Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing.
Rea M Lardelli, Ashleigh E Schaffer, Veerle R C Eggens, Maha S Zaki, Stephanie Grainger, Shashank Sathe, Eric L Van Nostrand, Zinayida Schlachetzki, Basak Rosti, Naiara Akizu, Eric Scott, Jennifer L Silhavy, Laura Dean Heckman, Rasim Ozgur Rosti, Esra Dikoglu, Anne Gregor, Alicia Guemez-Gamboa, Damir Musaev, Rohit Mande, Ari Widjaja, Tim L Shaw, Sebastian Markmiller, Isaac Marin-Valencia, Justin H Davies, Linda de Meirleir, Hulya Kayserili, Umut Altunoglu, Mary Louise Freckmann, Linda Warwick, David Chitayat, Susan Blaser, Ahmet Okay Çağlayan, Kaya Bilguvar, Huseyin Per, Christina Fagerberg, Henrik T Christesen, Maria Kibaek, Kimberly A Aldinger, David Manchester, Naomichi Matsumoto, Kazuhiro Muramatsu, Hirotomo Saitsu, Masaaki Shiina, Kazuhiro Ogata, Nicola Foulds, William B Dobyns, Neil C Chi, David Traver, Luigina Spaccini, Stefania Maria Bova, Stacey B Gabriel, Murat Gunel, Enza Maria Valente, Marie-Cecile Nassogne, Eric J Bennett, Gene W Yeo, Frank Baas, Jens Lykke-Andersen, Joseph G Gleeson
Nature genetics · 2017 · Vol. 49 (3) · pp. 457-464
Abstract
Deadenylases are best known for degrading the poly(A) tail during mRNA decay. The deadenylase family has expanded throughout evolution and, in mammals, consists of 12 Mg<sup>2+</sup>-dependent 3'-end RNases with substrate specificity that is mostly unknown. Pontocerebellar hypoplasia type 7 (PCH7) is a unique recessive syndrome characterized by neurodegeneration and ambiguous genitalia. We studied 12 human families with PCH7, uncovering biallelic, loss-of-function mutations in TOE1, which encodes an unconventional deadenylase. toe1-morphant zebrafish displayed midbrain and hindbrain degeneration, modeling PCH-like structural defects in vivo. Surprisingly, we found that TOE1 associated with small nuclear RNAs (snRNAs) incompletely processed spliceosomal. These pre-snRNAs contained 3' genome-encoded tails often followed by post-transcriptionally added adenosines. Human cells with reduced levels of TOE1 accumulated 3'-end-extended pre-snRNAs, and the immunoisolated TOE1 complex was sufficient for 3'-end maturation of snRNAs. Our findings identify the cause of a neurodegenerative syndrome linked to snRNA maturation and uncover a key factor involved in the processing of snRNA 3' ends.
Linked datasets 1
Biallelic mutations in the 3â exonuclease TOE1 cause Pontocerebellar Hypoplasia Type 7 and result in snRNA processing defects
Homo sapiens
308 data files
| File | Type | Size |
|---|---|---|
| Sample100_Expt3_input-U6-FLAGonly-siCaf1z.fastq.gz | RNA-Seq | 911.4 KB |
