Search publications
3 results for “SF3B1”
-
Proteomic discovery of chemical probes that perturb protein complexes in human cells.
Molecular cell · 2023 · 83(10): 1725-1742.e12
Most human proteins lack chemical probes, and several large-scale and generalizable small-molecule binding assays have been introduced to address this problem. How compounds discovered in such "binding-first" assays affect protein function, nonetheless, often remains unclear. Here, we describe a "function-first" …
PMID 37084731 DOI ↗
-
An important class of intron retention events in human erythroblasts is regulated by cryptic exons proposed to function as splicing decoys.
RNA (New York, N.Y.) · 2018 · 24(9): 1255-1265
During terminal erythropoiesis, the splicing machinery in differentiating erythroblasts executes a robust intron retention (IR) program that impacts expression of hundreds of genes. We studied IR mechanisms in the <i>SF3B1</i> splicing factor gene, which expresses ∼50% of its transcripts in …
PMID 29959282 DOI ↗
-
Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer.
Cancer discovery · 2017 · 7(4): 410-423
Recent studies have characterized the extensive somatic alterations that arise during cancer. However, the somatic evolution of a tumor may be significantly affected by inherited polymorphisms carried in the germline. Here, we analyze genomic data for 5,954 tumors to reveal …
PMID 28188128 DOI ↗
Datasets 9
RNA-seq on HepG2 cells treated with an shRNA knockdown against SF3B1. (SF3B1_BGHLV35)
Homo sapiens
RNA-seq on K562 cells treated with an shRNA knockdown against SF3B1. (SF3B1_BGKLV36)
Homo sapiens
RNA-seq on K562 cells treated with a CRISPR gRNA against SF3B1. (SF3B1-BGKcLV11)
Homo sapiens
RNA sequencing of bone marrow CD34+ hematopoietic stem and progenitor cells from patients with myelodysplastic syndrome and healthy controls
Homo sapiens · GPL20301
Proteomic discovery of chemical probes that perturb protein complexes in human cells
Homo sapiens · GPL24676
Proteomic discovery of chemical probes that perturb protein complexes in human cells II
Homo sapiens · GPL18573
Analyses 0
No analyses match this query.