Persistent mRNA localization defects and cell death in ALS neurons caused by transient cellular stress.
Sebastian Markmiller, Shashank Sathe, Kari L Server, Thai B Nguyen, Amit Fulzele, Neal Cody, Ashkan Javaherian, Sara Broski, Steven Finkbeiner, Eric J Bennett, Eric Lécuyer, Gene W Yeo
Cell reports · 2021 · Vol. 36 (10) · pp. 109685
Abstract
Persistent cytoplasmic aggregates containing RNA binding proteins (RBPs) are central to the pathogenesis of late-onset neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS). These aggregates share components, molecular mechanisms, and cellular protein quality control pathways with stress-induced RNA granules (SGs). Here, we assess the impact of stress on the global mRNA localization landscape of human pluripotent stem cell-derived motor neurons (PSC-MNs) using subcellular fractionation with RNA sequencing and proteomics. Transient stress disrupts subcellular RNA and protein distributions, alters the RNA binding profile of SG- and ALS-relevant RBPs and recapitulates disease-associated molecular changes such as aberrant splicing of STMN2. Although neurotypical PSC-MNs re-establish a normal subcellular localization landscape upon recovery from stress, cells harboring ALS-linked mutations are intransigent and display a delayed-onset increase in neuronal cell death. Our results highlight subcellular molecular distributions as predictive features and underscore the utility of cellular stress as a paradigm to study ALS-relevant mechanisms.
Linked datasets 1
Persistent mRNA localization defects and cell death in ALS neurons caused by transient cellular stress
Homo sapiens
260 data files
| File | Type | Size |
|---|---|---|
| CVB_iPSC_cyto_rep1.fastq.gz | RNA-Seq | 286.3 MB |
| CVB_iPSC_cyto_rep2.fastq.gz | RNA-Seq | 503.2 MB |
| CVB_iPSC_insol_rep1.fastq.gz | RNA-Seq | 528.3 MB |
| CVB_iPSC_insol_rep2.fastq.gz | RNA-Seq | 584.5 MB |
| CVB_iPSC_nuclei_rep1.fastq.gz | RNA-Seq | 393.9 MB |
| CVB_iPSC_nuclei_rep2.fastq.gz | RNA-Seq | 653.4 MB |
| CVB_iPSC_total_rep1.fastq.gz | RNA-Seq | 1.1 GB |
| CVB_iPSC_total_rep2.fastq.gz | RNA-Seq | 613.2 MB |
| CVB_TDP43_puro_input_rep1.fastq.gz | RIP-Seq | 805.9 MB |
| CVB_TDP43_puro_input_rep2.fastq.gz | RIP-Seq | 610.4 MB |
| CVB_TDP43_puro_IP_rep1.fastq.gz | RIP-Seq | 2.0 GB |
| CVB_TDP43_puro_IP_rep2.fastq.gz | RIP-Seq | 2.7 GB |
| CVB_TDP43_ut_input_rep1.fastq.gz | RIP-Seq | 622.1 MB |
| CVB_TDP43_ut_input_rep2.fastq.gz | RIP-Seq | 789.3 MB |
| CVB_TDP43_ut_IP_rep1.fastq.gz | RIP-Seq | 1.4 GB |
| CVB_TDP43_ut_IP_rep2.fastq.gz | RIP-Seq | 1.6 GB |
