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3 results for “LIN28”

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  1. Non-microRNA binding competitively inhibits LIN28 regulation.

    Cell reports · 2021 · 36(6): 109517

    RNA binding protein (RBP) expression is finite. For RBPs that are vastly outnumbered by their potential target sites, a simple competition for binding can set the magnitude of post-transcriptional control. Here, we show that LIN28, best known for its direct …

    PMID 34380031 DOI ↗

  2. A Transcriptome-wide Translational Program Defined by LIN28B Expression Level.

    Molecular cell · 2019 · 73(2): 304-313.e3

    LIN28 RNA binding proteins are dynamically expressed throughout mammalian development and during disease. However, it remains unclear how changes in LIN28 expression define patterns of post-transcriptional gene regulation. Here we show that LIN28 expression level is a key variable that …

    PMID 30527666 DOI ↗

  3. LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance.

    Molecular cell · 2012 · 48(2): 195-206

    LIN28 is a conserved RNA-binding protein implicated in pluripotency, reprogramming, and oncogenesis. It was previously shown to act primarily by blocking let-7 microRNA (miRNA) biogenesis, but here we elucidate distinct roles of LIN28 regulation via its direct messenger RNA (mRNA) …

    PMID 22959275 DOI ↗

Datasets 13

ENCSR598YQX ENCSR · ENCODE

RNA-seq on K562 cells treated with an shRNA knockdown against LIN28B. (LIN28B_BGKLV21)

Homo sapiens

ENCSR746ZSV ENCSR · ENCODE

eCLIP control experiment on HepG2 against LIN28B

Homo sapiens

ENCSR861GYE ENCSR · ENCODE

eCLIP experiment on HepG2 against Lin28B

Homo sapiens

ENCSR970NKP ENCSR · ENCODE

eCLIP experiment on K562 against Lin28B

Homo sapiens

ENCSR927SLP ENCSR · ENCODE

shRNA knockdown against LIN28B in HepG2 cells followed by RNA-seq. (LIN28B_BGHLV18)

Homo sapiens

ENCSR399CBP ENCSR · ENCODE

eCLIP control experiment on K562 against LIN28B

Homo sapiens

ENCSR094HGB ENCSR · ENCODE

RNA Bind-n-Seq (RBNS) input control experiment of LIN28B

ENCSR369RLA ENCSR · ENCODE

RNA Bind-n-Seq (RBNS) pulldown experiment against LIN28B

GSE109423 GSE · GEO

A transcriptome-wide divergence in protein translation scales with LIN28B expression

Mus musculus · GPL20301

GSE39855 GSE · GEO

LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance (splicing array)

Homo sapiens · GPL15106

GSE39873 GSE · GEO

LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance

Homo sapiens · GPL9052

GSE178259 GSE · GEO

Non-microRNA Binding Competitively Inhibits LIN28 Regulation

Mus musculus · GPL20301

GSE39872 GSE · GEO

LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance (HTS)

Homo sapiens · GPL9052

Analyses 5

GSE178259 Processing Pipeline

GSE178259 · 6 steps · RNA-Seq · code_examples

Non-microRNA binding competitively inhibits LIN28 regulation. (2021)

GSE109423 Processing Pipeline

GSE109423 · 6 steps · RNA-Seq · code_examples

A Transcriptome-wide Translational Program Defined by LIN28B Expression Level. (2019)

GSE39855 Processing Pipeline

GSE39855 · 3 steps · GSE · code_examples

LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance. (2012)

GSE39872 Processing Pipeline

GSE39872 · 3 steps · RNA-Seq · code_examples

LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance. (2012)

GSE39873 Processing Pipeline

GSE39873 · 3 steps · GSE · code_examples

LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance. (2012)