| Sample101_Expt3_input-U6-WTaddback-siCaf1z.fastq.gz | RNA-Seq | 860.2 KB |
| Sample102_Expt3_input-U6-DEaddback-siCaf1z.fastq.gz | RNA-Seq | 2.0 MB |
| Sample103_Expt3_elu-U6-DEaddback.fastq.gz | RIP-Seq | 880.6 KB |
| Sample104_Expt4_input-U6-FLAGonly-siLuc.fastq.gz | RNA-Seq | 1.1 MB |
| Sample105_Expt4_input-U6-FLAGonly-siCaf1z.fastq.gz | RNA-Seq | 1003.5 KB |
| Sample106_Expt4_input-U6-WTaddback-siCaf1z.fastq.gz | RNA-Seq | 1.1 MB |
| Sample107_Expt4_input-U6-DEaddback-siCaf1z.fastq.gz | RNA-Seq | 993.3 KB |
| Sample108_Expt4_elu-U6-Wtaddback.fastq.gz | RIP-Seq | 2.2 MB |
| Sample109_Expt4_elu-U6-DEaddback.fastq.gz | RIP-Seq | 256.0 KB |
| Sample10_Expt1_input-U2-DEaddback-siCaf1z.fastq.gz | RNA-Seq | 819.2 KB |
| Sample110_Expt4_FU4-01_siLUCtot_rip41.fastq.gz | RNA-Seq | 1.5 MB |
| Sample111_Expt4_FU4-02_siCaf1ztot_rip41.fastq.gz | RNA-Seq | 1.9 MB |
| Sample112_Expt4_FU4-03_WTtot_rip41.fastq.gz | RNA-Seq | 1.9 MB |
| Sample113_Expt4_FU4-04_DEtot_rip41.fastq.gz | RNA-Seq | 1.6 MB |
| Sample114_Expt4_FU4-05_WTrip_rip41.fastq.gz | RIP-Seq | 4.1 MB |
| Sample115_Expt4_FU4-06_DErip_rip41.fastq.gz | RIP-Seq | 2.8 MB |
| Sample116_Expt6_FU1-Vs-09_siL_tot_42.fastq.gz | RNA-Seq | 1.5 MB |
| Sample117_Expt6_FU1-Vs-10_siC_tot_42.fastq.gz | RNA-Seq | 1.8 MB |
| Sample118_Expt6_FU1-Vs-11_WT_tot_42.fastq.gz | RNA-Seq | 1.6 MB |
| Sample119_Expt6_FU1-Vs-12_DE_tot_42.fastq.gz | RNA-Seq | 1.9 MB |
| Sample11_Expt1_elu-U2-WTaddback.fastq.gz | RIP-Seq | 849.9 KB |
| Sample120_Expt6_FU1-Vs-01_WT_el_42_trizol.fastq.gz | RIP-Seq | 1.4 MB |
| Sample121_Expt6_FU1-Vs-02_WT_el_42_Mg.fastq.gz | RIP-Seq | 1.2 MB |
| Sample122_Expt6_FU1-Vs-03_WT_el_42_EDTA.fastq.gz | RIP-Seq | 471.0 KB |
| Sample123_Expt6_FU1-Vs-04_DE_el_42_trizol.fastq.gz | RIP-Seq | 1.1 MB |
| Sample124_Expt6_FU1-Vs-05_DE_el__42_Mg.fastq.gz | RIP-Seq | 1.2 MB |
| Sample125_Expt6_FU1-Vs-06_DE_el__42_EDTA.fastq.gz | RIP-Seq | 1.5 MB |
| Sample126_Expt7_FU1-Vs-20_siL_tot_40.fastq.gz | RNA-Seq | 1.3 MB |
| Sample127_Expt7_FU1-Vs-21_siC_tot_40.fastq.gz | RNA-Seq | 1.3 MB |
| Sample128_Expt7_FU1-Vs-22_WT_tot_40.fastq.gz | RNA-Seq | 1.2 MB |
| Sample129_Expt7_FU1-Vs-07_DE_tot_40.fastq.gz | RNA-Seq | 1.2 MB |
| Sample12_Expt1_elu-U2-Deaddback.fastq.gz | RIP-Seq | 870.4 KB |
| Sample130_Expt7_FU1-Vs-13_A103_tot_40.fastq.gz | RNA-Seq | 1.4 MB |
| Sample131_Expt7_FU1-Vs-14_F148_tot_40.fastq.gz | RNA-Seq | 1.3 MB |
| Sample132_Expt7_FU1-Vs-15_V173_tot_40.fastq.gz | RNA-Seq | 1.1 MB |
| Sample133_Expt7_FU1-Vs-16_E220_tot_40.fastq.gz | RNA-Seq | 962.6 KB |
| Sample134_Expt9_FU1V68-01_NPC__ATCC.fastq.gz | RNA-Seq | 757.8 KB |
| Sample135_Expt9_FU1V68-02_NPC_1603A1.fastq.gz | RNA-Seq | 931.8 KB |
