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20 results for “microRNA”

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  1. High-resolution mapping of CCR4-NOT recruitment elements reveals transcriptome-wide drivers of mRNA decay.

    Cell reports · 2026 · 45(5): 117348

    The CCR4-NOT complex is a central regulator of gene expression, orchestrating mRNA turnover through interactions with RNA-binding proteins (RBPs) and the microRNA (miRNA)-induced silencing complex. However, identifying which RBP- and miRNA-associated RNA elements recruit CCR4-NOT remains challenging, due in part …

    PMID 42154591 DOI ↗

  2. Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML.

    Cell reports · 2022 · 38(10): 110481

    Gene expression profiling and proteome analysis of normal and malignant hematopoietic stem cells (HSCs) point to shared core stemness properties. However, discordance between mRNA and protein signatures highlights an important role for post-transcriptional regulation by microRNAs (miRNAs) in governing this …

    PMID 35263585 DOI ↗

  3. Non-microRNA binding competitively inhibits LIN28 regulation.

    Cell reports · 2021 · 36(6): 109517

    RNA binding protein (RBP) expression is finite. For RBPs that are vastly outnumbered by their potential target sites, a simple competition for binding can set the magnitude of post-transcriptional control. Here, we show that LIN28, best known for its direct …

    PMID 34380031 DOI ↗

  4. Suppression of Endothelial AGO1 Promotes Adipose Tissue Browning and Improves Metabolic Dysfunction.

    Circulation · 2020 · 142(4): 365-379

    Metabolic disorders such as obesity and diabetes mellitus can cause dysfunction of endothelial cells (ECs) and vascular rarefaction in adipose tissues. However, the modulatory role of ECs in adipose tissue function is not fully understood. Other than vascular endothelial growth …

    PMID 32393053 DOI ↗

  5. A Transcriptome-wide Translational Program Defined by LIN28B Expression Level.

    Molecular cell · 2019 · 73(2): 304-313.e3

    LIN28 RNA binding proteins are dynamically expressed throughout mammalian development and during disease. However, it remains unclear how changes in LIN28 expression define patterns of post-transcriptional gene regulation. Here we show that LIN28 expression level is a key variable that …

    PMID 30527666 DOI ↗

  6. Systematic Discovery of RNA Binding Proteins that Regulate MicroRNA Levels.

    Molecular cell · 2018 · 69(6): 1005-1016.e7

    RNA binding proteins (RBPs) interact with primary, precursor, and mature microRNAs (miRs) to influence mature miR levels, which in turn affect critical aspects of human development and disease. To understand how RBPs contribute to miR biogenesis, we analyzed human enhanced …

    PMID 29547715 DOI ↗

  7. NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing.

    Nature structural & molecular biology · 2017 · 24(10): 816-824

    MicroRNA (miRNA) biogenesis is known to be modulated by a variety of RNA-binding proteins (RBPs), but in most cases, individual RBPs appear to influence the processing of a small subset of target miRNAs. Here, we report that the RNA-binding NONO-PSF …

    PMID 28846091 DOI ↗

  8. MicroRNA-101 Regulates Multiple Developmental Programs to Constrain Excitation in Adult Neural Networks.

    Neuron · 2016 · 92(6): 1337-1351

    A critical feature of neural networks is that they balance excitation and inhibition to prevent pathological dysfunction. How this is achieved is largely unknown, although deficits in the balance contribute to many neurological disorders. We show here that a microRNA …

    PMID 27939580 DOI ↗

  9. Pairing beyond the Seed Supports MicroRNA Targeting Specificity.

    Molecular cell · 2016 · 64(2): 320-333

    To identify endogenous miRNA-target sites, we isolated AGO-bound RNAs from Caenorhabditis elegans by individual-nucleotide resolution crosslinking immunoprecipitation (iCLIP), which fortuitously also produced miRNA-target chimeric reads. Through the analysis of thousands of reproducible chimeras, pairing to the miRNA seed emerged as …

