Discovery and functional interrogation of SARS-CoV-2 protein-RNA interactions.
Joy S Xiang, Jasmine R Mueller, En-Ching Luo, Brian A Yee, Danielle Schafer, Jonathan C Schmok, Frederick E Tan, Katherine Rothamel, Rachael N McVicar, Elizabeth M Kwong, Ben A Croker, Krysten L Jones, Hsuan-Lin Her, Chun-Yuan Chen, Anthony Q Vu, Wenhao Jin, Samuel S Park, Phuong Le, Kristopher W Brannan, Eric R Kofman, Yanhua Li, Alexandra T Tankka, Kevin D Dong, Yan Song, Alex E Clark, Aaron F Carlin, Eric L Van Nostrand, Sandra L Leibel, Gene W Yeo
Research square · 2022
Abstract
The COVID-19 pandemic is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The betacoronvirus has a positive sense RNA genome which encodes for several RNA binding proteins. Here, we use enhanced crosslinking and immunoprecipitation to investigate SARS-CoV-2 protein interactions with viral and host RNAs in authentic virus-infected cells. SARS-CoV-2 proteins, NSP8, NSP12, and nucleocapsid display distinct preferences to specific regions in the RNA viral genome, providing evidence for their shared and separate roles in replication, transcription, and viral packaging. SARS-CoV-2 proteins expressed in human lung epithelial cells bind to 4773 unique host coding RNAs. Nine SARS-CoV-2 proteins upregulate target gene expression, including NSP12 and ORF9c, whose RNA substrates are associated with pathways in protein N-linked glycosylation ER processing and mitochondrial processes. Furthermore, siRNA knockdown of host genes targeted by viral proteins in human lung organoid cells identify potential antiviral host targets across different SARS-CoV-2 variants. Conversely, NSP9 inhibits host gene expression by blocking mRNA export and dampens cytokine productions, including interleukin-1α/β. Our viral protein-RNA interactome provides a catalog of potential therapeutic targets and offers insight into the etiology of COVID-19 as a safeguard against future pandemics.
Linked datasets 4
Discovery and functional interrogation of the virus and host RNA interactome of SARS-CoV-2 proteins [eCLIP]
Homo sapiens
299 data files
| File | Type | Size |
|---|---|---|
| E-IN1_S86_L002_R1_001.fastq.gz | OTHER | 525.9 MB |
| E-IN2_S87_L002_R1_001.fastq.gz | OTHER | 766.1 MB |
| E-IP1_S65_L002_R1_001.fastq.gz | OTHER | 2.1 GB |
| E-IP2_S66_L002_R1_001.fastq.gz | OTHER | 1.1 GB |
| M-IN1_S53_L002_R1_001.fastq.gz | OTHER | 519.3 MB |
| M-IN2_S54_L002_R1_001.fastq.gz | OTHER | 537.8 MB |
