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3 results for “scRNA-seq”

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  1. Computational cell-cell interaction technologies drive mechanistic and biomarker discovery in the tumor microenvironment.

    Current opinion in biotechnology · 2024 · 85: 103048

    Complex networks of cell-cell interactions (CCIs) within the tumor microenvironment (TME) play a crucial role in cancer persistence. These communication axes represent prime targets for therapeutic intervention, but our incomplete understanding of the cellular heterogeneity and interacting partners within the …

    PMID 38142648 DOI ↗

  2. Heterogenous Populations of Tissue-Resident CD8<sup>+</sup> T Cells Are Generated in Response to Infection and Malignancy.

    Immunity · 2020 · 52(5): 808-824.e7

    Tissue-resident memory CD8<sup>+</sup> T cells (Trm) provide host protection through continuous surveillance of non-lymphoid tissues. Using single-cell RNA-sequencing (scRNA-seq) and genetic reporter mice, we identified discrete lineages of intestinal antigen-specific CD8<sup>+</sup> T cells, including a Blimp1<sup>hi</sup>Id3<sup>lo</sup> tissue-resident effector cell population …

    PMID 32433949 DOI ↗

  3. Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells.

    Frontiers in molecular neuroscience · 2018 · 11: 261

    The human brain is composed of a complex assembly of about 171 billion heterogeneous cellular units (86 billion neurons and 85 billion non-neuronal glia cells). A comprehensive description of brain cells is necessary to understand the nervous system in health …

    PMID 30147644 DOI ↗

Datasets 15

GSE315443 GSE · GEO

MBNL2 dysfunction in outer radial glial cells is associated with disrupted corticogenesis in congenital myotonic dystrophy [scRNA-Seq]

GPL24676

GSE314059 GSE · GEO

Single-cell and isoform-specific translational profiling of the mouse brain with long-read sequencing [scRNA-Seq, longread]

GPL34585

GSE314058 GSE · GEO

Single-cell and isoform-specific translational profiling of the mouse brain [scRNA-seq]

GPL34475

GSE122713 GSE · GEO

scRNA-seq, bulk RNA-seq, and ATAC-seq data from progenitor exhausted and terminally exhausted CD8+ T cells from tumors and chronic viral infection

Mus musculus · GPL19057

GSE162335 GSE · GEO

Transcriptional Survey of Ileal-Anal Pouch Immune Cells from Ulcerative Colitis

Homo sapiens · GPL20301

GSE147263 GSE · GEO

RNA-Seq of CD8+ T cell subsets in B16-GP33 tumor

Mus musculus · GPL17021

GSE155726 GSE · GEO

Robust single-cell discovery of RNA targets of RNA binding proteins and ribosomes [scRNA-seq]

Homo sapiens · GPL24676

GSE220461 GSE · GEO

Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size (scRNA-seq)

Mus musculus · GPL21103

GSE201891 GSE · GEO

MECP2-related pathways are dysregulated in a cortical organoid model of Myotonic dystrophy [scRNA-Seq]

Homo sapiens · GPL24676

GSE147021 GSE · GEO

RNA-Seq of CD8+ T cell subsets during LCMV infection I

Mus musculus · GPL17021

GSE125527 GSE · GEO

Single-Cell Analyses Elucidate the Cellular and Molecular Landscape of Ulcerative Colitis

Homo sapiens · GPL20301

GSE203086 GSE · GEO

The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression (scRNA-Seq)

Mus musculus · GPL21103

GSE213470 GSE · GEO

Gene expression profiles at the single cell level of CD8+ T cells from the spleens of LCMV-Armstrong or LCMV-Clone 13 infected mice