| CVC_G3BP_puro_input_rep1.fastq.gz | RIP-Seq | 1.5 GB |
| CVC_G3BP_puro_input_rep2.fastq.gz | RIP-Seq | 2.1 GB |
| CVC_G3BP_puro_IP_rep1.fastq.gz | RIP-Seq | 1.2 GB |
| CVC_G3BP_puro_IP_rep2.fastq.gz | RIP-Seq | 2.0 GB |
| CVC_G3BP_ut_input_rep1.fastq.gz | RIP-Seq | 1.8 GB |
| CVC_G3BP_ut_input_rep2.fastq.gz | RIP-Seq | 1.6 GB |
| CVC_G3BP_ut_IP_rep1.fastq.gz | RIP-Seq | 1.7 GB |
| CVC_G3BP_ut_IP_rep2.fastq.gz | RIP-Seq | 1.8 GB |
| cyto_CR463_puro_rep1.fastq.gz | RNA-Seq | 1.1 GB |
| cyto_CR463_puro_rep2.fastq.gz | RNA-Seq | 1.2 GB |
| cyto_CR463_rec_rep1.fastq.gz | RNA-Seq | 1.6 GB |
| cyto_CR463_rec_rep2.fastq.gz | RNA-Seq | 1.6 GB |
| cyto_CR463_ut_rep1.fastq.gz | RNA-Seq | 1.8 GB |
| cyto_CR463_ut_rep2.fastq.gz | RNA-Seq | 1.5 GB |
| cyto_CR464_puro_rep1.fastq.gz | RNA-Seq | 2.2 GB |
| cyto_CR464_puro_rep2.fastq.gz | RNA-Seq | 1.0 GB |
| cyto_CR464_rec_rep1.fastq.gz | RNA-Seq | 1.5 GB |
| cyto_CR464_rec_rep2.fastq.gz | RNA-Seq | 1.4 GB |
| cyto_CR464_ut_rep1.fastq.gz | RNA-Seq | 1.0 GB |
| cyto_CR464_ut_rep2.fastq.gz | RNA-Seq | 876.4 MB |
| H1_ESC_cyto_rep1.fastq.gz | RNA-Seq | 343.7 MB |
| H1_ESC_cyto_rep2.fastq.gz | RNA-Seq | 455.9 MB |
| H1_ESC_insol_rep1.fastq.gz | RNA-Seq | 575.7 MB |
| H1_ESC_insol_rep2.fastq.gz | RNA-Seq | 562.6 MB |
| H1_ESC_nuclei_rep1.fastq.gz | RNA-Seq | 418.8 MB |
| H1_ESC_nuclei_rep2.fastq.gz | RNA-Seq | 528.5 MB |
| H1_ESC_total_rep1.fastq.gz | RNA-Seq | 467.4 MB |
| H1_ESC_total_rep2.fastq.gz | RNA-Seq | 494.1 MB |
| H1_puro1_cyto_rep1.fastq.gz | RNA-Seq | 732.4 MB |
| H1_puro1_insol_rep1.fastq.gz | RNA-Seq | 1.1 GB |
| H1_puro1_nucl_rep1.fastq.gz | RNA-Seq | 680.8 MB |
| H1_puro1_total_rep1.fastq.gz | RNA-Seq | 391.1 MB |
| H1_puro_cyto_rep2.fastq.gz | RNA-Seq | 930.0 MB |
| H1_puro_insol_rep2.fastq.gz | RNA-Seq | 1.0 GB |
| H1_puro_nucl_rep2.fastq.gz | RNA-Seq | 828.4 MB |
| H1_puro_total_rep2.fastq.gz | RNA-Seq | 958.5 MB |
| H1_rec_cyto_rep1.fastq.gz | RNA-Seq | 774.3 MB |
| H1_rec_cyto_rep2.fastq.gz | RNA-Seq | 720.7 MB |
| H1_rec_insol_rep1.fastq.gz | RNA-Seq | 962.7 MB |
| H1_rec_insol_rep2.fastq.gz | RNA-Seq | 982.1 MB |
| H1_rec_nucl_rep1.fastq.gz | RNA-Seq | 256.8 MB |
| H1_rec_nucl_rep2.fastq.gz | RNA-Seq | 813.9 MB |
| H1_rec_total_rep1.fastq.gz | RNA-Seq | 996.3 MB |
| H1_rec_total_rep2.fastq.gz | RNA-Seq | 929.5 MB |
| H1_ut_cyto_rep1.fastq.gz | RNA-Seq | 179.0 MB |
| H1_ut_cyto_rep2.fastq.gz | RNA-Seq | 826.4 MB |
| H1_ut_insol_rep1.fastq.gz | RNA-Seq | 1.1 GB |
| H1_ut_insol_rep2.fastq.gz | RNA-Seq | 669.0 MB |