| M-IP1_S97_L002_R1_001.fastq.gz | OTHER | 661.8 MB |
| M-IP2_S98_L002_R1_001.fastq.gz | OTHER | 605.7 MB |
| N-IN1_S74_L002_R1_001.fastq.gz | OTHER | 406.4 MB |
| N-IN2_S76_L002_R1_001.fastq.gz | OTHER | 560.1 MB |
| N-IP1_S75_L002_R1_001.fastq.gz | OTHER | 474.7 MB |
| N-IP2_S77_L002_R1_001.fastq.gz | OTHER | 798.6 MB |
| nsp10-IN1__S63_L002_R1_001.fastq.gz | OTHER | 743.9 MB |
| nsp10-IN1_S64_L002_R1_001.fastq.gz | OTHER | 1.1 GB |
| nsp10-IP1_S103_L002_R1_001.fastq.gz | OTHER | 813.4 MB |
| nsp10-IP2_S104_L002_R1_001.fastq.gz | OTHER | 721.5 MB |
| Nsp11-1-IN_S28_L007_R1_001.fastq.gz | OTHER | 407.0 MB |
| NSP11_1_IP_S47_L003_R1_001.fastq.gz | OTHER | 734.6 MB |
| NSP11_2_iN_S18_L003_R1_001.fastq.gz | OTHER | 847.0 MB |
| NSP11_2_IP_S44_L003_R1_001.fastq.gz | OTHER | 727.6 MB |
| NSP1-1-IN_S1_L002_R1_001.fastq.gz | OTHER | 343.2 MB |
| NSP1-1-IP_S2_L002_R1_001.fastq.gz | OTHER | 1.4 GB |
| nsp12-1-IN_S24_L004_R1_001.fastq.gz | OTHER | 1.9 GB |
| nsp12-1-IP_S42_L004_R1_001.fastq.gz | OTHER | 1.4 GB |
| nsp12-2-IN_S26_L004_R1_001.fastq.gz | OTHER | 2.6 GB |
| nsp12-2-IP_S43_L004_R1_001.fastq.gz | OTHER | 1.4 GB |
| NSP1-2-IP_S4_L002_R1_001.fastq.gz | OTHER | 533.0 MB |
| NSP13_1_IN_S36_L003_R1_001.fastq.gz | OTHER | 811.0 MB |
| NSP13_1_IP_S45_L003_R1_001.fastq.gz | OTHER | 771.9 MB |
| Nsp13-2-IN_S29_L007_R1_001.fastq.gz | OTHER | 388.5 MB |
| NSP13_2_IP_S38_L003_R1_001.fastq.gz | OTHER | 804.8 MB |
| NSP14_1_IN_S2_L003_R1_001.fastq.gz | OTHER | 717.5 MB |
| NSP14_1_IP_S31_L003_R1_001.fastq.gz | OTHER | 641.1 MB |
| NSP14_2_iN_S3_L003_R1_001.fastq.gz | OTHER | 810.5 MB |
| NSP14_2_IP_S22_L003_R1_001.fastq.gz | OTHER | 719.3 MB |
| nsp15-IN1_S78_L002_R1_001.fastq.gz | OTHER | 307.1 MB |
| nsp15-IN2_S79_L002_R1_001.fastq.gz | OTHER | 673.1 MB |
| nsp15-IP1_S45_L002_R1_001.fastq.gz | OTHER | 613.1 MB |
| nsp15-IP2_S46_L002_R1_001.fastq.gz | OTHER | 470.8 MB |
| NSP16-1-IN_S9_L002_R1_001.fastq.gz | OTHER | 442.0 MB |
| NSP16-1-IP_S10_L002_R1_001.fastq.gz | OTHER | 465.3 MB |
| NSP16-2-IN_S11_L002_R1_001.fastq.gz | OTHER | 389.8 MB |
| NSP16-2-IP_S12_L002_R1_001.fastq.gz | OTHER | 436.8 MB |
| nsp2-1-IN_S3_L004_R1_001.fastq.gz | OTHER | 1.8 GB |
| nsp2-1-IP_S8_L004_R1_001.fastq.gz | OTHER | 1.6 GB |
| nsp2-2-IN_S4_L004_R1_001.fastq.gz | OTHER | 1.7 GB |
| nsp2-2-IP_S11_L004_R1_001.fastq.gz | OTHER | 1.6 GB |
| nsp3-1-IN_S5_L004_R1_001.fastq.gz | OTHER | 1.8 GB |
| nsp3-1-IP_S9_L004_R1_001.fastq.gz | OTHER | 1.9 GB |
