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2 results for “Upf1”
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AKT constitutes a signal-promoted alternative exon-junction complex that regulates nonsense-mediated mRNA decay.
Molecular cell · 2022 · 82(15): 2779-2796.e10
Despite a long appreciation for the role of nonsense-mediated mRNA decay (NMD) in destroying faulty, disease-causing mRNAs and maintaining normal, physiologic mRNA abundance, additional effectors that regulate NMD activity in mammalian cells continue to be identified. Here, we describe a …
PMID 35675814 DOI ↗
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Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity.
Molecular cell · 2015 · 59(3): 413-25
RNA quality-control pathways get rid of faulty RNAs and therefore must be able to discriminate these RNAs from those that are normal. Here we present evidence that the adenosine triphosphatase (ATPase) cycle of the SF1 helicase Upf1 is required for …
PMID 26253027 DOI ↗
Datasets 10
RNA-seq on K562 cells treated with an shRNA knockdown against UPF1. (UPF1_BGKLV34)
Homo sapiens
RNA-seq on HepG2 cells treated with an shRNA knockdown against UPF1. (UPF1_BGHLV33)
Homo sapiens
Enhanced CLIP (eCLIP) identified differential UPF1 binding sites in mouse neural progenitor cells (NPCs) samples
Mus musculus · GPL24247
Target discrimination in nonsense-mediated mRNA decay requires Upf1 ATPase activity
Homo sapiens · GPL11154
Target discrimination in nonsense-mediated mRNA decay requires Upf1 ATPase activity (RIP-Seq)
Homo sapiens · GPL11154
Target discrimination in nonsense-mediated mRNA decay requires Upf1 ATPase activity (CLIP-Seq)
Homo sapiens · GPL11154
Analyses 4
GSE210437 · 9 steps · RNA-Seq · code_examples
Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size. (2024)
GSE69584 · 8 steps · OTHER · code_examples
Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity. (2015)
GSE69585 · 5 steps · RIP-Seq · code_examples
Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity. (2015)
GSE69586 · 8 steps · GSE · code_examples
Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity. (2015)