | 1.5 GB |
| EC_TBO2_R2-IN_S12_L002_R1_001.fastq.gz | OTHER | 428.8 MB |
| EC_TBO2_R2-IN_S12_L002_R1_001.fastq.gz | OTHER | 428.8 MB |
| EC_TBO2_R2-IP_S16_L002_R1_001.fastq.gz | OTHER | 559.1 MB |
| EC_TBO2_R2-IP_S16_L002_R1_001.fastq.gz | OTHER | 559.1 MB |
| EC_TOB1_R1_IN_S37_L004_R1_001.fastq.gz | OTHER | 691.3 MB |
| EC_TOB1_R1_IN_S37_L004_R1_001.fastq.gz | OTHER | 691.3 MB |
| EC_TOB1_R1_IP_S39_L004_R1_001.fastq.gz | OTHER | 881.0 MB |
| EC_TOB1_R1_IP_S39_L004_R1_001.fastq.gz | OTHER | 881.0 MB |
| EC_TOB1_R2_IN_S38_L004_R1_001.fastq.gz | OTHER | 720.5 MB |
| EC_TOB1_R2_IN_S38_L004_R1_001.fastq.gz | OTHER | 720.5 MB |
| EC_TOB1_R2_IP_S40_L004_R1_001.fastq.gz | OTHER | 778.4 MB |
| EC_TOB1_R2_IP_S40_L004_R1_001.fastq.gz | OTHER | 778.4 MB |
| EC_UBAP2L_R1_IN_S7_L007_R1_001.fastq.gz | OTHER | 755.7 MB |
| EC_UBAP2L_R1_IN_S7_L007_R1_001.fastq.gz | OTHER | 755.7 MB |
| EC_UBAP2L_R1_IP_S8_L007_R1_001.fastq.gz | OTHER | 566.8 MB |
| EC_UBAP2L_R1_IP_S8_L007_R1_001.fastq.gz | OTHER | 566.8 MB |
| EC_UBAP2L_R2_IN_S9_L007_R1_001.fastq.gz | OTHER | 1.2 GB |
| EC_UBAP2L_R2_IN_S9_L007_R1_001.fastq.gz | OTHER | 1.2 GB |
| EC_UBAP2L_R2_IP_S10_L007_R1_001.fastq.gz | OTHER | 885.1 MB |
| EC_UBAP2L_R2_IP_S10_L007_R1_001.fastq.gz | OTHER | 885.1 MB |
| SRR11683611.lite | OTHER | 681.2 MB |
Large-scale tethered function assays identify factors that regulate mRNA stability and translation (polysome profiling)
Homo sapiens24 data files
| File | Type | Size |
|---|---|---|
| EC_Input_293T_1_S1_L001_R1_001.fastq.gz | RNA-Seq | 1.6 GB |
| EC_Input_293T_1_S1_L001_R1_001.fastq.gz | RNA-Seq | 1.6 GB |
| EC_Input_293T_2_S2_L001_R1_001.fastq.gz | RNA-Seq | 1.7 GB |
| EC_Input_293T_2_S2_L001_R1_001.fastq.gz | RNA-Seq | 1.7 GB |
| EC_Input_KO1_1_S3_L001_R1_001.fastq.gz | RNA-Seq | 873.8 MB |
| EC_Input_KO1_1_S3_L001_R1_001.fastq.gz | RNA-Seq | 873.8 MB |
| EC_Input_KO1_2_S4_L001_R1_001.fastq.gz | RNA-Seq | 527.9 MB |
| EC_Input_KO1_2_S4_L001_R1_001.fastq.gz | RNA-Seq | 527.9 MB |
| EC_Input_KO9_1_S5_L001_R1_001.fastq.gz | RNA-Seq | 1016.5 MB |