| H1_ut_nucl_rep1.fastq.gz | RNA-Seq | 773.0 MB |
| H1_ut_nucl_rep2.fastq.gz | RNA-Seq | 922.0 MB |
| H1_ut_total_rep1.fastq.gz | RNA-Seq | 1.1 GB |
| H1_ut_total_rep2.fastq.gz | RNA-Seq | 947.3 MB |
| H9_ESC_cyto_rep1.fastq.gz | RNA-Seq | 461.4 MB |
| H9_ESC_insol_rep1.fastq.gz | RNA-Seq | 519.9 MB |
| H9_ESC_nuclei_rep1.fastq.gz | RNA-Seq | 606.6 MB |
| H9_ESC_total_rep1.fastq.gz | RNA-Seq | 420.6 MB |
| insol_CR463_puro_rep1.fastq.gz | RNA-Seq | 1.2 GB |
| insol_CR463_puro_rep2.fastq.gz | RNA-Seq | 1.3 GB |
| insol_CR463_rec_rep1.fastq.gz | RNA-Seq | 1.9 GB |
| insol_CR463_rec_rep2.fastq.gz | RNA-Seq | 2.9 GB |
| insol_CR463_ut_rep1.fastq.gz | RNA-Seq | 1.7 GB |
| insol_CR463_ut_rep2.fastq.gz | RNA-Seq | 2.0 GB |
| insol_CR464_puro_rep1.fastq.gz | RNA-Seq | 1.8 GB |
| insol_CR464_puro_rep2.fastq.gz | RNA-Seq | 1.2 GB |
| insol_CR464_rec_rep1.fastq.gz | RNA-Seq | 2.5 GB |
| insol_CR464_rec_rep2.fastq.gz | RNA-Seq | 1.4 GB |
| insol_CR464_ut_rep1.fastq.gz | RNA-Seq | 1.0 GB |
| insol_CR464_ut_rep2.fastq.gz | RNA-Seq | 2.0 GB |
| Kin2-4_puro_cyto_rep1.fastq.gz | RNA-Seq | 935.0 MB |
| Kin2-4_puro_cyto_rep2.fastq.gz | RNA-Seq | 920.2 MB |
| Kin2-4_puro_insol_rep1.fastq.gz | RNA-Seq | 934.8 MB |
| Kin2-4_puro_insol_rep2.fastq.gz | RNA-Seq | 1004.7 MB |
| Kin2-4_puro_nucl_rep1.fastq.gz | RNA-Seq | 1.0 GB |
| Kin2-4_puro_nucl_rep2.fastq.gz | RNA-Seq | 814.0 MB |
| Kin2-4_puro_total_rep1.fastq.gz | RNA-Seq | 340.9 MB |
| Kin2-4_puro_total_rep2.fastq.gz | RNA-Seq | 1.1 GB |
| Kin2-4_ut_cyto_rep1.fastq.gz | RNA-Seq | 245.5 MB |
| Kin2-4_ut_cyto_rep2.fastq.gz | RNA-Seq | 802.8 MB |
| Kin2-4_ut_insol_rep1.fastq.gz | RNA-Seq | 903.1 MB |
| Kin2-4_ut_insol_rep2.fastq.gz | RNA-Seq | 789.8 MB |
| Kin2-4_ut_nucl_rep1.fastq.gz | RNA-Seq | 912.8 MB |
| Kin2-4_ut_nucl_rep2.fastq.gz | RNA-Seq | 1.0 GB |
| Kin2-4_ut_total_rep1.fastq.gz | RNA-Seq | 1.1 GB |
| Kin2-4_ut_total_rep2.fastq.gz | RNA-Seq | 817.9 MB |
| nuc_CR463_puro_rep1.fastq.gz | RNA-Seq | 951.7 MB |
| nuc_CR463_puro_rep2.fastq.gz | RNA-Seq | 2.5 GB |
| nuc_CR463_rec_rep1.fastq.gz | RNA-Seq | 645.6 MB |
| nuc_CR463_rec_rep2.fastq.gz | RNA-Seq | 1.1 GB |
| nuc_CR463_ut_rep1.fastq.gz | RNA-Seq | 1.9 GB |
| nuc_CR463_ut_rep2.fastq.gz | RNA-Seq | 1.2 GB |
| nuc_CR464_puro_rep1.fastq.gz | RNA-Seq | 2.3 GB |
| nuc_CR464_puro_rep2.fastq.gz | RNA-Seq | 1.1 GB |
| nuc_CR464_rec_rep1.fastq.gz | RNA-Seq | 1.2 GB |
| nuc_CR464_rec_rep2.fastq.gz | RNA-Seq | 1.3 GB |
| nuc_CR464_ut_rep1.fastq.gz | RNA-Seq | 1.1 GB |
| nuc_CR464_ut_rep2.fastq.gz | RNA-Seq | 1.4 GB |
| SRR12588329_GSM4766652 | RNA-Seq | 286.0 MB |
