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Assael A Madrigal

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Publications

Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress.
Nature neuroscience · 2025
Genome-Wide Interrogation of SARS-CoV-2 RNA-Protein Interactions Uncovers Hidden Regulatory Sites.
bioRxiv : the preprint server for biology · 2025
Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes.
Neuron · 2024
MECP2-related pathways are dysregulated in a cortical organoid model of myotonic dystrophy.
Science translational medicine · 2022
Crosstalk between CRISPR-Cas9 and the human transcriptome.
Nature communications · 2022
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer.
Molecular cell · 2021
Robust single-cell discovery of RNA targets of RNA-binding proteins and ribosomes.
Nature methods · 2021
Reintroduction of the archaic variant of <i>NOVA1</i> in cortical organoids alters neurodevelopment.
Science (New York, N.Y.) · 2021
Peptide Brush Polymers for Efficient Delivery of a Gene Editing Protein to Stem Cells.
Angewandte Chemie (International ed. in English) · 2019
Transcriptome-pathology correlation identifies interplay between TDP-43 and the expression of its kinase CK1E in sporadic ALS.
Acta neuropathologica · 2018