| EC_Input_KO9_1_S5_L001_R1_001.fastq.gz | RNA-Seq | 1016.5 MB |
| EC_Input_KO9_2_S6_L001_R1_001.fastq.gz | RNA-Seq | 723.3 MB |
| EC_Input_KO9_2_S6_L001_R1_001.fastq.gz | RNA-Seq | 723.3 MB |
| EC_Poly_293T_1_S7_L001_R1_001.fastq.gz | RNA-Seq | 893.3 MB |
| EC_Poly_293T_1_S7_L001_R1_001.fastq.gz | RNA-Seq | 893.3 MB |
| EC_Poly_293T_2_S8_L001_R1_001.fastq.gz | RNA-Seq | 534.6 MB |
| EC_Poly_293T_2_S8_L001_R1_001.fastq.gz | RNA-Seq | 534.6 MB |
| EC_Poly_KO1_1_S9_L001_R1_001.fastq.gz | RNA-Seq | 665.6 MB |
| EC_Poly_KO1_1_S9_L001_R1_001.fastq.gz | RNA-Seq | 665.6 MB |
| EC_Poly_KO1_2_S10_L001_R1_001.fastq.gz | RNA-Seq | 624.7 MB |
| EC_Poly_KO1_2_S10_L001_R1_001.fastq.gz | RNA-Seq | 624.7 MB |
| EC_Poly_KO9_1_S11_L001_R1_001.fastq.gz | RNA-Seq | 222.8 MB |
| EC_Poly_KO9_1_S11_L001_R1_001.fastq.gz | RNA-Seq | 222.8 MB |
| EC_Poly_KO9_2_S12_L001_R1_001.fastq.gz | RNA-Seq | 395.0 MB |
| EC_Poly_KO9_2_S12_L001_R1_001.fastq.gz | RNA-Seq | 395.0 MB |
Large-scale tethered function assays identify factors that regulate mRNA stability and translation
Homo sapiensLarge-scale tethered function assays identify factors that regulate mRNA stability and translation (HEK293T_RNA-seq)
Homo sapiens100 data files
| File | Type | Size |
|---|---|---|
| EC-KD-s1-CLK3-1-1_S7_L001_R1_001.fastq.gz | RNA-Seq | 647.4 MB |
| EC-KD-s1-CLK3-1-1_S7_L001_R1_001.fastq.gz | RNA-Seq | 647.4 MB |
| EC-KD-s1-CLK3-1-2_S8_L001_R1_001.fastq.gz | RNA-Seq | 597.8 MB |
| EC-KD-s1-CLK3-1-2_S8_L001_R1_001.fastq.gz | RNA-Seq | 597.8 MB |
| EC-KD-s1-CNOT7-1-1_S3_L001_R1_001.fastq.gz | RNA-Seq | 532.8 MB |
| EC-KD-s1-CNOT7-1-1_S3_L001_R1_001.fastq.gz | RNA-Seq | 532.8 MB |
| EC-KD-s1-CNOT7-1-2_S4_L001_R1_001.fastq.gz | RNA-Seq | 603.4 MB |
| EC-KD-s1-CNOT7-1-2_S4_L001_R1_001.fastq.gz | RNA-Seq | 603.4 MB |
| EC-KD-s1-CNOT7-2-1_S5_L001_R1_001.fastq.gz | RNA-Seq | 480.6 MB |
| EC-KD-s1-CNOT7-2-1_S5_L001_R1_001.fastq.gz | RNA-Seq | 480.6 MB |
| EC-KD-s1-CNOT7-2-2_S6_L001_R1_001.fastq.gz | RNA-Seq | 536.8 MB |
| EC-KD-s1-CNOT7-2-2_S6_L001_R1_001.fastq.gz | RNA-Seq | 536.8 MB |
