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8 results for “cell division”

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  1. Early transcriptional and epigenetic divergence of CD8+ T cells responding to acute versus chronic infection.

    PLoS biology · 2023 · 21(1): e3001983

    During a microbial infection, responding CD8+ T cells give rise to effector cells that provide acute host defense and memory cells that provide sustained protection. An alternative outcome is exhaustion, a state of T cell dysfunction that occurs in the …

    PMID 36716323 DOI ↗

  2. RNA binding protein DDX5 directs tuft cell specification and function to regulate microbial repertoire and disease susceptibility in the intestine.

    Gut · 2022 · 71(9): 1790-1802

    Tuft cells residing in the intestinal epithelium have diverse functions. In the small intestine, they provide protection against inflammation, combat against helminth and protist infections, and serve as entry portals for enteroviruses. In the colon, they had been implicated in …

    PMID 34853057 DOI ↗

  3. Early transcriptional and epigenetic regulation of CD8<sup>+</sup> T cell differentiation revealed by single-cell RNA sequencing.

    Nature immunology · 2017 · 18(4): 422-432

    During microbial infection, responding CD8<sup>+</sup> T lymphocytes differentiate into heterogeneous subsets that together provide immediate and durable protection. To elucidate the dynamic transcriptional changes that underlie this process, we applied a single-cell RNA-sequencing approach and analyzed individual CD8<sup>+</sup> T lymphocytes …

    PMID 28218746 DOI ↗

  4. A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions.

    Cell · 2016 · 165(2): 396-409

    Multiple division cycles without growth are a characteristic feature of early embryogenesis. The female germline loads proteins and RNAs into oocytes to support these divisions, which lack many quality control mechanisms operating in somatic cells undergoing growth. Here, we describe …

    PMID 27020753 DOI ↗

  5. Reply to: "CD8(+) T cell diversification by asymmetric cell division".

    Nature immunology · 2015 · 16(9): 893-4

    PMID 26287585 DOI ↗

  6. Regulation of asymmetric division and CD8+ T lymphocyte fate specification by protein kinase Cζ and protein kinase Cλ/ι.

    Journal of immunology (Baltimore, Md. : 1950) · 2015 · 194(5): 2249-59

    During an immune response against a microbial pathogen, activated naive T lymphocytes give rise to effector cells that provide acute host defense and memory cells that provide long-lived immunity. It has been shown that T lymphocytes can undergo asymmetric division, …

    PMID 25617472 DOI ↗

  7. Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses.

    Nature immunology · 2014 · 15(4): 365-372

    T lymphocytes responding to microbial infection give rise to effector cells that mediate acute host defense and memory cells that provide long-lived immunity, but the fundamental question of when and how these cells arise remains unresolved. Here we combined single-cell …

    PMID 24584088 DOI ↗

  8. Functional genomic analysis of the let-7 regulatory network in Caenorhabditis elegans.

    PLoS genetics · 2013 · 9(3): e1003353

    The let-7 microRNA (miRNA) regulates cellular differentiation across many animal species. Loss of let-7 activity causes abnormal development in Caenorhabditis elegans and unchecked cellular proliferation in human cells, which contributes to tumorigenesis. These defects are due to improper expression of …

    PMID 23516374 DOI ↗

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