| Sample136_Expt9_FU1V68-03_NPC_1603A3.fastq.gz | RNA-Seq | 768.0 KB |
| Sample137_Expt9_FU1V68-04_NPC_1603U3.fastq.gz | RNA-Seq | 890.9 KB |
| Sample138_Expt9_FU1V68-05_NPC_1603U4.fastq.gz | RNA-Seq | 716.8 KB |
| Sample139_Expt9_FU2-01_NPC__ATCC.fastq.gz | RNA-Seq | 942.1 KB |
| Sample13_Expt2_input-U1-FLAGonly-siLuc.fastq.gz | RNA-Seq | 471.0 KB |
| Sample140_Expt9_FU2-02_NPC_1603A1.fastq.gz | RNA-Seq | 788.5 KB |
| Sample141_Expt9_FU2-03_NPC_1603A3.fastq.gz | RNA-Seq | 768.0 KB |
| Sample142_Expt9_FU2-04_NPC_1603U3.fastq.gz | RNA-Seq | 911.4 KB |
| Sample143_Expt9_FU2-05_NPC_1603U4.fastq.gz | RNA-Seq | 655.4 KB |
| Sample144_Expt9_FU5-03_NPC__ATCC.fastq.gz | RNA-Seq | 1.4 MB |
| Sample145_Expt9_FU5-04_NPC_1603A1.fastq.gz | RNA-Seq | 1.2 MB |
| Sample146_Expt9_FU5-05_NPC_1603A3.fastq.gz | RNA-Seq | 1.6 MB |
| Sample147_Expt9_FU5-06_NPC_1603U3.fastq.gz | RNA-Seq | 1.3 MB |
| Sample148_Expt9_FU5-07_NPC_1603U4.fastq.gz | RNA-Seq | 1.4 MB |
| Sample149_Expt4_FU5-08_siLuc_tot_41.fastq.gz | RNA-Seq | 1.8 MB |
| Sample14_Expt2_input-U1-FLAGonly-siCaf1z.fastq.gz | RNA-Seq | 399.4 KB |
| Sample150_Expt4_FU5-09_siC_tot_41.fastq.gz | RNA-Seq | 2.4 MB |
| Sample151_Expt4_FU5-10_WT_tot_41.fastq.gz | RNA-Seq | 1.7 MB |
| Sample152_Expt4_FU5-11_DE_tot_41.fastq.gz | RNA-Seq | 1.5 MB |
| Sample153_Expt4_FU5-12_WT_el_41.fastq.gz | RIP-Seq | 522.2 KB |
| Sample154_Expt4_FU5-13_DE_el_41.fastq.gz | RIP-Seq | 573.4 KB |
| Sample15_Expt2_input-U1-WTaddback-siCaf1z.fastq.gz | RNA-Seq | 430.1 KB |
| Sample16_Expt2_input-U1-DEaddback-siCaf1z.fastq.gz | RNA-Seq | 471.0 KB |
| Sample17_Expt2_elu-U1-WTaddback.fastq.gz | RIP-Seq | 286.7 KB |
| Sample18_Expt2_elu-U1-DEaddback.fastq.gz | RIP-Seq | 245.8 KB |
| Sample19_Expt2_input-U2-FLAGonly-siLuc.fastq.gz | RNA-Seq | 276.5 KB |
| Sample1_Expt1_input-U1-FLAGonly-siLuc.fastq.gz | RNA-Seq | 522.2 KB |
| Sample20_Expt2_input-U2-FLAGonly-siCaf1z.fastq.gz | RNA-Seq | 235.5 KB |
| Sample21_Expt2_input-U2-WTaddback-siCaf1z.fastq.gz | RNA-Seq | 266.2 KB |
| Sample22_Expt2_input-U2-DEaddback-siCaf1z.fastq.gz | RNA-Seq | 276.5 KB |
| Sample23_Expt2_elu-U2-WTaddback.fastq.gz | RIP-Seq | 266.2 KB |
| Sample24_Expt2_elu-U2-DEaddback.fastq.gz | RIP-Seq | 286.7 KB |
| Sample25_Expt2_input-U4-FLAGonly-siLuc.fastq.gz | RNA-Seq | 563.2 KB |
| Sample26_Expt2_input-U4-FLAGonly-siCaf1z.fastq.gz | RNA-Seq | 532.5 KB |
| Sample27_Expt2_input-U4-WTaddback-siCaf1z.fastq.gz | RNA-Seq | 460.8 KB |
| Sample28_Expt2_input-U4-DEaddback-siCaf1z.fastq.gz | RNA-Seq | 440.3 KB |
| Sample29_Expt2_elu-U4-WTaddback.fastq.gz | RIP-Seq | 553.0 KB |
| Sample2_Expt1_input-U1-FLAGonly-siCaf1z.fastq.gz | RNA-Seq | 604.2 KB |
