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4 results for “cysteine”

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  1. ESCAPE: assigning site-specific activity to covalent ligands in cells by prime editing.

    bioRxiv : the preprint server for biology · 2026

    Chemical proteomics has identified covalent ligands targeting cysteine residues across many hundreds of human proteins. The functional effects of these liganding events, however, remain challenging to assign at scale. Here we describe ESCAPE (Endogenous Site-specific Competition Assays using Prime Editors), …

    PMID 42619774 DOI ↗

  2. Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO.

    Cell chemical biology · 2026 · 33(2): 256-267.e11

    RNA-binding proteins (RBPs) play important roles in mRNA transcription, processing, and translation. Chemical tools are lacking for RBPs, which has hindered efforts to perturb and understand RBP function in cells. We previously described a chloroacetamide compound (R)-SKBG-1 that covalently binds …

    PMID 41534524 DOI ↗

  3. Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO.

    bioRxiv : the preprint server for biology · 2025

    RNA-binding proteins (RBPs) play important roles in mRNA transcription, processing, and translation. Chemical tools are lacking for RBPs, which has hindered efforts to perturb and understand RBP function in cells. We recently reported a chloroacetamide compound ( <i>R</i> )-SKBG-1 that …

    PMID 40661397 DOI ↗

  4. Proteomic discovery of chemical probes that perturb protein complexes in human cells.

    Molecular cell · 2023 · 83(10): 1725-1742.e12

    Most human proteins lack chemical probes, and several large-scale and generalizable small-molecule binding assays have been introduced to address this problem. How compounds discovered in such "binding-first" assays affect protein function, nonetheless, often remains unclear. Here, we describe a "function-first" …

    PMID 37084731 DOI ↗

Datasets 5

GSE220185 GSE · GEO

Proteomic discovery of chemical probes that perturb protein complexes in human cells

Homo sapiens · GPL24676

GSE220845 GSE · GEO

Proteomic discovery of chemical probes that perturb protein complexes in human cells II

Homo sapiens · GPL18573

GSE198212 GSE · GEO

Remodeling of oncogenic transcriptomes by small-molecules targeting the RNA-binding protein NONO

Homo sapiens · GPL24676

GSE206674 GSE · GEO

SerRS mediates translational readthrough of through engagement of the selenocysteine incorporation machinery

Homo sapiens · GPL30173

GSE230349 GSE · GEO

Seryl-tRNA synthetase promotes translational readthrough via mRNA binding by involving the selenocysteine incorporation machinery

Homo sapiens · GPL20301

Analyses 2

GSE206674 eCLIP Data Processing

GSE206674 · 10 steps · eCLIP · geo_data_processing

Seryl-tRNA synthetase promotes translational readthrough by mRNA binding and involvement of the selenocysteine incorporation machinery. (2023)

GSE230349 Processing Pipeline

GSE230349 · 8 steps · OTHER · code_examples

Seryl-tRNA synthetase promotes translational readthrough by mRNA binding and involvement of the selenocysteine incorporation machinery. (2023)