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4 results for “Tumorigenesis”

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Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis.

Cellular and molecular life sciences : CMLS · 2022 · 79(3): 147

In addition to genomic alterations, aberrant changes in post-transcriptional regulation can modify gene function and drive cancer development. RNA-binding proteins (RBPs) are a large class of post-transcriptional regulators that have been increasingly implicated in carcinogenesis. By integrating multi-omics data, we …

PMID 35195778 DOI ↗
Transcriptome-wide profiles of circular RNA and RNA-binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression.

Genome medicine · 2020 · 12(1): 112

Circular RNAs (circRNAs) are stable, often highly expressed RNA transcripts with potential to modulate other regulatory RNAs. A few circRNAs have been shown to bind RNA-binding proteins (RBPs); however, little is known about the prevalence and distribution of these interactions …

PMID 33287884 DOI ↗
DDX5 promotes oncogene C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesis.

Life science alliance · 2020 · 3(10)

Tumorigenesis in different segments of the intestinal tract involves tissue-specific oncogenic drivers. In the colon, complement component 3 (C3) activation is a major contributor to inflammation and malignancies. By contrast, tumorigenesis in the small intestine involves fatty acid-binding protein 1 …

PMID 32817263 DOI ↗
Functional genomic analysis of the let-7 regulatory network in Caenorhabditis elegans.

PLoS genetics · 2013 · 9(3): e1003353

The let-7 microRNA (miRNA) regulates cellular differentiation across many animal species. Loss of let-7 activity causes abnormal development in Caenorhabditis elegans and unchecked cellular proliferation in human cells, which contributes to tumorigenesis. These defects are due to improper expression of …

PMID 23516374 DOI ↗

Datasets 4

GSE124023 GSE · GEO

DDX5 targets tissue specific RNAs to promote intestine tumorigenesis

Mus musculus · GPL21103

GSE234078 GSE · GEO

A super-enhancer regulated RNA-binding protein cascade drives pancreatic cancer

Mus musculus · GPL20301

GSE146014 GSE · GEO

DDX5 in colonic tumors

Mus musculus · GPL21103

GSE123881 GSE · GEO

DDX5 promotes oncogene C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesis

Mus musculus · GPL21103