| Sample30_Expt2_elu-U4-DEaddback.fastq.gz | RIP-Seq | 532.5 KB |
| Sample31_Expt2_input-U5-WTaddback-siCaf1z.fastq.gz | RNA-Seq | 399.4 KB |
| Sample32_Expt2_input-U5-DEaddback-siCaf1z.fastq.gz | RNA-Seq | 409.6 KB |
| Sample33_Expt2_elu-U5-WTaddback.fastq.gz | RIP-Seq | 419.8 KB |
| Sample34_Expt2_elu-U5-DEaddback.fastq.gz | RIP-Seq | 378.9 KB |
| Sample35_Expt2_input-U6-FLAGonly-siLuc.fastq.gz | RNA-Seq | 256.0 KB |
| Sample36_Expt2_input-U6-FLAGonly-siCaf1z.fastq.gz | RNA-Seq | 256.0 KB |
| Sample37_Expt2_input-U6-WTaddback-siCaf1z.fastq.gz | RNA-Seq | 286.7 KB |
| Sample38_Expt2_input-U6-DEaddback-siCaf1z.fastq.gz | RNA-Seq | 286.7 KB |
| Sample39_Expt2_elu-U6-Wtaddback.fastq.gz | RIP-Seq | 327.7 KB |
| Sample3_Expt1_input-U1-WTaddback-siCaf1z.fastq.gz | RNA-Seq | 573.4 KB |
| Sample40_Expt2_elu-U6-DEaddback.fastq.gz | RIP-Seq | 348.2 KB |
| Sample41_Expt3_input-U1-FLAGonly-siLuc.fastq.gz | RNA-Seq | 2.3 MB |
| Sample42_Expt3_input-U1-FLAGonly-siCaf1z.fastq.gz | RNA-Seq | 2.7 MB |
| Sample43_Expt3_input-U1-WTaddback-siCaf1z.fastq.gz | RNA-Seq | 3.6 MB |
| Sample44_Expt3_input-U1-DEaddback-siCaf1z.fastq.gz | RNA-Seq | 2.5 MB |
| Sample45_Expt3_elu-U1-WTaddback.fastq.gz | RIP-Seq | 3.1 MB |
| Sample46_Expt3_elu-U1-Deaddback.fastq.gz | RIP-Seq | 3.6 MB |
| Sample47_Expt3_input-U2-FLAGonly-siLuc.fastq.gz | RNA-Seq | 3.8 MB |
| Sample48_Expt3_input-U2-FLAGonly-siCaf1z.fastq.gz | RNA-Seq | 1.6 MB |
| Sample49_Expt3_input-U2-WTaddback-siCaf1z.fastq.gz | RNA-Seq | 2.1 MB |
| Sample4_Expt1_input-U1-DEaddback-siCaf1z.fastq.gz | RNA-Seq | 573.4 KB |
| Sample50_Expt3_input-U2-DEaddback-siCaf1z.fastq.gz | RNA-Seq | 1.4 MB |
| Sample51_Expt3_elu-U2-WTaddback.fastq.gz | RIP-Seq | 2.4 MB |
| Sample52_Expt3_elu-U2-DEaddback.fastq.gz | RIP-Seq | 1.7 MB |
| Sample53_Expt3_input-U4-FLAGonly-siLuc.fastq.gz | RNA-Seq | 4.4 MB |
| Sample54_Expt3_input-U4-FLAGonly-siCaf1z.fastq.gz | RNA-Seq | 3.7 MB |
| Sample55_Expt3_input-U4-WTaddback-siCaf1z.fastq.gz | RNA-Seq | 4.6 MB |
| Sample56_Expt3_input-U4-DEaddback-siCaf1z.fastq.gz | RNA-Seq | 2.9 MB |
| Sample57_Expt3_elu-U4-WTaddback.fastq.gz | RIP-Seq | 3.9 MB |
| Sample58_Expt3_elu-U4-DEaddback.fastq.gz | RIP-Seq | 3.8 MB |
| Sample59_Expt3_input-U5-WTaddback-siCaf1z.fastq.gz | RNA-Seq | 4.0 MB |
| Sample5_Expt1_elu-U1-WTaddback.fastq.gz | RIP-Seq | 542.7 KB |
| Sample60_Expt3_input-U5-DEaddback-siCaf1z.fastq.gz | RNA-Seq | 2.7 MB |
| Sample61_Expt3_elu-U5-WTaddback.fastq.gz | RIP-Seq | 2.5 MB |
| Sample62_Expt3_elu-U5-DEaddback.fastq.gz | RIP-Seq | 2.2 MB |
| Sample63_Expt8_PATFIB_U1_ATCC.fastq.gz | RNA-Seq | 8.7 MB |