| SRR12588330_GSM4766653 | RNA-Seq | 503.0 MB |
| SRR12588331_GSM4766654 | RNA-Seq | 528.0 MB |
| SRR12588332_GSM4766655 | RNA-Seq | 584.0 MB |
| SRR12588333_GSM4766656 | RNA-Seq | 393.0 MB |
| SRR12588334_GSM4766657 | RNA-Seq | 653.0 MB |
| SRR12588335_GSM4766658 | RNA-Seq | 1.1 GB |
| SRR12588336_GSM4766659 | RNA-Seq | 613.0 MB |
| SRR12588337_GSM4766660 | RNA-Seq | 1.1 GB |
| SRR12588338_GSM4766661 | RNA-Seq | 1.2 GB |
| SRR12588339_GSM4766662 | RNA-Seq | 1.6 GB |
| SRR12588340_GSM4766663 | RNA-Seq | 1.6 GB |
| SRR12588341_GSM4766664 | RNA-Seq | 1.8 GB |
| SRR12588342_GSM4766665 | RNA-Seq | 1.5 GB |
| SRR12588343_GSM4766666 | RNA-Seq | 2.2 GB |
| SRR12588344_GSM4766667 | RNA-Seq | 1.0 GB |
| SRR12588345_GSM4766668 | RNA-Seq | 1.5 GB |
| SRR12588346_GSM4766669 | RNA-Seq | 1.4 GB |
| SRR12588347_GSM4766670 | RNA-Seq | 1.0 GB |
| SRR12588348_GSM4766671 | RNA-Seq | 876.0 MB |
| SRR12588349_GSM4766672 | RNA-Seq | 343.0 MB |
| SRR12588350_GSM4766673 | RNA-Seq | 455.0 MB |
| SRR12588351_GSM4766674 | RNA-Seq | 575.0 MB |
| SRR12588352_GSM4766675 | RNA-Seq | 562.0 MB |
| SRR12588353_GSM4766676 | RNA-Seq | 418.0 MB |
| SRR12588354_GSM4766677 | RNA-Seq | 528.0 MB |
| SRR12588355_GSM4766678 | RNA-Seq | 467.0 MB |
| SRR12588356_GSM4766679 | RNA-Seq | 494.0 MB |
| SRR12588357_GSM4766680 | RNA-Seq | 732.0 MB |
| SRR12588358_GSM4766681 | RNA-Seq | 1.1 GB |
| SRR12588359_GSM4766682 | RNA-Seq | 680.0 MB |
| SRR12588360_GSM4766683 | RNA-Seq | 391.0 MB |
| SRR12588361_GSM4766684 | RNA-Seq | 929.0 MB |
| SRR12588362_GSM4766685 | RNA-Seq | 1.0 GB |
| SRR12588363_GSM4766686 | RNA-Seq | 828.0 MB |
| SRR12588364_GSM4766687 | RNA-Seq | 958.0 MB |
| SRR12588365_GSM4766688 | RNA-Seq | 774.0 MB |
| SRR12588366_GSM4766689 | RNA-Seq | 720.0 MB |
| SRR12588367_GSM4766690 | RNA-Seq | 962.0 MB |
| SRR12588368_GSM4766691 | RNA-Seq | 982.0 MB |
| SRR12588369_GSM4766692 | RNA-Seq | 256.0 MB |
| SRR12588370_GSM4766693 | RNA-Seq | 813.0 MB |
| SRR12588371_GSM4766694 | RNA-Seq | 996.0 MB |
| SRR12588372_GSM4766695 | RNA-Seq | 929.0 MB |
| SRR12588373_GSM4766696 | RNA-Seq | 179.0 MB |
| SRR12588374_GSM4766697 | RNA-Seq | 826.0 MB |
| SRR12588375_GSM4766698 | RNA-Seq | 1.1 GB |
| SRR12588376_GSM4766699 | RNA-Seq | 668.0 MB |
| SRR12588377_GSM4766700 | RNA-Seq | 773.0 MB |
| SRR12588378_GSM4766701 | RNA-Seq | 921.0 MB |
| SRR12588379_GSM4766702 | RNA-Seq | 1.1 GB |
| SRR12588380_GSM4766703 | RNA-Seq | 947.0 MB |
| SRR12588381_GSM4766704 | RNA-Seq | 461.0 MB |
| SRR12588382_GSM4766705 | RNA-Seq | 519.0 MB |