| nsp3-2-IN_S6_L004_R1_001.fastq.gz | OTHER | 1.8 GB |
| nsp3-2-IP_S12_L004_R1_001.fastq.gz | OTHER | 1.6 GB |
| NSP4_1_IN_S5_L003_R1_001.fastq.gz | OTHER | 743.2 MB |
| Nsp4-1-IP_S27_L007_R1_001.fastq.gz | OTHER | 396.0 MB |
| NSP4_2_iN_S4_L003_R1_001.fastq.gz | OTHER | 731.3 MB |
| NSP4_2_IP_S28_L003_R1_001.fastq.gz | OTHER | 737.6 MB |
| nsp5-1-IN_S20_L004_R1_001.fastq.gz | OTHER | 1.1 GB |
| nsp5-1-IP_S44_L004_R1_001.fastq.gz | OTHER | 1.7 GB |
| nsp5-2-IN_S17_L004_R1_001.fastq.gz | OTHER | 1.9 GB |
| nsp5-2-IP_S39_L004_R1_001.fastq.gz | OTHER | 2.7 GB |
| nsp5_C145A-IN1_S47_L002_R1_001.fastq.gz | OTHER | 557.6 MB |
| nsp5_C145A-IN2_S49_L002_R1_001.fastq.gz | OTHER | 628.0 MB |
| nsp5_C145A-IP1_S48_L002_R1_001.fastq.gz | OTHER | 522.0 MB |
| nsp5_C145A-IP2_S50_L002_R1_001.fastq.gz | OTHER | 528.5 MB |
| nsp6-1-IN_S2_L004_R1_001.fastq.gz | OTHER | 1.6 GB |
| nsp6-1-IP_S10_L004_R1_001.fastq.gz | OTHER | 1.6 GB |
| nsp6-2-IN_S1_L004_R1_001.fastq.gz | OTHER | 1.7 GB |
| nsp6-2-IP_S7_L004_R1_001.fastq.gz | OTHER | 1.9 GB |
| nsp7-1-IN_S13_L004_R1_001.fastq.gz | OTHER | 968.5 MB |
| nsp7-1-IP_S16_L004_R1_001.fastq.gz | OTHER | 829.7 MB |
| nsp7-2-IN_S14_L004_R1_001.fastq.gz | OTHER | 1.8 GB |
| nsp7-2-IP_S15_L004_R1_001.fastq.gz | OTHER | 1.2 GB |
| NSP8_1_IN_S35_L003_R1_001.fastq.gz | OTHER | 649.7 MB |
| NSP8_1_IP_S39_L003_R1_001.fastq.gz | OTHER | 1.0 GB |
| NSP8_2_iN_S33_L003_R1_001.fastq.gz | OTHER | 757.6 MB |
| NSP8_2_IP_S43_L003_R1_001.fastq.gz | OTHER | 942.8 MB |
| nsp8-IP2_S57_L002_R1_001.fastq.InvRNA2.fq.gz | OTHER | 407.6 MB |
| nsp9-1-IN_S5_L001_R1_001.fastq.gz | OTHER | 958.0 MB |
| nsp9-1-IP_S36_L001_R1_001.fastq.gz | OTHER | 775.2 MB |
| nsp9-2-IN_S4_L001_R1_001.fastq.gz | OTHER | 872.3 MB |
| nsp9-2-IP_S31_L001_R1_001.fastq.gz | OTHER | 1.1 GB |
| ORF10_1_IN_S14_L003_R1_001.fastq.gz | OTHER | 661.7 MB |
| ORF10_1_IP_S48_L003_R1_001.fastq.gz | OTHER | 673.3 MB |
| ORF10_2_iN_S7_L003_R1_001.fastq.gz | OTHER | 738.7 MB |
| ORF10_2_IP_S41_L003_R1_001.fastq.gz | OTHER | 762.8 MB |
| ORF3a-IN1_S82_L002_R1_001.fastq.gz | OTHER | 481.0 MB |
| ORF3a-IN2_S81_L002_R1_001.fastq.gz | OTHER | 538.6 MB |
| ORF3a-IP1_S51_L002_R1_001.fastq.gz | OTHER | 601.0 MB |
| ORF3a-IP2_S52_L002_R1_001.fastq.gz | OTHER | 632.0 MB |
| orf3b-1-IN_S23_L004_R1_001.fastq.gz | OTHER | 1.3 GB |
| orf3b-1-IP_S46_L004_R1_001.fastq.gz | OTHER | 1.2 GB |
| orf3b-2-IN_S22_L004_R1_001.fastq.gz | OTHER | 1.9 GB |