| Sample64_Expt8_PATFIB_U1_1603A.fastq.gz | RNA-Seq | 8.7 MB |
| Sample65_Expt8_PATFIB_U1_1603U.fastq.gz | RNA-Seq | 5.3 MB |
| Sample66_Expt8_PATFIB_U1_4127A.fastq.gz | RNA-Seq | 8.1 MB |
| Sample67_Expt8_PATFIB_U1_4128A.fastq.gz | RNA-Seq | 9.1 MB |
| Sample68_Expt8_PATFIB_U1_4128U.fastq.gz | RNA-Seq | 11.8 MB |
| Sample69_Expt4_input-U5-FLAGonly-siLuc.fastq.gz | RIP-Seq | 2.0 MB |
| Sample6_Expt1_elu-U1-DEaddback.fastq.gz | RIP-Seq | 716.8 KB |
| Sample70_Expt4_input-U5-FLAGonly-Caf1z.fastq.gz | RIP-Seq | 1.8 MB |
| Sample71_Expt5_FU1-Vs-01_V173_rip.fastq.gz | RIP-Seq | 1.2 MB |
| Sample72_Expt5_FU1-Vs-02_E220_rip.fastq.gz | RIP-Seq | 1.2 MB |
| Sample73_Expt5_FU1-Vs-03_wt_rip.fastq.gz | RIP-Seq | 819.2 KB |
| Sample74_Expt5_FU1-Vs-04_de_rip.fastq.gz | RIP-Seq | 1.8 MB |
| Sample75_Expt5_FU1-Vs-05_a103_rip.fastq.gz | RIP-Seq | 1.8 MB |
| Sample76_Expt5_FU1-Vs-06_f148_rip.fastq.gz | RIP-Seq | 1.1 MB |
| Sample77_Expt5_FU1-Vs-12_siL_tot.fastq.gz | RNA-Seq | 1.3 MB |
| Sample78_Expt5_FU1-Vs-13_siC_tot.fastq.gz | RNA-Seq | 1.6 MB |
| Sample79_Expt5_FU1-Vs-14_wt_tot.fastq.gz | RNA-Seq | 1.7 MB |
| Sample7_Expt1_input-U2-FLAGonly-siLuc.fastq.gz | RNA-Seq | 747.5 KB |
| Sample80_Expt5_FU1-Vs-15_de_tot.fastq.gz | RNA-Seq | 2.2 MB |
| Sample81_Expt5_FU1-Vs-16_a103_tot.fastq.gz | RNA-Seq | 1.5 MB |
| Sample82_Expt5_FU1-Vs-17_f148_tot.fastq.gz | RNA-Seq | 1.7 MB |
| Sample83_Expt5_FU1-Vs-18_v173_tot.fastq.gz | RNA-Seq | 1.8 MB |
| Sample84_Expt5_FU1-Vs-19_e220_tot.fastq.gz | RNA-Seq | 1.5 MB |
| Sample85_Expt8_PATFIB_U2_ATCC.fastq.gz | RNA-Seq | 901.1 KB |
| Sample86_Expt8_PATFIB_U2_1603A.fastq.gz | RNA-Seq | 686.1 KB |
| Sample87_Expt8_PATFIB_U2_1603U.fastq.gz | RNA-Seq | 778.2 KB |
| Sample88_Expt8_PATFIB_U2_4127A.fastq.gz | RNA-Seq | 1.1 MB |
| Sample89_Expt8_PATFIB_U2_4128A.fastq.gz | RNA-Seq | 727.0 KB |
| Sample8_Expt1_input-U2-FLAGonly-siCaf1z.fastq.gz | RNA-Seq | 716.8 KB |
| Sample90_Expt8_PATFIB_U2_4128U.fastq.gz | RNA-Seq | 1013.8 KB |
| Sample91_Expt8_PATFIB_U5_ATCC.fastq.gz | RNA-Seq | 1.7 MB |
| Sample92_Expt8_PATFIB_U5_1603A.fastq.gz | RNA-Seq | 614.4 KB |
| Sample93_Expt8_PATFIB_U5_1603U.fastq.gz | RNA-Seq | 962.6 KB |
| Sample94_Expt8_PATFIB_U5_4127A.fastq.gz | RNA-Seq | 921.6 KB |
| Sample95_Expt8_PATFIB_U5_4128A.fastq.gz | RNA-Seq | 1.3 MB |
| Sample96_Expt8_PATFIB_U5_4128U.fastq.gz | RNA-Seq | 911.4 KB |
| Sample97_Expt2_FU5-09_siLuc_totalrip35.fastq.gz | RNA-Seq | 2.8 MB |
| Sample98_Expt2_FU5-10_siCaf_totalrip35.fastq.gz | RNA-Seq | 2.7 MB |
| Sample99_Expt3_input-U6-FLAGonly-siLuc.fastq.gz | RNA-Seq | 890.9 KB |
| Sample9_Expt1_input-U2-WTaddback-siCaf1z.fastq.gz | RNA-Seq | 706.6 KB |