| SRR12588383_GSM4766706 | RNA-Seq | 606.0 MB |
| SRR12588384_GSM4766707 | RNA-Seq | 420.0 MB |
| SRR12588385_GSM4766708 | RNA-Seq | 1.2 GB |
| SRR12588386_GSM4766709 | RNA-Seq | 1.3 GB |
| SRR12588387_GSM4766710 | RNA-Seq | 1.9 GB |
| SRR12588388_GSM4766711 | RNA-Seq | 2.9 GB |
| SRR12588389_GSM4766712 | RNA-Seq | 1.7 GB |
| SRR12588390_GSM4766713 | RNA-Seq | 2.0 GB |
| SRR12588391_GSM4766714 | RNA-Seq | 1.8 GB |
| SRR12588392_GSM4766715 | RNA-Seq | 1.2 GB |
| SRR12588393_GSM4766716 | RNA-Seq | 2.5 GB |
| SRR12588394_GSM4766717 | RNA-Seq | 1.4 GB |
| SRR12588395_GSM4766718 | RNA-Seq | 1.0 GB |
| SRR12588396_GSM4766719 | RNA-Seq | 2.0 GB |
| SRR12588397_GSM4766720 | RNA-Seq | 934.0 MB |
| SRR12588398_GSM4766721 | RNA-Seq | 920.0 MB |
| SRR12588399_GSM4766722 | RNA-Seq | 934.0 MB |
| SRR12588400_GSM4766723 | RNA-Seq | 1004.0 MB |
| SRR12588401_GSM4766724 | RNA-Seq | 1.0 GB |
| SRR12588402_GSM4766725 | RNA-Seq | 814.0 MB |
| SRR12588403_GSM4766726 | RNA-Seq | 340.0 MB |
| SRR12588404_GSM4766727 | RNA-Seq | 1.0 GB |
| SRR12588405_GSM4766728 | RNA-Seq | 245.0 MB |
| SRR12588406_GSM4766729 | RNA-Seq | 802.0 MB |
| SRR12588407_GSM4766730 | RNA-Seq | 903.0 MB |
| SRR12588408_GSM4766731 | RNA-Seq | 789.0 MB |
| SRR12588409_GSM4766732 | RNA-Seq | 912.0 MB |
| SRR12588410_GSM4766733 | RNA-Seq | 1.0 GB |
| SRR12588411_GSM4766734 | RNA-Seq | 1.1 GB |
| SRR12588412_GSM4766735 | RNA-Seq | 817.0 MB |
| SRR12588413_GSM4766736 | RNA-Seq | 951.0 MB |
| SRR12588414_GSM4766737 | RNA-Seq | 2.5 GB |
| SRR12588415_GSM4766738 | RNA-Seq | 645.0 MB |
| SRR12588416_GSM4766739 | RNA-Seq | 1.1 GB |
| SRR12588417_GSM4766740 | RNA-Seq | 1.9 GB |
| SRR12588418_GSM4766741 | RNA-Seq | 1.2 GB |
| SRR12588419_GSM4766742 | RNA-Seq | 2.3 GB |
| SRR12588420_GSM4766743 | RNA-Seq | 1.1 GB |
| SRR12588421_GSM4766744 | RNA-Seq | 1.2 GB |
| SRR12588422_GSM4766745 | RNA-Seq | 1.3 GB |
| SRR12588423_GSM4766746 | RNA-Seq | 1.1 GB |
| SRR12588424_GSM4766747 | RNA-Seq | 1.4 GB |
| SRR12588425_GSM4766748 | RNA-Seq | 1.9 GB |
| SRR12588426_GSM4766749 | RNA-Seq | 1.1 GB |
| SRR12588427_GSM4766750 | RNA-Seq | 1.2 GB |
| SRR12588428_GSM4766751 | RNA-Seq | 2.2 GB |
| SRR12588429_GSM4766752 | RNA-Seq | 1.9 GB |
| SRR12588430_GSM4766753 | RNA-Seq | 2.0 GB |
| SRR12588431_GSM4766754 | RNA-Seq | 1.1 GB |
| SRR12588432_GSM4766755 | RNA-Seq | 1.2 GB |
| SRR12588433_GSM4766756 | RNA-Seq | 1.5 GB |
| SRR12588434_GSM4766757 | RNA-Seq | 1.3 GB |
| SRR12588435_GSM4766758 | RNA-Seq | 1.9 GB |
| SRR12588436_GSM4766759 | RNA-Seq | 1.7 GB |
| SRR12588437_GSM4766760 | RIP-Seq | 805.0 MB |
