Search publications
2 results for “Cas13”
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Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans.
Nature medicine · 2022 · 28(7): 1372-1376
RNA-guided RNA-targeting nucleases, such as CRISPR-Cas13 proteins, have therapeutic potential for gene editing. Among Cas13d enzymes, Cas13d from the bacteria Ruminococcus flavefaciens (RfxCas13d) is of particular interest owing to its small size and high specificity. However, the existence of pre-existing …
PMID 35668177 DOI ↗
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Evaluation of Engineered CRISPR-Cas-Mediated Systems for Site-Specific RNA Editing.
Cell reports · 2020 · 33(5): 108350
Site-directed RNA editing approaches offer great potential to correct genetic mutations in somatic cells while avoiding permanent off-target genomic edits. Nuclease-dead RNA-targeting CRISPR-Cas systems recruit functional effectors to RNA molecules in a programmable fashion. Here, we demonstrate a Streptococcus pyogenes …
PMID 33147453 DOI ↗
Datasets 5
RNA-Targeting CRISPR/Cas13d System Alleviates Disease-Related Phenotypes in Pre-clinical Models of Huntingtonâs Disease (Human).
Homo sapiens · GPL18573
RNA-Targeting CRISPR/Cas13d System Alleviates Disease-Related Phenotypes in Pre-clinical Models of Huntingtonâs Disease
Mus musculus · GPL18573
A phage nucleus-associated RNA-binding protein required for jumbo phage infection
287 · GPL24583
Discovery and evaluation of CRISPR/Cas-mediated systems for site-specific RNA editing
Homo sapiens · GPL20301
RNA-Targeting CRISPR/Cas13d System Alleviates Disease-Related Phenotypes in Pre-clinical Models of Huntingtonâs Disease (Mouse).
Mus musculus · GPL19057
Analyses 3
GSE214108 · 3 steps · RNA-Seq · code_examples
An RNA-targeting CRISPR-Cas13d system alleviates disease-related phenotypes in Huntington's disease models. (2023)
GSE214109 · 5 steps · RNA-Seq · code_examples
An RNA-targeting CRISPR-Cas13d system alleviates disease-related phenotypes in Huntington's disease models. (2023)
GSE214110 · 3 steps · GSE · code_examples
An RNA-targeting CRISPR-Cas13d system alleviates disease-related phenotypes in Huntington's disease models. (2023)