| SRR2134474_GSM1836489 | RNA-Seq | |
| SRR2134475_GSM1836490 | RNA-Seq | |
| SRR2134476_GSM1836491 | RNA-Seq | |
| SRR2134477_GSM1836492 | RNA-Seq | |
| SRR2134478_GSM1836493 | RIP-Seq | |
| SRR2134479_GSM1836494 | RIP-Seq | |
| SRR2134480_GSM1836495 | RNA-Seq | |
| SRR2134481_GSM1836496 | RNA-Seq | |
| SRR2134482_GSM1836497 | RNA-Seq | |
| SRR2134483_GSM1836498 | RNA-Seq | |
| SRR2134484_GSM1836499 | RIP-Seq | |
| SRR2134485_GSM1836500 | RIP-Seq | |
| SRR2134486_GSM1836501 | RNA-Seq | |
| SRR2134487_GSM1836502 | RNA-Seq | |
| SRR2134488_GSM1836503 | RNA-Seq | |
| SRR2134489_GSM1836504 | RNA-Seq | |
| SRR2134490_GSM1836505 | RIP-Seq | |
| SRR2134491_GSM1836506 | RIP-Seq | |
| SRR2134492_GSM1836507 | RNA-Seq | |
| SRR2134493_GSM1836508 | RNA-Seq | |
| SRR2134494_GSM1836509 | RNA-Seq | |
| SRR2134495_GSM1836510 | RNA-Seq | |
| SRR2134496_GSM1836511 | RIP-Seq | |
| SRR2134497_GSM1836512 | RIP-Seq | |
| SRR2134498_GSM1836513 | RNA-Seq | |
| SRR2134499_GSM1836514 | RNA-Seq | |
| SRR2134500_GSM1836515 | RNA-Seq | |
| SRR2134501_GSM1836516 | RNA-Seq | |
| SRR2134502_GSM1836517 | RIP-Seq | |
| SRR2134503_GSM1836518 | RIP-Seq | |
| SRR2134504_GSM1836519 | RNA-Seq | |
| SRR2134505_GSM1836520 | RNA-Seq | |
| SRR2134506_GSM1836521 | RIP-Seq | |
| SRR2134507_GSM1836522 | RIP-Seq | |
| SRR2134508_GSM1836523 | RNA-Seq | |
| SRR2134509_GSM1836524 | RNA-Seq | |
| SRR2134510_GSM1836525 | RNA-Seq | |
| SRR2134511_GSM1836526 | RNA-Seq | |
| SRR2134512_GSM1836527 | RIP-Seq | |
| SRR2134513_GSM1836528 | RIP-Seq | |
| SRR2134514_GSM1836529 | RNA-Seq | 2.0 MB |
| SRR2134515_GSM1836530 | RNA-Seq | 2.0 MB |
| SRR2134516_GSM1836531 | RNA-Seq | 3.0 MB |
| SRR2134517_GSM1836532 | RNA-Seq | 2.0 MB |
| SRR2134518_GSM1836533 | RIP-Seq | 3.0 MB |
| SRR2134519_GSM1836534 | RIP-Seq | 3.0 MB |
| SRR2134520_GSM1836535 | RNA-Seq | 3.0 MB |
| SRR2134521_GSM1836536 | RNA-Seq | 1.0 MB |
| SRR2134522_GSM1836537 | RNA-Seq | 2.0 MB |
| SRR2134523_GSM1836538 | RNA-Seq | 1.0 MB |
| SRR2134524_GSM1836539 | RIP-Seq | 2.0 MB |
| SRR2134525_GSM1836540 | RIP-Seq | 1.0 MB |
| SRR2134526_GSM1836541 | RNA-Seq | 4.0 MB |
| SRR2134527_GSM1836542 | RNA-Seq | 3.0 MB |
| SRR2134528_GSM1836543 | RNA-Seq | 4.0 MB |
| SRR2134529_GSM1836544 | RNA-Seq | 2.0 MB |
| SRR2134530_GSM1836545 | RIP-Seq | 3.0 MB |
| SRR2134531_GSM1836546 | RIP-Seq | 3.0 MB |
| SRR2134532_GSM1836547 | RNA-Seq | 3.0 MB |
| SRR2134533_GSM1836548 | RNA-Seq | 2.0 MB |
| SRR2134534_GSM1836549 | RIP-Seq | 2.0 MB |
| SRR2134535_GSM1836550 | RIP-Seq | 2.0 MB |
| SRR2134536_GSM1836551 | RNA-Seq | 8.0 MB |
| SRR2134537_GSM1836552 | RNA-Seq | 8.0 MB |
| SRR2134538_GSM1836553 | RNA-Seq | 5.0 MB |
