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  1. Single-cell and isoform-specific translational profiling of the mouse brain.

    Nature · 2026

    The brain displays the richest repertoire of post-transcriptional mechanisms regulating mRNA translation<sup>1-11</sup>. Among these, alternative splicing has been shown to drive cell-type specificity and, when disrupted, is strongly linked to neurological disorders<sup>12-17</sup>. However, genome-wide measurements of mRNA translation with isoform …

    PMID 41708856 DOI ↗

  2. Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted.

    Nature · 2025 · 639(8054): 483-492

    Tissue-resident memory CD8 T (T<sub>RM</sub>) cells provide protection from infection at barrier sites. In the small intestine, T<sub>RM</sub> cells are found in at least two distinct subpopulations: one with higher expression of effector molecules and another with greater memory potential<sup>1</sup>. …

    PMID 39843748 DOI ↗

  3. Xiphoid nucleus of the midline thalamus controls cold-induced food seeking.

    Nature · 2023 · 621(7977): 138-145

    Maintaining body temperature is calorically expensive for endothermic animals<sup>1</sup>. Mammals eat more in the cold to compensate for energy expenditure<sup>2</sup>, but the neural mechanism underlying this coupling is not well understood. Through behavioural and metabolic analyses, we found that mice …

    PMID 37587337 DOI ↗

  4. Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission.

    Nature · 2022 · 609(7925): 101-108

    As SARS-CoV-2 continues to spread and evolve, detecting emerging variants early is critical for public health interventions. Inferring lineage prevalence by clinical testing is infeasible at scale, especially in areas with limited resources, participation, or testing and/or sequencing capacity, which …

    PMID 35798029 DOI ↗

  5. Author Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes.

    Nature · 2022 · 605(7909): E3

    PMID 35474001 DOI ↗

  6. A multi-scale map of cell structure fusing protein images and interactions.

    Nature · 2021 · 600(7889): 536-542

    The cell is a multi-scale structure with modular organization across at least four orders of magnitude<sup>1</sup>. Two central approaches for mapping this structure-protein fluorescent imaging and protein biophysical association-each generate extensive datasets, but of distinct qualities and resolutions that are …

    PMID 34819669 DOI ↗

  7. Author Correction: A large-scale binding and functional map of human RNA-binding proteins.

    Nature · 2021 · 589(7842): E5

    PMID 33402748 DOI ↗

  8. Expanded encyclopaedias of DNA elements in the human and mouse genomes.

    Nature · 2020 · 583(7818): 699-710

    The human and mouse genomes contain instructions that specify RNAs and proteins and govern the timing, magnitude, and cellular context of their production. To better delineate these elements, phase III of the Encyclopedia of DNA Elements (ENCODE) Project has expanded …

    PMID 32728249 DOI ↗

  9. A large-scale binding and functional map of human RNA-binding proteins.

    Nature · 2020 · 583(7818): 711-719

    Many proteins regulate the expression of genes by binding to specific regions encoded in the genome<sup>1</sup>. Here we introduce a new data set of RNA elements in the human genome that are recognized by RNA-binding proteins (RBPs), generated as part …

    PMID 32728246 DOI ↗

  10. Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells.

    Nature · 2016 · 532(7600): 508-511

    Umbilical cord blood-derived haematopoietic stem cells (HSCs) are essential for many life-saving regenerative therapies. However, despite their advantages for transplantation, their clinical use is restricted because HSCs in cord blood are found only in small numbers. Small molecules that enhance …

    PMID 27121842 DOI ↗

  11. Differential L1 regulation in pluripotent stem cells of humans and apes.

    Nature · 2013 · 503(7477): 525-529

    Identifying cellular and molecular differences between human and non-human primates (NHPs) is essential to the basic understanding of the evolution and diversity of our own species. Until now, preserved tissues have been the main source for most comparative studies between …

    PMID 24153179 DOI ↗

  12. L1 retrotransposition in human neural progenitor cells.

    Nature · 2009 · 460(7259): 1127-31

    Long interspersed element 1 (LINE-1 or L1) retrotransposons have markedly affected the human genome. L1s must retrotranspose in the germ line or during early development to ensure their evolutionary success, yet the extent to which this process affects somatic cells …

    PMID 19657334 DOI ↗