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4 results for “Liver disease”

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  1. Zfp697/ZNF697 is an RNA-binding protein that modulates TGF-β1 signaling and hepatic inflammation in liver disease.

    Molecular metabolism · 2026 : 102457

    Liver diseases driven by metabolic dysfunction, inflammation, and fibrosis such as metabolic dysfunction-associated steatotic liver disease (MASLD), including metabolic dysfunction-associated steatohepatitis (MASH), and acute liver injury represent a growing global health burden. The zinc finger protein Zfp697 (ZNF697 in humans) …

    PMID 42875003 DOI ↗

  2. RNA-binding protein LARP6 coordinates hepatic stellate cell activation and liver fibrosis.

    The Journal of clinical investigation · 2026

    Metabolic syndrome and excessive alcohol consumption (MetALD) result in liver injury and fibrosis, which is driven by increased collagen production by activated hepatic stellate cells (HSCs). Our previous studies demonstrated that LARP6, an RNA-binding protein, may facilitate collagen production. However, …

    PMID 41746718 DOI ↗

  3. Imaging Cellular Metabolic Rewiring with SuMMIT-SRS.

    bioRxiv : the preprint server for biology · 2025

    Cells dynamically rewire their metabolic pathways in response to physiological and pathological cues. Such plasticity is particularly critical in neurons, stem cells, cancer cells, and immune cells, where biosynthetic demands can shift rapidly. However, current metabolic imaging techniques using isotope …

    PMID 41279865 DOI ↗

  4. LARP6 regulates the mRNA translation of fibrogenic genes in liver fibrosis.

    bioRxiv : the preprint server for biology · 2025

    Metabolic syndrome and excessive alcohol consumption result in liver injury and fibrosis, which is characterized by increased collagen production by activated Hepatic Stellate Cells (HSCs). LARP6, an RNA-binding protein, was shown to facilitate collagen production. However, LARP6 expression and functionality …

    PMID 39868246 DOI ↗

Datasets 2

GSE302600 GSE · GEO

Zfp697/ZNF697 is an RNA-binding protein that modulates TGF-β1 2 signaling and hepatic inflammation in liver disease

Mus musculus · GPL30172

GSE244832 GSE · GEO

Multi-Modal Comparison of human Hepatic Stellate Cells identifies novel therapeutic targets for Metabolic Dysfunction-Associated Steatotic Liver Disease

Homo sapiens · GPL24676, GPL37309

Analyses 1

GSE244832 scRNA-seq Data Processing

GSE244832 · 9 steps · scRNA-seq · geo_data_processing

RNA-binding protein LARP6 coordinates hepatic stellate cell activation and liver fibrosis. (2026)