Mus musculus · GPL19057

GSE147080 GSE · GEO

RNA-Seq of CD8+ T cell subsets during LCMV infection II

Mus musculus · GPL17021

GSE147081 GSE · GEO

Single Cell RNA-Seq of CD8+ T cell subsets responding to tumor

Mus musculus · GPL21103

Analyses 18

GSE244832 scRNA-seq Data Processing

GSE244832 · 9 steps · scRNA-seq · geo_data_processing

RNA-binding protein LARP6 coordinates hepatic stellate cell activation and liver fibrosis. (2026)

GSE314058 scRNA-seq Data Processing

GSE314058 · 7 steps · scRNA-seq · geo_data_processing

Single-cell and isoform-specific translational profiling of the mouse brain. (2026)

GSE314059 scRNA-seq Data Processing

GSE314059 · 4 steps · scRNA-seq · geo_data_processing

Single-cell and isoform-specific translational profiling of the mouse brain. (2026)

GSE315443 scRNA-seq Data Processing

GSE315443 · 2 steps · scRNA-seq · geo_data_processing

MBNL2 dysfunction in outer radial glial cells is associated with disrupted corticogenesis in congenital myotonic dystrophy. (2026)

GSE247544 scRNA-seq Data Processing

GSE247544 · 3 steps · scRNA-seq · geo_data_processing

Foxo1 regulates intestinal tissue-resident memory CD8 T cell biology in an anatomic compartment- and context-specific manner. (2025)

GSE143437 scRNA-seq Data Processing

GSE143437 · 7 steps · scRNA-seq · geo_data_processing

Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and remodeling. (2024)

GSE220461 Processing Pipeline

GSE220461 · 1 step · RNA-Seq · code_examples

Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size. (2024)

GSE154778 scRNA-seq Data Processing

GSE154778 · 1 step · scRNA-seq · geo_data_processing

A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer. (2023)

GSE162335 scRNA-seq Data Processing

GSE162335 · 2 steps · scRNA-seq · geo_data_processing

RNA binding protein DDX5 restricts RORγt<sup>+</sup> T<sub>reg</sub> suppressor function to promote intestine inflammation. (2023)

GSE205549 scRNA-seq Data Processing

GSE205549 · 3 steps · scRNA-seq · geo_data_processing

Small intestine and colon tissue-resident memory CD8<sup>+</sup> T cells exhibit molecular heterogeneity and differential dependence on Eomes. (2023)

GSE205941 scRNA-seq Data Processing

GSE205941 · 5 steps · scRNA-seq · geo_data_processing

Small intestine and colon tissue-resident memory CD8<sup>+</sup> T cells exhibit molecular heterogeneity and differential dependence on Eomes. (2023)

GSE205942 scRNA-seq Data Processing

GSE205942 · 3 steps · scRNA-seq · geo_data_processing

Small intestine and colon tissue-resident memory CD8<sup>+</sup> T cells exhibit molecular heterogeneity and differential dependence on Eomes. (2023)

GSE213470 scRNA-seq Data Processing

GSE213470 · 2 steps · scRNA-seq · geo_data_processing

Early transcriptional and epigenetic divergence of CD8+ T cells responding to acute versus chronic infection. (2023)

GSE201891 Processing Pipeline

GSE201891 · 3 steps · RNA-Seq · code_examples

MECP2-related pathways are dysregulated in a cortical organoid model of myotonic dystrophy. (2022)

GSE203086 Processing Pipeline

GSE203086 · 10 steps · RNA-Seq · code_examples

The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression. (2022)

GSE203092 scRNA-seq Data Processing

GSE203092 · 10 steps · scRNA-seq · geo_data_processing

The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression. (2022)

GSE155726 Processing Pipeline

GSE155726 · 12 steps · RNA-Seq · code_examples

Robust single-cell discovery of RNA targets of RNA-binding proteins and ribosomes. (2021)

GSE122713 Processing Pipeline

GSE122713 · 3 steps · GSE · code_examples

Heterogenous Populations of Tissue-Resident CD8<sup>+</sup> T Cells Are Generated in Response to Infection and Malignancy. (2020)