| EC-KD-s1-ctrl-2_S1_L001_R1_001.fastq.gz | RNA-Seq | 515.5 MB |
| EC-KD-s1-ctrl-2_S1_L001_R1_001.fastq.gz | RNA-Seq | 515.5 MB |
| EC-KD-s1-ctrl-3_S2_L001_R1_001.fastq.gz | RNA-Seq | 524.1 MB |
| EC-KD-s1-ctrl-3_S2_L001_R1_001.fastq.gz | RNA-Seq | 524.1 MB |
| EC-KD-s1-UBAP2L-1-1_S9_L001_R1_001.fastq.gz | RNA-Seq | 521.0 MB |
| EC-KD-s1-UBAP2L-1-1_S9_L001_R1_001.fastq.gz | RNA-Seq | 521.0 MB |
| EC-KD-s1-UBAP2L-1-2_S10_L001_R1_001.fastq.gz | RNA-Seq | 499.4 MB |
| EC-KD-s1-UBAP2L-1-2_S10_L001_R1_001.fastq.gz | RNA-Seq | 499.4 MB |
| EC-KD-s1-UBAP2L-2-1_S11_L001_R1_001.fastq.gz | RNA-Seq | 496.5 MB |
| EC-KD-s1-UBAP2L-2-1_S11_L001_R1_001.fastq.gz | RNA-Seq | 496.5 MB |
| EC-KD-s1-UBAP2L-2-2_S12_L001_R1_001.fastq.gz | RNA-Seq | 477.8 MB |
| EC-KD-s1-UBAP2L-2-2_S12_L001_R1_001.fastq.gz | RNA-Seq | 477.8 MB |
| EC-KD-s2-AIMP1-1-1_S13_L002_R1_001.fastq.gz | RNA-Seq | 882.9 MB |
| EC-KD-s2-AIMP1-1-1_S13_L002_R1_001.fastq.gz | RNA-Seq | 882.9 MB |
| EC-KD-s2-AIMP1-1-2_S14_L002_R1_001.fastq.gz | RNA-Seq | 534.1 MB |
| EC-KD-s2-AIMP1-1-2_S14_L002_R1_001.fastq.gz | RNA-Seq | 534.1 MB |
| EC-KD-s2-AIMP1-2-1_S15_L002_R1_001.fastq.gz | RNA-Seq | 428.5 MB |
| EC-KD-s2-AIMP1-2-1_S15_L002_R1_001.fastq.gz | RNA-Seq | 428.5 MB |
| EC-KD-s2-AIMP1-2-2_S16_L002_R1_001.fastq.gz | RNA-Seq | 562.2 MB |
| EC-KD-s2-AIMP1-2-2_S16_L002_R1_001.fastq.gz | RNA-Seq | 562.2 MB |
| EC-KD-s2-ctrl-1-1_S25_L003_R1_001.fastq.gz | RNA-Seq | 512.6 MB |
| EC-KD-s2-ctrl-1-1_S25_L003_R1_001.fastq.gz | RNA-Seq | 512.6 MB |
| EC-KD-s2-ctrl-1-2_S26_L003_R1_001.fastq.gz | RNA-Seq | 509.2 MB |
| EC-KD-s2-ctrl-1-2_S26_L003_R1_001.fastq.gz | RNA-Seq | 509.2 MB |
| EC-KD-s2-DDX6-1-1_S17_L002_R1_001.fastq.gz | RNA-Seq | 481.4 MB |
| EC-KD-s2-DDX6-1-1_S17_L002_R1_001.fastq.gz | RNA-Seq | 481.4 MB |
| EC-KD-s2-DDX6-1-2_S18_L002_R1_001.fastq.gz | RNA-Seq | 551.1 MB |
| EC-KD-s2-DDX6-1-2_S18_L002_R1_001.fastq.gz | RNA-Seq | 551.1 MB |
| EC-KD-s2-DDX6-2-1_S19_L002_R1_001.fastq.gz | RNA-Seq | 590.2 MB |
| EC-KD-s2-DDX6-2-1_S19_L002_R1_001.fastq.gz | RNA-Seq | 590.2 MB |
| EC-KD-s2-DDX6-2-2_S20_L002_R1_001.fastq.gz | RNA-Seq | 438.8 MB |