| orf3b-2-IP_S40_L004_R1_001.fastq.gz | OTHER | 1.5 GB |
| ORF6-IN1_S88_L002_R1_001.fastq.gz | OTHER | 512.9 MB |
| ORF6-IN2_S89_L002_R1_001.fastq.gz | OTHER | 522.2 MB |
| ORF6-IP1_S67_L002_R1_001.fastq.gz | OTHER | 874.8 MB |
| ORF6-IP2_S68_L002_R1_001.fastq.gz | OTHER | 956.5 MB |
| ORF7a-IN1_S59_L002_R1_001.fastq.gz | OTHER | 1.9 GB |
| ORF7a-IN2_S60_L002_R1_001.fastq.gz | OTHER | 1.3 GB |
| ORF7a-IP1_S101_L002_R1_001.fastq.gz | OTHER | 590.3 MB |
| ORF7a-IP2_S102_L002_R1_001.fastq.gz | OTHER | 774.5 MB |
| orf7b-1-IN_S29_L004_R1_001.fastq.gz | OTHER | 1.8 GB |
| orf7b-1-IP_S52_L004_R1_001.fastq.gz | OTHER | 1.5 GB |
| orf7b-2-IN_S21_L004_R1_001.fastq.gz | OTHER | 1.8 GB |
| orf7b-2-IP_S38_L004_R1_001.fastq.gz | OTHER | 1.6 GB |
| orf8-1-IN_S47_L004_R1_001.fastq.gz | OTHER | 1.3 GB |
| orf8-1-IP_S57_L004_R1_001.fastq.gz | OTHER | 1.6 GB |
| orf8-2-IN_S37_L004_R1_001.fastq.gz | OTHER | 1.3 GB |
| orf8-2-IP_S55_L004_R1_001.fastq.gz | OTHER | 1.5 GB |
| orf9b-1-IN_S30_L004_R1_001.fastq.gz | OTHER | 1.2 GB |
| orf9b-1-IP_S54_L004_R1_001.fastq.gz | OTHER | 1.2 GB |
| orf9b-2-IN_S32_L004_R1_001.fastq.gz | OTHER | 1.5 GB |
| orf9b-2-IP_S41_L004_R1_001.fastq.gz | OTHER | 3.2 GB |
| orf9c-1-IN_S27_L004_R1_001.fastq.gz | OTHER | 2.4 GB |
| orf9c-1-IP_S34_L004_R1_001.fastq.gz | OTHER | 1.6 GB |
| orf9c-2-IN_S35_L004_R1_001.fastq.gz | OTHER | 1.7 GB |
| orf9c-2-IP_S53_L004_R1_001.fastq.gz | OTHER | 1.8 GB |
| SPIKE_1_IN_S16_L003_R1_001.fastq.gz | OTHER | 750.8 MB |
| SPIKE_1_IP_S42_L003_R1_001.fastq.gz | OTHER | 1002.8 MB |
| SPIKE_2_iN_S17_L003_R1_001.fastq.gz | OTHER | 675.1 MB |
| SPIKE_2_IP_S34_L003_R1_001.fastq.gz | OTHER | 668.7 MB |
| SRR14343981_GSM5268670 | OTHER | 1.4 GB |
| SRR14343982_GSM5268671 | OTHER | 533.0 MB |
| SRR14343983_GSM5268672 | OTHER | 1.6 GB |
| SRR14343984_GSM5268673 | OTHER | 1.6 GB |
| SRR14343985_GSM5268674 | OTHER | 1.9 GB |
| SRR14343986_GSM5268675 | OTHER | 1.6 GB |
| SRR14343987_GSM5268676 | OTHER | 396.0 MB |
| SRR14343988_GSM5268677 | OTHER | 737.0 MB |
| SRR14343989_GSM5268678 | OTHER | 1.7 GB |
| SRR14343990_GSM5268679 | OTHER | 2.7 GB |
| SRR14343991_GSM5268680 | OTHER | 522.0 MB |
| SRR14343992_GSM5268681 | OTHER | 528.0 MB |
| SRR14343993_GSM5268682 | OTHER | 1.6 GB |
| SRR14343994_GSM5268683 | OTHER | 1.9 GB |
| SRR14343995_GSM5268684 | OTHER | 829.0 MB |
| SRR14343996_GSM5268685 | OTHER | 1.2 GB |
| SRR14343997_GSM5268686 | OTHER | 1.0 GB |
| SRR14343998_GSM5268687 | OTHER | 942.0 MB |
