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11 results for “Prevalence”

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  1. Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission.

    Nature · 2022 · 609(7925): 101-108

    As SARS-CoV-2 continues to spread and evolve, detecting emerging variants early is critical for public health interventions. Inferring lineage prevalence by clinical testing is infeasible at scale, especially in areas with limited resources, participation, or testing and/or sequencing capacity, which …

    PMID 35798029 DOI ↗

  2. Wastewater sequencing uncovers early, cryptic SARS-CoV-2 variant transmission.

    medRxiv : the preprint server for health sciences · 2022

    As SARS-CoV-2 continues to spread and evolve, detecting emerging variants early is critical for public health interventions. Inferring lineage prevalence by clinical testing is infeasible at scale, especially in areas with limited resources, participation, or testing/sequencing capacity, which can also …

    PMID 35411350 DOI ↗

  3. Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing.

    Molecular cell · 2022 · 82(3): 645-659.e9

    Pseudouridine is a modified nucleotide that is prevalent in human mRNAs and is dynamically regulated. Here, we investigate when in their life cycle mRNAs become pseudouridylated to illuminate the potential regulatory functions of endogenous mRNA pseudouridylation. Using single-nucleotide resolution pseudouridine …

    PMID 35051350 DOI ↗

  4. Emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States.

    Cell · 2021 · 184(10): 2587-2594.e7

    The highly transmissible B.1.1.7 variant of SARS-CoV-2, first identified in the United Kingdom, has gained a foothold across the world. Using S gene target failure (SGTF) and SARS-CoV-2 genomic sequencing, we investigated the prevalence and dynamics of this variant in …

    PMID 33861950 DOI ↗

  5. Genomic epidemiology identifies emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States.

    medRxiv : the preprint server for health sciences · 2021

    As of January of 2021, the highly transmissible B.1.1.7 variant of SARS-CoV-2, which was first identified in the United Kingdom (U.K.), has gained a strong foothold across the world. Because of the sudden and rapid rise of B.1.1.7, we investigated …

    PMID 33564780 DOI ↗

  6. Transcriptome-wide profiles of circular RNA and RNA-binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression.

    Genome medicine · 2020 · 12(1): 112

    Circular RNAs (circRNAs) are stable, often highly expressed RNA transcripts with potential to modulate other regulatory RNAs. A few circRNAs have been shown to bind RNA-binding proteins (RBPs); however, little is known about the prevalence and distribution of these interactions …

    PMID 33287884 DOI ↗

  7. Context-dependent functional compensation between Ythdf m<sup>6</sup>A reader proteins.

    Genes & development · 2020 · 34(19-20): 1373-1391

    The N6-methyladenosine (m<sup>6</sup>A) modification is the most prevalent post-transcriptional mRNA modification, regulating mRNA decay and splicing. It plays a major role during normal development, differentiation, and disease progression. The modification is regulated by a set of writer, eraser, and reader …

    PMID 32943573 DOI ↗

  8. Systematic review of dementia prevalence and incidence in United States race/ethnic populations.

    Alzheimer's & dementia : the journal of the Alzheimer's Association · 2017 · 13(1): 72-83

    To identify incidence and prevalence of dementia in racial and ethnic populations in the United States. A systematic review of literature. A total of 1215 studies were reviewed; 114 were included. Dementia prevalence rates reported for age 65+ years from …

    PMID 27599209 DOI ↗

  9. Pairing beyond the Seed Supports MicroRNA Targeting Specificity.

    Molecular cell · 2016 · 64(2): 320-333

    To identify endogenous miRNA-target sites, we isolated AGO-bound RNAs from Caenorhabditis elegans by individual-nucleotide resolution crosslinking immunoprecipitation (iCLIP), which fortuitously also produced miRNA-target chimeric reads. Through the analysis of thousands of reproducible chimeras, pairing to the miRNA seed emerged as …

    PMID 27720646 DOI ↗

  10. Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity.

    Molecular cell · 2015 · 59(3): 413-25

    RNA quality-control pathways get rid of faulty RNAs and therefore must be able to discriminate these RNAs from those that are normal. Here we present evidence that the adenosine triphosphatase (ATPase) cycle of the SF1 helicase Upf1 is required for …

    PMID 26253027 DOI ↗

  11. Human cytomegalovirus infection of human embryonic stem cell-derived primitive neural stem cells is restricted at several steps but leads to the persistence of viral DNA.

    Journal of virology · 2014 · 88(8): 4021-39

    Congenital human cytomegalovirus (HCMV) infection is a major cause of central nervous system structural anomalies and sensory impairments. It is likely that the stage of fetal development, as well as the state of differentiation of susceptible cells at the time …

    PMID 24453373 DOI ↗

Datasets 2

GSE69585 GSE · GEO

Target discrimination in nonsense-mediated mRNA decay requires Upf1 ATPase activity (RIP-Seq)

Homo sapiens · GPL11154

GSE69584 GSE · GEO

Target discrimination in nonsense-mediated mRNA decay requires Upf1 ATPase activity (CLIP-Seq)

Homo sapiens · GPL11154

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