    PMID 27720646 DOI ↗

  10. The Period protein homolog LIN-42 negatively regulates microRNA biogenesis in C. elegans.

    Developmental biology · 2014 · 390(2): 126-35

    MicroRNAs (miRNAs) are small RNAs that post-transcriptionally regulate gene expression in many multicellular organisms. They are encoded in the genome and transcribed into primary (pri-) miRNAs before two processing steps that ultimately produce the mature miRNA. In order to generate …

    PMID 24699545 DOI ↗

  11. Functional genomic analysis of the let-7 regulatory network in Caenorhabditis elegans.

    PLoS genetics · 2013 · 9(3): e1003353

    The let-7 microRNA (miRNA) regulates cellular differentiation across many animal species. Loss of let-7 activity causes abnormal development in Caenorhabditis elegans and unchecked cellular proliferation in human cells, which contributes to tumorigenesis. These defects are due to improper expression of …

    PMID 23516374 DOI ↗

  12. LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance.

    Molecular cell · 2012 · 48(2): 195-206

    LIN28 is a conserved RNA-binding protein implicated in pluripotency, reprogramming, and oncogenesis. It was previously shown to act primarily by blocking let-7 microRNA (miRNA) biogenesis, but here we elucidate distinct roles of LIN28 regulation via its direct messenger RNA (mRNA) …

    PMID 22959275 DOI ↗

  13. High-resolution profiling and analysis of viral and host small RNAs during human cytomegalovirus infection.

    Journal of virology · 2012 · 86(1): 226-35

    Human cytomegalovirus (HCMV) contributes its own set of microRNAs (miRNAs) during lytic infection of cells, likely fine-tuning conditions important for viral replication. To enhance our understanding of this component of the HCMV-host transcriptome, we have conducted deep-sequencing analysis of small …

    PMID 22013051 DOI ↗

  14. Genome-wide approaches in the study of microRNA biology.

    Wiley interdisciplinary reviews. Systems biology and medicine · 2011 · 3(5): 491-512

    MicroRNAs (miRNAs), a class of ∼21-23 nucleotide long non-coding RNAs (ncRNAs), have critical roles in diverse biological processes that encompass development, proliferation, apoptosis, stress response, and fat metabolism. miRNAs recognize their target mRNA transcripts by partial sequence complementarity and collectively …

    PMID 21197653 DOI ↗

  15. Comprehensive identification of miRNA target sites in live animals.

    Methods in molecular biology (Clifton, N.J.) · 2011 · 732: 169-85

    MicroRNAs (miRNAs) are small RNA molecules that posttranscriptionally regulate the expression of protein-coding genes. The mature miRNAs are loaded into Argonaute-containing protein complexes (miRISC, miRNA Induced S ilencing Complex), and guide these complexes to the 3' UTR of targeted mRNA …

    PMID 21431713 DOI ↗

  16. LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in Caenorhabditis elegans.

    Nature structural & molecular biology · 2011 · 18(3): 302-8

    The highly conserved let-7 microRNA (miRNA) regulates developmental pathways across animal phyla. Mis-expression of let-7 causes lethality in C. elegans and has been associated with several human diseases. We show that timing of let-7 expression in developing worms is under …

    PMID 21297634 DOI ↗

  17. A distinct microRNA signature for definitive endoderm derived from human embryonic stem cells.

    Stem cells and development · 2010 · 19(6): 797-807

    Human embryonic stem cells (hESCs) have the potential to differentiate into many adult cell types, and they are being explored as a resource for cell replacement therapies for multiple diseases. In order to optimize in vitro differentiation protocols, it will …

    PMID 19807270 DOI ↗

  18. Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans.