| SRR2134539_GSM1836554 | RNA-Seq | 8.0 MB |
| SRR2134540_GSM1836555 | RNA-Seq | 9.0 MB |
| SRR2134541_GSM1836556 | RNA-Seq | 11.0 MB |
| SRR2134542_GSM1836557 | RIP-Seq | 2.0 MB |
| SRR2134543_GSM1836558 | RIP-Seq | 1.0 MB |
| SRR2134544_GSM1836559 | RIP-Seq | 1.0 MB |
| SRR2134545_GSM1836560 | RIP-Seq | 1.0 MB |
| SRR2134546_GSM1836561 | RIP-Seq | |
| SRR2134547_GSM1836562 | RIP-Seq | 1.0 MB |
| SRR2134548_GSM1836563 | RIP-Seq | 1.0 MB |
| SRR2134549_GSM1836564 | RIP-Seq | 1.0 MB |
| SRR2134550_GSM1836565 | RNA-Seq | 1.0 MB |
| SRR2134551_GSM1836566 | RNA-Seq | 1.0 MB |
| SRR2134552_GSM1836567 | RNA-Seq | 1.0 MB |
| SRR2134553_GSM1836568 | RNA-Seq | 2.0 MB |
| SRR2134554_GSM1836569 | RNA-Seq | 1.0 MB |
| SRR2134555_GSM1836570 | RNA-Seq | 1.0 MB |
| SRR2134556_GSM1836571 | RNA-Seq | 1.0 MB |
| SRR2134557_GSM1836572 | RNA-Seq | 1.0 MB |
| SRR2134558_GSM1836573 | RNA-Seq | |
| SRR2134559_GSM1836574 | RNA-Seq | |
| SRR2134560_GSM1836575 | RNA-Seq | |
| SRR2134561_GSM1836576 | RNA-Seq | 1.0 MB |
| SRR2134562_GSM1836577 | RNA-Seq | |
| SRR2134563_GSM1836578 | RNA-Seq | |
| SRR2134564_GSM1836579 | RNA-Seq | 1.0 MB |
| SRR2134565_GSM1836580 | RNA-Seq | |
| SRR2134566_GSM1836581 | RNA-Seq | |
| SRR2134567_GSM1836582 | RNA-Seq | |
| SRR2134568_GSM1836583 | RNA-Seq | 1.0 MB |
| SRR2134569_GSM1836584 | RNA-Seq | |
| SRR2134570_GSM1836585 | RNA-Seq | 2.0 MB |
| SRR2134571_GSM1836586 | RNA-Seq | 2.0 MB |
| SRR2134572_GSM1836587 | RNA-Seq | |
| SRR2134573_GSM1836588 | RNA-Seq | |
| SRR2134574_GSM1836589 | RNA-Seq | |
| SRR2134575_GSM1836590 | RNA-Seq | 2.0 MB |
| SRR2134576_GSM1836591 | RIP-Seq | |
| SRR2134577_GSM1836592 | RNA-Seq | 1.0 MB |
| SRR2134578_GSM1836593 | RNA-Seq | |
| SRR2134579_GSM1836594 | RNA-Seq | 1.0 MB |
| SRR2134580_GSM1836595 | RNA-Seq | |
| SRR2134581_GSM1836596 | RIP-Seq | 2.0 MB |
| SRR2134582_GSM1836597 | RIP-Seq | |
| SRR2134583_GSM1836598 | RNA-Seq | 1.0 MB |
| SRR2134584_GSM1836599 | RNA-Seq | 1.0 MB |
| SRR2134585_GSM1836600 | RNA-Seq | 1.0 MB |
| SRR2134586_GSM1836601 | RNA-Seq | 1.0 MB |
| SRR2134587_GSM1836602 | RIP-Seq | 4.0 MB |
| SRR2134588_GSM1836603 | RIP-Seq | 2.0 MB |
| SRR2134589_GSM1836604 | RNA-Seq | 1.0 MB |
| SRR2134590_GSM1836605 | RNA-Seq | 1.0 MB |
| SRR2134591_GSM1836606 | RNA-Seq | 1.0 MB |
| SRR2134592_GSM1836607 | RNA-Seq | 1.0 MB |
| SRR2134593_GSM1836608 | RIP-Seq | 1.0 MB |
| SRR2134594_GSM1836609 | RIP-Seq | 1.0 MB |
| SRR2134595_GSM1836610 | RIP-Seq | |
| SRR2134596_GSM1836611 | RIP-Seq | 1.0 MB |
| SRR2134597_GSM1836612 | RIP-Seq | 1.0 MB |
| SRR2134598_GSM1836613 | RIP-Seq | 1.0 MB |
| SRR2134599_GSM1836614 | RNA-Seq | 1.0 MB |
| SRR2134600_GSM1836615 | RNA-Seq | 1.0 MB |