| SRR14343999_GSM5268688 | OTHER | 775.0 MB |
| SRR14344000_GSM5268689 | OTHER | 1.1 GB |
| SRR14344001_GSM5268690 | OTHER | 813.0 MB |
| SRR14344002_GSM5268691 | OTHER | 721.0 MB |
| SRR14344003_GSM5268692 | OTHER | 734.0 MB |
| SRR14344004_GSM5268693 | OTHER | 727.0 MB |
| SRR14344005_GSM5268694 | OTHER | 1.4 GB |
| SRR14344006_GSM5268695 | OTHER | 1.4 GB |
| SRR14344007_GSM5268696 | OTHER | 771.0 MB |
| SRR14344008_GSM5268697 | OTHER | 804.0 MB |
| SRR14344009_GSM5268698 | OTHER | 641.0 MB |
| SRR14344010_GSM5268699 | OTHER | 719.0 MB |
| SRR14344011_GSM5268700 | OTHER | 613.0 MB |
| SRR14344012_GSM5268701 | OTHER | 470.0 MB |
| SRR14344013_GSM5268702 | OTHER | 465.0 MB |
| SRR14344014_GSM5268703 | OTHER | 436.0 MB |
| SRR14344015_GSM5268704 | OTHER | 1002.0 MB |
| SRR14344016_GSM5268705 | OTHER | 668.0 MB |
| SRR14344017_GSM5268706 | OTHER | 601.0 MB |
| SRR14344018_GSM5268707 | OTHER | 631.0 MB |
| SRR14344019_GSM5268708 | OTHER | 1.2 GB |
| SRR14344020_GSM5268709 | OTHER | 1.5 GB |
| SRR14344021_GSM5268710 | OTHER | 2.1 GB |
| SRR14344022_GSM5268711 | OTHER | 1.1 GB |
| SRR14344023_GSM5268712 | OTHER | 661.0 MB |
| SRR14344024_GSM5268713 | OTHER | 605.0 MB |
| SRR14344025_GSM5268714 | OTHER | 874.0 MB |
| SRR14344026_GSM5268715 | OTHER | 956.0 MB |
| SRR14344027_GSM5268716 | OTHER | 590.0 MB |
| SRR14344028_GSM5268717 | OTHER | 774.0 MB |
| SRR14344029_GSM5268718 | OTHER | 1.5 GB |
| SRR14344030_GSM5268719 | OTHER | 1.6 GB |
| SRR14344031_GSM5268720 | OTHER | 1.6 GB |
| SRR14344032_GSM5268721 | OTHER | 1.5 GB |
| SRR14344033_GSM5268722 | OTHER | 474.0 MB |
| SRR14344034_GSM5268723 | OTHER | 798.0 MB |
| SRR14344035_GSM5268724 | OTHER | 1.2 GB |
| SRR14344036_GSM5268725 | OTHER | 3.2 GB |
| SRR14344037_GSM5268726 | OTHER | 1.6 GB |
| SRR14344038_GSM5268727 | OTHER | 1.8 GB |
| SRR14344039_GSM5268728 | OTHER | 673.0 MB |
| SRR14344040_GSM5268729 | OTHER | 762.0 MB |
| SRR14344041_GSM5268730 | OTHER | 884.0 MB |
| SRR14344042_GSM5268731 | OTHER | 407.0 MB |
| SRR14344043_GSM5268732 | OTHER | 1.0 GB |
| SRR14344044_GSM5268733 | OTHER | 1.1 GB |
| SRR14344045_GSM5268734 | OTHER | 689.0 MB |
| SRR14344046_GSM5268735 | OTHER | 447.0 MB |
| SRR14344047_GSM5268736 | OTHER | 393.0 MB |
| SRR14344048_GSM5268737 | OTHER | 686.0 MB |
| SRR14344049_GSM5268738 | OTHER | 1.6 GB |
| SRR14344050_GSM5268739 | OTHER | 1.8 GB |
| SRR14344051_GSM5268740 | OTHER | 2.2 GB |
| SRR14344052_GSM5268741 | OTHER | 2.2 GB |
