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5 results for “germline”

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  1. Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer.

    Cancer discovery · 2017 · 7(4): 410-423

    Recent studies have characterized the extensive somatic alterations that arise during cancer. However, the somatic evolution of a tumor may be significantly affected by inherited polymorphisms carried in the germline. Here, we analyze genomic data for 5,954 tumors to reveal …

    PMID 28188128 DOI ↗

  2. A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions.

    Cell · 2016 · 165(2): 396-409

    Multiple division cycles without growth are a characteristic feature of early embryogenesis. The female germline loads proteins and RNAs into oocytes to support these divisions, which lack many quality control mechanisms operating in somatic cells undergoing growth. Here, we describe …

    PMID 27020753 DOI ↗

  3. Differential L1 regulation in pluripotent stem cells of humans and apes.

    Nature · 2013 · 503(7477): 525-529

    Identifying cellular and molecular differences between human and non-human primates (NHPs) is essential to the basic understanding of the evolution and diversity of our own species. Until now, preserved tissues have been the main source for most comparative studies between …

    PMID 24153179 DOI ↗

  4. Retrotransposon long interspersed nucleotide element-1 (LINE-1) is activated during salamander limb regeneration.

    Development, growth & differentiation · 2012 · 54(7): 673-85

    Salamanders possess an extraordinary capacity for tissue and organ regeneration when compared to mammals. In our effort to characterize the unique transcriptional fingerprint emerging during the early phase of salamander limb regeneration, we identified transcriptional activation of some germline-specific genes …

    PMID 22913491 DOI ↗

  5. The PIWI proteins SMEDWI-2 and SMEDWI-3 are required for stem cell function and piRNA expression in planarians.

    RNA (New York, N.Y.) · 2008 · 14(6): 1174-86

    PIWI proteins are expressed in germ cells in a wide variety of metazoans, where they participate in the synthesis and function of a novel class of small RNAs called PIWI associated RNAs (piRNAs). One function of piRNAs is to preserve …

    PMID 18456843 DOI ↗

Datasets 4

GSE134971 GSE · GEO

An In Vivo Genome-Wide CRISPR Screen Identifies the RNA-Binding Protein Staufen2 as a Key Regulator of Myeloid Leukemia

Homo sapiens · GPL16791

GSE87211 GSE · GEO

Colorectal cancer susceptibility loci as predictive markers of rectal cancer prognosis after surgery

Homo sapiens · GPL13497

GSE75128 GSE · GEO

A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions

6239 · GPL18245

GSE47626 GSE · GEO

Differential LINE-1 retrotransposition in induced pluripotent stem cells between humans and great apes

9598 · GPL11154

Analyses 1

GSE75128 Processing Pipeline

GSE75128 · 7 steps · RNA-Seq · code_examples

A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions. (2016)