Search publications
6 results for “nonsense-mediated mRNA decay”
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Enhancing RNA base editing on mammalian transcripts with small nuclear RNAs.
Nature chemical biology · 2025
Endogenous uridine-rich small nuclear RNAs (U snRNAs) form RNA-protein complexes to process eukaryotic pre-mRNA into mRNA. Previous studies have demonstrated programmable U snRNA guide-targeted exon inclusion and exclusion. Here we investigated whether snRNAs can also enhance RNA base editing over …
PMID 40968292 DOI ↗
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Human CCR4 deadenylase homolog Angel1 is a non-stop mRNA decay factor.
RNA (New York, N.Y.) · 2025 · 31(8): 1195-1205
Translation elongation stalls trigger mRNA decay and degradation of the nascent polypeptide via translation-dependent quality control pathways. One such pathway, non-stop mRNA decay (NSD), targets aberrant mRNAs that lack stop codons, for example, due to premature polyadenylation. Here we identify …
PMID 40441874 DOI ↗
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Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size.
Neuron · 2024 · 112(13): 2157-2176.e12
Mutations in human nonsense-mediated mRNA decay (NMD) factors are enriched in neurodevelopmental disorders. We show that deletion of key NMD factor Upf2 in mouse embryonic neural progenitor cells causes perinatal microcephaly but deletion in immature neurons does not, indicating NMD's …
PMID 38697111 DOI ↗
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AKT constitutes a signal-promoted alternative exon-junction complex that regulates nonsense-mediated mRNA decay.
Molecular cell · 2022 · 82(15): 2779-2796.e10
Despite a long appreciation for the role of nonsense-mediated mRNA decay (NMD) in destroying faulty, disease-causing mRNAs and maintaining normal, physiologic mRNA abundance, additional effectors that regulate NMD activity in mammalian cells continue to be identified. Here, we describe a …
PMID 35675814 DOI ↗
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Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity.
Molecular cell · 2015 · 59(3): 413-25
RNA quality-control pathways get rid of faulty RNAs and therefore must be able to discriminate these RNAs from those that are normal. Here we present evidence that the adenosine triphosphatase (ATPase) cycle of the SF1 helicase Upf1 is required for …
PMID 26253027 DOI ↗
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The EJC factor eIF4AIII modulates synaptic strength and neuronal protein expression.
Cell · 2007 · 130(1): 179-91
Proper neuronal function and several forms of synaptic plasticity are highly dependent on precise control of mRNA translation, particularly in dendrites. We find that eIF4AIII, a core exon junction complex (EJC) component loaded onto mRNAs by pre-mRNA splicing, is associated …
PMID 17632064 DOI ↗
Datasets 5
Target discrimination in nonsense-mediated mRNA decay requires Upf1 ATPase activity
Homo sapiens · GPL11154
Target discrimination in nonsense-mediated mRNA decay requires Upf1 ATPase activity (RIP-Seq)
Homo sapiens · GPL11154
Target discrimination in nonsense-mediated mRNA decay requires Upf1 ATPase activity (CLIP-Seq)
Homo sapiens · GPL11154
Enhancing RNA base editing on mammalian transcripts with small nuclear RNAs
Homo sapiens · GPL34284
Nonsense-mediated mRNA decay counteracts TRP53 to maintain the progenitor cell pool for brain development (snRNA-seq_e15invivo)
Mus musculus · GPL21103
Analyses 4
GSE253825 · 1 step · RNA-Seq · code_examples
Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size. (2024)
GSE69584 · 8 steps · OTHER · code_examples
Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity. (2015)
GSE69585 · 5 steps · RIP-Seq · code_examples
Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity. (2015)
GSE69586 · 8 steps · GSE · code_examples
Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity. (2015)