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4 results for “autism”
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Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes.
Cell reports · 2024 · 43(8): 114637
Reactive changes of glial cells during neuroinflammation impact brain disorders and disease progression. Elucidating the mechanisms that control reactive gliosis may help us to understand brain pathophysiology and improve outcomes. Here, we report that adult ablation of autism spectrum disorder …
PMID 39154337 DOI ↗
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MECP2-related pathways are dysregulated in a cortical organoid model of myotonic dystrophy.
Science translational medicine · 2022 · 14(651): eabn2375
Myotonic dystrophy type 1 (DM1) is a multisystem, autosomal-dominant inherited disorder caused by CTG microsatellite repeat expansions (MREs) in the 3' untranslated region of the dystrophia myotonica-protein kinase (<i>DMPK</i>) gene. Despite its prominence as the most common adult-onset muscular dystrophy, …
PMID 35767654 DOI ↗
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Widespread RNA editing dysregulation in brains from autistic individuals.
Nature neuroscience · 2019 · 22(1): 25-36
Transcriptomic analyses of postmortem brains have begun to elucidate molecular abnormalities in autism spectrum disorder (ASD). However, a crucial pathway involved in synaptic development, RNA editing, has not yet been studied on a genome-wide scale. Here we profiled global patterns …
PMID 30559470 DOI ↗
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A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells.
Cell · 2010 · 143(4): 527-39
Autism spectrum disorders (ASD) are complex neurodevelopmental diseases in which different combinations of genetic mutations may contribute to the phenotype. Using Rett syndrome (RTT) as an ASD genetic model, we developed a culture system using induced pluripotent stem cells (iPSCs) …
PMID 21074045 DOI ↗
Datasets 10
Disruption of human-specific synaptogenesis program in autism [RNA-seq]
9598 · GPL11154
Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [bulk RNA-seq]
Mus musculus · GPL24247
Widespread RNA editing dysregulation in Autism Spectrum Disorders
Homo sapiens · GPL20301
Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [ATAC-seq]
Mus musculus · GPL24247
Widespread RNA editing dysregulation in Autism Spectrum Disorders [eCLIP-seq]
Homo sapiens · GPL20301
MECP2-related pathways are dysregulated in a cortical organoid model of Myotonic dystrophy [bulk RNA-Seq]
Homo sapiens · GPL24676
Widespread RNA editing dysregulation in Autism Spectrum Disorders II
Homo sapiens · GPL11154
Widespread RNA editing dysregulation in Autism Spectrum Disorders [RNA-Seq]
Homo sapiens · GPL20301
Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [Microglia RNA-seq]
Mus musculus · GPL24247
MECP2-related pathways are dysregulated in a cortical organoid model of Myotonic dystrophy [eCLIP]
Homo sapiens · GPL16791
Analyses 8
GSE271650 · 5 steps · RNA-Seq · code_examples
Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes. (2024)
GSE271651 · 8 steps · RNA-Seq · code_examples
Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes. (2024)
GSE271652 · 5 steps · ATAC-seq · code_examples
Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes. (2024)
GSE107867 · 14 steps · RNA-Seq · code_examples
Widespread RNA editing dysregulation in brains from autistic individuals. (2019)
GSE107895 · 32 steps · RIP-Seq · code_examples
Widespread RNA editing dysregulation in brains from autistic individuals. (2019)
GSE107896 · 14 steps · GSE · code_examples
Widespread RNA editing dysregulation in brains from autistic individuals. (2019)
GSE117776 · 14 steps · RNA-Seq · code_examples
Widespread RNA editing dysregulation in brains from autistic individuals. (2019)
GSE59288 · 3 steps · RNA-Seq · code_examples
Widespread RNA editing dysregulation in brains from autistic individuals. (2019)