| EC-KD-s2-DDX6-2-2_S20_L002_R1_001.fastq.gz | RNA-Seq | 438.8 MB |
| EC-KD-s2-MEX3C-1-1_S21_L002_R1_001.fastq.gz | RNA-Seq | 383.7 MB |
| EC-KD-s2-MEX3C-1-1_S21_L002_R1_001.fastq.gz | RNA-Seq | 383.7 MB |
| EC-KD-s2-MEX3C-1-2_S22_L002_R1_001.fastq.gz | RNA-Seq | 647.6 MB |
| EC-KD-s2-MEX3C-1-2_S22_L002_R1_001.fastq.gz | RNA-Seq | 647.6 MB |
| EC-KD-s2-MEX3C-2-1_S23_L002_R1_001.fastq.gz | RNA-Seq | 340.8 MB |
| EC-KD-s2-MEX3C-2-1_S23_L002_R1_001.fastq.gz | RNA-Seq | 340.8 MB |
| EC-KD-s2-MEX3C-2-2_S24_L002_R1_001.fastq.gz | RNA-Seq | 569.3 MB |
| EC-KD-s2-MEX3C-2-2_S24_L002_R1_001.fastq.gz | RNA-Seq | 569.3 MB |
| EC-KD-s3-ctrl-1-1_S39_L004_R1_001.fastq.gz | RNA-Seq | 678.9 MB |
| EC-KD-s3-ctrl-1-1_S39_L004_R1_001.fastq.gz | RNA-Seq | 678.9 MB |
| EC-KD-s3-ctrl-1-2_S40_L004_R1_001.fastq.gz | RNA-Seq | 563.8 MB |
| EC-KD-s3-ctrl-1-2_S40_L004_R1_001.fastq.gz | RNA-Seq | 563.8 MB |
| EC-KD-s3-MTDH-1-1_S27_L003_R1_001.fastq.gz | RNA-Seq | 390.9 MB |
| EC-KD-s3-MTDH-1-1_S27_L003_R1_001.fastq.gz | RNA-Seq | 390.9 MB |
| EC-KD-s3-MTDH-1-2_S28_L003_R1_001.fastq.gz | RNA-Seq | 425.8 MB |
| EC-KD-s3-MTDH-1-2_S28_L003_R1_001.fastq.gz | RNA-Seq | 425.8 MB |
| EC-KD-s3-MTDH-2-1_S29_L003_R1_001.fastq.gz | RNA-Seq | 664.9 MB |
| EC-KD-s3-MTDH-2-1_S29_L003_R1_001.fastq.gz | RNA-Seq | 664.9 MB |
| EC-KD-s3-MTDH-2-2_S30_L003_R1_001.fastq.gz | RNA-Seq | 619.9 MB |
| EC-KD-s3-MTDH-2-2_S30_L003_R1_001.fastq.gz | RNA-Seq | 619.9 MB |
| EC-KD-s3-PARN-1-1_S31_L003_R1_001.fastq.gz | RNA-Seq | 322.0 MB |
| EC-KD-s3-PARN-1-1_S31_L003_R1_001.fastq.gz | RNA-Seq | 322.0 MB |
| EC-KD-s3-PARN-1-2_S32_L003_R1_001.fastq.gz | RNA-Seq | 479.3 MB |
| EC-KD-s3-PARN-1-2_S32_L003_R1_001.fastq.gz | RNA-Seq | 479.3 MB |
| EC-KD-s3-PARN-2-1_S33_L003_R1_001.fastq.gz | RNA-Seq | 564.2 MB |
| EC-KD-s3-PARN-2-1_S33_L003_R1_001.fastq.gz | RNA-Seq | 564.2 MB |
| EC-KD-s3-PARN-2-2_S34_L003_R1_001.fastq.gz | RNA-Seq | 660.1 MB |
| EC-KD-s3-PARN-2-2_S34_L003_R1_001.fastq.gz | RNA-Seq | 660.1 MB |
| EC-OE-BOLL-1_S49_L005_R1_001.fastq.gz | RNA-Seq | 622.9 MB |