    Nature structural & molecular biology · 2010 · 17(2): 173-9

    MicroRNAs (miRNAs) regulate gene expression by guiding Argonaute proteins to specific target mRNA sequences. Identification of bona fide miRNA target sites in animals is challenging because of uncertainties regarding the base-pairing requirements between miRNA and target as well as the …

    PMID 20062054 DOI ↗

  19. Deep sequencing identifies new and regulated microRNAs in Schmidtea mediterranea.

    RNA (New York, N.Y.) · 2009 · 15(8): 1483-91

    MicroRNAs (miRNAs) play important roles in directing the differentiation of cells down a variety of cell lineage pathways. The planarian Schmidtea mediterranea can regenerate all lost body tissue after amputation due to a population of pluripotent somatic stem cells called …

    PMID 19553344 DOI ↗

  20. Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells.

    Human molecular genetics · 2008 · 17(R1): R67-75

    Elucidating the molecular changes that arise during neural differentiation and fate specification is crucial for building accurate in vitro models of neurodegenerative diseases using human embryonic stem cells (hESCs). Here we review the importance of hESCs and derived progenitors in …

    PMID 18632700 DOI ↗

Datasets 10

GSE136911 GSE · GEO

small RNA Seq of Subcutaneous adipose tissue from endothelial-AGO1-knockout (EC-AGO1-KO) mice and wild-type (WT) littermates fed 16 week of high fat high sucrose diet

Mus musculus · GPL17021

GSE102497 GSE · GEO

Systematic discovery of RNA binding proteins that control microRNA processing

Homo sapiens · GPL20301

GSE16689 GSE · GEO

MicroRNA expression data from differentiation of human H9 ESCs into definitive endoderm on MEF feeder layers

Homo sapiens · GPL8733

GSE39855 GSE · GEO

LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance (splicing array)

Homo sapiens · GPL15106

GSE16687 GSE · GEO

MicroRNA expression data from differentiation of human Cyt49 ESCs into definitive endoderm on MEF feeder layers

Homo sapiens · GPL8733

GSE90650 GSE · GEO

The LncRNA NEAT1 Nests RNA Binding Proteins and the Microprocessor to Globally Enhance Pri-miRNA Processing

Homo sapiens · GPL20301

GSE16678 GSE · GEO

MicroRNA expression data from differentiation of human Cyt49 ESCs into definitive endoderm in feeder-free conditions

Homo sapiens · GPL8733

GSE178259 GSE · GEO

Non-microRNA Binding Competitively Inhibits LIN28 Regulation

Mus musculus · GPL20301

GSE16690 GSE · GEO

A distinct microRNA signature for definitive endoderm derived from human embryonic stem cells

Homo sapiens · GPL7363

GSE39872 GSE · GEO

LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance (HTS)

Homo sapiens · GPL9052

Analyses 7

GSE178259 Processing Pipeline

GSE178259 · 6 steps · RNA-Seq · code_examples

Non-microRNA binding competitively inhibits LIN28 regulation. (2021)

GSE102497 Processing Pipeline

GSE102497 · 5 steps · miRNA-Seq · code_examples

Systematic Discovery of RNA Binding Proteins that Regulate MicroRNA Levels. (2018)

GSE16678 Processing Pipeline

GSE16678 · 7 steps · GSE · code_examples

A distinct microRNA signature for definitive endoderm derived from human embryonic stem cells. (2010)

GSE16681 Processing Pipeline

GSE16681 · 1 step · GSE · code_examples

A distinct microRNA signature for definitive endoderm derived from human embryonic stem cells. (2010)

GSE16687 Processing Pipeline

GSE16687 · 7 steps · GSE · code_examples

A distinct microRNA signature for definitive endoderm derived from human embryonic stem cells. (2010)

GSE16689 Processing Pipeline

GSE16689 · 7 steps · GSE · code_examples

A distinct microRNA signature for definitive endoderm derived from human embryonic stem cells. (2010)

GSE16690 Processing Pipeline

GSE16690 · 7 steps · GSE · code_examples

A distinct microRNA signature for definitive endoderm derived from human embryonic stem cells. (2010)