| SRR14344053_GSM5268742 | OTHER | 3.2 GB |
| SRR14344054_GSM5268743 | OTHER | 1.9 GB |
| SRR14344055_GSM5268744 | OTHER | 343.0 MB |
| SRR14344056_GSM5268745 | OTHER | 1.8 GB |
| SRR14344057_GSM5268746 | OTHER | 1.7 GB |
| SRR14344058_GSM5268747 | OTHER | 1.8 GB |
| SRR14344059_GSM5268748 | OTHER | 1.8 GB |
| SRR14344060_GSM5268749 | OTHER | 743.0 MB |
| SRR14344061_GSM5268750 | OTHER | 731.0 MB |
| SRR14344062_GSM5268751 | OTHER | 1.1 GB |
| SRR14344063_GSM5268752 | OTHER | 1.9 GB |
| SRR14344064_GSM5268753 | OTHER | 557.0 MB |
| SRR14344065_GSM5268754 | OTHER | 627.0 MB |
| SRR14344066_GSM5268755 | OTHER | 1.6 GB |
| SRR14344067_GSM5268756 | OTHER | 1.7 GB |
| SRR14344068_GSM5268757 | OTHER | 968.0 MB |
| SRR14344069_GSM5268758 | OTHER | 1.8 GB |
| SRR14344070_GSM5268759 | OTHER | 649.0 MB |
| SRR14344071_GSM5268760 | OTHER | 757.0 MB |
| SRR14344072_GSM5268761 | OTHER | 957.0 MB |
| SRR14344073_GSM5268762 | OTHER | 872.0 MB |
| SRR14344074_GSM5268763 | OTHER | 1.1 GB |
| SRR14344075_GSM5268764 | OTHER | 743.0 MB |
| SRR14344076_GSM5268765 | OTHER | 407.0 MB |
| SRR14344077_GSM5268766 | OTHER | 847.0 MB |
| SRR14344078_GSM5268767 | OTHER | 1.9 GB |
| SRR14344079_GSM5268768 | OTHER | 2.6 GB |
| SRR14344080_GSM5268769 | OTHER | 810.0 MB |
| SRR14344081_GSM5268770 | OTHER | 388.0 MB |
| SRR14344082_GSM5268771 | OTHER | 717.0 MB |
| SRR14344083_GSM5268772 | OTHER | 810.0 MB |
| SRR14344084_GSM5268773 | OTHER | 307.0 MB |
| SRR14344084.lite | OTHER | 307.1 MB |
| SRR14344085_GSM5268774 | OTHER | 673.0 MB |
| SRR14344086_GSM5268775 | OTHER | 442.0 MB |
| SRR14344087_GSM5268776 | OTHER | 389.0 MB |
| SRR14344088_GSM5268777 | OTHER | 750.0 MB |
| SRR14344089_GSM5268778 | OTHER | 675.0 MB |
| SRR14344090_GSM5268779 | OTHER | 480.0 MB |
| SRR14344091_GSM5268780 | OTHER | 538.0 MB |
| SRR14344092_GSM5268781 | OTHER | 1.3 GB |
| SRR14344093_GSM5268782 | OTHER | 1.9 GB |
| SRR14344093.lite | OTHER | 1.9 GB |
| SRR14344094_GSM5268783 | OTHER | 525.0 MB |
| SRR14344095_GSM5268784 | OTHER | 766.0 MB |
| SRR14344096_GSM5268785 | OTHER | 519.0 MB |
| SRR14344097_GSM5268786 | OTHER | 537.0 MB |
| SRR14344098_GSM5268787 | OTHER | 512.0 MB |
| SRR14344098.lite | OTHER | 512.9 MB |
| SRR14344099_GSM5268788 | OTHER | 522.0 MB |
| SRR14344100_GSM5268789 | OTHER | 1.9 GB |
| SRR14344101_GSM5268790 | OTHER | 1.3 GB |
| SRR14344102_GSM5268791 | OTHER | 1.8 GB |
| SRR14344103_GSM5268792 | OTHER | 1.8 GB |