| EC-OE-BOLL-1_S49_L005_R1_001.fastq.gz | RNA-Seq | 622.9 MB |
| EC-OE-BOLL-2_S50_L005_R1_001.fastq.gz | RNA-Seq | 545.8 MB |
| EC-OE-BOLL-2_S50_L005_R1_001.fastq.gz | RNA-Seq | 545.8 MB |
| EC-OE-FLAG-1_S57_L005_R1_001.fastq.gz | RNA-Seq | 713.2 MB |
| EC-OE-FLAG-1_S57_L005_R1_001.fastq.gz | RNA-Seq | 713.2 MB |
| EC-OE-FLAG-2_S58_L005_R1_001.fastq.gz | RNA-Seq | 678.1 MB |
| EC-OE-FLAG-2_S58_L005_R1_001.fastq.gz | RNA-Seq | 678.1 MB |
| EC-OE-IFIT2-1_S43_L004_R1_001.fastq.gz | RNA-Seq | 533.2 MB |
| EC-OE-IFIT2-1_S43_L004_R1_001.fastq.gz | RNA-Seq | 533.2 MB |
| EC-OE-IFIT2-2_S44_L004_R1_001.fastq.gz | RNA-Seq | 560.3 MB |
| EC-OE-IFIT2-2_S44_L004_R1_001.fastq.gz | RNA-Seq | 560.3 MB |
| EC-OE-NANOS3-1_S41_L004_R1_001.fastq.gz | RNA-Seq | 617.8 MB |
| EC-OE-NANOS3-1_S41_L004_R1_001.fastq.gz | RNA-Seq | 617.8 MB |
| EC-OE-NANOS3-2_S42_L004_R1_001.fastq.gz | RNA-Seq | 532.1 MB |
| EC-OE-NANOS3-2_S42_L004_R1_001.fastq.gz | RNA-Seq | 532.1 MB |
| EC-OE-SNRPA-1_S55_L005_R1_001.fastq.gz | RNA-Seq | 688.4 MB |
| EC-OE-SNRPA-1_S55_L005_R1_001.fastq.gz | RNA-Seq | 688.4 MB |
| EC-OE-SNRPA-2_S56_L005_R1_001.fastq.gz | RNA-Seq | 676.4 MB |
| EC-OE-SNRPA-2_S56_L005_R1_001.fastq.gz | RNA-Seq | 676.4 MB |
| EC-OE-TOB1-1_S51_L005_R1_001.fastq.gz | RNA-Seq | 771.7 MB |
| EC-OE-TOB1-1_S51_L005_R1_001.fastq.gz | RNA-Seq | 771.7 MB |
| EC-OE-TOB1-2_S52_L005_R1_001.fastq.gz | RNA-Seq | 568.2 MB |
| EC-OE-TOB1-2_S52_L005_R1_001.fastq.gz | RNA-Seq | 568.2 MB |
| EC-OE-TOB2-1_S53_L005_R1_001.fastq.gz | RNA-Seq | 601.9 MB |
| EC-OE-TOB2-1_S53_L005_R1_001.fastq.gz | RNA-Seq | 601.9 MB |
| EC-OE-TOB2-2_S54_L005_R1_001.fastq.gz | RNA-Seq | 641.4 MB |
| EC-OE-TOB2-2_S54_L005_R1_001.fastq.gz | RNA-Seq | 641.4 MB |
Potentially Related Datasets (1)
These accessions were text-mined from the PMC full text. They may be referenced for comparison, cited from other studies, or otherwise mentioned without being primary data for this paper.
Analysis Pipelines (4)
GSE117290 eCLIP Data Processing
7 steps
GSE117294 Data Processing
5 steps
geo_data_processing
GSE117294