Search publications
2 results for “chemical probe”
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Remodeling oncogenic transcriptomes by small molecules targeting NONO.
Nature chemical biology · 2023 · 19(7): 825-836
Much of the human proteome is involved in mRNA homeostasis, but most RNA-binding proteins lack chemical probes. Here we identify electrophilic small molecules that rapidly and stereoselectively decrease the expression of transcripts encoding the androgen receptor and its splice variants …
PMID 36864190 DOI ↗
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Proteomic discovery of chemical probes that perturb protein complexes in human cells.
Molecular cell · 2023 · 83(10): 1725-1742.e12
Most human proteins lack chemical probes, and several large-scale and generalizable small-molecule binding assays have been introduced to address this problem. How compounds discovered in such "binding-first" assays affect protein function, nonetheless, often remains unclear. Here, we describe a "function-first" …
PMID 37084731 DOI ↗
Datasets 4
Function-first proteomic strategies for chemical probe discovery in human cells
Homo sapiens · GPL24676
Proteomic discovery of chemical probes that perturb protein complexes in human cells
Homo sapiens · GPL24676
Proteomic discovery of chemical probes that perturb protein complexes in human cells II
Homo sapiens · GPL18573
Remodeling of oncogenic transcriptomes by small-molecules targeting the RNA-binding protein NONO
Homo sapiens · GPL24676
Analyses 3
GSE185373 · 4 steps · RNA-Seq · code_examples
Proteomic discovery of chemical probes that perturb protein complexes in human cells. (2023)
GSE220185 · 4 steps · RIP-Seq · code_examples
Proteomic discovery of chemical probes that perturb protein complexes in human cells. (2023)
GSE220845 · 1 step · RNA-Seq · code_examples
Proteomic discovery of chemical probes that perturb protein complexes in human cells. (2023)