Search publications

6 results for “T lymphocytes”

Clear

  1. Early precursors and molecular determinants of tissue-resident memory CD8<sup>+</sup> T lymphocytes revealed by single-cell RNA sequencing.

    Science immunology · 2020 · 5(47)

    During an immune response to microbial infection, CD8<sup>+</sup> T cells give rise to distinct classes of cellular progeny that coordinately mediate clearance of the pathogen and provide long-lasting protection against reinfection, including a subset of noncirculating tissue-resident memory (T<sub>RM</sub>) cells …

    PMID 32414833 DOI ↗

  2. Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease.

    Cell stem cell · 2019 · 24(6): 1006

    PMID 31173705 DOI ↗

  3. Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease.

    Cell stem cell · 2018 · 23(1): 123-131.e6

    Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive degeneration of midbrain neurons (MBNs). Recent evidence suggests contribution of the adaptive immune system in PD. Here, we show a role for human T lymphocytes as cell death inducers …

    PMID 29979986 DOI ↗

  4. Early transcriptional and epigenetic regulation of CD8<sup>+</sup> T cell differentiation revealed by single-cell RNA sequencing.

    Nature immunology · 2017 · 18(4): 422-432

    During microbial infection, responding CD8<sup>+</sup> T lymphocytes differentiate into heterogeneous subsets that together provide immediate and durable protection. To elucidate the dynamic transcriptional changes that underlie this process, we applied a single-cell RNA-sequencing approach and analyzed individual CD8<sup>+</sup> T lymphocytes …

    PMID 28218746 DOI ↗

  5. Regulation of asymmetric division and CD8+ T lymphocyte fate specification by protein kinase Cζ and protein kinase Cλ/ι.

    Journal of immunology (Baltimore, Md. : 1950) · 2015 · 194(5): 2249-59

    During an immune response against a microbial pathogen, activated naive T lymphocytes give rise to effector cells that provide acute host defense and memory cells that provide long-lived immunity. It has been shown that T lymphocytes can undergo asymmetric division, …

    PMID 25617472 DOI ↗

  6. Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses.

    Nature immunology · 2014 · 15(4): 365-372

    T lymphocytes responding to microbial infection give rise to effector cells that mediate acute host defense and memory cells that provide long-lived immunity, but the fundamental question of when and how these cells arise remains unresolved. Here we combined single-cell …

    PMID 24584088 DOI ↗

Datasets 4

GSE157072 GSE · GEO

RNA-Seq of CD8+ T cell subsets during LCMV infection III

Mus musculus · GPL17021

GSE131847 GSE · GEO

Molecular determinants and heterogeneity of circulating and tissue-resident memory CD8+ T lymphocytes revealed by single-cell RNA sequencing

Mus musculus · GPL21103

GSE89405 GSE · GEO

Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA-seq

Mus musculus · GPL17021

GSE54321 GSE · GEO

Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene expression analyses

Mus musculus · GPL18198

Analyses 1

GSE131847 Processing Pipeline

GSE131847 · 5 steps · RNA-Seq · code_examples

Early precursors and molecular determinants of tissue-resident memory CD8<sup>+</sup> T lymphocytes revealed by single-cell RNA sequencing. (2020)