| SRR14344104_GSM5268793 | OTHER | 1.3 GB |
| SRR14344105_GSM5268794 | OTHER | 1.3 GB |
| SRR14344106_GSM5268795 | OTHER | 406.0 MB |
| SRR14344107_GSM5268796 | OTHER | 560.0 MB |
| SRR14344108_GSM5268797 | OTHER | 1.2 GB |
| SRR14344109_GSM5268798 | OTHER | 1.5 GB |
| SRR14344110_GSM5268799 | OTHER | 2.4 GB |
| SRR14344110.lite | OTHER | 2.4 GB |
| SRR14344111_GSM5268800 | OTHER | 1.7 GB |
| SRR14344112_GSM5268801 | OTHER | 661.0 MB |
| SRR14344113_GSM5268802 | OTHER | 738.0 MB |
| SRR14344114_GSM5268803 | OTHER | 580.0 MB |
| SRR14344115_GSM5268804 | OTHER | 494.0 MB |
| SRR14344116_GSM5268805 | OTHER | 459.0 MB |
| SRR14344117_GSM5268806 | OTHER | 569.0 MB |
| SRR14344118_GSM5268807 | OTHER | 631.0 MB |
| SRR14344119_GSM5268808 | OTHER | 765.0 MB |
| SRR14344120_GSM5268809 | OTHER | 610.0 MB |
| SRR14344121_GSM5268810 | OTHER | 558.0 MB |
| SRR14344122_GSM5268811 | OTHER | 1.9 GB |
| SRR14344123_GSM5268812 | OTHER | 1.4 GB |
| SRR14344124_GSM5268813 | OTHER | 2.0 GB |
| SRR14344125_GSM5268814 | OTHER | 2.0 GB |
| SRR14344126_GSM5268815 | OTHER | 2.3 GB |
| SRR14344127 | OTHER | 2.7 GB |
| SRR14344127_GSM5268816 | OTHER | 2.7 GB |
| Vero_N-1-IN_S13_L001_R1_001.fastq.gz | OTHER | 1.9 GB |
| Vero_N-1-IP_S5_L001_R1_001.fastq.gz | OTHER | 1.6 GB |
| Vero_N-2-IN_S14_L001_R1_001.fastq.gz | OTHER | 1.4 GB |
| Vero_N-2-IP_S6_L001_R1_001.fastq.gz | OTHER | 1.8 GB |
| Vero_NSP12-1-IN_S11_L001_R1_001.fastq.gz | OTHER | 2.3 GB |
| Vero_NSP12-1-IP_S3_L001_R1_001.fastq.gz | OTHER | 2.2 GB |
| Vero_NSP12-2-IN_S12_L001_R1_001.fastq.gz | OTHER | 2.7 GB |
| Vero_NSP12-2-IP_S4_L001_R1_001.fastq.gz | OTHER | 1.9 GB |
| Vero_NSP8-1-IN_S9_L001_R1_001.fastq.gz | OTHER | 2.0 GB |
| Vero_NSP8-1-IP_S1_L001_R1_001.fastq.gz | OTHER | 2.2 GB |
| Vero_NSP8-2-IN_S10_L001_R1_001.fastq.gz | OTHER | 2.0 GB |
| Vero_NSP8-2-IP_S2_L001_R1_001.fastq.gz | OTHER | 3.2 GB |
| WTH_1_IN_S13_L003_R1_001.fastq.gz | OTHER | 631.3 MB |
| WTH_1_IP_S30_L003_R1_001.fastq.gz | OTHER | 689.2 MB |
| WTH_2_iN_S12_L003_R1_001.fastq.gz | OTHER | 765.8 MB |
| WTH_2_IP_S24_L003_R1_001.fastq.gz | OTHER | 447.4 MB |
| WT-high-IN1_S92_L002_R1_001.fastq.gz | OTHER | 580.9 MB |
| WT-high-IN2_S93_L002_R1_001.fastq.gz | OTHER | 494.1 MB |
| WT-high-IP1_S71_L002_R1_001.fastq.gz | OTHER | 884.3 MB |
| WTL_1_IN_S10_L003_R1_001.fastq.gz | OTHER | 610.6 MB |
| WTL_1_IP_S11_L003_R1_001.fastq.gz | OTHER | 393.3 MB |
| WTL_2_iN_S20_L003_R1_001.fastq.gz | OTHER | 558.5 MB |