| SRR12588438_GSM4766761 | RIP-Seq | 610.0 MB |
| SRR12588439_GSM4766762 | RIP-Seq | 2.0 GB |
| SRR12588440_GSM4766763 | RIP-Seq | 2.7 GB |
| SRR12588441_GSM4766764 | RIP-Seq | 622.0 MB |
| SRR12588442_GSM4766765 | RIP-Seq | 789.0 MB |
| SRR12588443_GSM4766766 | RIP-Seq | 1.4 GB |
| SRR12588444_GSM4766767 | RIP-Seq | 1.6 GB |
| SRR12588445_GSM4766768 | RIP-Seq | 1.5 GB |
| SRR12588446_GSM4766769 | RIP-Seq | 2.1 GB |
| SRR12588447_GSM4766770 | RIP-Seq | 1.2 GB |
| SRR12588448_GSM4766771 | RIP-Seq | 2.0 GB |
| SRR12588449_GSM4766772 | RIP-Seq | 1.8 GB |
| SRR12588450_GSM4766773 | RIP-Seq | 1.6 GB |
| SRR12588451_GSM4766774 | RIP-Seq | 1.7 GB |
| SRR12588452_GSM4766775 | RIP-Seq | 1.8 GB |
| SRR12588453_GSM4766776 | RIP-Seq | 2.3 GB |
| SRR12588454_GSM4766777 | RIP-Seq | 2.1 GB |
| SRR12588455_GSM4766778 | RIP-Seq | 2.8 GB |
| SRR12588456_GSM4766779 | RIP-Seq | 2.3 GB |
| SRR12588457_GSM4766780 | RIP-Seq | 6.1 GB |
| SRR12588458_GSM4766781 | RIP-Seq | 6.9 GB |
| TIA1_MN_input_rep1_R1.fastq.gz | RIP-Seq | 2.3 GB |
| TIA1_MN_input_rep2_R1.fastq.gz | RIP-Seq | 2.1 GB |
| TIA1_MN_IP_rep1_R1.fastq.gz | RIP-Seq | 2.8 GB |
| TIA1_MN_IP_rep2_R1.fastq.gz | RIP-Seq | 2.3 GB |
| TIA1_Stressed_MN_input_rep1_R1.fastq.gz | RIP-Seq | 6.1 GB |
| TIA1_Stressed_MN_IP_rep1_R1.fastq.gz | RIP-Seq | 6.9 GB |
| total_CR463_puro_rep1.fastq.gz | RNA-Seq | 1.9 GB |
| total_CR463_puro_rep2.fastq.gz | RNA-Seq | 1.1 GB |
| total_CR463_rec_rep1.fastq.gz | RNA-Seq | 1.2 GB |
| total_CR463_rec_rep2.fastq.gz | RNA-Seq | 2.2 GB |
| total_CR463_ut_rep1.fastq.gz | RNA-Seq | 1.9 GB |
| total_CR463_ut_rep2.fastq.gz | RNA-Seq | 2.0 GB |
| total_CR464_puro_rep1.fastq.gz | RNA-Seq | 1.1 GB |
| total_CR464_puro_rep2.fastq.gz | RNA-Seq | 1.2 GB |
| total_CR464_rec_rep1.fastq.gz | RNA-Seq | 1.5 GB |
| total_CR464_rec_rep2.fastq.gz | RNA-Seq | 1.3 GB |
| total_CR464_ut_rep1.fastq.gz | RNA-Seq | 1.9 GB |
| total_CR464_ut_rep2.fastq.gz | RNA-Seq | 1.7 GB |
Potentially related datasets 1
These accessions were text-mined from the PMC full text. They may be referenced for comparison, cited from other studies, or otherwise mentioned without being primary data for this paper.
Analysis pipelines 1
| Pipeline | Assay | Steps | Dataset |
|---|---|---|---|
| GSE157467 Data Processing geo_data_processing | — | 6 | GSE157467 |
Funding 4 grants
| Grant | Funder |
|---|---|
| R01 HG004659 | NHGRI NIH HHS (United States) |
| P01 AG054407 | NIA NIH HHS (United States) |
| RF1 AG058476 | NIA NIH HHS (United States) |
| U54 NS091046 | NINDS NIH HHS (United States) |