| SRR2134601_GSM1836616 | RNA-Seq | 1.0 MB |
| SRR2134602_GSM1836617 | RNA-Seq | 1.0 MB |
| SRR2134603_GSM1836618 | RNA-Seq | 1.0 MB |
| SRR2134604_GSM1836619 | RNA-Seq | 1.0 MB |
| SRR2134605_GSM1836620 | RNA-Seq | 1.0 MB |
| SRR2134606_GSM1836621 | RNA-Seq | |
| SRR2134607_GSM1836622 | RNA-Seq | |
| SRR2134608_GSM1836623 | RNA-Seq | |
| SRR2134609_GSM1836624 | RNA-Seq | |
| SRR2134610_GSM1836625 | RNA-Seq | |
| SRR2134611_GSM1836626 | RNA-Seq | |
| SRR2134612_GSM1836627 | RNA-Seq | |
| SRR2134613_GSM1836628 | RNA-Seq | |
| SRR2134614_GSM1836629 | RNA-Seq | |
| SRR2134615_GSM1836630 | RNA-Seq | |
| SRR2134616_GSM1836631 | RNA-Seq | |
| SRR2134617_GSM1836632 | RNA-Seq | 1.0 MB |
| SRR2134618_GSM1836633 | RNA-Seq | 1.0 MB |
| SRR2134619_GSM1836634 | RNA-Seq | 1.0 MB |
| SRR2134620_GSM1836635 | RNA-Seq | 1.0 MB |
| SRR2134621_GSM1836636 | RNA-Seq | 1.0 MB |
| SRR2134622_GSM1836637 | RNA-Seq | 1.0 MB |
| SRR2134623_GSM1836638 | RNA-Seq | 2.0 MB |
| SRR2134624_GSM1836639 | RNA-Seq | 1.0 MB |
| SRR2134625_GSM1836640 | RNA-Seq | 1.0 MB |
| SRR2134626_GSM1836641 | RIP-Seq | |
| SRR2134627_GSM1836642 | RIP-Seq |
Potentially related datasets 1
These accessions were text-mined from the PMC full text. They may be referenced for comparison, cited from other studies, or otherwise mentioned without being primary data for this paper.
Analysis pipelines 1
| Pipeline | Assay | Steps | Dataset |
|---|---|---|---|
| GSE71536 Data Processing geo_data_processing | — | 4 | GSE71536 |
Funding 22 grants
| Grant | Funder |
|---|---|
| R01 HG004659 | NHGRI NIH HHS (United States) |
| R35 GM118069 | NIGMS NIH HHS (United States) |
| P30 NS047101 | NINDS NIH HHS (United States) |
| T32 GM007240 | NIGMS NIH HHS (United States) |
| K12 GM068524 | NIGMS NIH HHS (United States) |
| R01 NS075449 | NINDS NIH HHS (United States) |
| UM1 HG008900 | NHGRI NIH HHS (United States) |
| 260888 | European Research Council (International) |
| R01 GM077243 | NIGMS NIH HHS (United States) |
| F32 GM106706 | NIGMS NIH HHS (United States) |
| R01 NS048453 | NINDS NIH HHS (United States) |
| U54 HG006504 | NHGRI NIH HHS (United States) |
| R00 HD082337 | NICHD NIH HHS (United States) |
| R01 NS098004 | NINDS NIH HHS (United States) |
| UM1 HG006493 | NHGRI NIH HHS (United States) |
| R01 NS058721 | NINDS NIH HHS (United States) |
| U54 HG003067 | NHGRI NIH HHS (United States) |
| R01 NS050375 | NINDS NIH HHS (United States) |
| R01 NS041537 | NINDS NIH HHS (United States) |
| K99 HD082337 | NICHD NIH HHS (United States) |
| R01 NS052455 | NINDS NIH HHS (United States) |
| P01 HD070494 | NICHD NIH HHS (United States) |