| WTL_2_IP_S21_L003_R1_001.fastq.gz | OTHER | 686.8 MB |
| WT-low-IN1_S90_L002_R1_001.fastq.gz | OTHER | 459.6 MB |
| WT-low-IN2_S91_L002_R1_001.fastq.gz | OTHER | 569.8 MB |
| WT-low-IP1_S69_L002_R1_001.fastq.gz | OTHER | 1.0 GB |
| WT-low-IP2_S70_L002_R1_001.fastq.gz | OTHER | 1.1 GB |
Discovery and functional interrogation of the virus and host RNA interactome of SARS-CoV-2 proteins [Ribo-Seq]
Homo sapiens
16 data files
| File | Type | Size |
|---|---|---|
| Ctrl-input-1_S43_L002_R1_001.fastq.gz | OTHER | 1.3 GB |
| Ctrl-input-2_S44_L002_R1_001.fastq.gz | OTHER | 1.3 GB |
| Ctrl-poly-1_S49_L002_R1_001.fastq.gz | OTHER | 2.0 GB |
| Ctrl-poly-2_S50_L002_R1_001.fastq.gz | OTHER | 1.8 GB |
| ORF9c-input-1_S41_L002_R1_001.fastq.gz | OTHER | 1.4 GB |
| ORF9c-input-2_S42_L002_R1_001.fastq.gz | OTHER | 1.6 GB |
| ORF9c-poly-1_S47_L002_R1_001.fastq.gz | OTHER | 1.6 GB |
| ORF9c-poly-2_S48_L002_R1_001.fastq.gz | OTHER | 1.6 GB |
| SRR18360416_GSM5959190 | OTHER | 1.3 GB |
| SRR18360417_GSM5959189 | OTHER | 1.3 GB |
| SRR18360418_GSM5959188 | OTHER | 1.8 GB |
| SRR18360419_GSM5959187 | OTHER | 2.0 GB |
| SRR18360420_GSM5959186 | OTHER | 1.6 GB |
| SRR18360421_GSM5959185 | OTHER | 1.4 GB |
| SRR18360422_GSM5959184 | OTHER | 1.6 GB |
| SRR18360423_GSM5959183 | OTHER | 1.6 GB |
Discovery and functional interrogation of the virus and host RNA interactome of SARS-CoV-2 proteins
Homo sapiens
Discovery and functional interrogation of the virus and host RNA interactome of SARS-CoV-2 proteins [RNA-Seq]
Homo sapiens
8 data files
| File | Type | Size |
|---|---|---|
| A549-APO-moi-3_S9_L004_R1_001.fastq.gz | RNA-Seq | 11.7 GB |
| SRR14346737_GSM5268956 | RNA-Seq | 11.7 GB |
| SRR14346738_GSM5268957 | RNA-Seq | 14.2 GB |
| SRR14346739_GSM5268958 | RNA-Seq | 635.0 MB |
| SRR14346740_GSM5268959 | RNA-Seq | 6.0 GB |
| Veros-APO-moi-0p1_S1_L004_R1_001.fastq.gz | RNA-Seq | 14.2 GB |
| WT-1__S34_L004_R1_001.fastq.gz | RNA-Seq | 635.4 MB |
| WT-2_S21_L004_R1_001.fastq.gz | RNA-Seq | 6.0 GB |
Potentially related datasets 1
These accessions were text-mined from the PMC full text. They may be referenced for comparison, cited from other studies, or otherwise mentioned without being primary data for this paper.
Funding 4 grants
| Grant | Funder |
|---|---|
| S10 OD026929 | NIH HHS (United States) |
| T32 CA067754 | NCI NIH HHS (United States) |
| R00 HG009530 | NHGRI NIH HHS (United States) |
| K08 AI130381 | NIAID NIH HHS (United States) |