Search publications

4 results for “Diabetes”

Clear

  1. AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation.

    Genes & development · 2020 · 34(19-20): 1330-1344

    Despite being the frontline therapy for type 2 diabetes, the mechanisms of action of the biguanide drug metformin are still being discovered. In particular, the detailed molecular interplays between the AMPK and the mTORC1 pathway in the hepatic benefits of …

    PMID 32912901 DOI ↗

  2. Suppression of Endothelial AGO1 Promotes Adipose Tissue Browning and Improves Metabolic Dysfunction.

    Circulation · 2020 · 142(4): 365-379

    Metabolic disorders such as obesity and diabetes mellitus can cause dysfunction of endothelial cells (ECs) and vascular rarefaction in adipose tissues. However, the modulatory role of ECs in adipose tissue function is not fully understood. Other than vascular endothelial growth …

    PMID 32393053 DOI ↗

  3. Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes.

    Cell reports · 2016 · 15(10): 2200-2213

    Alternative splicing (AS) defects that adversely affect gene expression and function have been identified in diabetic hearts; however, the mechanisms responsible are largely unknown. Here, we show that the RNA-binding protein RBFOX2 contributes to transcriptome changes under diabetic conditions. RBFOX2 …

    PMID 27239029 DOI ↗

  4. Reactivation of fetal splicing programs in diabetic hearts is mediated by protein kinase C signaling.

    The Journal of biological chemistry · 2013 · 288(49): 35372-86

    Diabetic cardiomyopathy is one of the complications of diabetes that eventually leads to heart failure and death. Aberrant activation of PKC signaling contributes to diabetic cardiomyopathy by mechanisms that are poorly understood. Previous reports indicate that PKC is implicated in …

    PMID 24151077 DOI ↗

Datasets 6

GSE68618 GSE · GEO

Aging-dependent demethylation of regulatory elements correlates with chromatin state and improved insulin secretion by pancreatic β cells

Mus musculus · GPL13112

GSE92602 GSE · GEO

Identification of islet-enriched long non-coding RNAs contributing to beta-cell failure in type 2 diabetes

Mus musculus · GPL9250

GSE69889 GSE · GEO

Genome-wide Circadian Control of Transcription at Active Enhancers Regulates Insulin Secretion and Diabetes Risk

Mus musculus · GPL17021

GSE157049 GSE · GEO

RNA-seq of metformin treatment in liver in WT, Raptor Ser-Ala mutant, Tsc2-null, Raptor mutant;Tsc2-null, and Ampk-null

Mus musculus · GPL24247

GSE157048 GSE · GEO

RNA-seq of metformin treatment in primary murine hepatocytes in WT, Raptor Ser-Ala mutant, Tsc2-null, Raptor mutant;Tsc2-null, and Ampk-null cells

Mus musculus · GPL17021

GSE157050 GSE · GEO

Ribosome profiling of metformin treatment in primary murine hepatocytes in WT, Raptor Ser-Ala mutant, Tsc2-null, Raptor mutant;Tsc2-null, and Ampk-null cells

Mus musculus · GPL17021

Analyses 3

GSE69889 Processing Pipeline

GSE69889 · 5 steps · RNA-Seq · code_examples

A role for alternative splicing in circadian control of exocytosis and glucose homeostasis. (2020)

GSE92602 Processing Pipeline

GSE92602 · 5 steps · RNA-Seq · code_examples

A role for alternative splicing in circadian control of exocytosis and glucose homeostasis. (2020)

GSE80664 Processing Pipeline

GSE80664 · 9 steps · RNA-Seq · code_examples

Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes. (2016)